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blockade in Medical News

Protein Blockade For HIV Infection

Scientists have found out that langerin, a protein produced by the human genitalia may have contained the spread of HIV infection//. New transmission can be brought under control by augmenting the activity of langerin. This research was conducted by Teunis Geijtenbeek and his team at Vrije Universi...

Inhibition of morphine tolerance by spinal melanocortin receptor blockade

Recent research suggests that the melanocortin system is an important component influencing the changes in the spinal neuronal plasticity observed after chronic morphine administration//. The chronic use of morphine is accompanied by the development of morphine tolerance, which is one of the maj...

TGen-led team is 1 of 7 selected for $1 million skin-cancer grants

... Krauthammer, M.D., Ph.D., Yale University David Stern, Ph.D., Yale University Combinatorial Immunotherapy for Melanoma with B7-H1/PD-1 Checkpoint blockade Principal Investigators: Team Lead: Drew Pardoll, M.D., Ph.D., Johns Hopkins University Lieping Chen, M.D., Ph.D., Johns Hopkins University Suza...

Accumetrics' VerifyNow(R) P2Y12 Test Provides Physicians With Information to Assess a Patient's Response to Newly-Approved Prasugrel (Effient(R))

...therapy that best achieves the desired antiplatelet effect." Accumetrics' VerifyNow P2Y12 Test is used to measure the level of P2Y12 receptor blockade and has been in used globally to assess a patient's response to both clopidogrel and prasugrel in clinical trials as well as in clinical practice with...

2-drug combination appears safe and active in metastatic kidney cancer

... ORLANDO (May 31, 2009)Fox Chase Cancer Center investigators report that a two-drug blockade of mTOR signaling appears safe in metastatic kidney cancer in a phase I trial. Early data suggests that a combination of temsirolimus and bryostatin m...

A potential new target for treatment of hormone refractory prostate cancer

...he University of Maryland School of Medicine. "However, many patients inevitably develop deadly recurrent cancers, which no longer respond to androgen blockade and are resistant to current therapy." To better understand mechanisms associated with advanced prostate cancer, Dr. Qiu and colleagues performed ...

Cordex Pharma Files ATPace Formulation Patent

...mpetition in the U.S. The maintenance of intact ATP molecules in the solution is critical for the unique bradycardic effects of ATP, in particular its blockade of atrio-ventricular (AV) nodal conduction. Specifically, ATP is believed to have dual inhibitory action, one mediated by adenosine, the product of it...

Cordex Pharma Submits to the FDA an Amended Special Protocol Assessment for ATPace

...nosine 5'-triphosphate (ATP) administered by intravenous injection for the acute termination of PSVT. The bradycardic effect of ATP, in particular its blockade of atrio-ventricular (AV) nodal conduction, has been shown in multiple published clinical studies to safely and effectively terminate re-entrant PSVT ...

Gene mutations increase risk for aggressive prostate cancer

...ich the growth of the cancer is monitored and treatment is held in abeyanceand instead opt for surgery or radiation treatments with or without hormone blockade therapy. For early-stage prostate cancer patients in the general population, knowing they carry the BRCA1 or BRCA2 mutation would also be useful, ...

Support cells, not neurons, lull the brain to sleep

...G), a means of recording brain activity. Mice subjected to the genetic blockade exhibited less sleep pressure than control mice. Following sleep deprivati...eceptors that enable them to respond to adenosine, but only pharmacological blockade of the A1 type of receptor was effective. That result shows that adenosine...
blockade in Medical Technology

Sugammadex Trials Demonstrate Rapid Recovery from Profound Neuromuscular Blockade During General Anesthesia

SAN FRANCISCO, Oct. 16 /PRNewswire/ -- Sugammadex -- the novel selective relaxant binding agent (SRBA) being developed by Organon -- demonstrated a faster recovery from profound neuromuscular blockade as compared to neostigmine in the Phase III pivotal Signal trial.(1) In a second trial, named...

YM BIOSCIENCES ANNOUNCES NIMOTUZUMAB PRESENTATIONS TO BE MADE AT THE 100TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH AND EUROPEAN SOCIETY FOR MEDICAL ONCOLOGY

...r clinical benefit of EGFR-targeting antibodies in general, but only as markers of indiscriminate targeting of that particular antibody, with the EGFR blockade of normal cells by the marketed antibodies disrupting the cell's function. This finding is especially important in view of the recent papers describin...

Cordex Pharma Announces Strategic Master Services Equity Agreement With Cato BioVentures

...nosine 5'-triphosphate (ATP) administered by intravenous injection for the acute termination of PSVT. The bradycardic effect of ATP, in particular its blockade of atrio-ventricular (AV) nodal conduction, has been shown in multiple published clinical studies to safely and effectively terminate re-entrant PSVT ...

Intra-Cellular Therapies Announces Successful Outcome of a Phase II Clinical Trial with ITI-007 in Patients with Sleep Maintenance Insomnia

.... ITI-007 has dual properties; it acts as a post-synaptic antagonist and as a pre-synaptic partial agonist. The combination of ITI-007's high-potency blockade of 5HT2A receptors and unique dopamine receptor activity should allow a personalized approach to patient treatment for schizophrenia by making it poss...

Schering-Plough Highlights R&D Pipeline Progress, Innovation and Breadth of Research Projects

...rcent of patients receiving placebo; BRIDION(R) (sugammadex), the first and only selective relaxant binding agent for reversing neuromuscular blockade in anesthesia (approved in EU; under review in U.S. and Japan); Boceprevir, an oral protease inhibitor for treating hepatitis C with peginterf...

Duska Therapeutics Applies for Phase 3 Special Protocol Assessment

...sphate (ATP) for intravenous injection, is an investigational drug for the acute termination of PSVT. The bradycardic effect of ATP, in particular its blockade of atrio-ventricular (AV) nodal conduction, has been shown in multiple published clinical studies to safely and effectively terminate re-entrant PSVT ...

BRIDION(R) (sugammadex) Injection - First and Only Selective Relaxant Binding Agent - Approved in European Union

... rapidly regain muscle function after surgery and breathe on their own. BRIDION is approved in the European Union (EU) for reversal of neuromuscular blockade induced by rocuronium or vecuronium. In children and adolescents, BRIDION is only recommended for routine reversal of rocuronium induced blockade. I...

Device Blocking Stomach Nerve Signals Shows Promise in Obesity

...ccess to behavioral counseling and dietary modifications, which will lead to a more realistic comparison of the magnitude of weight loss through vagal blockade as compared with bariatric surgery. The findings published this month are promising, but the next study will tell us whether VBLOC therapy is a viable...

New Study Shows BENICAR(R) (olmesartan medoxomil) Reverses Blood Vessel Damage Independent of Blood Pressure Lowering

...an Society of Hypertension demonstrate that early blockade of angiotensin II reversed vascular ...he VIOS trial, olmesartan medoxomil, through early blockade of angiotensin II, improved the structure abnormal... hypertrophy in hypertensive patients through blockade of angiotensin II receptors. J Am Soc Hyperte...

Pharmacyclics Novel Btk Inhibitor Shows Efficacy in Preclinical Models of Rheumatoid Arthritis and Lymphoma

...suggesting that Btk inhibition could be a novel drug target in lymphoma. "This study suggests that treatment with PCI-32765 causes a potent combined blockade of both B-cell and mast cell activation," said Joseph J. Buggy, Ph.D., vice president of research for Pharmacyclics. "This dual blockade may account f...
blockade in Medical Products

Stimuplex® Dig RC Peripheral Nerve Stimulator with Remote Control

Description:... It has always been a dedicated peripheral nerve stimulator, built specifically to enhance your technique and increase success in peripheral nerve blockade of the upper and lower extremities. And, the Stimuplex Dig from B. Braun has always been part of a system approach to peripheral nerve blocks when use...
Company:B. Braun Medical Inc.

Cohen Tip Deflecting Endobronchial Blocker Set

Description:... Used for endobronchial blockade of the left or right lung for procedures which require one-lung ventilation. Supplied sterile in peel-open packages. Intended for one-time use....
Company:Cook Critical Care

Arndt Endobronchial Blocker - Eliptical Balloon

Description:... Used for endobronchial blockade of the left or right lung for procedures which require one-lung ventilation. The set consists of an endobronchial blocker catheter and an Arndt Multip...
Company:Cook Critical Care

Arndt Endobronchial Blocker - Spherical Balloon

Description:... Used for endobronchial blockade of the left or right lung for procedures which require one-lung ventilation. The set consists of an endobronchial blocker catheter and an Arndt Multip...
Company:Cook Critical Care
blockade in Medical Dictionary

Phenytoin overdose

...ht, and conditionName of product as well as the ingredients and strength if knownThe time it was ... In overdose , the extent of sodium channel blockade increases, and phenytoin is ... Phenytoin toxicity : Predictions of clinical course. Vet Hum Toxicol 1989; 31: ... Signs and symptoms of phe...
blockade in Biological News

Burnham researchers present at 100th AACR Meeting

...ition to Dr. Reed, Burnham researchers presenting at the AACR meeting include: Lilach Agemy, Ph.D., who will present Nanoparticle-induced Vascular blockade in Prostate Cancer. Jason Garrison, Ph.D., who will discuss ARTS and Siah Collaborate in a Novel Pathway for XIAP Degradation Shi Ranxin, Ph.D., who...

Cutting-edge amfAR grants fight HIV/AIDS in the lab and on the phone

...lpha to overcome HIV. Understanding these additional cooperative functions may serve as the basis of new therapeutics that either mimic or enhance the blockade of the virus that occurs in monkeys. Dana Gabuzda, M.D. Dana-Farber Cancer Institute, Inc., Boston, MA $120,000 High-throughput screens for i...

La Jolla Institute signs exclusive license agreement with Medimmune on major asthma discovery

...lammation-causing cells to communicate with the rest of the immune system. blockade of interactions of TNF, the first member of the family to be discovered, wi...id arthritis and inflammatory bowel disease. It is therefore possible that blockade of other members of this family, such as OX40L, might benefit some patients...

LSUSHC researchers find potential new target for hypertension treatment

...s, the researchers found that by blocking one of these receptors AT1Rs ACE2 activity increased. In order to determine the relationship between AT1Rs blockade and ACE2, as well as the significance of ACE2, the LSUHSC researchers generated a triple-transgenic mouse model with increased ACE2 on a background of...

Wistar scientists find key to keeping killer T cells in prime shape for fighting infection, cancer

...ociated with an antitumor response. These observations may explain why PD-1 blockade did not completely restore T cell responses in previous work. The invest...reater improvement in T cell responses and viral control compared to either blockade alone. "The goal now is to understand the pathways the receptors contro...

Forgotten but not gone -- how the brain takes care of things

...owever, was that the majority of the appendages which developed in response to the information blockade, continued to exist, despite the fact that the blockade was abolished ", project leader Mark Hbener explains. Everything seems to point to the fact that synapses are only disabled, but not physically remove...

Johnson & Johnson honors 2008 recipients of the Dr. Paul Janssen Award for Biomedical Research

...ted globally. "It is very pleasing that our research defining TNF as a good therapeutic target for rheumatoid arthritis has subsequently led to TNF blockade in Crohn's disease, psoriasis, ankylosing spondylitis and ulcerative colitis," said Feldmann. "Blocking other cytokines such as IL-6 has been succes...

Researchers block damage to fetal brain following maternal alcohol consumption

...in pH in the fetal cerebellar cells and prevented any reduction in the number of these cells. "This study demonstrates that direct pharmacological blockade of TASK 1 and TASK 3 channels protects the most sensitive target of fetal alcohol exposure, cerebellar Purkinje cells," the authors concluded. Fi...

Mitochondrial dysfunction and redox signaling in atrial tachyarrhythmia

...le tachycardia-associated factors appear to contribute to this response, which all are directly or indirectly linked to oxidative stress. Accordingly, blockade of the angiotensin II type 1 receptor, inhibition of L-type calcium channels, inhibition of NADPH oxidase, applications of antioxidants, and inhibitio...

Genetic variant mimics effect of heart failure medications

...locker therapy. Those patients who were given beta-blockers did not experience additional benefits from the medications because their own genetic beta blockade was already protecting them. The researchers say their discovery adds to the accumulating evidence that genetic differences contribute to ...
blockade in Biological Technology

Data Published in Cell Stem Cell Demonstrates Potent Anti-Cancer Activity for OncoMed Pharmaceuticals' Lead Antibody

...is product advances through the clinic." These data are published in the August 7, 2009 edition of Cell Stem Cell in an article titled "DLL4 blockade Inhibits Tumor Growth and Reduces Tumor Initiating Cell Frequency." The authors of the article include Dr. Michael Clarke of Stanford University, Dr....

Neurocrine Biosciences Reports Second Quarter 2009 Results

...tional intervention will be compared to standard-of-care treatment; enrollment of 50 subjects is planned. VMAT2 Update The highly selective blockade of the Vesicular Monoamine Transporter 2 (VMAT2) with NBI-98854 should be of clinical benefit in patients with a variety of CNS diseases, especially t...

Cordex Completes Production of ATPace(TM) Clinical Trial Material

...d competition in the U.S. The maintenance of intact ATP molecules in solution is critical for the unique bradycardic effects of ATP, in particular its blockade of atrio-ventricular nodal conduction. Cordex has filed a formulation patent covering this stable liquid formulation of ATP for intravenous administra...

Intra-Cellular Therapies Reports Positive Final Results of a Phase II Clinical Trial with ITI-007 in Patients with Sleep Maintenance Insomnia

.... ITI-007 has dual properties; it acts as a post-synaptic antagonist and as a pre-synaptic partial agonist. The combination of ITI-007's high-potency blockade of 5HT2A receptors and unique dopamine receptor activity should allow a personalized approach to patient treatment for schizophrenia by making it poss...

Duska Therapeutics Provides Program Update and Reports Third Quarter 2008 Financial Results

...ion, is an investigational drug for the acute termination of PSVT. The bradycardic (slowing heart rate) effect of ATP, in particular its blockade of atrio-ventricular (AV) nodal conduction, has been shown in numerous published clinical studies to safely and effectively terminate re...

New Clinical Studies Presented at the American Society of Anesthesiology (ASA) Annual Meeting Show Masimo Technologies Provide Advanced Clinical Intelligence

...e Estanol, M.S., Fine Brian, B.S., Ghandi Vipal, B.S. Anesthesiology, Long Beach VAHS, Long Beach, California. (8) Impact of lower extreminity nerve blockade on PI and PVI. Darin V. Allred, M.D., Nitin K. Shah, M.D., Laverne Estanol, M.S. Anesthesiology, University of California Irvine, Orange, California. ...

Duska Therapeutics Submits Phase 3 ATPace(TM) Protocol to FDA for Comment

...jection) is a proposed product for the termination of paroxysmal supraventricular tachycardia (PSVT). The bradycardic effect of ATP, in particular its blockade of atrio-ventricular nodal (AVN) conduction, has been shown to effectively terminate re-entrant PSVT involving the AV node. Adenosine is the only appr...

Medarex Announces Presentations at Annual Meeting of the American Association for Cancer Research

...nd ipilimumab" (Abstract #2538, Clinical Immunotherapy Session) - Oral presentation scheduled for Monday, April 14, 2008 at 1:25 p.m. -- "CTLA-4 blockade for hormone refractory prostate cancer: dose-dependent induction of CD8+ T cell activation and clinical responses" (Abstract #2539, Clinical I...

Schering-Plough Announces Sugammadex New Drug Application Filed in Japan

...In clinical trials to date, sugammadex has demonstrated the ability to rapidly reverse shallow and profound depths of rocuronium-induced neuromuscular blockade (NMB), thereby enabling control of the onset and offset of skeletal muscle relaxation through the use of both drugs. Sugammadex also has demonstrated ...

Genmab Announces HuMax-CD32b Pre-Clinical Program

... In animal models, HuMax-CD32b has been shown to induce impressive anti-tumor responses. The CD32b receptor has an inhibitory role on immune cells and blockade of CD32b has been documented to strongly potentiate the therapeutic effects of other anti-tumor antibodies. An antibody targeting CD32b may thus be at...
blockade in Biological Definition

Long-term potentiation

...S A . 1996 Sep 3;93(18):9931-6. PMID 8790434 ( full text PDF ) Morris RG, Anderson E, Lynch GS, Baudry M. "Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5." Nature . 1986 Feb 27-Mar 5;319(6056):774-6. PMID 2869411 McHug...
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