Topical treatment shown to inhibit HIV and herpes simplex virus infection
Mount Sinai School of Medicine researchers demonstrated that a gel applied in the vagina provides protection from both the human immunodeficiency virus (HIV) and the herpes simplex Virus. The study, presented at the 12th Conference on Retroviruses and Opportunistic Infections, is the first to show that a gel can retain anti-viral activity within the human vagina. The study, which was fund...Novel antiviral technology inhibits RSV infection in mice
A novel antiviral treatment combiningnanoparticle and gene silencing technologies thwarts attacks ofrespiratory syncytial virus (RSV) -- a virus associated with severebronchitis and asthma, an animal study by University of South Floridaresearchers found. The study was reported in the January 2005 issue ofthe journal Nature Medicine.RSV infects lung cells and can be life-threatening in very...HIV Patients May Be at Risk of Heart Problems When Taking Protease Inhibitor Drugs
A widely-used class of drugs that keep the HIV-virus infection from progressing to AIDS may cause serious and potentially lethal heart rhythm disturbances in some patients. The finding of a Mayo Clinic-led investigation appears in the current edition of The Lancet. In collaboration with colleagues from the HIV Program of Hennepin County Medical Center, Minneapolis; the University of Minn...Breast Cancer May Be 'Uniquely Sensitive' To Inhibitors Of PI3K Pathway
"Because up to 75 percent of breast cancerpatients have an abnormality in a specific cell signaling pathway,drugs that target different molecules along that pathway may beespecially effective for treating the disease, says a researcher fromThe University of Texas M. D. Anderson Cancer Center." A clearer picture is now emergingabout the importance of the phosphatidylinositol 3 kinase...Novel gene-silencing nanoparticles shown to inhibit Ewing's sarcoma
A novel delivery system that transports gene silencing nanoparticles into tumor cells has been shown to inhibit Ewing's sarcoma in an animal model of the disease. In this classic "Trojan horse" approach, a protein called transferrin that normally delivers iron into cells is modified to also smuggle into tumor cells siRNA (short interfering RNA) encased in nano-sized sugar polymers. The si...Mouse Anti-C1-inhibitor (C1-INH) Monoclonal Antibody, Unconjugated, Clone 8F3 from AntibodyShop A/S
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It is common knowledge in most laboratories that RNA is more susceptible to degradation than DNA. Unlike Deoxyribonucleases (DNases), which require metal ions for activity (and can therefore easily be inactivated with chelating agents such as EDTA), ribonucleases (RNases) have virtually no cofactor requirements and adv...Measurement of proteasome inhibition in live cells in Molecular Devices microplate fluorometers
Proteins inside eukaryotic cells exist in a dynamic state, in a highly-regulated balance between synthesis and degradation. Whereas prot...Protector RNase Inhibitor Enhance the Protection of RNA against Degradation
Is a new type of RNase inhibitor and inhibits a wide known spectrum ofRNases. Does not interfere with the performance of enzymes in an assay - evenwhen high amounts (e.g., up to 16-fold the standard concentr...Selective serotonin reuptake inhibitor
(5-hydroxytryptamine or 5-HT), in the <a href="/ ?q=/ Biology-De...Sweet Candies replace bitter Pills for Anaemia
Anaemia due to iron deficiency is one of the major cause of morbidity in most of the underdeveloped countries. Children with iron deficiency anemia may be reluctant to take extra vitamins or iron pills, as they are inadvertently inedible. But now Iron-fortified candies were effective for improving the iron status of young children and might be an affordable way to combat iron deficiency...Doctor samples come under the ambit of advertisement
The supreme court of India has declared that distribution of physician's sample by pharmaceutical companies to the medical profession is in nature of advertisement expenditure falling within restrictive provisions of sub section (3A) of section 37 of Income Tax Act. The nature of the advertisement or publicity depends upon the nature and quality of the article in question. The p...Food Habits Could Change Your Genes
Eating specific food could change your genes, say researchers after success in a rodent study.Researchers Moshe Szyf, Michael Meaney and colleagues at McGill University in Montreal have found that nutrients // and supplements changed genetics by switching on or off certain genes in rodents, reports science portal EurekAlert. The new research was conducted in the lines of a two-year-o...Kids More Prone To Mosquito Bites
Children are more vulnerable to bites of mosquitoes that carry the malaria parasites, according to a study. Each year, malaria kills about two million people around the world, most of them children under five. //The disease kills more than one million children - 2,800 per day - each year in Africa alone, according to World Health Organisation (WHO). Researchers led by David Smith,...Pharmacies in for a dose of bitter medicine
In a long-delayed move, the Foods and Drugs Department is beginning to bare its fangs at chemists and druggists operating without qualified pharmacists, an offence under the Indian Drugs and Cosmetics Act, 1940. According to official sources, not only does this common practice jeopardise the health of the masses -- it allows untrained people to deal with high-risk drugs -- it also end...Sidebiting Antrum Punch Forceps
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Description:The new Inferior Medial Orbital Rim Implant (IMORI) provides surgeons with an excellent alternative for patients with a deficient or recessed "tear trough" area often characterized as a look of fatigue or circles under the eyes....Data Available From Erbitux Phase III Study in First-Line Treatment of Advanced Lung Cancer
NEW YORK, July 12, 2007 /PRNewswire-FirstCall/ -- ImCloneSystems Incorporated and Bristol-Myers Squibb Company todayannounced results from an open-label Phase III study of ERBITUX(R)(Cetuximab) plus a taxane and carboplatin in the first-linetreatment for metastatic non-small cell lung cancer (NSCLC). Thestudy did not meet its primary endpoint of progression-freesurvival (PFS) as assessed...Major New Review Supports the Broader Potential of CeNeS COMT Inhibitor Discovery Programme
CAMBRIDGE, U.K. 2nd July 2007 - CeNeS Pharmaceuticals (AIM:CEN)("CeNeS" or "the Company") the Cambridge-based biopharmaceuticalcompany today announced that a paper published this week in CNSDrugs(1) further supports the hypothesis that acatechol-O-methyltransferase (COMT) inhibitor that acts in thebrain would be a useful agent to address profound cognitivedeficits in schizophrenia and bi...Arisaph Pharmaceuticals Announces Results of its Potent Smart DPP-4 Inhibitor, ARI-2243, at the ADA
- ARI-2243 is an highly potent DPP-4 inhibitor, possessing Ki of 27pM BOSTON, June 25, 2007 /PRNewswire/ -- Arisaph Pharmaceuticals,Inc., a privately held drug discovery biopharmaceutical company,announced today the results of its potent, smart DPP-4 inhibitor,ARI-2243, presented at the 67th session of the American DiabetesAssociation meeting in Chicago, Illinois. The results showed that...