X-Rays Help Predict Permanent Bone Damage From Bisphosphonates

...can easily regenerate," says Dr. Shetty. "But, because jawbones have rapid cell turnover, they can fail to heal properly in patients taking any of the bisphosphonate drugs. It's very important for patients to know about complications from dental surgery or extractions. Since these drugs linger in the bone indefinit...

Osteoporosis Drugs Might Not Raise Cancer Risk

...ancer. This is in contrast to news earlier this year that the U.S. Food and Drug Administration had received reports of 23 patients taking the oral bisphosphonate Fosamax (alendronate), who had been diagnosed with cancer of the esophagus. Bisphosphonates have come under scrutiny in recent years for a variety ...

Once-a-Year Drug Helps Counter Steroid-Linked Bone Loss

... new study finds that a once-yearly injection of a bisphosphonate bone-building drug, Reclast, may work better than a once-daily bisphosphonate pill for these patients. Specifically, Reclast ...gs in the April 11 issue of The Lancet . While bisphosphonate drugs can strengthen bone, they are not without th...

Link between widely used osteoporosis drugs and heart problems probed

... and clinical trials to determine the link between bisphosphonate therapy and irregular heart beat. Researchers found that bisphosphonate use was associated with a significant increase in ...ted risk. "The amount of data on the outcome of bisphosphonate use is insufficient to make a definitive conclusio...

ADA Informs Patients About Osteoporosis Medications and Oral Health

...radiation therapy to the head and neck and who are taking, or have taken, a bisphosphonate medication. The chance of developing osteonecrosis of the jaw for pat...s. Bisphosphonates are commonly prescribed to prevent broken bones. Common bisphosphonate medications include alendronate (Fosamax(R)), ibandronate (Boniva(R)), rise...

Study Links Osteoporosis Drugs to Jaw Trouble

...tooth removed. Fosamax (alendronate) is the most widely prescribed oral bisphosphonate and has been the 21st most prescribed drug in the United States since 2006,...iu explained. The USC School of Dentistry now screens every patient for bisphosphonate use. "As a school now, we don't have complications any more, we only ha...

USC dentist links Fosomax-type drugs to jaw necrosis

... to a 2007 report released by IMS Health. "Oral bisphosphonate Use and the Prevalence of Osteonecrosis of the Jaw... U.S. to investigate the relationship between oral bisphosphonate use and jaw bone death, said principal investigato... from many conventional antibiotic treatments, and bisphosphonate use may make the infection more aggressive in adhe...

Susan Lark, MD Speaks Out Against the Newest Osteoporosis Drug, Reclast

...hat are meant to dismantle old, damaged bone tissue so it can be replaced by new tissue, made by osteoblasts. This means the bones in a woman taking a bisphosphonate are increasingly constructed of over-aged, damaged bone cells that have been encouraged to linger longer than is good for the skeleton at large. W...

Cancer treatment may result in bone loss

...ners who frequently encounter these patients." bisphosphonate treatment reduces bone loss Dr. Saad's group also evaluated data that included bisphosphonate treatment for cancer patients receiving chemotherapy. Prostate cancer patients who received bisphosphonate treatment and androgen deprivation therapy did sho...

Bone drug could help prevent the spread of breast cancer

...r, which can release growth factors and produce a favorable environment for cancer cells. The suppression of bone turnover by zoledronic acid or other bisphosphonate drugs could make bones less friendly surroundings for cancer. "We found that patients who are negative for tumor cells in bone marrow have a very g...

Bisphosphonate in Medical Technology

Halozyme Therapeutics Begins Phase 1 Clinical Trial of Bisphosphonate Administered With rHuPH20 Enzyme

SAN DIEGO, Dec. 10 /PRNewswire-FirstCall/ -- Halozyme Therapeutics, Inc. (Nasdaq: HALO ), a biopharmaceutical company developing and commercializing products targeting the extracellular matrix for the endocrinology, oncology, dermatology, and drug delivery markets, today announced the commenceme...

Radius' Investigational Bone Anabolic Agent, BA058, Increased Bone Mineral Density (BMD) at Key Fracture Sites in Phase 2 Clinical Trial in Postmenopausal Osteoporosis

...e advantage for patients that would eliminate the refrigeration requirement of daily-injected Forteo(R). Sales of PTH analogs are projected to surpass bisphosphonate sales and reach $2.3 billion by 2018, driven by robust efficacy data in reducing fractures. About Osteoporosis Osteoporosis is a leading ca...

Video: Zometa(R) Reduces Risk of Breast Cancer Recurrence in Premenopausal Women, Study in The New England Journal of Medicine Reports

...red baseline renal function and multiple cycles of bisphosphonate treatment. Zometa is not recommended in patie...ata are available as to whether discontinuation of bisphosphonate therapy reduces the risk of ONJ in patients requir...g dental procedures. A causal relationship between bisphosphonate use and ONJ has not been established. Clinical jud...

AAOMS Updates BRONJ Position Paper

...ect patients undergoing intravenous cancer-related bisphosphonate therapy or more rarely, patients treated with oral...rong evidence supporting an association between IV bisphosphonate therapy for cancer-related conditions and BRONJ, t...veloping BRONJ is linked to: 1. The potency the bisphosphonate used in therapy; and 2. The length of exposure ...

More Than 200 Abstracts at ASH and SABCS Reveal Potential Compelling Patient Benefits From Novartis Oncology Current and Pipeline Therapies

...red baseline renal function and multiple cycles of bisphosphonate treatment. Zometa is not recommended in ...ata are available as to whether discontinuation of bisphosphonate therapy reduces the risk of ONJ in patients requir...g dental procedures. A causal relationship between bisphosphonate use and ONJ has not been established. Clinical jud...

Video: Major Independent Trial Demonstrates Significant Anticancer Benefit of Zometa(R) in Women With Early-Stage Breast Cancer

...as to whether discontinuation of bisphosphonate therapy reduces the risk of ONJ in patients requiring dental procedures. A causal relationship between bisphosphonate use and ONJ has not been established. Clinical judgment of the treating physician should guide the management plan of each patient based on individual...

Halozyme Therapeutics Presents Findings on Combinations of rHuPH20 Enzyme With Bisphosphonates at the American Association for Cancer Research Conference

...tinued success." The Company plans to bring its SC bisphosphonate program into the clinic in the third quarter of th...r or see a specialist to receive their intravenous bisphosphonate infusion. Subcutaneous injections of bisphosphonat...entering the clinic for the company's subcutaneous bisphosphonate program) that involve risk and uncertainties that ...

Study Shows Once-Yearly Reclast Better than Risedronate at Increasing Bone Mass in Patients With Osteoporosis Caused by Glucocorticoids

...last 2.6%, risedronate 0.6%; P<0.0001)(3). Risedronate is one of the established treatments for GIO(4). Like Reclast, risedronate is a member of the bisphosphonate class of drugs(4). Risedronate is taken in the form of a daily pill for the indication of GIO, whereas Reclast was studied as a once-yearly 15-minute ...

New Study Shows Once-Monthly Boniva(R) is as Clinically Effective as Once-Weekly Fosamax(R) at Increasing Bone Mineral Density in Postmenopausal Women With Osteoporosis

...quate intake of calcium and Vitamin D is important in all patients. Rarely, patients have reported severe bone, joint and/or muscle pain after taking bisphosphonate therapy for osteoporosis. Additionally, osteonecrosis of the jaw has been reported in patients treated with bisphosphonates; most cases have been in c...

Targanta Presents First Data Demonstrating In Vitro Activity and In Vivo Efficacy of Prodrugs in Osteomyelitis Models

...yelitis," researchers synthesized a total of 45 bisphosphonated fluoroquinolone prodrugs by tethering ciprofloxacin, gatifloxacin or moxifloxacin to a bisphosphonate via cleavable linkers. The affinity of the prodrugs for bone was determined by exposing individual compounds to a suspension of bovine bone powder. Mo...

Bisphosphonate in Medical Dictionary

Mandible

...here may be a malocclusion, a TMJ problem or jaw fracture, Normal number of teeth in cat ... Left mandible (jaw) is shorter than the ... ... bisphosphonate • BRONJ • mandible • osteonecrosis • osteoporosis • jaw ... (D) Extensive necrosis of the anterior mandible in a patient with a history of...

Jaw

... and the mandible. Jaw bone (osteo-) damage and death (-necrosis) occurs as a result of reduced local blood supply... Cancer patients taking bisphosphonate drugs for the prevention of fractures due to bone metastases appear more likely to develop jaw disease than patients who do not ... jaw ...

Bisphosphonate in Biological News

New drug agent knocks out multiple enzymes in cancer pathway

...th hormone therapy in a recent clinical trial, the bisphosphonate drug zoledronate significantly reduced the recurre...nt research scientist Yonghui Zhang engineered new bisphosphonate compounds that bound tightly to multiple enzyme ta...r progression in mice much better than do existing bisphosphonate molecules." ...

Anti-cancer drug prevents, reverses cardiovascular damage in mouse model of premature aging disorder

...riments involving a different type of mouse model for progeria, a group of researchers from Spain and France reported that a combination of statin and bisphosphonate drugs slowed development of the visible symptoms of aging and extended life spans in the animals. Both drugs act upon the same biological pathway as F...

Majority of osteoporosis patients not receiving calcium and vitamin D with treatment

...tion and supplementation. i This need for help is supported by patient preference data, which shows that over 70% of patients believe that providing a bisphosphonate with calcium and vitamin D in one box can help them take their supplements regularly and correctly. Some European countries are performing better...

USC School of Dentistry researchers uncover link between osteoporosis drugs and jaw infection

...e causing jaw tissue infections in patients taking bisphosphonate drugs, said Parish Sedghizadeh, lead researcher an... that identifies microbial biofilms in the bone of bisphosphonate patients who have osteonecrosis of the jaw, Sedghi... The scientists are now trying to determine why bisphosphonate drugs seem to open the door for biofilm-associated...

New study reveals promising osteoporosis treatment

...rican Association for Dental Research annual meeting on March 9, 2006. Current FDA-approved pharmaceutical-based osteoporosis treatments, such as bisphosphonate drugs and hormone therapies, do not effectively repair bone that has already been lost. In fact, bisphosphonates have been shown to actually inhibit b...

Bisphosphonate in Biological Technology

New Report Just Published: World Prostate Cancer Therapeutics Market Report

... for Hormone- Refractory Prostate Cancer II-47 Chemotherapy II-47 Taxotere(R) (Docetaxel) II-48 Bone Complication Treatments II-48 bisphosphonate Drugs II-48 Doxazosin, a Cytotoxic Drug for Prostate Cancer II-49 Radiation Therapy II-49 Strategies to Enhance Recurrent Prostate Cancer ...

Halozyme Therapeutics Appoints Head of Endocrinology Clinical Development

...nteraction in academic, research, and corporate settings. Doug's addition to Halozyme will immediately add value to the advancement of our insulin and bisphosphonate programs," said Jonathan Lim, MD, President and CEO of Halozyme Therapeutics. "His decision to join Halozyme further validates the quality of our rese...

Halozyme Therapeutics Reports 2008 First Quarter Financial Results

...orption of bisphosphonates in the skin and subcutaneous tissues with PH20 could modify injection site reaction profiles from two intravenous bisphosphonate formulations, zoledronic acid and ibandronate. The pharmacokinetics of bisphosphonates in blood were also examined and compared to intraven...

Stonegate Report About Unigene Laboratories Inc.

...y concerns could dramatically increase sales of calcitonin-based products - bisphosphonate therapies and selective estrogen receptor modulators (SERMS) are the curren...2008 and involves the FDA's evaluation of reports of atrial fibrillation in bisphosphonate patients. After a series of serious side effects linked to long-term use of...

Targanta Therapeutics to Have Significant Presence at 47th Annual ICAAC Meeting

...esistant gram-positive bacteria. In addition, two presentations at ICAAC will highlight Targanta's proprietary drug discovery platform, which utilizes bisphosphonate prodrugs of antibiotics to generate molecules that deliver antibiotics directly to the bone. The following abstracts have been accepted for poster or...

Reclast(R) Receives US FDA Approval as First and Only Once-Yearly Treatment for Women With Postmenopausal Osteoporosis

...enopausal osteoporosis, offering an important new approach to the treatment of a bone disease affecting eight million women in the US(1). Unlike oral bisphosphonate therapies that have to be taken daily, weekly or monthly, Reclast is given as a once-yearly 15-minute intravenous (IV) infusion. This means with a sin...