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biosynthesis in Medical News

Beauty and grooming science evolves

...opical cosmetic compound, using human skin equivalents. The results demonstrated that the compound increased the expression of genes involved in lipid biosynthesis and metabolism of the stratum corneum, leading to new appreciation of its potential in improving barrier maintenance and repair. Hair Science ...

FASgen, Inc. Announces Research and License Agreement With Centocor, Inc.

...iotech Oncology Research and Development division affiliates the opportunity to discover and develop novel small molecule inhibitors of the fatty acid biosynthesis pathway via selective inhibition of Fatty Acid Synthase (FAS) for use in Oncology. The FASgen researchers have extensive experience studying the ov...

A new class of anti-inflammatory drugs

... print]). Aspirin and the related NSAR drugs act on the arachidonic acid biosynthesis cascade, which plays a central role in the onset of pain and inflammation. ...ge of this new class of drugs is that they not only specifically target the biosynthesis of prostaglandin, but also of leukotrienes, which are metabolites in the se...

The Results From a Clinical Trial Led by the Montreal Heart Institute Demonstrate That Drug Reduces Inflammation in Patients With Serious Cardiovascular Disease

...rdiac events (MACE), including heart attack and stroke. VIA-2291 is designed to be a selective and reversible inhibitor of 5-LO, a key enzyme in the biosynthesis of leukotrienes, that are important mediators of inflammation believed to be involved in the development and progression of atherosclerosis. "VIA-22...

Melanin production discovered in fat tissue

...ce the incidence of chronic diseases among the morbidly obese. "This opens an entirely new avenue for medical interventions because the process of biosynthesis of melanin is relatively easy to meddle with," says Baranova. "We hope that this study will spur the development of preventive medications aimed at cu...

Existing anti-obesity drugs may be effective against flu, hepatitis and HIV

...e-to-fatty acid metabolism could stop viral replication, because fatty acid biosynthesis is not essential in adult humans. It does appear, however, to be essential ... the American Cancer Society. "Recent studies have shown that fatty acid biosynthesis is important for the replication of diverse enveloped viruses," Munger said...
biosynthesis in Medical Technology

VIA Pharmaceuticals Meets With FDA to Discuss Next Steps For VIA-2291 and Phase 3 Outcome Trial in Cardiovascular Disease

...s from the Agency on the Company's Phase 3 trial design. VIA-2291 is a selective and reversible inhibitor of 5 Lipoxygenase, a key enzyme in the biosynthesis of leukotrienes, which are important mediators of the inflammation believed to be involved in the development and progression of atherosclerosis. The ...

VIA Pharmaceuticals Announces Positive Results of Phase 2 Studies of VIA-2291 in Patients With Serious Cardiovascular Disease

...erse cardiac events, including heart attack and stroke. VIA-2291 is designed to be a selective and reversible inhibitor of 5-LO, a key enzyme in the biosynthesis of leukotrienes, that are important mediators of inflammation believed to be involved in the development and progression of atherosclerosis. ACS and...

VIA Pharmaceuticals Completes Patient Visits in Phase 2 Carotid Endarterectomy (CEA) Trial

...measurements of inflammation. About VIA-2291 VIA-2291 is a selective and reversible inhibitor of 5-LO, which is believed to be a key enzyme in the biosynthesis of leukotrienes (important mediators of inflammation involved in the development and progression of atherosclerosis). Potentially a complement to curr...

VIA Pharmaceuticals Completes Enrollment in Phase 2 Acute Coronary Syndrome (ACS) Trial

...esented in the third quarter. About VIA-2291 VIA-2291 is a selective and reversible inhibitor of 5-LO, which is believed to be a key enzyme in the biosynthesis of leukotrienes (important mediators of inflammation involved in the development and progression of atherosclerosis). Potentially a complement to curr...

VIA Pharmaceuticals Announces Updated DSMB Safety Results for VIA-2291 Ongoing Phase 2 Clinical Program

...ficer of VIA Pharmaceuticals. About VIA-2291 VIA-2291 is a selective and reversible inhibitor of 5-LO, which is believed to be a key enzyme in the biosynthesis of leukotrienes (important mediators of inflammation involved in the development and progression of atherosclerosis). Potentially a complement to curr...

VIA Pharmaceuticals Completes Enrollment In Phase 2 Carotid Endarterectomy (CEA) Trial

...opment of our lead compound." About VIA-2291 VIA-2291 is a selective and reversible inhibitor of 5-LO, which is believed to be a key enzyme in the biosynthesis of leukotrienes (important mediators of inflammation involved in the development and progression of atherosclerosis). Potentially a complement to curr...
biosynthesis in Medical Dictionary

Nicotine

...Nicotine is an alkaloid found in the nightshade family of plants (Solanaceae) which constitutes approximately 0.6–3.0% of dry weight of tobacco, with biosynthesis taking place in the roots, and accumulating in the leaves. It... nicotine ( ) n. A colorless, poisonous alkaloid, C 10 H 14 N 2 , derived from t...

Melatonin

..... proportion of unmetabolized melatonin is also excreted in ... Melatonin is a principal hormone of the vertebrate pineal gland. ... In the biosynthesis of melatonin , tryptophan is first converted by tryptophan ... A summary of the sleep-inducing, anti-oxidant and other actions of the horm...

Lipid

...its potential additive and possibly ... The European Bioinformatics Institute ... The structure of lipid A is relatively invariant ... Lipid A biosynthesis lauroyl (or palmitoleoyl) acyltransferase ... The lipid environment is defined by the family of molecules that are ... Three members of the lip...

Folic Acid

...id and pteroyl-L-glutamate, are forms of the water-soluble vitamin B9. Vitamin B9 is essential to numerous bodily functions ranging from nucleotide biosynthesis to the... Folic acid is a B vitamin needed for cell replication and growth. ... Women who take folic acid -containing multivitamin supp...

Folate

...id and pteroyl-L-glutamate, are forms of the water-soluble vitamin B9. Vitamin B9 is essential to numerous bodily functions ranging from nucleotide biosynthesis to the... Women with folate deficiency who become pregnant are more likely to give birth ... In infants and children, folate defici...

Aspartic acid

...acidic amino acids. ... Note that aspartic acid has an α-keto homolog, oxaloacetate, just as pyruvate is ... Aspartic acid is pervasive in biosynthesis and is the precursor to several amino ... In aspartic acid , only the L-stereoisomer is involved in protein synthesis. ... Pharmaceutical gra...
biosynthesis in Biological News

Discovery of new molecular tools for biosynthesis could lead to advances in use of pectin

Most people know pectin as a common household gelling agent in making jams and jellies, but its uses are vast. It has anticancer properties, for instance, and may have a role in important biological functions including plant growth and development and defense against disease. Despite the importan...

U Alberta researcher in same group as Darwin and Hawking

...d antibiotics. Currently, more than 50 per cent of hospital-acquired infections are resistant to common antibiotics. Veredas' work also centres around biosynthesis by fungi of important metabolites including cholesterol-lowering drugs such as statins. "The appointment is a great honour and I was very surprise...

Comprehensive genetic study paves way for new blood-pressure medicines

...tain several genes that probably play a role in regulating blood pressure. The CYP17A1 gene on chromosome 10q24, for instance, plays a key role in the biosynthesis of glucorticoid hormones, which influence the metabolism of salt. In another area on chromosome 1p36 there are genes for two peptides with natrium-exp...

A new way to assemble cells into 3-D microtissues

... applications. Beyond that, Bertozzi hopes to refine the present method of modifying cell-surface DNA. "As it stands, the need for unnatural sugar biosynthesis limits the kinds of cells that we can use in microtissue construction," she says. "There are other ways in which DNA can be conjugated to cells, indep...

A new gene silencing platform -- silence is golden

... RNAi." Gunderson went on to say that the range of possible targets is very broad due to the mechanism of action in which inhibition occurs during the biosynthesis of mRNA at the near universal 3' end processing step. Perhaps the most interesting aspect of this technology is that U1 Adaptors can possibly inhibit ...

American Chemical Society's Weekly PressPac -- Jan. 7, 2009

..., perhaps in a class of its own." JS ARTICLE #4 FOR IMMEDIATE RELEASE "Salicylic Acid sans Aspirin in Animals and Man: Persistence in Fasting and biosynthesis from Benzoic Acid" DOWNLOAD FULL TEXT ARTICLE http://pubs.acs.org/stoken/presspac/presspac/full/10.1021/jf800974z CONTACT: Gwen Baxter, Ph.D....
biosynthesis in Biological Technology

Vanda Pharmaceuticals to Present Data on Fanapt(TM) and Tasimelteon at the 162nd American Psychiatric Association Annual Meeting

...ne receptor 2 gene on iloperidone efficacy for the treatment of patients with schizophrenia. NR7-009 Common effect of antipsychotics on biosynthesis and regulation of fatty acids and cholesterol supports a role of lipid homeostasis in schizophrenia. NR1-092 Selective estrogen rec...

VIA Pharmaceuticals Announces Complete Enrollment in FDG-PET Phase 2 Study of VIA-2291 in Cardiovascular Patients

...to report data in the second half of 2009. VIA-2291 is designed to be a selective and reversible inhibitor of 5 Lipoxygenase, a key enzyme in the biosynthesis of leukotrienes, which are important mediators of inflammation believed to be involved in the development and progression of atherosclerosis. The FDG-...

Dow AgroSciences Confirms Efficacy of Zinc Finger Nucleases for Precise Genome Modification in Maize

... herbicide tolerance gene was targeted to disrupt ZmIPK1 in corn, an especially attractive choice because ZmIPK1 encodes an enzyme that is involved in biosynthesis of phytate, a component of feed corn that is particularly difficult to digest for certain animals like pigs and chickens causing excess phosphate pres...

New Insights into the Mechanism of Action of Antipsychotic Drugs

...h Society, of a manuscript entitled "Common effect of antipsychotics on the biosynthesis and regulation of fatty acids and cholesterol supports a key role of lipid ... (1) Polymeropoulos M.H. et al., "Common effect of antipsychotics on the biosynthesis and regulation of fatty acids and cholesterol supports a key role of lipid ...

Chromatide and Novasep Have Extended Their Partnership to Develop Large Scale Solid Phase Peptide and Oligonucleotide Synthesis Technology.

...s, and Dr. Saeed Gulzar, formerly Custom Peptide Synthesis Manager at Avecia/Zeneca. The IP-driven company is highly innovative, specialising in novel biosynthesis and purification technologies designed to facilitate, and reduce costs, of the processes involved in production of biomolecules in the biotechnology a...

Evotec Appoints Mario Polywka and Klaus Maleck to the Management Board

...a doctorate from the University of Oxford in mechanistic organometallic chemistry and continued at Oxford with post-doctoral studies on aspects of the biosynthesis of penicillins. Dr Klaus Maleck, 35, has served as Executive Vice President Finance and a member of Evotec's Executive Committee since April 2007. P...
biosynthesis in Biological Definition

Protein biosynthesis

Protein biosynthesis is the process in which cells build proteins . The term is sometimes used to refer only to protein translation but more often it refers to a multi-step process, beginning with transcription and ending with translation . Protein biosynthesis although very similar, ...

Alternative splicing

...o different ripe mRNA molecules and therefore to different proteins. Also viruses have adapted to this biochemical process when using the protein biosynthesis apparatus. When the pre-mRNA has been transcribed from the DNA , it includes several introns and exons . In nematodes , the mean is 4-5 exons a...

Cell biology

...rocesses in cell biology Movement of proteins Proteins are synthesized by ribosomes in the cytoplasm . This process is also known as protein biosynthesis or simply protein translation . Some proteins, such as those to be incorporated in membranes ( membrane proteins ), are transported into the ER du...

Cytoskeleton

...nes encoding actin-like proteins, and these proteins form a helical network beneath the cell membrane that guides the proteins involved in cell wall biosynthesis . Some plasmids encode a partitioning system that involves an actin-like protein ParM . Filaments of ParM exhibit dynamic instability , and may pa...

Endosymbiont

...opriate amino acids , and (2) after the Buchnera genome was sequenced, analysis uncovered a large number of genes that likely code for amino acid biosynthesis genes; most bacteria that live inside other organisms do not have such genes, so their existence in Buchnera is noteworthy. Similarly, the primary ...

Endosymbiont

...opriate amino acids , and (2) after the Buchnera genome was sequenced, analysis uncovered a large number of genes that likely code for amino acid biosynthesis genes; most bacteria that live inside other organisms do not have such genes, so their existence in Buchnera is noteworthy. Similarly, the primary ...
biosynthesis in Biological Dictionary

Protein biosynthesis

Protein synthesis is the process in which cells build proteins. The term is sometimes used to refer only to protein translation but more often it refers to a multi-step process, beginning with amino acid synthesis and... Category: Protein biosynthesis . From Wikipedia, the free en...

Translocation

...ation in plants, transport of food or pesticides through phloem or xylem. Protein translocation or protein targeting, a process in protein biosynthesis ... reciprocal translocation ( ri′siprəkəl ′tranzlō′kāshən ) ( cell and molecular biology ) The special case of translocation in which two ...

Suberin

...s water ... Very long chain aliphatic compounds occur in the suberin polymer and associated wax. Up to now only few genes involved in suberin biosynthesis have been identified. ... ...

Small nuclear RNA

...lear RNA (snRNA) ... Small Nuclear RNA (snRNA) ... Small Nucleolar RNA (snoRNA) ... BioInfoBank Library :: RNA , Small Nuclear :: biosynthesis :: RNA interference by small hairpin RNAs synthesised under control of the human 7S K RNA promoter. TFIID ... BioInfoBank Library :: R...

Secondary metabolite

...tes can be classified by their chemical structure or physical ... WARF Technology Summary P02379US: A Global Regulator of Secondary Metabolite biosynthesis in Fungi ... Secondary metabolites display a broad range of ... Prkofiles of secondary metabolites of fusarium spp. ... Secondary metabo...

Recombinant DNA

... ... The RWJMS Recombinant DNA form should be completed and submitted to the IBC, ... Formation of recombinant DNA containing genes for the biosynthesis of toxin ... Recombinant DNA summary with 15 pages of encyclopedia entries, essays, summaries, research information, and more. ... Get Recombi...
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