Biomarkers

Biomarkers isolated from saliva successfully predict oral and breast cancer

Screening for breast cancer and the early detection of other tumors one day may be as simple as spitting into a collection tube or cup, according to recent studies by UCLA researchers. In one early study based on a risk model, presented here at the 96th Annual Meeting of the American Association for Cancer Research, the UCLA scientists reported that genetic "biomarkers" isolated in saliva...

Measurement Challenges In Detecting Cancer Biomarkers

Effective control of sexually transmitted diseases (STDs) requires treatment of the sexual partners of infected patients. A new study shows that providing infected men with antibiotics to give their partners is more effective than traditional means of contacting and treating the partners, according to an article in the Sept. 1 issue of Clinical Infectious Diseases, now available online. Men with...

Biomarkers may hone anti-aging therapies

Lotions and potions that promise to remove wrinkles and other effects of aging crowd cosmetics aisle shelves, but do these treatments really work? Vanderbilt University Medical Center investigators have identified new molecular indicators -- or "biomarkers" -- of aging in the skin that could be used to evaluate anti-aging therapies. Their findings are reported in the February issue of the...

Scientists create dual-modality microbeads to improve identification of disease biomarkers

Analyzing human blood for a very low virus concentration or a sample of water for a bioterrorism agent has always been a time-consuming and difficult process. Researchers at the Georgia Institute of Technology and Emory University have developed an easier and faster method to detect these types of target molecules in liquid samples using highly porous, micron-sized, silica beads. The res...

Genes and biomarkers that allow doctors to choose the right therapy for the right patient

Genetic and epigenetic variations ensure that no two people are exactly alike, and the same holds true for any two cancers. Now, researchers have the tools and the knowledge to help predict how individuals will respond to cancer therapies, enabling them to create more effective therapies for individual cancers ?personalized medicine. At the 2007 Annual Meeting of the American Association for Can...

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MicroRNA Profiling by Array Analysis Reveals Critical BioMarkers

Jaclyn Shingara, Kerri Keiger, Ila Wolf, Jeffrey Shelton, Emmanuel Labourier, and David Brown R&D Division, Ambion, Inc. MicroRNAs (miRNAs) are small, siRNA-like molecules, encoded in the genomes of plants and animals,...

Multiplexed Quantitative Peptide Assays for Protein Biomarkers of Cardiovascular Disease in Human Plasma

As the study of protein biomarkers increases in importance, extensive lists of candidate markers are being developed based on protein pathway information and discovery-based proteomics experiments. Even larger numbers of candidate genomic markers exist from DNA transcriptional profiling based on microarray-based gene expressio...

Biomarkers at Medicine News

Biomarkers May Indicate Alzheimer's Disease

The early signs of Alzheimer's disease can be identified by using the compounds, or biomarkers in the cerebrospinal fluid, according to scientific research conducted by Sweden’s Lund University.// Loss of memory and confusion can also be interpreted as early signs of the onset of the disease, and it is not always easy to differentiate the symptoms of Alzheimer's, and that of growing old....

Biomarkers Could Prove Significant In Understanding Aging Process

Researchers at the Vanderbilt University Medical Center have zoned in on new molecular indicators, called "biomarkers", // for aging of the skin that could be an interesting pointer when evaluating anti-aging therapies. The findings of this particular study are reported in the latest issue of the Journal of Investigative Dermatology. “There's a lot of interest in the pharmaceutical and...

Researchers Find Mix of Biomarkers Predicting Mortality

Previous research has uncovered a range of biological markers that can predict disability, morbidity and mortality in older adults. In this study, the researchers// analyzed 13 biomarkers representing neuroendocrine and vascular functions and immune and metabolic activity over 12 years in 1,189 high-functioning men and women aged 70-79 enrolled in the MacArthur Study of Successful Aging. The goal...

Biomarkers Predicting Mortality Found Using Statistical Technique

A recent study was conducted to identify biomarker combinations associated with mortality among people.Previous research //has uncovered a range of biological markers that can predict disability, morbidity and mortality in older adults. In this study, the researchers analyzed 13 biomarkers representing neuroendocrine and vascular functions and immune and metabolic activity over 12 yea...

Biomarkers Found Harmful For Human Lupus

A team of Wake Forest University School of Medicine has found biomarkers for lupus that may play a role in causing the disease. //The biomarkers are micro-ribonucleic acids (micro-RNAs), said Nilamadhab Mishra, M.D. Mr. Mishra and his colleagues reported at the American College of Rheumatology meeting in Washington that they had found profound differences in the expression of micro-RNAs...

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Pharmacyclics Identifies Functional Biomarkers for its Novel HDAC Inhibitor and Demonstrates Preclinical Anti-Tumor Activity with Bruton's Tyrosine Kinase Inhibitors

SUNNYVALE, Calif. and LOS ANGELES, April 18, 2007/PRNewswire-FirstCall/ -- Pharmacyclics, Inc. today announced datafrom two preclinical studies, one identifying a functionalbiomarker for its novel histone deacetylase (HDAC) inhibitor andanother demonstrating preclinical anti-tumor activity with itsBruton's tyrosine kinase (BTK) inhibitor compounds. The data werepresented at the American...

Millennium Discovers Biomarkers Potentially Predictive of Response to Velcade (Bortezomib) for Injection

- Findings Published in Blood Highlight Millennium Leadership inPersonalized Medicine and Could Strengthen the Role of VELCADE asFoundation of Therapy in Broad Range of Multiple Myeloma Patients - CAMBRIDGE, Mass., April 17, 2007 /PRNewswire-FirstCall/ --Findings published in the April 15th issue of Blood show that ateam of researchers led by Millennium Pharmaceuticals, Inc. hasdiscovered...