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bioavailability in Medical News

Clinical Study Demonstrates Superior Bioavailability of Jarrow's Proprietary QH-absorb Formula

Clinical study demonstrates superior bioavailability of Jarrow Formula's proprietary ubiquinol Co-Q10 formula Los Angeles, CA (PRWEB) June 13, 2009 -- The results of a clinical trial investigating the bioavailability of Jarrow Formulas®' QH-absorb ®, a stabiliz...

Poniard Pharmaceuticals Presents Final Results of Phase 1 Study of Oral Picoplatin Demonstrating Bioavailability

- Pharmacologic Data Presented at American Association for Cancer Research's 100th Annual Meeting 2009 - SOUTH SAN FRANCISCO, Calif. and DENVER, April 21 /PRNewswire-FirstCall/ -- Poniard Pharmaceuticals, Inc. (Nasdaq: PARD ), a biopharmaceutical company focused on oncology, today announced...

CoQ10 bioavailability increased by Nanotechnology

The results of two human clinical trials support the enhanced bioavailability// of CoQ10 delivered into beverages using its novel technology which will interest manufacturers of CoQ10 products. Increasing its bioavailability, or the body's absorption of the ingredient, allows supplement and ...

Latest Berry Health Benefits Revealed

..., Ph.D., William Harvey Research Institute of London "Healthy Eating: bioavailability of Dietary Flavonoids and Phenolics" Alan Crozier Ph.D., University of Glasgow, Scotland " Berry Consumption in Humans: bioavailability of Polyphenols and Effects on Cardiovascular Risk Factors" Iris Erlun...

Horse Study: RBC Life Sciences' Antioxidant, Microhydrin, Reduced Lactic Acid Buildup and Improved Hydration During Strenuous Exercise

... including an increase in surface area--bonding absorbed water as well as minerals. Specific silicate interactions play a substantial role in nutrient bioavailability by enhancing solubility properties, improving ion and water transport and also providing free radical antioxidant protection. About RBC Life Sci...

Valensa Selects Parry Organic Spirulina as Ingredient of Choice for Premium Product Development

...umer the best nutrition and supplement solutions based on a thorough understanding of natural ingredients and then delivering them with high levels of bioavailability for maximum efficacy," Moerck said. "Parry Organic Spirulina delivers the nutrients that consumers are looking for when they select a spirulina produc...

AstraZeneca Studies Show Relief of Nighttime Heartburn and Reduction in GERD-Related Sleep Disturbances

...ombin time. Like other proton pump inhibitors, esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability (e.g., ketoconazole, iron salts, and digoxin). Concomitant use of NEXIUM and atazanavir or nelfinavir is not recommended because the plasma conce...

Trius Presents New Data on Torezolid Antibiotic for Treatment of Methicillin-Resistant Staphylococcus Aureus (MRSA) Infections

...al studies showed that oral torezolid, administered at doses from 200 to 400 mg once a day over 21 days, is safe and well tolerated, and that its oral bioavailability is not affected by the administration of food. "These new study results presented by Trius and external investigators validate the compound's inc...

Nektar Announces UCB's Cimzia(R) Approved by U.S. FDA for Adult Patients Suffering From Moderate to Severe Rheumatoid Arthritis

... conjugate technology platform with naloxol, a derivative of the opioid-antagonist drug, naloxone. Nektar's technology has been shown to increase oral bioavailability and inhibit penetration across the blood-brain barrier, an important potential advance for small molecule therapies. The product is being developed ...

FDA Approves Lamictal(R) ODT(TM) Orally Disintegrating Tablets

...DA since 2001 and has a pipeline of product candidates in development for itself and its collaboration partners. Eurand's technology platforms include bioavailability enhancement of poorly soluble drugs, custom release profiles, taste-masking orally disintegrating tablet (ODT) formulations, and drug conjugation. Eur...
bioavailability in Medical Technology

Poniard Pharmaceuticals Announces Final Top-Line Results from Phase 1 Trial Demonstrating Positive Bioavailability with Oral Picoplatin

SOUTH SAN FRANCISCO, Calif., Nov. 6 /PRNewswire-FirstCall/ -- Poniard Pharmaceuticals, Inc. (Nasdaq: PARD ), a biopharmaceutical company focused on oncology, today announced top-line results from its Phase 1 clinical trial of an oral formulation of picoplatin in patients with solid tumors sho...

Intermezzo(R) 3.5 mg Achieves Greater Early Bioavailability Than Ambien(R) 10 mg Despite 65% Lower Dose

Data Presented as Poster Presentation at the Associated Professional Sleep Societies 2008 Annual Meeting BALTIMORE, June 11 /PRNewswire/ -- Data was presented today at the 22nd Annual Meeting of the Associated Professional Sleep Societies (APSS) demonstrating that within 20 ...

Fuisz Tobacco Announces Clinical Study Results for Fuisz Tobacco Sheet Strip; Super Enhanced Bioavailability of Nicotine From Its Tobacco Sheet Strip Supports Efficacy of Low Dose Tobacco Product

WASHINGTON, May 20 /PRNewswire-USNewswire/ -- Fuisz Tobacco today announces the results of a cross-over clinical study comparing the absorption of nicotine from the use of Fuisz Tobacco's dissolving tobacco strip and the use of a nicotine 2mg chewing gum -- the study's control. (Photo: http...

NKTR-118 Shows Substantial Oral Bioavailability and Extended Half-Life in Phase 1 Clinical Data Presented at American Pain Society Meeting

SAN CARLOS, Calif., May 7 /PRNewswire-FirstCall/ -- New Phase 1 clinical trial results for NKTR-118 (oral PEG-naloxol) were presented by Nektar Therapeutics (Nasdaq: NKTR ) this week at the Annual Meeting of the American Pain Society (APS) in Tampa, Florida. In this multiple-dose Phase 1 stud...

Poniard Pharmaceuticals' Oral Picoplatin Demonstrates Positive Bioavailability in Ongoing Phase 1 Trial

- Picoplatin Also Shown to Overcome Platinum Resistance in Preclinical Study - - Data Presented at Annual Meeting of American Association for Cancer Research - SOUTH SAN FRANCISCO, Calif. and SAN DIEGO, April 13 /PRNewswire-First...

Bema Fentanyl Demonstrates Substantial Transmucosal Delivery In Absolute Bioavailability Study

MORRISVILLE, N.C.--(BUSINESS WIRE)--May 7, 2007 - BioDelivery Sciences International, Inc. (Nasdaq:BDSI) announced the results of a 12 subject, crossover study comparing the absorption of fentanyl from both single and multiple BEMA(TM) Fentanyl discs, as well as oral and intravenous doses of fentan...

Nektar Therapeutics Reports Second Quarter 2009 Financial Results

... conjugate technology platform with naloxol, a derivative of the opioid-antagonist drug, naloxone. Nektar's technology has been shown to increase oral bioavailability and inhibit penetration across the blood-brain barrier, an important potential advance for small molecule therapies. The product is being developed to...

Cardax Pharmaceuticals Nominates Clinical Candidate Heptax for Liver Disease; Heptax Ameliorates Inflammation and Oxidative Stress Related to Liver Disease and Metabolic Syndrome

...vative of the natural carotenoid astaxanthin exhibits dramatically improved bioavailability relative to the parent compound," adds Chief Medical Officer, Fred Pashkow, M.D. "Our drug enables the oral bioavailability and dose control required for clinical study and it is converted to the nat...

King Pharmaceuticals Showcases Data From Pain Pipeline of Medicines Designed to Deter Common Methods of Non-Therapeutic Use

...safety concern. For extended-release opioids, there is an added concern that ethanol (EtOH) may disrupt the formulation mechanism leading to increased bioavailability of the opioid. Although the combination of EtOH and prescription opioids is frequently cited as having increased impairing effects, very few studies h...

Poniard Pharmaceuticals Reports First Quarter 2009 Financial Results and Provides a Corporate Update

...ors was also presented at the AACR Annual Meeting. Results showed that the bioavailability of oral picoplatin is nearly 100 percent at doses of 50 mg and 100 mg, indicating sufficient bioavailability to support further clinical development of this formulation. ...
bioavailability in Medical Products

SHBG IRMA Test

Description:...one (combined 95% bound to SHBG) and, to a much lesser extent, estradiol [1]. SHBG specifically binds C18 and C19 steroid structures and regulates the bioavailability of sex steroids. SHBG is produced primarily in the liver. SHBG synthesis and release are regulated by a number of factors which lead to increased ( i....
Company:Diagnostic Systems Laboratories, Inc.

PAPP-A, Ultra-Sensitive ELISA Test

Description:...y factor. It has been shown that PAPP-A specifically proteolyses insulin-like growth factor binding protein-4 (IGFBP-4), thereby regulating local IGF bioavailability and mitogenic effectiveness [3]. Qin Q-P, et al. Clin Chem 43: 2323-2332, 1997 Bischof P, et al. Arch Gynecol. 273: 109-116, 1986 Conover CA et ...
Company:Diagnostic Systems Laboratories, Inc.

PAPP-A ELISA Test

Description:...y factor. It has been shown that PAPP-A specifically proteolyses insulin-like growth factor binding protein-4 (IGFBP-4), thereby regulating local IGF bioavailability and mitogenic effectiveness [3]. Qin Q-P, et al. Clin Chem 43: 2323-2332, 1997 Bischof P, et al. Arch Gynecol. 273: 109-116, 1986 Conover CA et ...
Company:Diagnostic Systems Laboratories, Inc.
bioavailability in Biological News

Jefferson researcher awarded Landenberger Foundation grant for ALS research

...e is no viable drug therapy for ALS may be that in designing both mouse and human clinical trials, scientists have overlooked critical aspects of drug bioavailability and metabolism." said Dr. Pasinelli. "Proteins called multi-drug resistance transporters are increased during the disease, rendering pharmacological ...

Cleaning up oil spills can kill more fish than spills themselves, say Queen's biologists

...ls in the long term because the dispersed oil is diluted and degraded," says Biology professor Peter Hodson. "But in the short term, they increase the bioavailability and toxicity of the fuel to rainbow trout by 100-fold." The detergents are oil dispersants that decrease the surface tension between oil and water...

Moderate alcohol intake associated with bone protection

...BMD scores in the men who reported consuming one or two servings of total alcohol or beer per day, citing previous studies finding silicon has greater bioavailability as a liquid. It is less clear why liquor and wine might protect BMD. "We cannot say definitively what component of these alcoholic drinks might be...

LSUHSC research identifies key contributor to Alzheimer's disease process

...ement factor H (CFH). Testing both control cells and Alzheimer's disease-affected tissues, they found that miRNA-164a appears to reduce the amount and bioavailability of CFH, promoting the inflammation of brain cells and contributing to the development of Alzheimer's disease. The most common form of dementia, Al...

Dartmouth workshop sets research agenda for environmental mercury

...h on the way mercury accumulates in fish and other wildlife that inhabit inland forests, streams, lakes, and reservoirs. The meeting, titled "Fate and bioavailability of Mercury in Aquatic Ecosystem and Effects on Human Exposure," also included experts on mercury in marine systems. All gathered agreed that insights ...

Food, health get top billing at national chemistry meeting

...he chemical makeup of fruits and vegetables interact in humans. "While we continue to consume various healthy foods, several challenges of toxicity, bioavailability of certain bioactive compounds, and food-drug interactions are yet to be understood," he noted. ...

New technology may prevent vitamin B12 deficient seniors and vegetarians from needing injections

...eight loss can occur in those who are deficient. Currently, physicians rely on B12 shots for people with vitamin B12 deficiency because of the poor bioavailability of oral formulations. Past studies have shown that only approximately one percent of a vitamin B12 tablet gets absorbed in the bloodstream after trave...

American Chemical Society's Weekly PressPac -- Dec. 12, 2007

...t effects in humans are uncertain, he notes, without adequate attention to bioavailability how much of a dose actually can be used by the body and how phytochemical... of breast cancer. MTS ARTICLE #4 FOR IMMEDIATE RELEASE Commentary: bioavailability of Flavonoids and Polyphenols Call to Arms DOWNLOAD PDF http://pubs.ac...

Between water and rock -- a new science

... were there. Now we know that lead in solution is different than if it is attached to a particle. But finding the particles is not easy. And impact on bioavailability is still unknown. He asks, Are the metals less toxic if they are associated with nanoparticles than if dissolved as atoms in water? If a person, an...

Curry-derived molecules might be too spicy for colorectal cancers

... catenin), and induction of programmed cell death (apoptosis) in colorectal cancer. Unfortunately, natural curcumin has what researchers term low bioavailability -- the molecule quickly loses its anti-cancer attributes when ingested, Shibata says. With the aim of improving the therapeutic potential of curcumin...
bioavailability in Biological Technology

Pharsight to Present on IVIVC at Bioequivalence & Bioavailability Strategies Conference

Talk Will Cover the Use of Pharsight Software for In-Vitro / In-Vivo Correlation Modeling in Drug Development MOUNTAIN VIEW, Calif., June 23 /PRNewswire-FirstCall/ -- Pharsight(R) Corporation (Nasdaq: PHST ), a leading provider of software, strategic consulting, and regulator...

Nektar Therapeutics to Present at the BMO Capital Markets 9th Annual Focus on Healthcare Conference in New York City

... conjugate technology platform with naloxol, a derivative of the opioid-antagonist drug, naloxone. Nektar's technology has been shown to increase oral bioavailability and inhibit penetration across the blood-brain barrier, an important potential advance for small molecule therapies. The product is being developed to...

Nektar to Announce Financial Results for the Second Quarter of 2009 on Tuesday, August 4, 2009, After Close of U.S.-Based Financial Markets

... conjugate technology platform with naloxol, a derivative of the opioid-antagonist drug, naloxone. Nektar's technology has been shown to increase oral bioavailability and inhibit penetration across the blood-brain barrier, an important potential advance for small molecule therapies. The product is being developed to...

ImmuneRegen BioSciences Confirms Homspera's Therapeutic Anti-Influenza Effect on Pandemic H1N1 Influenza Virus After Oral Administration

...tive on oral administration and provides therapeutic effects against the current pandemic H1N1 virus infection. Preliminary analysis of ongoing bioavailability studies in rats had revealed the oral administration of Homspera resulted in measurable amounts of the drug in lung tissue. Systemic absorption and a...

Tobira Therapeutics Inc. Announces Phase I Data Demonstrating Pharmacokinetic Properties of TAK-652 for the Treatment of HIV

...igational compound being developed for the treatment of HIV. These data suggest that TAK-652 is rapidly absorbed and demonstrate relatively good oral bioavailability (as shown by the plasma TBR-652 concentration data) and has a long plasma half-life of TBR-652 (approximate mean of 35 hours) supporting once-daily do...

DOR BioPharma Announces Issuance of European Patent for its LPM(TM) Oral Drug Delivery Technology

..., DOR has demonstrated that the LPM(TM) technology results in high systemic bioavailability of intestinally absorbed leuprolide. In both animal models, the bioavailability of leuprolide ranged from 20 to 40 percent, compared to 2.2 percent for the...

Particle Sciences and Microfluidics Collaborate to Share Formulation and Nanotechnology Expertise for Pharmaceutical Drug Product Development, Analysis and Commercialization

...es, Americas, at Microfluidics. "With several well-known drugs on the market, customers use our processors to reduce particle sizes uniformly, improve bioavailability and target drug delivery. Through this relationship, our users now have access to our technology combined with the scientific ingenuity and experience...

Exosome Diagnostics and DxS Diagnostic Innovations Collaborate to Develop Blood-Based Tests for Key Cancer Mutations

...tations for predicting patient response to targeted therapies. Blood-based mutation measurement is particularly valuable in circumstances where tissue bioavailability is limited such as in lung, pancreatic and ovarian cancers. Exosomes are small microvesicles precipitously shed by all solid tumors into blood. ...

Nektar Therapeutics Promotes Lorianne Masuoka, M.D. to Chief Medical Officer

... conjugate technology platform with naloxol, a derivative of the opioid-antagonist drug, naloxone. Nektar's technology has been shown to increase oral bioavailability and inhibit penetration across the blood-brain barrier, an important potential advance for small molecule therapies. The product is being developed to...

Celator(R) Pharmaceuticals Presents Data on the Activity of CPX-351 Against Leukemia at the European Hematology Association Congress

...inical data demonstrating the extended therapeutic bioavailability and tumor cell selectivity of CPX-351 (Cytarabine:...tio of cytarabine:daunorubicin in CPX-351, extends bioavailability beyond that seen with conventional administration ...ter administration. It also showed that while the bioavailability of the encapsulated drugs was similar to that expe...
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