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bind in Medical News

New understanding of how big molecules bind will lead to better drugs, synthetic organic materials

Biological and medical research is on the threshold of a new era based on better understanding of how large organic molecules bind together and recognise each other. There is great potential for exploiting the molecular docking processes that are commonplace in all organisms to develop new drugs t...

Mind in a Bind – Alternative Intervention

“The mind is its own place, and in itself, can make heaven of Hell, and a hell of Heaven” reflected John Milton three centuries ago. Though delicate as the most exquisite silk ever woven it is imbibed with a tensile strength// that can withstand the strongest forces in this universe. Yet when subje...

Keryx Biopharmaceuticals Settles License Dispute With Alfa Wassermann

...iseases, including renal disease and cancer. Keryx is developing Zerenex((TM)) (ferric citrate), an oral, iron-based compound that has the capacity to bind to phosphate and form non-absorbable complexes. Zerenex has recently completed a Phase 2 clinical program as a treatment for hyperphosphatemia (elevat...

New microchip technology performs 1,000 chemical reactions at once

...ible to the eye. The chemical reactions were performed using in situ click chemistry, a technique often used to identify potential drug molecules that bind tightly to protein enzymes to either activate or inhibit an effect in a cell, and were analyzed using mass spectrometry. While traditionally o...

Keryx Biopharmaceuticals Announces Agreement with FDA on a Special Protocol Assessment for Phase 3 Trial of KRX-0401 (Perifosine) in the Treatment of Multiple Myeloma

... diseases, including renal disease and cancer. Keryx is developing Zerenex(TM) (ferric citrate), an oral, iron-based compound that has the capacity to bind to phosphate and form non-absorbable complexes. Zerenex has recently completed a Phase 2 clinical program as a treatment for hyperphosphatemia (elevat...

Preventing toxic shock syndrome and other severe diseases

...ore than $9.55 million. "We are looking at how these superantigen toxins bind to proteins on the surface of white blood cells. This binding causes the o...use potent activation of the immune system, so if we could engineer them to bind only to cancer cells, we could get the immune system to destroy the cancer....

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bind in Medical Technology

Keryx Biopharmaceuticals, Inc. Commences Phase 1 Study of KRX-0401 (Perifosine) in Recurrent Pediatric Solid Tumors at Memorial Sloan-Kettering Cancer Center

...g diseases, including renal disease and cancer. Keryx is developing Zerenex(TM)(ferric citrate), an oral, iron-based compound that has the capacity to bind to phosphate and form non-absorbable complexes. Zerenex has recently completed a Phase 2 clinical program as a treatment for hyperphosphatemia (elevat...

Amicus Therapeutics Commences Phase 3 Trial Evaluating Amigal(TM) for the Treatment of Fabry Disease

...ncreased risk of heart attack and stroke. Amigal is designed to selectively bind to and stabilize a-Gal A, which facilitates proper trafficking of the enzym...l chaperone technology involves the use of small molecules that selectively bind to and stabilize proteins in cells, leading to improved protein folding and...

Keryx Biopharmaceuticals Announces Positive Data from a Randomized, Multi-Center, Placebo-Controlled, Phase 2 Combination Study of KRX-0401 (Perifosine) in the Treatment of Advanced Metastatic Colon Cancer

...g diseases, including renal disease and cancer. Keryx is developing Zerenex(TM)(ferric citrate), an oral, iron-based compound that has the capacity to bind to phosphate and form non-absorbable complexes. Zerenex has recently completed a Phase 2 clinical program as a treatment for hyperphosphatemia (elevat...

Keryx Biopharmaceuticals Reports Positive Data from a Randomized, Multi-Center, Placebo-Controlled, Phase 2 Combination Study of KRX-0401 (Perifosine) in the Treatment of Advanced Metastatic Colon Cancer

... diseases, including renal disease and cancer. Keryx is developing Zerenex(TM)(ferric citrate), an oral, iron-based compound that has the capacity to bind to phosphate and form non-absorbable complexes. Zerenex has recently completed a Phase 2 clinical program as a treatment for hyperphosphatemia (eleva...

Keryx Biopharmaceuticals Reports Single Agent Phase 2 Data of KRX-0401 (Perifosine) Further Demonstrating KRX-0401's Activity in the Treatment of Advanced Metastatic Renal Cell Cancer

...iseases, including renal disease and cancer. Keryx is developing Zerenex((TM)) (ferric citrate), an oral, iron-based compound that has the capacity to bind to phosphate and form non-absorbable complexes. Zerenex has recently completed a Phase 2 clinical program as a treatment for hyperphosphatemia (elevat...

Novel Vaccine Approach Offers Hope in Fight Against HIV

...vided into two phases. In the first phase, the research team created antibody-like proteins (called immunoadhesins) that were specifically designed to bind to SIV and block it from infecting cells. Once proven to work against SIV in the laboratory, DNA representing SIV-specific immunoadhesins was engineer...
bind in Medical Products

Free Activin AB ELISA Test

Description:...a-2 macroglobulin. Activins are bound with high affinity to follistatin with a possible regulatory role, while both inhibins and activins are found to bind reversibly with a2-macroglobulin (3). Despite numerous studies investigating the circulating levels of the various activin molecules in numerous dis...
Company:Diagnostic Systems Laboratories, Inc.

Free Activin A ELISA Test

Description:...a-2 macroglobulin. Activins are bound with high affinity to follistatin with a possible regulatory role, while both inhibins and activins are found to bind reversibly with a2-macroglobulin (3). Despite numerous studies investigating the circulating levels of the various activin molecules in numerous dis...
Company:Diagnostic Systems Laboratories, Inc.

Free Activin B ELISA Test

Description:...a-2 macroglobulin. Activins are bound with high affinity to follistatin with a possible regulatory role, while both inhibins and activins are found to bind reversibly with a2-macroglobulin (3). Despite numerous studies investigating the circulating levels of the various activin molecules in numerous dis...
Company:Diagnostic Systems Laboratories, Inc.

IGFBP-2 RIA Test

Description:...Human Insulin-like growth factor binding protein-2 (IGFBP-2) is one of six characterized IGFBPs (further IGFBPs have been proposed) which specifically bind and modulate the actions of IGF-I and IGF-II. The binding affinity of IGFBP-2 for IGF-II is estimated to be significantly higher than for IGF-I [1], s...
Company:Diagnostic Systems Laboratories, Inc.

IGFBP-2 ELISA Test

Description:...Human Insulin-like growth factor binding protein-2 (IGFBP-2) is one of six characterized IGFBPs (further IGFBPs have been proposed) which specifically bind and modulate the actions of IGF-I and IGF-II. The binding affinity of IGFBP-2 for IGF-II is estimated to be significantly higher than for IGF-I [1], s...
Company:Diagnostic Systems Laboratories, Inc.

IGFBP-3

Description:...mates of between 43 and 56 kDa. Insulin-like growth factor binding proteins bind IGF-I and IGF-II with high affinity but do not bind insulin. Of the six distinct IGF binding proteins structurally characterize...
Company:Nichols Institute Diagnostics

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bind in Medical Dictionary

TIBC

... Total iron-binding capacity ( TIBC ) is a medical laboratory test which measures the blood's capacity to bind iron with transferrin. It is performed by drawing blood and measuring the maximum amount of iron that it can carry,... Total iron binding capaci...

Soy

...getarianism. ... A possible relationship between dietary soy and the prevention of hormone ... Soy phytoestrogens are very complex -- they bind to estrogen receptors and ... Mayo Clinic offers award-winning medical and health information and tools for healthy living. ... Soy has been a...

Rheumatoid factor

...on MedicineNet.com Explanation of the significance of rheumatoid factor . ... Rheumatoid factor is an immunoglobulin (antibody) which can bind to other antibodies. ... Rheumatoid factor (RF) is a blood test that measures the amount of the RF antibody in the blood. ... High levels ...

Methemoglobinemia

...aracterized by the presence of a higher than normal level of methemoglobin (metHb) in the blood. Methemoglobin is a form of hemoglobin that does not bind oxygen. When its concentration is... More about Methemoglobinemia : Causes and symptoms Diagnosis Treatment Alternative Treatment Prognosis Preve...

Intracellular

... Examples are the class of nuclear receptors located in the cell nucleus and the IP3 receptor located on the endoplasmic reticulum. The ligands that bind to them are usually... Comparison of the levels in the intracellular lysates with the virion lysates on ... About 0.1-0.2% of the intracellular...

Immunoglobulin

...ive vaccines to prevent infections and diseases from developing. ... If the blood contains immunoglobulin antibodies (substances that detect and bind ... Intravenous immunoglobulin (IVIG) replacement thera ... Immunoglobulin replacement has been standard thera ... functionally intact immuno...
bind in Biological News

Uncharged organic molecule can bind negatively charged ions

BLOOMINGTON, Ind. -- Indiana University Bloomington chemists have designed an organic molecule that binds negatively charged ions, a feat they hope will lead to the development of a whole new molecular toolbox for biologists, chemists and medical researchers who want to remove chlorine, fluorine a...

'Nano-keys' bind cell receptors and trigger allergic reactions

The tumblers of life continue to click as Cornell University researchers have fabricated a set of "nano-keys" on the molecular scale to interact with receptors on cell membranes and trigger larger-scale responses within cells -- such as the release of histamines in an allergic response. How cell ...

Navigating in the ocean of molecules

...or navigating chemical space. It generates maps of chemically-related structures and links them to biological activity, that is, to their potential to bind to proteins, in particular medically relevant proteins. With the help of this new tool, the Max Planck scientists, together with colleagues from the u...

New cancer drug delivery system is effective and reversible

...o the liposome membrane. Ideally the antibody will bind to a cancer cell receptor so that it can deliver t...nd the ability of antibody-conjugated liposomes to bind to cancer cells can be inconsistent. Some small... laboratory specializes in isolating aptamers that bind to specific molecules and converting them into eff...

New DNA and RNA aptamers offer unique therapeutic advantages

...ass of drugs composed of single strands of DNA or RNA, called aptamers, can bind protein targets with a high strength and specificity and are currently in c...he authors describe the methods used to identify aptamers that specifically bind protein drug targets of interest, the types of modifications that have been...

Parasites ready to jump

...l for the production of endo-siRNAs. It turns out that this is a previously unknown variant of the protein "Loquacious". In Drosophila, Loquacious can bind to specific RNA molecules that serve as precursors of the endo-siRNAs. Furthermore, the team pinpointed an entirely novel feature of this system: Repr...
bind in Biological Technology

Keryx Biopharmaceuticals, Inc. Announces Second Quarter 2009 Financial Results

... diseases, including renal disease and cancer. Keryx is developing Zerenex(TM) (ferric citrate), an oral, iron-based compound that has the capacity to bind to phosphate and form non-absorbable complexes. Zerenex has recently completed a Phase 2 clinical program as a treatment for hyperphosphatemia (elevat...

Amicus Therapeutics Announces Second Quarter 2009 Financial Results

...ones for the treatment of a range of human genetic diseases. Pharmacological chaperone technology involves the use of small molecules that selectively bind to and stabilize proteins in cells, leading to improved protein folding and trafficking, and increased activity. Amicus is initially targeting lysosom...

Keryx Biopharmaceuticals, Inc. to Hold Conference Call on Second Quarter 2009 Financial Results on Thursday, August 6, 2009 at 8:30am EDT

... diseases, including renal disease and cancer. Keryx is developing Zerenex(TM) (ferric citrate), an oral, iron-based compound that has the capacity to bind to phosphate and form non-absorbable complexes. Zerenex has recently completed a Phase 2 clinical program as a treatment for hyperphosphatemia (elevat...

Palatin Technologies, Inc. Receives U.S. Patent Allowance for Heart Failure Drug Candidate

...eptide Constructs." Allowed claims cover a family of cyclic compounds that bind to natriuretic peptide receptor A (NPRA), including PL-3994, Palatin's lead... pharmacokinetic properties. These are the only drugs we are aware of that bind to NPRA and are suitable for subcutaneous administration, with the possibil...

Amicus Therapeutics Announces Second Quarter 2009 Financial Results Release Date

...ones for the treatment of a range of human genetic diseases. Pharmacological chaperone technology involves the use of small molecules that selectively bind to and stabilize proteins in cells, leading to improved protein folding and trafficking, and increased activity. Amicus is initially targeting lysosom...

NYU physicists find way to explore microscopic systems through holographic video

... pharmaceuticals, stick together. One approach, called a "bead-based assay," creates micrometer-scale beads whose surfaces have active groups that bind to the target molecule. Because of their small size, the challenge for researchers is to determine if these beads actually stick to the target molecul...

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bind in Biological Products

Biotin-OSu from Biosearch Technologies

Description:...s, DNA and synthetic oligonucleotides. Biotin labeling is detected through enzymatically labeled avidin or streptavidin proteins that conformationally bind the Biotin moiety....
Company:Biosearch Technologies

Phagocytosis Fluorometric (dichlorofluorescein) Assay Kit, OxyBURST from Molecular Probes (Invitrogen)

Description:...y linked to dichlorodihydrofluorescein (H2DCF) and then complexed with purified rabbit polyclonal anti-BSA IgG antibodies. When these immune complexes bind to Fc receptors, the nonfluorescent H2DCF molecules are internalized within the phagovacuole and subsequently oxidized to green fluorescent dichlorofl...
Company:Molecular Probes (Invitrogen)

ImmunoPure IgM Purification Kit from Pierce Biotechnology, Inc.

Description:...can be obtained from a single pass over the affinity column. Human IgM will bind to the support and yield a product at least 88% pure by HPLC upon elution. ...m has not yet been optimized. Studies in Pierce labs show that MBP does not bind F(ab)2 and Fab. Mannan Binding Protein is immobilized on two supports:...
Company:Pierce Biotechnology, Inc.

Rabbit Anti-Human PHAS-II Polyclonal Antibody, Unconjugated from Lab Vision

Description:...anslation initiation. PHAS-II is highest in liver and kidney. PHAS proteins bind to eIF-4E, the mRNA cap-binding protein, and inhibit translation of capped ...te(s) promotes dissociation of PHAS/eIF-4E complexes. This allows eIF-4E to bind to eIF-4G (p220), thereby increasing the amount of the eIF-4F complex and t...
Company:Lab Vision

Mito Casp from BACHEM

Description:...ve caspases are detected by carboxyfluorescein (FAM)-labelled fluoromethylketone (FMK) peptide inhibitors, which are cell-permeable, non-cytotoxic and bind covalently to the active caspases within the cells. At the same time the mitochondrial membrane potential is visualized by a cell-permeable cationic r...
Company:BACHEM

Mouse IR Cytokine Array 12plex from Pierce Biotechnology, Inc.

Description:...ic cytokines in standards and samples added to the plate. After nonbound proteins are washed away, the biotinylated detecting antibodies are added and bind to a second site on the target proteins. Excess detecting antibody is then removed and Streptavidin-DyLight™ 800 Fluor is added. Signal from the ...
Company:Pierce Biotechnology, Inc.

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bind in Biological Definition

Actin

...ion . In the cytosol , actin is predominantly bound to ATP , but can also bind to ADP . An ATP-actin complex polymerizes faster and dissociates slower th...rgy. The ATP allows, through hydrolysis , the myosin head to extend up and bind with the actin filament. The myosin head then releases after moving the act...

Active site

...e such that the active site is rendered useless. Uncompetitive inhibition , is similar to noncompetitive inhibition except that the inhibitor can only bind the enzyme-substrate complex rather than the free enzyme. Models There are several models of how enzymes work. The lock and key model and the i...

Affinity chromatography

...pled separately. The serum is initially allowed to bind to the GST affinity matrix, this will cause any anti-GST antibodies to bind (that is any antibodies against the GST part of th...hen separated from the solid medium and allowed to bind to the GST-fusion protein matrix. This allows the ...

Alcohol

...lindness or death. Interestingly, an effective treatment to prevent formaldehyde toxicity after methanol ingestion is to administer ethanol. This will bind to alcohol dehydrogenase, preventing methanol from binding and thus its acting as a substrate . Chemistry of alcohols Preparation ...

Allostery

...nsed (T) or relaxed (R), and that relaxed subunits bind substrate more readily than those in the tense sta...uential model dictates that molecules of substrate bind via an induced fit protocol. Namely, when a subun...in the same conformation molecules of substrate bind via induced fit protocol conformational changes...

Allostery

...nsed (T) or relaxed (R), and that relaxed subunits bind substrate more readily than those in the tense sta...uential model dictates that molecules of substrate bind via an induced fit protocol. Namely, when a subun...in the same conformation molecules of substrate bind via induced fit protocol conformational changes...
bind in Biological Dictionary

Zona pellucida

...eceptor also stimulates ... The zona pellucida binding assay assesses the ability of ... to spermatozoa on subsequent sperm– zona pellucida bind ... that the zona pellucida's ability to ... Sperm– zona pellucida binding and penetration were assessed on the oocytes that ... In conclu...

Zinc finger

...ward Guide: What Is a Zinc Finger ? ... Zinc finger proteins often bind to DNA and RNA because their shape allows close ... Finding Zinc Fingers that bind ... Zinc fingers are a common protein motif ... A particular six z...

Uracil

... Uracil pairs with adenine through hydrogen bonding. Uracil is the hydrogen bond acceptor and can form two hydrogen bonds. Uracil can also bind with a ribose. Ribose ... Encyclopedia article about uracil . Information about uracil in the Columbia Encyclopedia, Computer Desktop Encycloped...

Transcription factor

...anscription factor IID) Thalamus. THC ... Some transcription factors bind to specific sequences of DNA (promoters and ... Transcription ... In E...han the enzymes themselves, are ... Transcription factors are able to bind to specific sets of ... transcription factor complex. Term informati...

Streptavidin

... is ... A 52.8 kDa non-glycosylated protein with a very high affinity for biotin. ... unit is defined as the amount of Streptavidin required to bind 1 µg biotin. ... ...

Sigma Factor

...erent environmental conditions. Every molecule of RNA polymerase... In the regulation of gene expression in prokaryotes, anti- sigma factors bind to sigma factors and inhibit their transcriptional activity. Anti- sigma factors have been found in Escherichia coli, Salmonella, and T4 bacterioph...
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