Researchers add new tool to tumor-treatment arsenal
A new study demonstrates the potential effectiveness of treating tumors by combining agents that damage DNA with a drug that sensitizes cancer cells to these agents. The research, led by George Thomas, PhD, professor at the University of Cincinnati's (UC) Genome Research Institute, and Heidi Lane of Novartis Institutes for Biomedical Research, appears in the March 25, 2005, issue of the jo...New Drugs For Bad Bugs: UF Approach Could Bolster Antibiotic Arsenal
Call it a chemical crystal ball. A new approach to predict whether a drug in development is likely to work and which dose is best could get antibiotics to market faster and more cheaply, say University of Florida researchers. In recent years, scientists worldwide have sounded the alarm: There simply aren’t enough drugs to combat bad bugs. Bacteria are increasingly adept at outwitting the t...Cellular Pathway Yields Potential New Weapon in Vaccine Arsenal
When a cell has to destroy any of its organelles or protein aggregates, it envelops them in a membrane, forming an autophagosome// , and then moves them to another compartment, the lysosome, for digestion. Two years ago, Rockefeller University assistant professor Christian Münz showed that this process, called autophagy, sensitizes cells for recognition by the immune system’s helper...