Alzheimer's-linked apolipoprotein E produced by neurons, Gladstone study
Scientists at the Gladstone Institute of Neurological Disease have now proved using a specialized mouse model that the controversial protein, apolipoprotein
E, is indeed produced by neurons.// The results of this study have for the first time established a definitive association between the two. ...
Three dimensional structure of apolipoprotein revealed
Researchers from Gladstone Institute of Cardiovascular Disease have for the first time created the three dimensional structure of apolipoprotein
E using X-ray crystallography. X-ray crystallography technique // is used for determining three dimensional structures so molecules by determining the x-r...
A 'Heart Healthy' Diet and Ongoing, Moderate Physical Activity May Protect Against Cognitive Decline as We Age
... known about how this relationship is impacted by the Alzheimer's risk gene apolipoprotein
E (APOE). The APOE gene comes in three types, or alleles, known as e2, e3, ... Thomas Obisesan, et al -Aerobic-related physical activity interacting with apolipoprotein
E genotypes, is associated with better cognitive function in a nationally r...
Brain Imaging (MRI/PET) and Measurements of Proteins in Spinal Fluid May Improve Alzheimer's Prediction and Diagnosis
...ppocampal volume measured with MRI; relative rates of glucose metabolism in certain, prespecified brain regions measured with FDG-PET scans; number of apolipoprotein
E4 (ApoE4) alleles, which is an Alzheimer's risk gene; CSF measurement of Alzheimer's related proteins, including beta amyloid (AB1-42), total tau (t-...
Memory test and PET scans detect early signs of Alzheimer's
...e Auditory Verbal Learning Test; the volume of the hippocampus, the part of the brain associated with the formation of new memory; the presence of the apolipoprotein
E4 gene, which has been linked to increased risk of Alzheimer's; certain proteins found in the cerebrospinal fluid; and glucose metabolism detected in...
Gene May Help Predict Timing of Alzheimer's Onset
... Dr. Allen Roses, director of the Deane Drug Discovery Institute at Duke, said in a university news release.
In previous research, Roses found that apolipoprotein
E (APOE) genotypes, particularly APOE4, are associated with increased risk and younger age of development of Alzheimer's disease. APOE4 accounts for a...
Pluronic L-81 is a potential anti-diabetic drug?
...e the potential anti-diabetic activity of L-81. In addition to exploration of the underlying molecular mechanism, they examined the effects of L-81 on apolipoprotein
B (apoB) secretion and the mRNA level of the MTP gene.
In their study, Genetically diabetic (db /db ) mice were fed on chow supplemented with or...
Living Alone Increases Odds of Developing Dementia
...looking at the association between marital status and dementia, the researchers also examined the link between living alone and being a carrier of the apolipoprotein
E e4 gene variant, a known risk factor for Alzheimer's disease.
The study found the highest risk of developing Alzheimer's disease among people wit...
15-Point Test Gauges Alzheimer's Risk
...ercent were black.
Risk factors in the index included: older age; poor performance on cognitive tests; low body-mass index; having the predisposing apolipoprotein
E (APOE) gene; abnormal MRI findings; thicker carotid artery measurements and other vascular indications; slowness buttoning a shirt or performing oth...
Study in Nature Medicine establishes major new treatment target in diseased arteries
...ese disease-causing effects if CypA is not there to pass on its message? To clarify the role of CypA, Berk's team engineered mice to no longer produce apolipoprotein
E, which increased their cholesterol levels and made them prone to atherosclerosis. From this original line, the team further engineered one group wit...
Apolipoprotein in Medical Technology
Isis and Collaborators Present New Research at the ATVB Annual Conference
...that treatment with mipomersen reduced circulating apoC-III. ApoC-III is an apolipoprotein
that transports triglycerides in the blood. Patients with cardiovascular di...riglycerides and diabetes. In a presentation titled "In vivo knock down of apolipoprotein
F decreases liver triglyceride levels" S. Khetarpal from University of Pen...
Colesevelam HCl Lowered LDL Cholesterol in Pediatric Patients With Heterozygous Familial Hypercholesterolemia
...orrected reductions from baseline in total cholesterol
(7 percent; p<0.01), apolipoprotein
B (8 percent; p<0.01) and non-HDL
cholesterol (11 percent; p less than or equal to 0.0001) as well as an
increase in apolipoprotein
A-I (7 percent; p<0.01). There was a
non-significant, placebo-adjusted, 5.1...
Genzyme and Isis Begin Second Phase 3 Trial Of Mipomersen
...ties in Europe,
where the development path for mipomersen may differ from that in the U.S.
The patent entitled "Antisense Modulation of apolipoprotein
Expression," U.S. Patent No. 7,407,943 is the first allowance in a series
of broad filings protecting the therapeutic use of targeting apoB f...
Ion Mobility Diagnostic Test from Quest Diagnostics is First to Provide Direct Physical Measurement of Lipoprotein Particles, Cardiovascular Disease Indicators, Study Finds
...romoting atherosclerosis and other
cardiovascular diseases. Because particles of LDL, intermediate-density
lipoprotein (IDL) and VLDL each contain one apolipoprotein
protein, ApoB concentration may give a better indication of large
lipoprotein particle concentration than measurements of cholesterol
Isis Reports Reduction of apoB-100 Levels in a Murine Model Resulting in Up to 92% Reduction of Atherosclerosis
...clerosis, Thrombosis and Vascular Biology (ATVB)
Conference in Atlanta, Georgia. The data were presented in a poster
entitled "Antisense Inhibition of apolipoprotein
B Ameliorated Diet-Induced
Hypercholesterolemia and Reduced Atherosclerosis in LDL Receptor-Deficient
Mice" by Adam E. Mullick, Ph.D. of Isis yesterda...
Isis Reports Preclinical Data Supporting Liver Safety of ISIS 301012
...cal data presented provide a mechanistic explanation for
Isis' previous observations that, in mice and monkeys, treatment with
antisense inhibitors of apolipoprotein
B-100 (apoB) is associated with
reduced liver fat content. This observation is in contrast to the effects
of either small molecule or antisense inhibi...
Experimental Drug Ketasyn(TM) Improves Memory in Age-Associated Memory Impairment Study
study was 65. Subjects underwent genomic testing for variations in the
coding regions of genes known to influence memory and cognition, including
E gene (APOE), a known genetic risk factor for
Alzheimer's disease (AD) that occurs in 15-20% of the general population.
On days 0, 30, 60, 90 and 104...
Isis Pharmaceuticals Announces Its Participation at the Upcoming
ACC 56th Annual Scientific Session in New Orleans and Its Live
Analyst/Investor Webcast Presentation
...ent Reductions in LDL-C and
B With ISIS 301012, an Antisense
Inhibitor of apolipoprotein
B, in Subjects With
Polygen... ISIS 301012, an Antisense Inhibitor of apolipoprotein
Produces Significant Add...
Study Presented at ACC Shows Treatment With ISIS 301012 Added to
Statins for Only 5 Weeks Results in 75% of Patients Achieving LDL-C
Levels Less Than 100 mg/dL and 50% of Patients Achieving LDL-C
Levels of Less Than 70 mg/dL
... J.P. Kastelein
Title: ISIS 301012, an Antisense Inhibitor of apolipoprotein
Produces Significant Additional Reduction of Low-Density
Lipoprotein Cholesterol and apolipoprotein
Hypercholesterolemic Subjects on Statins Not Meet...
CSL Therapy That Mimics “Good” Cholesterol May Reduce
Plaque Volume in Coronary Arteries
...till experience a serious
cardiovascular problem in the 12 months following an episode of
CSL-111 is a patented biologic product, consisting
A-I purified from human plasma that is
reconstituted to form a particle that chemically and biologically
resembles human HDL. A 40 mg/kg dose of CSL-1...
Apolipoprotein in Medical Definition
... by a similar mechanism, including AA amyloidosis, apolipoprotein
AII amyloidosis, and Aβ amyloidosis.  [10...is
Apolipoprotein in Medical Dictionary
...ng and medical management of lipid ... Journal of Lipid Research, Vol. 40, 2293-2302, December 1999 ... We examined the effect of lipid -free apolipoprotein
A-I (apoA-I) and apoA-II on ... Imaging of lipid species by MALDI mass spectrometry ... History of the JLR and Lipid Classification. Special F...
Apolipoprotein in Biological News
Mechanism explains link between apolipoprotein E and Alzheimer's disease
Scientists have discovered a previously unknown mechanism by which apolipoprotein
E, a molecule whose mutation is linked to Alzheimer's disease (AD), stimulates degradation of sticky amyloid beta (A?) protein within the brain. The research, published by Cell Press in the June 12 issue of the journ...
A 'heart healthy' diet and ongoing, moderate physical activity may protect against cognitive decline
...e performance as we age is a subject of considerable research, much less is known about how this relationship is impacted by the Alzheimer's risk gene apolipoprotein
E (APOE). The APOE gene comes in three types, or alleles, known as e2, e3, and e4. Each person gets one type of APOE from each parent, making the poss...
A protein that protects against Alzheimer's?
...ute and the University of Valladolid in Spain.
Do Carmo and her collaborators have successfully demonstrated the protective and reparative role of apolipoprotein
D, or ApoD, in neurodegenerative diseases. Their discovery suggests interesting avenues for preventing and slowing the progression of this type of ill...
Scientists make strides toward defining genetic signature of Alzheimer's disease
...lzheimer's disease, the most common form, with the apolipoprotein
E gene. However, the genetics of the disease are complex and are not well understood. "Though apolipoprotein
E has been universally confirmed as a risk gene fo...ide of DNA.
The researchers confirmed the known apolipoprotein
E association and identified a new association wit...
Apolipoprotein(a): A natural regulator of inflammation
...gy and Medicine , Hoover-Plow and co-workers in seeking to define a role of apo(a) in leukocyte recruitment have identified a novel activity of apo(a) apolipoprotein
that may function as a natural and cell specific suppressor of the inflammatory response in vivo. In addition, a mechanism for this novel function of ...
Friend or foe? How the body's clot-busting system speeds up atherosclerosis
...tion and chronic coronary artery disease treatment.
In recently published research, Dichek and his team bred transgenic mice that were deficient in apolipoprotein
E (and therefore had high cholesterol and triglyceride readings) and whose macrophagesthe blood cells that engulf and digest germs and other cellular ...
LSUHSC awarded patent for compound inhibiting cancer and other diseases
...s tumors and diseases like diabetic retinopathy, obesity, and psoriasis.
A-I is the major protein component of lipoproteins water soluble carrier mo...hat would feed tumors," notes Dr. Woltering.
There is also evidence that apolipoprotein
A-1 will be effective in treating other diseases reliant upon angiogenesis....
Aspirin and atherosclerosis
...agues observed that aspirin specifically its active byproduct salicylate can greatly increase the expression of two proteins: paraoxonase 1 (PON1) and apolipoprotein
A1 (ApoA1); in the mouse studies, low dose aspirin supplements could increase PON1 and ApoA1 levels by 7- and 12- fold, respectively.
Both of thes...
International TGen-led team finds link between brain protein and Alzheimer's disease
...finding when individuals were grouped according to whether they carried the most powerful genetic indicator for Alzheimer's -- the epsilon 4 allele of apolipoprotein
E. In the current study, the effects of this allele were controlled for, yet similar observations were made. This suggests that KIBRA may play a role ...
Genetic variant increases triglyceride levels in Asian-Americans
.... In fact, all 11 subjects who carried both copies of this rare variant for apolipoprotein
A-V had extremely high and dangerous triglyceride levels in their blood.
A-V is a recently discovered lipid-binding protein that likely plays an imp...
Apolipoprotein in Biological Technology
Detection of Apolipoprotein Gene Variants by DGGE Using the DCode System
Clive R. Pullinger, Arghavan K. Shahidi, Andrea L. Verhagen and John
P. Kane *
Cardiovascular Research Institute, * Department of Medicine, Department
of Biochemistry and Biophysics, University of California, San Francisco,
Matrix Genomics, Elizabeth Corder, PhD - Gene Variation in the LRRK2 Gene and High Risk for Parkinson's Disease
...order was the lead author on the Science article that described how risk for Alzheimer's disease multiplied according to the number of copies of the apolipoprotein
E allele 4 inherited from parents. This finding has been replicated in hundreds of studies and remains the one established genetic risk factor for Alz...
Atherotech Receives Patent for ApoB Measurement
... /PRNewswire/ -- Atherotech, Inc., developer of the VAP Cholesterol Test, has announced it has received a patent on its method to derive and report apolipoprotein
B100 (apoB) using the Vertical Auto Profile (VAP) technology. The patent recognizes the unique ability of the VAP Cholesterol Test to accurately repor...
SemBioSys' plant-derived Apo AI(Milano) demonstrates encouraging biologic activity in seven preclinical models
About SemBioSys' Apo AI(Milano)
Apo AI (also known as apolipoprotein
AI) is a naturally occurring human protein being developed as a cardiovascu...new generation of cardiovascular drugs (HDL therapies). Apo AI is the major apolipoprotein
associated with HDL, commonly referred to as "good cholesterol", which natu...
Atherotech to Exhibit the VAP(R) Cholesterol Test at ACC.09 in Orlando
...d is the only single cholesterol test that routinely reports apoAI, apoB, and the apoB/apoAI ratio.
Atherotech recently announced the addition of apolipoprotein
AI (apoAI), the main component of protective HDL cholesterol, to its reporting. Several large, prospective studies, including INTERHEART and the AMORI...
Atherotech Announces Addition of ApoAI Heart Disease, Diabetes Risk Marker to VAP(R) Test
...erotech, Inc., a cardio-diagnostic company, today announced the addition of apolipoprotein
A (apoAI) to its VAP(R) Cholesterol Test. The VAP (Vertical Auto Profile) T...
ApoAI is the main protein component of protective HDL cholesterol while apolipoprotein
BI00 (apoB) particles are the main component of atherogenic (bad) LDL chole...
OLIGOMERIX Awarded NIH Grant to Develop Novel Biomarkers for Alzheimer's Disease
...ealth (NIH). The focus of the program is to develop novel biomarker assays for Alzheimer's disease (AD). Tau oligomers in complex with beta-amyloid or apolipoprotein
E (apoE) proteins will be monitored in cerebrospinal fluid (CSF) and plasma from AD patients. The work will be done in collaboration with Drs. Lawrenc...
Resverlogix Board of Directors Update
...hird arm will commence shortly.
RVX-208, a first in class novel small molecule therapeutic that facilitates endogenous apolipoprotein
A-I (ApoA-I) production, is positioned to be one of the most promising emerging drugs in the treatment of atherosclerosis and vascular disorders such ...
RVX-208 Data Demonstrates Increase in Functional HDL Particles
...e of the most promising emerging
drugs in the treatment of atherosclerosis. apolipoprotein
A-I (ApoA-I), the
main component of high-density lipoprotein (HDL) represen...ituents of RCT include acceptors such as
high-density lipoprotein (HDL) and apolipoprotein
A-I (ApoA-I). A critical
part of RCT is cholesterol efflux, in which accumu...
RVX-208 Exploratory Study Illustrates Early Potential for Alzheimer's Disease
...h Dr. Sparks in this important
RVX-208, a first in class novel small molecule therapeutic that
facilitates endogenous apolipoprotein
A-I (ApoA-I) production, is
positioned to be one of the most promising emerging drugs in the treatment
of atherosclerosis and vascular disorders such ...
Apolipoprotein in Biological Products
Apolipoprotein in Biological Dictionary
...ed research links. ... (AD) may be clinically confirmed in patients with apolipoprotein
E2 homozygote . ... apolipoprotein
E2 homozygote has been associated with a protective effect ... ...