antiretrovirals

Study Attributes Elevated Liver Enzymes in HIV/hepatitis to Coinfection Rather Than Antiretrovirals

Many HIV/hepatitis coinfected individuals on antiretroviral therapy (ART) experience liver enzyme elevation (LEE), and for that reason,// caution is generally advised when prescribing ART in this population. Results from the ICoNA (Italian Cohort of Na?ve for Antiretrovirals) study indicate that co...

HIV Drugs Provide Breast-Fed Babies With Some Protection

... causes AIDS. The chance of a mother with HIV transmitting the virus through breast-feeding is about one in five. The results of the Breastfeeding, antiretrovirals and Nutrition (BAN) study, conducted in more than 2,000 HIV-infected mother-child pairs in Malawi in Africa, are scheduled to be presented in South Af...

New global subsidy for malaria medicines must ensure quality of care

... A new subsidy designed to increase access to life-saving antiretrovirals must remain focused on quality patient care if it is to succeed, argues Tido von Schoen-Angerer and colleagues in this week's open access journal PLo...

Starting HIV Therapy Earlier Saves Lives

... Study casts doubt on notion that antiretrovirals can be postponed till later in infection WEDNESDAY, April 1 (HealthDay News) -- Initiating HIV treatment before the patient's immune syste...

UCSF symposium considers biomedical approaches to HIV/AIDS prevention

...logy and Immunology (GIVI) and co-director of the UCSF-GIVI CFAR. Use of antiretrovirals for HIV prevention in uninfected individuals at high risk for infection, he... circumcision and the successful treatment of HIV-infected individuals with antiretrovirals are some of the approaches that will be under discussion at the symposium. ...

PREZISTA(R) Now Available for Pediatric Patients Six Years of Age and Older as part of HIV Combination Therapy

...C114-C212) is an open-label, Phase 2 trial evaluating the pharmacokinetics, safety, tolerability, and efficacy of PREZISTA/r in combination with other antiretrovirals in 80 antiretroviral treatment-experienced HIV-1-infected pediatric subjects 6 to <18 years of age and weighing at least 44 lbs (20 kg). Virologic ...

Anti-HIV gel shows promise in large-scale study in women

...015, a clinical study examining the nature of HIV progression and treatment response in HIV-infected women who were using topical microbicides or oral antiretrovirals as an HIV preventive measure when they acquired HIV infection. A separate clinical study sponsored by the Medical Research Council (MRC) and the De...

Cell death from cytomegalovirus may bring new life to treatment of retinal disease

...ction came with the AIDS epidemic of the 1980s, when nearly half of patients who were dying were going blind as well, Dr. Atherton said. The advent of antiretrovirals to keep HIV in check helped silence cytomegalovirus retinitis as well but today the incidence is again increasing, she said. A suppressed immune syste...

A dangerous precedent in HIV

...l fluids," says Dr Jonathan Anderson, the president of the Australasian Society for HIV Medicine, who is also based at NCHECR. "This may be confusing. antiretrovirals can complement consistent condom use but replacing condom use with medications may end in disaster." Other factors that increase the risk of HIV tr...

Tibotec Pharmaceuticals a Respectful Partner to HIV Community in Pricing of Novel New HIV NNRTI, INTELENCE

...n NNRTI and a protease inhibitor which is both toxic and weakening. I think this is quite a common phenomena among patients with long-term exposure to antiretrovirals and so Tibotec's determination to develop new, non-cross resistant drugs for HIV, and just as importantly, oral compounds for hepatitis C - the compan...

antiretrovirals in Medical Technology

New PRO2000 HIV-Prevention Findings Important Milestone on Path Toward Development of Effective Vaginal Microbicide

...of protection that was observed in the MTN study. IPM and others are now testing a new generation of microbicide candidates that contain highly potent antiretrovirals (ARVs) that specifically target HIV. These ARV microbicides are based on the same antiretroviral drugs being used successfully in HIV treatment and to...

Indevus Pharmaceuticals Announces PRO 2000 Found to Show Promise in Large HIV Prevention Study

...a clinical study examining the nature of HIV progression and treatment response in HIV-positive women who had been using a topical microbicide or oral antiretrovirals as an HIV preventive measure when they acquired HIV infection. A second large trial testing the safety and effectiveness of the 0.5% dose of PRO ...

New Phase 3 Study in Treatment-Naive Adults with HIV Evaluates Efficacy and Safety of Once-Daily PREZISTA(TM)/ritonavir vs. KALETRA(R) as Part of HIV Combination Therapy

...nd anti-infectives for diseases of high unmet medical need. Tibotec Pharmaceuticals is developing a Global Access Program to facilitate access to its antiretrovirals for patients living with HIV/AIDS in developing countries. The Global Access Program for PREZISTA includes access pricing, registration, medical educa...

New Phase 3 Study Published in The Lancet Evaluates Efficacy and Safety of Prezista/Ritonavir vs. Kaletra as Part of HIV Combination Therapy in Treatment-Experienced Adults With HIV

...d anti-infectives for diseases of high unmet medical need. Tibotec Pharmaceuticals is developing a Global Access Program to facilitate access to its antiretrovirals for patients living with HIV/AIDS in developing countries. The Global Access Program for PREZISTA includes access pricing, registration, medical educa...

antiretrovirals in Biological News

Access to antiretrovirals unlikely to reduce HIV infection rates

A new study by Rebecca Baggaley, Neil Ferguson, and Geoff Garnett (of Imperial College London) suggests that the HIV epidemic in poor countries will not be controlled through antiretroviral drugs alone, even if universal access is achieved. As they demonstrate in an article in the open-access inter...

Using hair to manage HIV/AIDS and predict treatment success

...bruary 20 issue of AIDS , note that the levels of antiretrovirals found in the hair of patients on treatment correla...circulating in patients' blood. "High levels of antiretrovirals in hair correlated with success in HIV viral suppr...r pill-taking in clinical trials of single or dual antiretrovirals in high risk, HIV negative individuals to prevent ...

ACS PressPac -- Sept. 17, 2008

...pment, particularly for something as difficult as HIV," notes one researcher. ARTICLE #5 EMBARGOED FOR 9 A.M., EASTERN TIME, Sept. 22, 2008 "New antiretrovirals Change HIV Treatment" This story will be available on Sept. 22 at http://pubs.acs.org/cen/coverstory/86/8638cover.html FOR ADVANCE INFORM...

Resistant HIV quickly hides in infants' cells

... transmission. All had uncommon drug-resistance mutations that some resistance tests would miss. Earlier studies looking at infants treated with antiretrovirals in an unsuccessful attempt to prevent mother-to-child transmission found the virus quickly developed resistance, but levels of resistant virus decline...

Viral 'fitness' explains different resistance patterns to aids drugs

...on therapy usually includes either one NNRTI or protease inhibitor (non-boosted or boosted with a small amount of another potent PI) and two different antiretrovirals from the nucleoside reverse transcriptase inhibitor class. ...

World faces challenge as life expectancies lengthen, scientist says

...t stay locked out." Medical technologies around the globe An example of this inequality, Tuljapurkar said, is the lack of availability of AIDS antiretrovirals in Africa. Although these medications are widely available in the West, they are out of reach for many African patients, who make up more than 60 perc...

Study shows AIDS drugs cost-effective, care underfunded

...t clinic visits, and more. According to the study, as long as a patient sticks to HAART treatment, "the happy paradox is that paying high costs for antiretrovirals decreases overall cost of care," said senior author Michael Saag, MD. The HAART costs were about the same for patients who were sicker ?that is, who h...

antiretrovirals in Biological Technology

Half of Surveyed Physicians Expect to Replace Between 6 Percent and 15 Percent of Their Sustiva Prescriptions with Isentress

...herapies: Physician and Payer Perspective on Recently Launched and Emerging antiretrovirals finds that surveyed infectious disease specialists estimate that they will ...herapies: Physician and Payer Perspective on Recently Launched and Emerging antiretrovirals is based on a U.S. survey of 103 infectious disease specialists and 20 MCO ...

FDA Approves Administration of LEXIVA(R) with Lower Dose of 'Boosting' Medication Ritonavir

...eviously approved 200mg dose of ritonavir. This information has been added to the LEXIVA product label. LEXIVA is indicated in combination with other antiretrovirals for the treatment of HIV infections. Ritonavir works with LEXIVA and other protease inhibitors to boost the medication level in the bloodstream making...

A simple and rapid LC-MS/MS method for the simultaneous determination of nine antiretroviral drugs commonly used in Europe (protease Inhibitors and non-nucleoside reverse transcriptase inhibitors)

..., Alexander C, Ting L, Soldin SJ. Simple rapid method for quantification of antiretrovirals by liquid chromatography-tandem mass-spectrometry. Clinical Biochemistry 20... 2. Ghoshal AK, Soldin SJ. Improved Method for Concurrent Quantification of antiretrovirals by LC-MSMS. Therapeutic Drug Monitoring 2003; 25:541-543. 3. Koa...