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Antiretroviral in Medical News

HIV integrase inhibitor effective for patients beginning antiretroviral treatment

A member of a new class of antiretroviral drugs is safe and effective for patients beginning treatment against HIV, according to researchers who have completed a two-year multisite phase III clinical trial comparing it with standard antiretroviral drugs. The results are online and scheduled for...

Sales of Antiretroviral Agents Will Drive Substantial Six Percent Annual Growth in the HIV Drug Market Through 2013

By 2018, Gilead's Quad Will Become the Highest-Selling Antiretroviral in the World's Major Markets, According to a New Report from Decision Resources WALTHAM, Mass., May 19 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and health...

Mylan's Matrix Receives Final FDA Approval for the Generic Version of the Antiretroviral Zerit(R) Capsules

PITTSBURGH, Dec. 30 /PRNewswire-FirstCall/ -- Mylan Inc. (Nasdaq: MYL ) today announced that Matrix Laboratories Limited, its India-based subsidiary in which it holds a 71.5% controlling interest, received final approval from the U.S. Food and Drug Administration (FDA) on December 29, for its A...

Researchers estimate lives lost due to delay in antiretroviral drug use for HIV/AIDS in South Africa

Boston, MA More than 330,000 lives were lost to HIV/AIDS in South Africa from 2000 and 2005 because a feasible and timely antiretroviral (ARV) treatment program was not implemented, assert researchers from the Harvard School of Public Health (HSPH) in a study published online by the Journal of A...

Rare case explains why some infected with HIV remain symptom free without antiretroviral drugs

AIDS experts at Johns Hopkins say they have compelling evidence that some people with HIV who for years and even decades show extremely low levels of the virus in their blood never progress to full-blown AIDS and remain symptom free even without treatment, probably do so because of the strength of...

Increasing access to antiretroviral drugs would drastically cut AIDS deaths in South Africa

More that 1.2 million deaths could be prevented in South Africa over the next five years by accelerating efforts to provide access to antiretroviral therapy (ART), according to a study released online today by the Journal of Infectious Diseases. Using a sophisticated mathematical model of HIV di...

IPM Reaches Landmark Agreement with Pfizer to Develop FDA-Approved Antiretroviral Drug as Vaginal Microbicide

SILVER SPRING, Md., Jan. 30 /PRNewswire-USNewswire/ -- Expanding the pipeline of HIV prevention tools in development, the International Partnership for Microbicides (IPM) today announced that Pfizer Inc. (Pfizer) has agreed to give IPM a royalty-free license to maraviroc, its newly-approved HI...

Brazilian President Silva Issues Compulsory License for Merck's Antiretroviral Efavirenz

Brazilian President Luiz Inacio Lula da Silva on Friday issued a compulsory license to produce a lower-cost, generic version of Merck's antiretroviral Efavirenz, the AP/Forbes reports. World Trade Organization regulations allow governments to declare a "national emergency" and issue compul...

GlaxoSmithKline, Brazil Expected To Sign Deal on Providing Antiretroviral at Reduced Cost

GlaxoSmithKline and Brazil by Friday are expected to sign an agreement that would reduce the cost of GSK's antiretroviral Abacavir by 27% in the country , an unnamed health ministry official announced on Thursday, Dow Jones reports. Although the official did not specify how much Brazil woul...

Brazil Will Purchase Merck’s Antiretroviral If Price Not Lowere

Brazilian Health Minister Jose Gomes Temporao on Wednesday signed a decree declaring that the country would purchase from an India-based drug maker a generic version of Merck's// antiretroviral Efavirenz if the company does not offer the drug at a lower price. According to the decree, Efavir...

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Antiretroviral in Medical Technology

New Results From ARTEN Study of Nevirapine Plus Tenofovir and Emtricitabine (TDF/FTC) Versus Boosted Protease Inhibitor Regimen of Atazanavir/Ritonavir Plus TDF/FTC Revealed

...he effect of VIRAMUNE on patient lipid profiles in antiretroviral naive patients." Efficacy Data ...eek 48 and without subsequent rebound or change of antiretroviral therapy prior to or at week 48.(1) In patients who...UNE is indicated for use in combination with other antiretroviral agents for the treatment of HIV infection. ...

Tibotec Pharmaceuticals Announces Agreement to Develop and Commercialize a New Fixed-Dose Combination of TMC278 and Truvada(R) With Gilead Sciences

...d commercialization of a new once-daily fixed-dose antiretroviral product containing Tibotec's investigational non-n...ved, it would become the first complete once-daily antiretroviral treatment regimen for HIV to include an antiretroviral from Tibotec. Tibotec is currently studying the co...

Schering-Plough Expands Vicriviroc Phase II Study in Treatment-Naive Patients With HIV

...o combine three drugs from two classes to initiate antiretroviral therapy. The combinations characteristically use ...rtment of Health and Human Services guidelines for antiretroviral therapy. Additionally, like vicriviroc, it is adm...f total treatment duration as part of an optimized antiretroviral regimen. AIDS-associated opportunistic infections...

IBM and EU Partners Create a Better Way to Fight AIDS Virus

...he virus that causes AIDS, HIV has the ability to develop resistance to any antiretroviral compound. This means that doctors need to continuously monitor and prescrib...tion. "EuResist has managed to create the largest clinically oriented antiretroviral drug resistance database in the world," explained Professor Maurizio Zazzi,...

HIV/AIDS Research Network Recommends Use of Abbott RealTime Viral Load Test for NIH-Sponsored Clinical Trials

...tion with clinical presentation and other laboratory markers as an indicator of disease prognosis and for use as an aid in assessing viral response to antiretroviral treatment as measured by changes in plasma HIV-1 RNA levels. The assay is not intended to be used as a donor-screening test for HIV-1 or as a diagnos...

AstraZeneca Submits NDA for Low Dose Aspirin/Esomeprazole Combination Product

...n). Concomitant use of NEXIUM and atazanavir or nelfinavir is not recommended because the plasma concentrations and therapeutic effects of those antiretroviral drugs may be reduced . NEXIUM may increase the plasma levels of saquinavir. Dose reduction of saquinavir should be considered. Please see...

Ground-Breaking Combination of All-Oral Agents Demonstrates Potential as Hepatitis C Treatment Regimen

...gh class A) and patients with HIV disease that are clinically stable (e.g., antiretroviral therapy not required or receiving stable antiretroviral therapy). In addition, PEGASYS in combination with COPEGUS is the first and...

Roche and Pharmasset Initiate Phase IIb Clinical Trial of R7128, Most Advanced Nucleoside Polymerase Inhibitor in Development for Chronic Hepatitis C

...gh class A) and patients with HIV disease that are clinically stable (e.g., antiretroviral therapy not required or receiving stable antiretroviral therapy). In addition, PEGASYS in combination with COPEGUS is the first an...

New PRO2000 HIV-Prevention Findings Important Milestone on Path Toward Development of Effective Vaginal Microbicide

...of microbicide candidates that contain highly potent antiretrovirals (ARVs) that specifically target HIV. These ARV microbicides are based on the same antiretroviral drugs being used successfully in HIV treatment and to prevent mother-to-child transmission of HIV. These next-generation microbicides are following th...

Tibotec Data Presented at ICAAC and HIV9 Follow Key Regulatory Approvals for Anti-HIV Compounds

...nation with a boosted protease inhibitor and other antiretroviral medicinal products, for the treatment of human ...unodeficiency virus type 1 (HIV-1) infection in antiretroviral treatment-experienced adult patients. - 21 Oc...e treatment of HIV-1 in combination with other antiretroviral medicines in highly pre-treated adult patients ...
Antiretroviral in Medical Products

Saquinavir Antiretroviral Serum Level, HPLC

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Nelfinavir, Antiretroviral Level, HPLC

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories
Antiretroviral in Medical Dictionary

Drug Resistance

...sistance mutations. ... in stimulating further research into HIV resistance testing for both drug development and ... resistance testing in antiretroviral drug development. ... Project Inform provides information on the diagnosis, treatment and research of HIV ... These drug - resistance tests ...
Antiretroviral in Biological News

Early administration of antiretroviral therapy can improve survival

This release is available in Spanish . The first antiretroviral treatments appeared in 1996. Since then, new and better drugs have been discovered that have almost turned AIDS into a chronic disease. Nevertheless, there is still room to improve the performance of the the therapeutic strate...

Study shows interruption of antiretroviral therapy increases risk of disease and death

Findings from one of the largest HIV/AIDS therapy studies conducted to date show that a specific strategy of interrupting antiretroviral therapy more than doubles the risk of AIDS or death from any cause. Researchers affiliated with the Mailman School of Public Health and Harlem Hospital Hospital l...

International HIV/AIDS trial finds continuous antiretroviral therapy superior to episodic therapy

The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), today announced that enrollment into a large international HIV/AIDS trial comparing continuous antiretroviral therapy with episodic drug treatment guided by levels of CD4+ cells has b...

HIV mortality in India drops with introduction of generic antiretroviral therapy

The survival rate of HIV-infected patients in India has risen in response to a 20-fold drop in the price of antiretroviral therapy (ART), according to an article in the Nov. 15 issue of Clinical Infectious Diseases, now available online. The introduction of generic drugs into the country has encour...

NIH funds $9.5 million for research on HIV and the human innate immune system

...ogical Sciences at the dental school, a team of 22 researchers will unravel changes in the human body's innate immune system in HIV-infected people on antiretroviral therapies to provide new insights into how the body keeps us stay healthy. "New evidence surfaces repeatedly that oral health plays an important and i...

'Shock and kill' research gives new hope for HIV-1 eradication

...es to the development of weapons able to eliminate the HIV-infected cells from the body", says Dr. Andrea Savarino, "Such weapons, in combination with antiretroviral therapies, could hopefully allow people living with HIV/AIDS to get rid of the virus and return to a normal life. Of note, there are testable drug com...

Potential new HIV drug may help patients not responding to treatment

...ns, we start to run out of options for treating them and delaying the onset of AIDS. "Our early findings suggest that D-1mT could be used alongside antiretroviral therapy to stop the virus from replicating. The disease can only progress if the virus is replicating, so if we can slow replication down we can reduc...

HIV-1 protease inhibitor induced oxidative stress in pancreatic B-cells: thymoquinone protection

...sity School of Medicine, New Orleans, Louisiana have discovered that the HIV-1 protease inhibitors (PIs), such as nelfinavir included in highly active antiretroviral therapy (HAART) regimen for the treatment of HIV-1 patients, induce deleterious effects on insulin secretion mediated through the oxidative stress pat...

Waking up dormant HIV

...ch exposes the infected cell to HAART drugs. SAHA could activate HIV in both laboratory cells as well as from blood samples taken from HIV patients on antiretroviral therapy. Importantly, this successful activation was achieved using clinical doses of SAHA, suggesting toxicity will not be a problem. ...

Using hair to manage HIV/AIDS and predict treatment success

...SF researchers have found that examining levels of antiretroviral drugs in hair samples taken from HIV patients on t...of medication, Gandhi said. "Hair sampling for antiretroviral levels could become a new standard to look at how ...nts that may allow for the monitoring of levels of antiretroviral drugs absorbed over time and the prediction of tre...

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Antiretroviral in Biological Technology

New Test from Quest Diagnostics Helps Physicians Choose HIV Antiretroviral Therapy in Patients with History of Drug Resistance

Faster reporting aids physicians in identifying HIV mutations that can inhibit effectiveness of newest class of antiretroviral therapy MADISON, N.J., June 12 /PRNewswire-FirstCall/ -- Quest Diagnostics Incorporated (NYSE: DGX ), the world's leading provider of diagnostic testing, informatio...

A simple and rapid LC-MS/MS method for the simultaneous determination of nine antiretroviral drugs commonly used in Europe (protease Inhibitors and non-nucleoside reverse transcriptase inhibitors)

Purpose In clinical research, the monitoring of protease inhibitor (PI) and non-nucleoside reverse transcriptase inhibitor (NNRTI) antiretroviral drugs is of significant interest due to the importance of assessing inter-individual and intra-individual metabolism variability. ...

A Worldwide Milestone in Cell Analysis - 40 Years of Flow Cytometry

...ent signals are collected. With the obtained data, cells can be characterized, classified, quantified and sorted. For HIV monitoring, accompanying the antiretroviral therapy of AIDS patients, it is necessary to determine the number of CD4 cells. Partec has developed a generation of robust, easy to operate an...

Virco Lab, Inc. Enters Into Collaboration with SmartGene, Inc. Enhancing HIV Resistance Test Services for Laboratories and Physicians

... when a patient is first diagnosed, whether or not antiretroviral (ARV) treatment is initiated immediately. If treat...capabilities. References 1. Panel on antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolesc...

Mylan's Matrix Selected by the Clinton HIV/AIDS Initiative and UNITAID as the Primary Supplier of Five Second-Line and Seven Pediatric HIV/AIDS Treatments

...2% controlling interest, has been selected by the Clinton HIV/AIDS Initiative (CHAI) under its UNITAID-funded projects as the primary supplier of five antiretroviral (ARV) drugs used in second-line HIV/AIDS treatment regimens. Matrix also has been selected as the primary supplier of seven ARVs used for pediatric tr...

Mylan Reports Adjusted Diluted EPS of $0.26 for the Quarter Ended Dec. 31, 2008, and Adjusted Diluted EPS of $0.80 for the Year Ended Dec. 31, 2008

...1, 2008, compared to $92.9 million for the same prior year period. The impact of higher revenues primarily from Matrix's finished dosage form ("FDF") antiretroviral franchise, which was launched in late calendar year 2007, was offset by the negative impact of foreign currency translation. Gross profit for t...

ImQuest Presents IND-Enabling Safety Pharmacology and Pharmacokinetic Data for the Therapeutic HIV Compound IQP-0410 at Conference on Retroviruses and Opportunistic Infections

...and Chief Scientific Officer. "We look forward to our upcoming clinical trial and believe that IQP-0410 will be an attractive new addition to existing antiretroviral therapies for HIV infection." ImQuest recently submitted an Investigational New Drug application to the FDA to initiate human clinical trials wit...

Sangamo BioSciences Initiates Phase 1 Trial of CCR5-ZFP Therapeutic to Treat HIV/AIDS

...rolled in this trial in two treatment cohorts. The first cohort to be treated comprises six subjects who have failed two or more HAART (Highly Active antiretroviral Therapy) regimen. The first three subjects in this cohort will be treated sequentially and monitored for the first 21-days post treatment before an ad...

Half of Surveyed Physicians Expect to Replace Between 6 Percent and 15 Percent of Their Sustiva Prescriptions with Isentress

...s Do Not Place Cost Control Measures on Branded antiretroviral Drugs, According to a New Report from Decision ... do not place cost controls on many of the branded antiretroviral products that are covered in their private health plans. As a result, most antiretroviral drugs -- including Isentress and Sustiva -- will n...

Medical Policy Guideline for Trofile(TM) Established By Wellpoint, Inc.

...ecessary for selecting individuals for treatment with CCR5 antagonists (i.e. Selzentry(TM)) for patients who have experienced virologic failure during antiretroviral treatment regimens and who have evidence of ongoing HIV-1 viral replication. Further, these guidelines confirm that Trofile is the only assay approved...
Antiretroviral in Biological Dictionary

Transcriptase

...randed RNA into single-stranded DNA. It also helps in the formation of a double helix... Reverse transcriptase inhibitors (RTIs) are a class of antiretroviral drug used to treat HIV infection, tumors, and cancer . RTIs inhibit activity of reverse transcriptase , a viral DNA polymerase enzyme that retr...

Reverse transcriptase

...nded RNA into single-stranded DNA. It also helps in the formation of a double helix... Reverse transcriptase inhibitors (RTIs) are a class of antiretroviral drug used to treat HIV infection, tumors, and cancer . RTIs inhibit activity of reverse transcriptase , a viral DNA polymerase enzyme that retr...

Nucleoside

...... Steps in Phosphorylation: Nucleoside analogs (zidovudine, didanosine, zalcitabine, stavudine, abacavir, lamivudine) have been administered as antiretroviral agents ... Information on EC 2.4.2.1 - purine- nucleoside phosphorylase ... ordered bi-bi mechanism with nucleoside being the first substrate ...
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Breaking Medicine News(10 mins):Health News:Local CPA Firm Gears Up To Revamp Detroit Elementary School Playground 2Health News:Local CPA Firm Gears Up To Revamp Detroit Elementary School Playground 3Health News:Behavioral Counseling Urged for Teens, Young Adults at Risk for STDs 2Health News:Behavioral Counseling Urged for Teens, Young Adults at Risk for STDs 3Health News:Newborn ICUs With Private Family Rooms Benefit Preemies: Study 2Health News:Newborn ICUs With Private Family Rooms Benefit Preemies: Study 3Health News:Growing scientists: World's future jobs are rooted in STEM 2Health News:Growing scientists: World's future jobs are rooted in STEM 3Health News:A two-generation lens: Current state policies fail to support families with young children 2
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Breaking Biology News(10 mins):Immune system of newborn babies is stronger than previously thought 2Soft robotics 'toolkit' features everything a robot-maker needs 2Environmental pollutants make worms susceptible to cold 2Environmental pollutants make worms susceptible to cold 3
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