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antihypertensive in Medical News

Mylan Announces Tentative FDA Approval for Generic Version of Antihypertensive Avalide(R) Tablets

PITTSBURGH, June 16 /PRNewswire-FirstCall/ -- Mylan Inc. (NYSE: MYL ) today announced that its subsidiary, Mylan Pharmaceuticals Inc., has received tentative approval from the U.S. Food and Drug Administration (FDA) for its Abbreviated New Drug Application (ANDA) for Irbesartan and Hydrochlor...

Arete Therapeutics Initiates Phase 1 Clinical Trial For AR9281 as a First-in-Class Antihypertensive Agent

HAYWARD, Calif., Nov. 1 /PRNewswire/ -- Arete Therapeutics Inc. today announced the initiation of a phase 1 clinical trial for its lead compound, AR9281, for the treatment of hypertension. AR9281 is a "first-in-class," orally-active inhibitor of soluble epoxide hydrolase (s-EH), a novel target...

Relating heart protection and antihypertensive drugs

Maintaining a normal blood pressure is essential in the prevention of heart disease and is controlled by antihypertensive drugs, say researchers. Dr Jan Staessen and colleagues from Leuven, in Belgium, set out to determine whether it is the pharmacological properties of antihypertensive drugs or th...

Wrong dose of heart meds too frequent in children

...daho. Most of the harmful errors involved diuretics, used to treat heart failure and lower blood pressure by ridding the body of excess water, and antihypertensive (blood-pressure lowering) drugs, both of which are now widely used in infants with congenital heart disease and increasingly in older children and tee...

Intensive management can improve blood pressure in non-adherent hypertensive patients

...edicine (BUSM) have shown that patients with uncontrolled hypertension respond to treatment intensification regardless of their degree of adherence to antihypertensive medications. This study, which has been published online in Hypertension could have an immediate impact on clinical care, as it challenges a widely ...

Center receives grant renewal for hypertension and vascular disease studies

...esity and diabetes, and develop new medicines that are specific and without side effects. Our new studies will pave the way for the development of new antihypertensive medicines that are directed to block the action of hormones that contribute to hypertension and diabetes. "The renewal of our research program eff...

Patients with lower urinary tract symptoms more likely to suffer from metabolic syndrome

...ics of 1) waist circumference greater than 102 cm; 2) systolic blood pressure 130 mm Hg or greater or diastolic blood pressure 85 mm Hg or greater, or antihypertensive medication use; 3) HDL cholesterol less than 40 mg/dl or lipid medication use; 4) self-reported type 2 diabetes or increased blood sugar or diabetes m...

New research confirms milestone study on blood pressure meds

...ng heart failure, coronary heart disease, stroke and kidney failure. The antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) is the ...ystolic Hypertension (ACCOMPLISH). Davis said the large meta-analysis of antihypertensive treatment trials involving 162,341 patients confirmed initial findings of t...

AZOR(R) Receives FDA Approval as First-Line Treatment for High Blood Pressure

...-line' therapy in patients likely to need multiple antihypertensive agents to achieve their blood pressure (BP) goals....the treatment of hypertension, alone or with other antihypertensive agents. AZOR may be used as initial therapy in patients who are likely to need multiple antihypertensive agents to achieve their blood pressure goals. Init...

All Blood Pressure Drugs Lower Risk of Heart Attack and Stroke

...tion. Their conclusions: For heart attacks, all antihypertensive drugs work, with the exception of angiotensin rece... studies to confirm their benefit. For stroke, all antihypertensive drugs were better than placebo, but diuretics, ARB... two separate and distinct types of meta-analyses, antihypertensive drugs do reduce the risk of the two most feared en...
antihypertensive in Medical Technology

FDA Approves Tekturna HCT(R) as Initial Treatment in Patients Unlikely to Achieve Their Blood Pressure Goals With a Single Agent

...t assigned doses as initial therapy without titration from monotherapy. The antihypertensive effect of Tekturna HCT were largely manifested within 1 week. The maximum antihypertensive effect was generally attained after about 4 weeks of therapy. Abo...

Research: Popular Diabetes Medications Associated with Increase in Bone Fractures

... (ACE-I) and angiotensin receptor blockers (ARB), two major categories of antihypertensives, appear to have unique clinical benefits compared to other antihypertensive therapies. New Medco research points to a simple fax communication as an important vehicle for increasing the use of these medications among people w...

Ongoing Landmark ROADMAP Study Demonstrates Significant Improvement in Blood Pressure Control at One Year, According to Blinded Results

...r to olmesartan or placebo in addition to standard antihypertensive treatment (excluding RAS inhibition). After one ye...mesartan medoxomil is a member of the ARB class of antihypertensive medications that help lower blood pressure by bloc...car may be used alone or in combination with other antihypertensive agents. IMPORTANT SAFETY INFORMATION ABOUT ...

New Data Shows Blood Pressure Reduction Therapy with BENICAR(R) and BENICAR HCT(R) Effectively Reduces Blood Pressure in Elderly Patients to Target Blood Pressure

... to an elevation in blood pressure. BENICAR is a member of the ARB class of antihypertensive medications that help lower blood pressure by blocking the angiotensin II r...atment of hypertension. They may be used alone or in combination with other antihypertensive agents. BENICAR HCT is not indicated for initial therapy. IMPORTA...

New Data Shows AZOR(R) (amlodipine and olmesartan medoxomil) Significantly Improves 24-Hour Ambulatory Blood Pressure

...ute and Research Center. "Most patients require treatment with at least two antihypertensive agents to achieve their recommended goal BP. The results of this study demo...7. AZOR is indicated for the treatment of hypertension, alone or with other antihypertensive agents. AZOR is not indicated for the initial therapy of hypertension. AZOR...

Schering-Plough Announces Results of the Early ACS Trial

...; severe hypertension (systolic blood pressure greater than 200 mm Hg or diastolic blood pressure greater than 110 mm Hg) not adequately controlled on antihypertensive therapy; major surgery within the preceding six weeks; history of stroke within 30 days, or any history of hemorrhagic stroke; current or planned admi...

Diabetes Patients with High Triglycerides and Low HDL Cholesterol Get the Most Benefit From Fenofibrate Treatment: New Data From the FIELD Study

...50 mg/dL -- HDL cholesterol <40 mg/dL in men and <50 mg/dL in women -- Blood pressure greater than or equal to 130/85 mmHg (or on antihypertensive treatment) -- Elevated fasting plasma glucose (greater than or equal to 100 mg/dL). What is meant by number needed to treat? The N...

New Study Shows BENICAR(R) (olmesartan medoxomil) Reverses Blood Vessel Damage Independent of Blood Pressure Lowering

..., Stephens N, Cooper A, Aalkjaer C, Heagerty AM, Mulvany MJ. Effect of antihypertensive treatment on small arteries of patients with previously untreated esse...deling of resistance arteries in essential hypertension and effects of antihypertensive treatment. Am J Hypertens 2004;17:1192-200 13. http://www.americanhe...

Azor(TM) Reduces Blood Pressure in Difficult to Treat Special Populations

...quire treatment with a combination of at least two antihypertensive agents in order to achieve their recommended goal ...ally high-risk subgroups, and use of complementary antihypertensive drug classes is advocated in such patients.(15)(16.... Blood Pressure Control in Hispanics in the antihypertensive and Lipid-Lowering Treatment to Prevent Heart Atta...

New Data Shows 45 Percent of Patients with Stage 1 Hypertension Reached Normotension with BENICAR(R) and BENICAR HCT(R)

...etic hydrochlorothiazide. BENICAR and BENICAR HCT are indicated for the treatment of hypertension. They may be used alone or in combination with other antihypertensive agents. BENICAR HCT is not indicated for initial therapy. Important Safety Information USE IN PREGNANCY When used in pregnancy during the second...
antihypertensive in Medical Dictionary

Antihypertensives

...ns used to treat high blood pressure are called antihypertensive agents. ... Generally, an antihypertensive agent is started at a relatively low dose, and ... antihypertensive adj. Reducing or controlling high blood pressur...
antihypertensive in Biological News

NIH grants Phylonix Phase II SBIR to develop high-throughput in vivo zebrafish assays

...atening toxicity. Examples of costly high-profile drug withdrawals due to CYP-related DDIs include the antihistamines terfenadine and astemizole, the antihypertensive mibefradil and statins such as cerivastatin. A validated, simple, cost-effective in vivo CYP assay will be useful for profiling drug metabolism prior...

Hypertension treatment effective in reversing vascular damage

...e patients and returned arterial architecture to normal levels. This was not seen with the atenolol. Olmesartan medoxomil is a member of a class of antihypertensive medications that help lower blood pressure by blocking the angiotensin II receptor on the blood vessels that causes constriction and increase blood pr...

UF scientists discover compound that could lead to new blood pressure drugs

...rtension. The findings, which appear in todays (May 1) edition of the American Heart Association journal Hypertension, could lead to a new class of antihypertensive drugs designed to address two major problems associated with cardiovascular disease: high blood pressure and the tissue damage associated with it, kno...

Blood pressure drug telmisartan shows powerful activity against stroke

...g alone or in combination with a different type of antihypertensive medication, ramipril, Weill Cornell Medical Colleg...nd name Micardis) is one of a class of widely used antihypertensive drugs known as angiotensin receptor blockers (ARBs...lly just wanted to look and see if combinations of antihypertensive drugs were better at lowering blood pressure and s...

JCI table of contents: Aug. 16, 2007

...1-specific agonists. The authors therefore suggest that targeting the PGE2 receptor EP1 might be a viable approach to treating hypertension. TITLE: antihypertensive effects of selective prostaglandin E2 receptor subtype 1 targeting AUTHOR CONTACT: Matthew D. Breyer Vanderbilt University Medical Center, Nashvill...

8 plants from South Africa may hold potential for treating high blood pressure

... patients with type 1 diabetes. In an effort to identify indigenous plants consumed by the local population in Kwa-Zulu Natal that hold potential antihypertensive properties, the researchers examined 16 plants to identify ACE inhibitor activity. The plants were: Amaranthus dubius, a flowering plant also k...

How nice, brown rice: Study shows rice bran lowers blood pressure in rats

...nimals with high cholesterol, does suggest that certain fractions of rice bran can lower levels of unhealthy LDL cholesterol. The Tohoku study adds antihypertensive activity to the picture, along with a host of other biochemical markers that track blood glucose (implicated in diabetes), lipid profile, kidney funct...

NIH renews network focused on how genes influence drug responses

... commonly used prescription drugs. (Kathleen M. Giacomini, Ph.D., University of California, San Francisco) Pharmacogenomic Evaluation of antihypertensive Responses --$11.1 million provided by NIGMS to identify which genes play a role in people's widely variable responses to high blood pressure drugs. (J...
antihypertensive in Biological Technology

Mylan Launches First Generic Version of Antihypertensive Sular(R) ER in the United States

PITTSBURGH, July 28 /PRNewswire-FirstCall/ -- Mylan Inc. (NYSE: MYL ) today announced that its subsidiary, Mylan Pharmaceuticals Inc., has received final approval from the U.S. Food and Drug Administration (FDA) for its Abbreviated New Drug Application (ANDA) for Nisoldipine Extended-release ...

Sinobiopharma Updates on Progress; Projects Increases in Sales and Revenues In 2009

...re projected in 2009. The Company is currently in the process of launching in the domestic Chinese market. Sinobiopharma's formulation of this antihypertensive is the world's first in capsule form, making it easier to swallow. Sales of more than 500,000 capsules are projected in 2009. As the first Chinese mak...

Financial Results for Full Year 2008: NicOx in a Unique Position to Deliver Significant Shareholder Value

...inical studies in volunteers with mild to moderate hypertension. This program is part of the March 2006 agreement to develop new nitric oxide-donating antihypertensive drugs and is testing a number of compounds with single and multiple ascending dosing, prior to the selection of a candidate to be advanced into phase ...

NicOx' Naproxcinod Shows Highly Significant Reduction in Daytime Blood Pressure Versus Naproxen

...urrent Non-Steroidal Anti-Inflammatory Drug (NSAID) users, had controlled hypertension, and could receive stable doses of up to 2 different classes of antihypertensive drugs. NicOx is developing naproxcinod in late phase 3 clinical studies, which are designed to demonstrate that it is safe, well tolerated and effec...

NicOx Reports Results for the First Three Quarters of 2008

...lance of the spreading of the initial payment of EUR9.2 million received from Merck following the signature of a collaboration agreement for new antihypertensive drug candidates in March 2006 These amounts initially recorded as prepaid income were deferred over the estimated duration of NicOx' involvement ...

Forest Laboratories, Inc. and Daiichi Sankyo, Inc. Announce the Termination of the AZOR Co-Promotion Agreement

...reement with Forest provided us with important additional resources to build our franchise of Benicar and Benicar HCT into significant products in the antihypertensive market while we built our own sales force. Our second co-promotion collaboration for AZOR allowed us to quickly and comprehensively educate the medica...

NicOx Initiates Two Large ABPM Studies for Naproxcinod in Hypertensive Patients with Osteoarthritis

...gical mechanisms by which NSAIDs increase blood pressure are not well understood, although an increase in blood vessel constriction, interference with antihypertensive treatment and retaining dietary salt all seem to contribute. The extent of the increase is not fully defined, although there appears to be a variation...

Experts and Representatives From Leading International Health-Care Organizations Call to Stop the Hypertension Pandemic, a Worldwide Silent Killer

...n DJ. How well are we managing and monitoring high blood pressure? Curr Opin Nephrol Hypertens 2003; 12: 299-304 (5) Waeber B et al. Compliance with antihypertensive therapy. Clin Exp Hypertens 1999; 21: 973-85 (6) Berlowitz DR et al. Inadequate management of blood pressure in a hypertensive population. N Engl J ...

Presentation of Phase IIa Results for Cytos Biotechnology's Hypertension Vaccine at the American Heart Association Scientific Sessions 2007

...d. The RAS has already been successfully targeted by three major classes of antihypertensive drugs on the market: inhibitors of the angiotensin-converting enzyme (ACEI)...essure. Antibody: class of blood proteins generated by the immune system. antihypertensive drugs: a class of drugs used for treatment of high blood pressure. Cardiov...

DAIICHI SANKYO EUROPE is Applying for Approval of its New Combination Product of Olmesartan and Amlodipin

...h Blood Pressure - Approval Requested in 28 European Countries DAIICHI SANKYO EUROPE GmbH has applied in 28 European countries for approval of a new antihypertensive medication. It is a fixed combination (CS-8663) of two substances, the angiotensin receptor blocker (ARB) Olmesartan and the calcium antagonist Amlodi...
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