antidiabetic

A Weight Neutral Oral Antidiabetic Drug Would Earn a 25 Percent Patient Share in the Type 2 Diabetes Drug Market

Advantages in Efficacy and Safety Will Make Liraglutide the New Clinical Gold Standard Drug by 2011, According to a New Report from Decision Resources WALTHAM, Mass., July 1 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firm...

Fat Screen Delivers Plant-derived Chemical With Antidiabetic Effects

After screening hundreds of compounds for their effects on fat development, researchers have discovered that an ingredient found in some plants fights diabetes in mice without some of the side effects attributed to other antidiabetes drugs. The chemical they pinpointed, known as harmine, was ...

New target for antidiabetic agents identified

U.S. researchers have identified a protein that could serve as a new target for drugs designed to treat type II diabetes. The protein, known as TRB3, is actually a homolog of a protein found in the fruit fly Drosophila tribbles, senior author Dr. Marc Montminy, from the Salk Institute for Biologica...

Pancreatic cancer risk decreased by one anti-diabetic therapy, increased by others

... Bethesda, MD (August 1, 2009) The antidiabetic medication metformin is associated with a reduced ...vidence to previous study findings indicating that antidiabetic therapy can affect the development of cancer." ...opulations to confirm or refute a possible role of antidiabetic therapy in pancreatic cancer. Since pancreatic can...

Amylin Pharmaceuticals Reports Second Quarter Financial Results

...study that showed the risk of acute pancreatitis among patients initiating therapy with BYETTA was not increased compared to patients initiating other antidiabetic therapies A meta-analysis of clinical data that showed there was no increased risk of cardiovascular events associated with the use of exena...

For Treatment of Type 2 Diabetes, 89 Percent of Surveyed Endocrinologists Identify a Need for Additional GLP-1 Analogues and 71 Percent Say the Same About DPP-IV Inhibitors

...analogue class, and 70 percent indicate a need for additional agents from the DPP-IV inhibitor class. Forty-five percent of MCOs indicate that a novel antidiabetic agent's glucose-lowering efficacy compared with that of existing drugs carries the most weight in their decision whether to include the novel drug in ...

What is the relationship between hepatocellular carcinoma and type 2 diabetes mellitus?

...llitus has been associated with HCC. However, the relationship between type 2 diabetes mellitus and the underlying liver cirrhosis, and the effects of antidiabetic therapy on HCC risk have not yet been fully evaluated. A research team led by Dr. Valter Donadon from Pordenone Hospital addressed this question. T...

Two-Year Data Show Investigational Drug Liraglutide More Effective at Lowering Blood Sugar Than Glimepiride

...ily) to glimepiride (8 mg, once daily) in patients with type 2 diabetes. Patients were treated previously with diet/exercise or low doses of one oral antidiabetic drug (OAD). The trial had a 52-week randomized, double-blind period followed by the one year extension; 59% entered the extension period of the trial...

Amylin Pharmaceuticals to Present Compelling Efficacy and Safety Data From Diabetes Programs at ADA 2009

...rry Shen, Ph.D. on Monday, June 8 at 6:15 PM CT (7:15 PM ET). Oral: "Incidence of Acute Pancreatitis in Exenatide Initiators Compared to Other antidiabetic Drug Initiators: A Retrospective, Cohort Study" will be presented by Gary Bloomgren, M.D. on Sunday, June 7 at 8:00 AM CT (9:00 AM ET). Oral: ...

The Launch and Uptake of More Than 20 Novel Drugs Over The Next 10 Years Will Drive $12.5 Billion Growth in the Type 2 Diabetes Market

...ne of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that the launch and uptake of more than 20 novel antidiabetic drugs over the next 10 years will drive the type 2 diabetes market to increase by $12.5 billion in the United States, France, Germany, Italy, Spain, t...

antidiabetic in Medical Technology

Takeda Provides Update on the Investigational Fixed-Dose Combination of alogliptin and ACTOS(R) (pioglitazone HCl)

...nformed Takeda that based on the December 2008 FDA Guidance titled, "Guidance for Industry: Diabetes Mellitus -- Evaluating Cardiovascular Risk in New antidiabetic Therapies to Treat Type 2 Diabetes," the amount of existing alogliptin clinical data in the alogliptin monotherapy NDA was not sufficient to meet cert...

Takeda Receives FDA Complete Response Letter for Alogliptin, an Investigational Treatment for Type 2 Diabetes

...iled prior to the release of the December 2008 FDA Guidance titled, "Guidance for Industry: Diabetes Mellitus -- Evaluating Cardiovascular Risk in New antidiabetic Therapies to Treat Type 2 Diabetes," the FDA did not believe that the amount of existing alogliptin clinical data was sufficient to meet certain stati...

The Lancet Publishes Direct Comparison Study Between Liraglutide and Exenatide

...ere not reaching recommended blood sugar targets on either the maximally tolerated doses of metformin, sulphonylurea, or both, which are standard oral antidiabetic medications currently available. Both treatments led to a weight reduction of on average 3 kg during the 26-week study. Nausea was the most comm...

Two-Year Data Show Investigational Drug Liraglutide More Effective at Lowering Blood Sugar Than Glimepiride: Oral 162

...ily) to glimepiride (8 mg, once daily) in patients with type 2 diabetes. Patients were treated previously with diet/exercise or low doses of one oral antidiabetic drug (OAD). The trial had a 52-week randomized, double-blind period followed by the one-year extension; 59% entered the extension period of the trial...

New Study Showed Lantus(R) Plus One, Two or Three Shots of Apidra(R) Lowered Patients' Blood Sugar

...ered before 1 meal, 2 meals or 3 meals daily, already taking basal insulin, Lantus(R) (insulin glargine [rDNA origin] injection), with or without oral antidiabetic drugs (OADs).The study was presented as a poster during the 69th Annual Scientific Sessions of the American Diabetes Association (ADA). The stu...

Boehringer Ingelheim Unveils Diabetes Pipeline

...ringer Ingelheim Pharmaceuticals, Inc. today announced its pipeline of oral antidiabetic compounds, establishing itself in the type 2 diabetes therapeutic area. Th...porter-2 inhibitors (SGLT-2 inhibitors), which are a new, emerging class of antidiabetic compounds that block tubular reabsorption of glucose in the kidney.(4) Phas...

AFRESA(R) Phase 3 Pulmonary Function Safety Data in Patients with Diabetes Presented at ADA

...acting insulin with changes in pulmonary function tests comparable to usual antidiabetic treatment, according to data presented today at the American Diabetes Assoc...jects with type 1 and 2 diabetes mellitus receiving AFRESA (n=730) or usual antidiabetic treatment (n=824), along with nondiabetic subjects (n=145). The main study ...

Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma

...d drugs that are inhibitors or inducers of cytochrome P450 3A4 should be closely monitored for either toxicities or reduced efficacy. Patients on oral antidiabetic medication while receiving VELCADE should check blood sugar levels frequently. Adverse Reaction Data Safety data from Phase II and III s...

Modified Insulin Most Effective For Controlling Post-Meal Blood Sugar Levels

...ms of the frequency of hypoglycemia reported. -- Pre-mixed insulin analogues are associated with a higher frequency of hypoglycemic events than oral antidiabetic (non-insulin) agents are. The report, Comparative Effectiveness, Safety and Indications of Pre-mixed Insulin Analogues for Adults With Type 2 Diabet...

Novo Nordisk New Data From a Phase 3 Study Confirms Clinical Benefits of Once-Daily Liraglutide in the Management of Type 2 Diabetes

...ers effective glucose lowering as monotherapy or as an add on to other oral antidiabetic therapies while also consistently lowering weight and blood pressure and en... -5.6* -1.1 *p FPG, fasting plasma glucose; OAD, oral antidiabetic drug; PPG, post-prandial glucose Safety and tolerability of liraglutide...

antidiabetic in Medical Dictionary

Insulin

...nse to insulin , so the times ... (NovoLog), and insulin glulisine (Apidra), begin to work about 15 minutes ... Abstract and Introduction: Oral antidiabetic therapy in combination with insulin provides an effective therapeutic option for patients who are unable to achieve or ... Fact sheet explaini...

antidiabetic in Biological News

Fat screen delivers plant-derived chemical with antidiabetic effects

After screening hundreds of compounds for their effects on fat development, researchers have discovered that an ingredient found in some plants fights diabetes in mice without some of the side effects attributed to other antidiabetes drugs. The chemical they pinpointed, known as harmine, was first ...

antidiabetic in Biological Technology

Merck Will Obtain Blockbuster Antidiabetic Drug Sales in Type 2 Diabetes Market by 2011

Takeda Will Continue to Dominate the Type 2 Diabetes Market, According to a New Report from Decision Resources WALTHAM, Mass., Oct. 17 /PRNewswire/ -- Decision Resources and Millennium Research Group have released a new report finding that Merck will obtain blockbuster antidiab...

Sanofi Aventis : New Study Results Support the "Basal Plus" Strategy With LANTUS(R) and APIDRA(R) to Improve Blood Sugar Control in Patients With Type 2 Diabetes

...t breakfast or main meal to basal insulin and oral antidiabetic therapy) clinical studies, patients previously tre...ptimized titration of LANTUS(R) combined with oral antidiabetic drug therapy." The ELEONOR study also confirmed ...portion of patients with secondary failure to oral antidiabetic agents, both Telecare and standard blood glucose m...

JCI table of contents: Dec. 3, 2007

...ecent study in the Journal of Clinical Investigation indicated that in mice, under certain circumstances (either a high-fat diet or treatment with the antidiabetic drug rosiglitazone), cells derived from the bone marrow known as BMDCPCs can act as precursors of fat cells (adipocytes). However, a new study in mice...

antidiabetic in Biological Definition

Diabetes mellitus

... restore insulin sensitivity, even when the weight lost is modest e.g. around 5 kg (10 to 15 lb). The next step, if necessary, is treatment with oral antidiabetic drugs : the sulphonylureas , metformin , or (if these are insufficient) thiazolidinediones . When these have failed, insulin therapy may be necessa...