Antidepressant

Results of phase III study on Labopharm's novel antidepressant published in Psychiatry (Edgemont) Journal

- Company to Also Present Clinical Data at Upcoming Scientific Meeting - LAVAL, QC, May 19 /PRNewswire-FirstCall/ - Labopharm Inc. (TSX: DDS; NASDAQ: DDSS ) today announced the publication of Extended Release Trazodone in Major Depressive Disorder:...

Participants in antidepressant drug trials are atypical patients, UT Southwestern researchers report

DALLAS May 13, 2009 One reason antidepressant medication treatments do not work as well in real life as they do in clinical studies could be the limited type of study participants selected, researchers at UT Southwestern Medical Center have found. "We are basing our judgment of clinical care ...

AstraZeneca Licenses Novel Antidepressant Compounds Discovered by Mayo Clinic and Virginia Tech Collaboration

Agreement includes research collaboration to generate follow-up TRI compounds WILMINGTON, Del., Feb. 9 /PRNewswire-FirstCall/ -- AstraZeneca, Mayo Clinic, and Virginia Tech Intellectual Properties Inc. today announced that AstraZeneca has licensed a portfolio of preclinical Triple Reuptake In...

Mylan Receives Final FDA Approval for the Generic Version of the Antidepressant Sarafem(R) Pulvules(R) Capsules

PITTSBURGH, Nov. 18 /PRNewswire-FirstCall/ -- Mylan Inc. (NYSE: MYL ) today announced that its subsidiary, Mylan Pharmaceuticals Inc., received final approval from the U.S. Food and Drug Administration (FDA) for its Abbreviated New Drug Application (ANDA) for Fluoxetine Capsules USP, 10 mg and 2...

Gene Variations May Predict Antidepressant Response

Finding could help advance individualized medicine for psychiatric patients FRIDAY, July 18 (HealthDay News) -- Scientists may have found more evidence that a person's genetic make-up may help determine whether or not they respond to the antidepressant Celexa (citalopram). Specifica...

New study replicates association between genetic variation and antidepressant treatment response

Philadelphia, PA, July 15, 2008 Pharmacogenetics, the study of genetic variation that influences an individual's response to drugs, is an important and growing focus in all of medical research, including psychiatry. It is a complex field, however, revealed by the lack of consistent and replicabl...

Mylan Announces Final FDA Approval for Generic Version of Antidepressant Effexor(R)

PITTSBURGH, June 16 /PRNewswire-FirstCall/ -- Mylan Inc. (NYSE: MYL ) today announced that its subsidiary, Mylan Pharmaceuticals Inc., has received final approval from the U.S. Food and Drug Administration (FDA) for its Abbreviated New Drug Application (ANDA) for Venlafaxine Hydrochloride (HC...

Hunger hormone increases during stress, may have antidepressant effect

DALLAS June 15, 2008 New research at UT Southwestern Medical Center may explain why some people who are stressed or depressed overeat. While levels of the so-called "hunger hormone" ghrelin are known to increase when a person doesn't eat, findings by UT Southwestern scientists suggest that t...

Inflammation, depression and antidepressant response: Common mechanisms

Major depressive disorder is a common and complex condition that impacts about 15% of the population of the United States, yet very little is known about the mechanisms behind the psychiatric disorder. What is known is that there are clinical parallels between depressive symptoms and the sympto...

A Drug That Carries a Lower Risk of Weight Gain Than AstraZeneca's Seroquel and Has Antimanic and Antidepressant Effects Would Earn a 30 Percent Patient Share in Bipolar Disorder Treatment

Seroquel's Successor, Seroquel XR, Will Earn a 16 Percent Patient Share in the Bipolar Disorder Market by 2016, According to a New Report from Decision Resources WALTHAM, Mass., April 22 /PRNewswire/ -- Decision Resources, one of the world's leading research and advis...

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Antidepressant in Medical Technology

CeNeRx BioPharma Initiates Phase II Clinical Trial of Its Novel Antidepressant Agent Tyrima(TM)

RESEARCH TRIANGLE PARK, N.C., Oct. 17 /PRNewswire/ -- CeNeRx BioPharma, Inc., a clinical stage company developing and commercializing innovative treatments for diseases of the central nervous system, today announced that it has initiated a Phase II clinical trial for its lead product candidate...

CeNeRx BioPharma Finalizes Plans to Initiate Phase II Trials for Its Novel Antidepressant Agent Tyrima(TM) Using Innovative Brain Imaging Study

- State-of-the-Art PET Study Confirms Tyrima Exhibits Excellent Drug-Like Properties - - Results Support Initiation of Phase II Clinical Trials - RESEARCH TRIANGLE PARK, N.C., July 22 /PRNewswire/ -- CeNeRx BioPharma, Inc., a clinical stage company developing ...

Intra-Cellular Therapies Announces the Discovery of Potent Antidepressant Activity in ITI-007

NEW YORK, April 9, 2008 /PRNewswire/ -- Intra-Cellular Therapies, Inc., today announced additional preclinical data from its ongoing development programs for ITI-007, the Company's first-in-class dual 5HT2A receptor antagonist/dopamine receptor phosphoprotein modulator (DPPM), and ITI-722, a l...

Intra-Cellular Therapies Announces the Discovery of Potent Antidepressant Activity in ITI-007/ITI-722

NEW YORK, April 9, 2008 /PRNewswire/ -- Intra-Cellular Therapies, Inc., today announced additional preclinical data from its ongoing development programs for ITI-007, the Company's first-in-class dual 5HT2A receptor antagonist/dopamine receptor phosphoprotein modulator (DPPM), and ITI-722, a l...

CeNeRx BioPharma Announces Successful Completion of Phase l Clinical Program for Novel Antidepressant Agent Tyrima(TM)

- Tyrima Exhibits Excellent Safety Profile and Favorable Pharmacokinetics in Phase I Studies - RESEARCH TRIANGLE PARK, N.C., Jan. 16 /PRNewswire/ -- CeNeRx BioPharma, Inc., a clinical stage company developing and commercializing innovative treatments for diseases of the...

Labopharm files New Drug Submission with Health Canada for novel antidepressant

LAVAL, QC, Aug. 5 /PRNewswire-FirstCall/ - Labopharm Inc. (TSX: DDS; NASDAQ: DDSS ) today announced it has filed a New Drug Submission (NDS) with the Therapeutic Products Directorate of Health Canada for its novel formulation of the antidepressant trazodone. "We are pleased to file our New Dru...

FDA Proposes New Warnings About Suicidal Thinking, Behavior in Young Adults Who Take Antidepressant Medications

ROCKVILLE, Md., May 2, 2007-The U.S. Food and Drug Administration (FDA) today proposed that makers of all antidepressant medications update the existing black box warning on their products' labeling to include warnings about increased risks of suicidal thinking and behavior, known as suicidality, ...

CeNeRx BioPharma Announces Positive Phase I Results in First Human Trial of Third Generation RIMA Antidepressant

- Tyrima Demonstrates Good Safety Profile and Excellent Pharmacokinetic Properties - RESEARCH TRIANGLE PARK, N.C., March 13, 2007 /PRNewswire/ -- CeNeRx BioPharma, Inc., a clinical stage company developing and commercializing innovative treatments for diseases of the central nervous system, today ...

Blood Levels of Paliperidone Extended-Release Tablets are Not Increased by Common Antidepressant

Study shows paroxetine produced no significant drug interaction with paliperidone ER SAN DIEGO, May 22, 2007 /PRNewswire/ -- After administration of paliperidone extended-release (ER) tablets, blood levels of the drug were not affected when given with a common antidepressant, according to new data...

Popular Breast Cancer Drug Used with Certain Antidepressants Puts New Jersey Women at Risk

...ing tamoxifen are depressed, or to treat hot flashes -- a common side effect of the breast cancer drug. Paxil, Prozac and Zoloft are among a group of antidepressant drugs known as CYP2D6 inhibitors. These drugs prevent the CYP2D6 enzyme from working properly, and cause less of the active form of tamoxifen, called ...

Antidepressant in Medical Dictionary

Serotonin

...t an imbalance in serotonin levels may influence mood in a way that leads to depression. Clinical depression information: symptoms, treatment, antidepressant medications, ... Serotonin acts both as a chemical messenger that transmits nerve signals between ... New discoveries about the mind and our s...

Manic Depression

...part of the ... Clinical depression information: symptoms, treatment, antidepressant medications, ... Manic - depression : Alternating moods of abnormal highs ...and mania ... Clinical depression information: symptoms, treatment, antidepressant medications, ... Depression Poses Pregnancy Risks. Sad Dads May Lead to C...

Electroconvulsive

...r Online Dictionary with audio pronunciations, thesaurus, Word of the Day, and word games. Clinical depression information: symptoms, treatment, antidepressant medications, ... Why is electroconvulsive therapy performed? ... Electroconvulsive Therapy glossary includes a list of Electroconvulsive The...

Depression

...pes, and statistics of depressive disorders. Comprehensive resources for depression and depressive disorders including information on treatment, antidepressant medications, and support groups. Depression is very common. For more information about depression and feeling better, check out this article. ...

ADD

...y. Will make you In addition to genetics, researchers are looking at possible environmental ... Adding a prescription for a low dose of an antidepressant or a blood pressure ... How to focus on results, gifts, and making a difference in people's lives. ADD and other invisible problems need a pos...

Antidepressant in Biological News

Millisecond brain signals predict response to fast-acting antidepressant

Images of the brain's fastest signals reveal an electromagnetic marker that predicts a patient's response to a fast-acting antidepressant, researchers have discovered. "Such biomarkers that identify who will benefit from a new class of antidepressants could someday minimize trial-and-error pres...

Nobelist discovers antidepressant protein in mouse brain

A protein that seems to be pivotal in lifting depression has been discovered by a Nobel Laureate researcher funded by the National Institutes of Health's National Institute of Mental Health (NIMH). "Mice deficient in this protein, called p11, display depression-like behaviors, while those with s...

22nd Congress of the European College of Neuropsychopharmacology, Sept. 12-16, 2009, Turkey

...ogical progress achieved in recent decades is mainly due to the development of receptor-specific drugs. For instance, the currently most commonly used antidepressant drugs, the SSRIs, selectively inhibit the transport of the neurotransmitter serotonin, prolonging its activity in the synapse between the nerve cells....

Team identifies a molecular switch linking infectious disease and depression

...on. More research will establish if that is true, they said. In the meantime, the study highlights IDO as a potential target for development of new antidepressant drugs. The study also demonstrates the robust link between the immune system and the nervous system, a connection often ignored by immunologists an...

Depression during pregnancy can double risk of preterm delivery

...sive symptoms early in pregnancy, long before the preterm delivery occurred, therefore avoiding recall bias. In addition, the study was not clouded by antidepressant use because only 1.5 percent of the study population was prescribed antidepressants and we could exclude them in the analyses," Li said. "Considering ...

NARSAD announces 2008 Prizes for Outstanding Achievement in Research on Mental Health Disorders

...of brain imaging and stimulation to understand depression and to devise new antidepressant treatments, who will both receive the Falcone Prize for Outstanding Achieve...of brain imaging and stimulation to understand depression and to devise new antidepressant treatments. In early research at the National Institute of Mental Health, D...

Healthy Minds Across America features 48 public forums on mental health research, Sept. 14

...n our communities: The possibility of recovering from traumatic events; Depression: Risk factors for depression across the life cycle, the safety of antidepressant medications, and new therapies such as deep brain stimulation; The biological basis of addiction: The biology and brain circuitry of addiction; ...

Study finds connections between genetics, brain activity and preference

... of theirs associated the same variation with a threefold greater risk of suicidal thinking in major depressive disorder patients soon after beginning antidepressant therapy. The 28 participants in the current study had no evidence of any psychiatric disorder or physical disorder that might influence brain activit...

N.Y. research team discovers how antidepressants and cocaine interact with brain cell targets

...described the specifics of how brain cells process antidepressant drugs, cocaine and amphetamines. These novel findi...he cell. In the bacterial transporter studied, antidepressant molecules bind in the outer one of two sites, and ...sporter cocaine binds in the deep site, unlike the antidepressant binding in the bacterial transporter. Therefore, t...

At Boston symposium, NARSAD researchers report on genes and family traits

...an half are not helped by their initial course of antidepressant treatment, whether medication or talk therapy. In addition, antidepressant medications often come with troubling side effects...s may influence how individual patients respond to antidepressant therapies, which is why his research team is using...

Antidepressant in Biological Technology

REMERON(R) Now Approved in Japan for the Treatment of Depression in Adult Patients

...Important Safety Information Suicidality and antidepressant Drugs Antidepressants increased the risk compare...zapine) Orally Disintegrating Tablets or any other antidepressant in a child, adolescent, or young adult must balanc...f suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and obse...

Genomas and Institute of Living Among Organizers of Pharmacogenetics Symposium at 2009 Annual Meeting of the American Psychiatric Association

...es for patients treated for major depressive disorder (MDD). Data were obtained from the DNA of 150 psychiatric in-patients being treated for MDD with antidepressant and atypical antipsychotic medications at the Institute of Living. "These genetic variations may contribute to a reduction in efficacy or an incr...

Psylin Neurosciences Commences Development of Compound for Depression

...ts in multiple preclinical tests of depression, but also in preclinical tests of anxiety. The peptide has several anticipated advantages over current antidepressant medications including cognitive enhancement, weight loss, a lack of sexual side effects, and an enhanced safety and side effect profile. Psylin's pri...

Valdoxan(R) Granted Marketing Authorisation for the Treatment of Major Depressive Episodes in Europe

.../Thymanax(R) (agomelatine), the first melatonergic antidepressant for the treatment of adult patients with major dep...from major depressive episode. Valdoxan's powerful antidepressant efficacy combined with its good safety and tolerab...its unique receptor profile. Valdoxan is the first antidepressant with melatonin receptor (MT1) and (MT2) agonist pr...

Governor Rendell Says Life Science Industry Will Fuel New Breakthroughs, Generate Jobs for Decades to Come

...netic Stimulation) therapy system is the first and only non-systemic and non-invasive treatment cleared for patients who have not benefited from prior antidepressant treatment. Neuronetics is a portfolio company of Quaker BioVentures -- one of the four private venture firms selected by the Tobacco Settleme...

Lilly Highlights Transformation Strategy for Wall Street, Reviews Robust Pipeline and Sets 2009 Financial Guidance

...three quarters have grown 28 percent in the U.S. and 74 percent internationally. In the U.S., Cymbalta is the only established branded medicine in the antidepressant category that is growing its share of market, and formulary access continues to be strong. U.S. Cymbalta sales are also expected to benefit from its r...

CeNeRx BioPharma Completes $15 Million Series B Financing

...ation of a Phase II clinical trial to evaluate the antidepressant efficacy of Tyrima in patients with MDD. "We wel...ch has the potential to be the first triple-action antidepressant with a safety profile appropriate for use by the m...ovel compounds being developed for the underserved antidepressant market, and we are in early discussions with poten...

US Neuropathic Pain Market Value Doubles to $5 Billion by 2018

...th over the next 5 years due to penetration of the market for fibromyalgia. Two yet to be launched products, Forest Laboratories/Cypress Biosciences's antidepressant milnacipran and Schwarz Pharma's sodium ion channel antagonist/CRMP2 modulator lacosamide (Vimpat), will compete for market share as well as provide t...

Marinus Pharmaceuticals Appoints John Krayacich as President and Chief Executive Officer

...years focused on neuroscience diseases. Most recently, he was with Novartis Pharmaceuticals Corporation where he served as global program head for the antidepressant agomelatine, and vice president and global head of neuroscience project management. "We are pleased that John is taking the helm at Marinus, particu...

Wyeth and Impax Announce Final Settlement of Effexor XR Patent Suit

...ditions of a settlement of the U.S. patent infringement litigation pertaining to Impax's proposed generic capsule formulation of Wyeth's EFFEXOR XR(R) antidepressant have been approved by the United States District Court for the District of Delaware. The Court entered a consent judgment resulting in termination of ...

Antidepressant in Biological Definition

Selective serotonin reuptake inhibitor

...f a bodily disease." The mode of action of these antidepressant drugs on their direct target, the serotonin transp...loxetine are both members of the SNRI class of antidepressant medication. SNRIs (serotonin-norepinephrine reupt...pinephrine and serotonin, but it is a tetracyclic antidepressant , not a SSRI or SNRI. The arrival of these new dru...