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anthracis in Medical News

Elusys Therapeutics and Lonza Enter Into Manufacturing Agreement

...s. Anthim Background Anthim is a high-affinity, humanized and deimmunized monoclonal antibody that targets the protective antigen of B. anthracis and neutralizes the lethal effects of anthrax toxins. It is being developed for prevention and treatment of inhalation anthrax. Anthim has been grant...

Scott Miller and Company Premieres "A CALL TO ARMS 2009 EDITION" at the Camelot Theaters in Palm Springs

...ective against many naturally occurring anthrax strains. Vaccines created from killed anthrax cultures, which contain a significant fraction of B. anthracis capsid protein, have proven to be effective against a wide-range of anthrax strains. Killed anthrax vaccines are typically given to farm animals arou...

Researchers Pursuing Nasal Anthrax Vaccine

...e published in the April issue of Clinical and Vaccine Immunology . Anthrax is the infection caused by the naturally occurring bacterium Bacillus anthracis . These spore-forming bacteria are found in wild and domestic animals, such as camels, goats, sheep, cattle and deer. Spores can live in the soil fo...

Is a cup of tea really the answer to everything -- even anthrax?

...as revealed how the humble cup of tea could well be an antidote to Bacillus anthracis more commonly know as anthrax. As a nation, Brits currently drink 165...lity of tea to bring solace and steady the mind, and to inactivate Bacillus anthracis and its toxin, perhaps the Boston Tea Party was not such a good idea after ...

Researchers find possible target to treat deadly bloodstream infections

...es of anthrax infections," Samant said. "We found that, similar to E. coli, anthracis bacilli that could not biosynthesize nucleotides also were unable to grow i...ne at the University of Illinois Medical Center at Chicago, showed Bacillus anthracis mutants that were unable to synthesize nucleotides were not able to infect ...

Key Anthrax Virulence Factor Discovered

...immune cells called macrophages use to kill pathogens. That research involved Bacillus subtilis , a close relative of the anthrax pathogen, Bacillus anthracis . In the present study, the team found that when they mutated the bNOS gene in the anthrax pathogen, the resulting bacteria were far more susceptib...

PharmAthene and Medarex Announce Additional $0.8 Million U.S. Government Appropriation for Continued Development of Anthrax Therapeutic Valortim(TM)

...n anthrax, the most lethal form of illness in humans caused by the Bacillus anthracis bacterium. The investigational antibody is designed to target a protein com...ions, including: (1) lack of activity against the toxins produced by the B. anthracis bacteria (2) need for long-term dosing to achieve full protection, complica...

Southern Research Institute Names Vladimir Yamshchikov Director of Infectious Disease Research Department in Birmingham

...work with both animal and human risk group Level 3 pathogens, including highly-pathogenic avian influenza (HPAi), West Nile, SARS viruses and Bacillus anthracis (anthrax). About Southern Research Institute Southern Research Institute is a not-for-profit organization that conducts basic and applied research ...

Replidyne Pipeline Featured at 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy

...t 11:15 AM, Hall D: -- Poster A-1435, titled "Pharmacokinetic-Pharmacodynamic (PK-PD) Assessment of Faropenem (FAR) in a Lethal Murine-Bacillus anthracis (BA) Inhalation Post-Exposure Prophylaxis Model." REP8839 Presentation Thursday, September 20 at 10:00 AM, Room E253D: -- Poster F1-2116, t...

Physicists Unite To Develop Anthrax Detection Method

...mizing the background “noise” from extraneous molecules and maximizing the coherent molecular oscillations crucial to detecting endospores of Bacillus anthracis (anthrax). They have accomplished this by using a succession of femtosecond pulses (one femtosecond is one billionth of one millionth of a second) so ...
anthracis in Medical Technology

PharmAthene Submits Proposal to BARDA in Response to Broad Agency Announcement for Advanced Research and Development for Valortim(R)

...l anthrax, the most lethal form of illness in humans caused by the Bacillus anthracis bacterium. The investigational antibody is designed to target a protein com...ions, including: (1) lack of activity against the toxins produced by the B. anthracis bacteria, (2) need for long-term dosing to achieve full protection, complic...

Human Genome Sciences Submits Biologics License Application to FDA for ABthrax(TM)

...m the U.S. Government upon FDA licensure of raxibacumab. About Anthrax Anthrax infection is caused by a spore-forming bacterium, Bacillus anthracis , which multiplies in the body and produces lethal toxins. Most anthrax fatalities are caused by the irreversible effects of the anthrax toxins. Resea...

Elusys' Anthrax Anti-Toxin, Anthim(TM), Enters Second Phase I Clinical Study

...acute. Anthim Background Anthim is a high-affinity, humanized and deimmunized monoclonal antibody that targets the protective antigen of B. anthracis and neutralizes the lethal effects of anthrax toxins. It is being developed for prevention and treatment of inhalation anthrax. Anthim has been gra...

Novel Valortim(R) Mechanism of Action Data Presented at the Keystone Symposia on Molecular and Cellular Biology

...age model, Valortim(R) enhanced the killing of B. anthracis (anthrax) by macrophages in a time and dose-depen...ole of Valortim(R) in enhancing the killing of B. anthracis . We hypothesize that Valortim(R) may protect aga...ow Valortim(R) enhances the immune response to B. anthracis infection." David P. Wright, President and C...

Human Genome Sciences Begins Delivery of First-in-Class Anthrax Treatment to U.S. Strategic National Stockpile

...cally targets the deadly toxins released within the human body by Bacillus anthracis that are the real culprits in most anthrax-related deaths. ABthrax is bei...trains of anthrax. ABthrax is a human monoclonal antibody to Bacillus anthracis protective antigen that was discovered and developed by HGS, using technol...

PharmAthene Presents Data for Protexia(R) and Valortim(R) at 2008 BARDA Industry Conference / PHEMCE Stakeholders Workshop

...Valortim(R) is a fully human antibody designed to protect against inhalation anthrax, the most lethal form of illness in humans caused by the Bacillus anthracis bacterium. The investigational antibody is designed to target a protein component known as the anthrax protective antigen of the lethal toxin complex ...

New Approach to Treating Anthrax Significantly Improves Survival Rates in Pivotal Efficacy Studies

... way to address the anthrax threat. While antibiotics can kill the Bacillis anthracis bacteria, they are not effective against the deadly toxins that the bacteri...nt strains of anthrax. ABthrax is a human monoclonal antibody to Bacillus anthracis protective antigen that was discovered and developed by HGS, using technolo...

Anthrax Monoclonal Antibody Valortim Demonstrates Therapeutic Effect in New Primate Model of Established Anthrax Infection

...expected in humans exposed to aerosolized Bacillus anthracis spores. B. anthracis is the bacterium responsible for anthrax infection...ective antigen is one of the toxins produced by B. anthracis and its presence in the blood is being evaluated a...

Anthrax Monoclonal Antibody Valortim(tm) Demonstrates Therapeutic Effect in New Primate Model of Established Anthrax Infection

...expected in humans exposed to aerosolized Bacillus anthracis spores. B. anthracis is the bacterium responsible for anthrax infection...ective antigen is one of the toxins produced by B. anthracis and its presence in the blood is being evaluated a...

Targanta Study Shows Oritavancin Treatment Effective in a Mouse Model of Anthrax

...ce were exposed to spores of the Ames strain of B. anthracis at seventy five times the lethal dose necessary to...All treatments began 24 hours after exposure to B. anthracis spores. Survival rates at 30 days post- exposure w...rax, including five deaths. If treated promptly B. anthracis usually responds effectively to several antibiotic...
anthracis in Medical Dictionary

Bacillus anthracis

Bacillus anthracis is a Gram-positive spore-forming, rod-shaped bacterium, with a width of 1-1.2µm and a length of 3-5µm. It can be grown in an ordinary nutrient medium under aerobic or anaerobic conditions. It is the only... Anthrax is an acute disease caused by Bacillus anthracis ....

Spores

... Starting with single-cell organisms, players work on designing life with ever more complexity. Anthrax disease begins when spores of Bacillus anthracis invade an ... When inhaled, anthrax spores germinate and grow in the lymph nodes nearest the lungs. ... Large selection of exotic Psilocybin...
anthracis in Biological News

American Society for Microbiology honors James W. Snyder

...the other professional groups in the LRN. The 2001 anthrax attack was diagnosed by a clinical laboratory using the techniques outlined in the Bacillus anthracis Sentinel Protocol. Dr. Snyder received his Ph.D. from the University of Dayton. He is a Fellow of the American Academy of Microbiology and a Colo...

New technique used to profile anthrax genome

...t we can see in a much more detailed way how each of the 5,000+ genes in B. anthracis genome is expressed and regulated." The RNA-Seq approach works by using ..., Bergman and colleagues sequenced mRNA samples that were collected from B. anthracis cells growing in a variety of conditions. They collected more than 270 mill...

Scripps research scientists identify blood component that turns bacteria virulent

...discovered the key chemical that signals Bacillus anthracis , the bacterium that causes anthrax, to become let...ce in cells, as providing the signal for Bacillus anthracis to unleash virulence factors. Without the presenc... carbon dioxide, that signals the gram-positive B. anthracis to become virulent. This finding also is significa...

FBI unveils science of anthrax investigation

... killed. Sandia's work demonstrated to the FBI that the form of bacillus anthracis contained in those letters was not a weaponized form, a form of the bacteri...were prepared, which made examination initially difficult. When bacillus anthracis spores are weaponized, the spores are coated with silica nanoparticles that...

Tests show LLNL detection instrument can monitor the air for all major terrorist threat substances

...rials terrorists might use -- spores of a non-pathogenic strain of Bacillus anthracis (other strains of this bacteria cause anthrax); diethyl phthalate (a nerve ...e of natural cobalt powder and RDX, and a non-pathogenic strain of Bacillus anthracis and RDX. In field experiments, SPAMS has been tested at San Francisco In...

NIST, Army researchers pave the way for anthrax spore standards

...ctivity and stability of laboratory-grade Bacillus anthracis spores under different storage conditions. Bacillus anthracis (Sterne), a harmless vaccine strain, was used in t...icrobiological techniques to quantify the Bacillus anthracis concentrations: counting spores under a microscope...

Anthrax cellular entry point uncovered

...c-1 receptor, and use this entry point to boost its lethality. Bacillus anthracis infection occurs in three forms: cutaneous (skin), inhalation and through ...c-1 receptors, this discovery points toward a precise entry point which B. anthracis uses to proliferate and trigger lethal consequences, said Claudia Oliva, P...

Anthrax attack posed greater potential threat than thought

...irmed to have had anthrax, and 12 with no known B. anthracis exposure. The results: Immune responses occur... the incidence of both subclinical and clinical B. anthracis infection. In an accompanying editorial, Jam...'s data suggest that cell-mediated responses in B. anthracis infection may be more sensitive than antibody resp...

Penn study on lung-infecting bacterial enzyme suggests new approach to cystic fibrosis treatment

...measuring electrical current. The researchers found that direct exposure of the CFTR-containing oocytes to SMase of Staphylococcus aureus and Bacillus anthracis bacteria shuts off the electrical current passing through not only the normal, but also the CF-causing mutant CFTR. The next step for the resea...

Scientists design potent anthrax toxin inhibitor

...AID Director Anthony S. Fauci, M.D. The spore-forming bacterium Bacillus anthracis produces a toxin that causes anthrax symptoms. Antibiotics are used to trea... test the action of their inhibitor in animals after infecting them with B. anthracis and allowing the disease process to begin. They also will evaluate the inhi...
anthracis in Biological Technology

Human Genome Sciences Announces New Order for Raxibacumab (ABthrax(TM)) from U.S. Government

...S. Government upon FDA licensure of raxibacumab. About Anthrax Anthrax infection is caused by a spore-forming bacterium, Bacillus anthracis , which multiplies in the body and produces lethal toxins. Most anthrax fatalities are caused by the irreversible effects of the anthrax toxins. Resea...

Data Published in The New England Journal of Medicine Support Use of Raxibacumab (ABthrax(TM)) for the Treatment of Inhalation Anthrax

...m the U.S. Government upon FDA licensure of raxibacumab. About Anthrax Anthrax infection is caused by a spore-forming bacterium, Bacillus anthracis , which multiplies in the body and produces lethal toxins. Most anthrax fatalities are caused by the irreversible effects of the anthrax toxins. Resea...

PharmAthene Presents Data for SparVax(TM), a Novel Vaccine for the Prevention and Treatment of Anthrax Infection, at the 12th Annual Conference on Vaccine Research

...an acute infectious disease caused by the spore-forming bacterium Bacillus anthracis . Anthrax most commonly occurs in hoofed mammals and can also infect humans...ons, including: (1) lack of activity against the toxins produced by the B. anthracis bacteria, (2) need for long-term dosing to achieve full protection, compli...

PharmAthene Presents Data for SparVax(TM) and Valortim(R), a Novel Vaccine and Anti-Toxin for the Prevention and Treatment of Anthrax Infection at the 7th Annual ASM Biodefense Meeting

... form of illness in humans caused by the Bacillus anthracis bacterium. The investigational antibody is design...se caused by the spore-forming bacterium Bacillus anthracis . Anthrax most commonly occurs in hoofed mammals a...of activity against the toxins produced by the B. anthracis bacteria, (2) need for long-term dosing to achiev...

FBI unveils science of anthrax investigation

... killed. Sandia's work demonstrated to the FBI that the form of bacillus anthracis contained in those letters was not a weaponized form, a form of the bacteri...were prepared, which made examination initially difficult. When bacillus anthracis spores are weaponized, the spores are coated with silica nanoparticles that...

Medarex And PharmAthene Announce New Therapeutic Data for Anthrax Anti-Toxin, Valortim(R)

...herapy, while useful, is believed to be associated with a number of limitations, including: (1) lack of activity against the toxins produced by the B. anthracis bacteria (2) need for long-term dosing to achieve full protection, complicated by side effects and non-compliance (3) lack of efficacy when administer...

PharmAthene Awarded NIAID Contract For Up to $83.9 Million For Third Generation rPA Anthrax Vaccine Program

... stated should be announced by year-end 2008." About Anthrax Anthrax is an acute infectious disease caused by the spore-forming bacterium Bacillus anthracis and has the potential to be used as a weapon of bioterror when delivered in an aerosolized form. Following germination of the spores, the bacteria rep...

FBI unveils science of anthrax investigation

... killed. Sandia's work demonstrated to the FBI that the form of bacillus anthracis contained in those letters was not a weaponized form, a form of the bacteri...were prepared, which made examination initially difficult. When bacillus anthracis spores are weaponized, the spores are coated with silica nanoparticles that...

Tests show LLNL detection instrument can monitor the air for all major terrorist threat substances

...rials terrorists might use -- spores of a non-pathogenic strain of Bacillus anthracis (other strains of this bacteria cause anthrax); diethyl phthalate (a nerve ...e of natural cobalt powder and RDX, and a non-pathogenic strain of Bacillus anthracis and RDX. In field experiments, SPAMS has been tested at San Francisco In...

Elusys' Anthim(TM) Dramatically Improves Survival of Animals Treated After Active Anthrax Infection

...s of anthrax. Anthim Background Anthim is a high-affinity, humanized and deimmunized monoclonal antibody that targets the protective antigen of B. anthracis and neutralizes the lethal effects of anthrax toxins. It is being developed for prevention and treatment of inhalation anthrax. Anthim has been grante...
anthracis in Biological Products

Rabbit Anti-Bacillus anthracis (Anthrax) Spore Antigen Antibody, Unconjugated from HyTest Ltd.

Description: In Western blotting antibodies recognize 94 K protein band, which corresponds to S-layer protein...
Company:HyTest Ltd.
anthracis in Biological Dictionary

Bacillus

...ver, Bacillus (written with a capital ... Characteristically, Bacillus cultures are Gram-positive when young, but may ... Details of Bacillus anthracis biology, toxicity, and effect on the human immune ... Living in the soil are huge numbers of bacteria belonging to the genus Bacillus . ... ...

Bacilli

...s to a taxonomic class of bacteria. It includes two orders, Bacillales and Lactobacillales, which contain several well-known pathogens like Bacillus anthracis . For rod-shaped bacteria in general, see Bacillus (shape) ... For the class, see Bacilli . ... Many Bacillus species are able to secret...
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(Date:4/17/2014)... as many as 10 million older Americans suffer from ... isolation. , However, new research a project that ... for six years found that Internet use among ... more than 30 percent. , "That,s a very strong ... of telecommunication, information studies and media who led the ...
(Date:4/17/2014)... one in five infants in the United States annually ... several months after birth. Research into probiotic use for ... April 1, 2014 issue of the British Medical ... "Probiotics and Infant Colic," concluding that the use of ... did not reduce crying or fussing in infants ...
(Date:4/17/2014)... Boston University School of Medicine (BUSM) have discovered ... in an experimental model. The findings, reported in ... Abuse , may lead to more effective treatments ... one of the leading causes of illness and ... economic impact by limiting the productivity of workers ...
(Date:4/17/2014)... (SACRAMENTO, Calif.) An international team led by researchers ... protein complex, which plays a key role in cell ... process. This is the first time the complex has ... could make cyclin B1/Cdk1 an excellent target to control ... medicine. The research was published online today in the ...
(Date:4/17/2014)... by Cesar A. Arias, M.D., Ph.D., at The University ... identified a new superbug that caused a bloodstream infection ... April 17 issue of The New England Journal ... of a class of highly-resistant bacteria known as methicillin-resistant ... major cause of hospital and community-associated infections. The superbug ...
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(Date:4/17/2014)... Gene expression is the process whereby the genetic ... products, such as proteins, which have numerous different ... as an important intermediary during gene expression, by ... molecular mechanisms involved in manufacturing proteins. , ... mRNA molecules present in an organism at a ...
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