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antagonists in Medical News

TorreyPines Therapeutics Licenses Intellectual Property from Johns Hopkins Related to Novel Uses of Glutamate Receptor Antagonists for Prevention, Treatment of Stroke, Heart Attack

- Research Published in March Issue of Journal of Experimental Medicine - - Findings Underscore Versatility of TorreyPines' AMPA/Kainate Receptor Antagonists as Possible Antithrombotic Agents - LA JOLLA, Calif., May 1 /PRNewswire/ -- TorreyPines Therapeutics, Inc. (Nasdaq: TPTX ) ...

Breast Cancer risk for women on dopamine antagonists

A study, by researchers of the Harvard Medical School, of more than 100,000 women, indicates that women who use dopamine antagonists, i.e. anti-psychotics, for either psychiatric// illnesses or other conditions, may have an increased risk of breast cancer. The study involved about 52,000 women...

Does the Crowded TNF Market Really Need Two New Agents? Rheumatologists Provide Insight in the Wave One Report of LaunchTrends(TM): SIMPONI and CIMZIA

...ends (TM): SIMPONI and CIMZIA report. The survey was completed by U.S. Rheumatologists in late June 2009. While awareness of both new TNF antagonists is relatively high, there are some troubling signs regarding initial impressions of these agents. The initial favorability rating for Simponi, for exa...

Michael J. Fox Foundation Awards $3.8 Million To Drive Nine Industry Partnerships For Pre-Clinical Parkinson's Drug Development

...of levodopa-induced dyskinesia in Parkinson's disease Kristen Jordan, PhD, Targacept, Winston-Salem, North Carolina Optimization of MOR antagonists for the treatment of L-DOPA-induced dyskinesias in Parkinson's disease Patrick Little, PhD, Adolor Corporation, Exton, Pennsylvania TDI ...

Sundia MediTech Appoints Dr. Chen Chen as Senior VP of Chemistry

...-binding protein. In addition, Dr. Chen identified the first selective antagonist of the melanocortin-5 receptor, and discovered numerous agonists and antagonists for the melanocortin-4 receptor for eating disorders. Dr. Chen has extensive experience in CNS drug research and GPCRs as drug targets. His kno...

Amira Pharmaceuticals Announces Initial Positive Phase 1 Clinical Data for AM211, a Novel Product Candidate for the Treatment of Respiratory Diseases

...of AM211. The pharmacokinetic profile indicates safety multiples as compared to exposures observed in safety species. While there are no DP2 selective antagonists approved for therapeutic use, there is a strong scientific rationale for this target to be a novel treatment of asthma, chronic obstructive pulmonary ...

An Increase in the Diagnosed Prevalent Population Will Drive Growth of Nearly $4.3 Billion in the Chronic Obstructive Pulmonary Disease Market

...ents who receive them. The report finds that as new long-acting beta2 agonist (LABA)/inhaled corticosteroid (ICS) combinations, long-acting muscarinic antagonists (LAMAs), and LABA/LAMA products emerge from clinical development over the next decade, the use of maintenance therapies will continue to increase. ...

Nicotine Receptors Could Be Lung Cancer Treatment Target

...the mice. "This research clearly has profound clinical implications regarding the role of nicotine in stimulating lung cancer and nicotine receptor antagonists in treating the disease," said Dr. John Heffner, past president of the American Thoracic Society, in a news release from the society. Heffner, who was...

Asthma Drugs Get 'Precaution' Labeling for Possible Psychiatric Side Effects

...ve with depression." Joks said he had seen headaches develop as a side effect of Singulair, but not psychiatric problems. Leukotriene receptor antagonists target part of the body's inflammatory process. They are prescribed to treat asthma and the symptoms of allergic rhinitis, as well as to prevent exerc...

Defeating nicotine's double role in lung cancer

...ess often. Likewise, nicotine may promote lung cancer yet nicotine receptor antagonists may offer treatment options for patients with lung cancer. John Heffner...rding the role of nicotine in stimulating lung cancer and nicotine receptor antagonists in treating the disease. The highly addictive nature of nicotine, however, ...
antagonists in Medical Technology

Weight Management is Not Enough for Cannabinoid Type 1 (CB1) Receptor Antagonists to Become a Commercial Success

Huge clinical development program of first-in-class CB1 antagonist rimonabant to show benefits beyond weight reduction and avoid image as life-style drug BARCELONA, Spain | March 08, 2007 | The Business Intelligence firm La Merie S.L. reported today that Sanofi-Aventis’ first-in-class CB1 ...

SIMPONI(TM) (golimumab) Receives Positive Opinion From CHMP for Once-Monthly Subcutaneous Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis

...rious infections, including sepsis, pneumonia, tuberculosis, invasive fungal and other opportunistic infections have been observed with the use of TNF antagonists including SIMPONI. Some of these infections have been fatal. SIMPONI should not be given to patients with a clinically important, active infection. ...

Ongoing Landmark ROADMAP Study Demonstrates Significant Improvement in Blood Pressure Control at One Year, According to Blinded Results

...f five years. Patients with hypertension were also treated at the investigator's discretion with diuretics, alpha- or beta-blockers or calcium channel antagonists to achieve a target BP of <130/80. Patients requiring treatment with an ARB or ACEi were withdrawn from the study. About the ROADMAP One-Year...

Paloma Pharmaceuticals Presents at the Association for Research in Vision and Ophthalmology 2009 Meeting

... beneficial effects without toxicity to normal tissues since loss of TORC2 in genetically altered mice does not appear to affect normal tissue. TORC1 antagonists such as rapamycin (Sirolimus) have shown activity in both animal models of ocular disease and in human clinical trials. The inhibition of both TORC1 ...

Radius Initiates Phase 2a Clinical Trial of RAD1901 in Menopausal Hot Flashes

...timulate or block estrogen's activity in different types of tissue, functioning as estrogen receptor agonists in some tissues and as estrogen receptor antagonists in others. Currently available SERMS are approved for the treatment and prevention of breast cancer and osteoporosis but tend to respectively increase...

Vantia Therapeutics' Pipeline Continues to Mature

... this news and developments in Vantia's preclinical pipeline, the company is continuing to generate value from its extensive library of small molecule antagonists of hormones and proteases. Following the completion of the 27-patient Phase IIa trial of VA106483, a vasopressin agonist, results are expected ...

Study Shows Leconotide, an Investigative Calcium Channel Blocker, Has Potential as a Selective, Efficacious, Non-Opioid Pain Treatment

... contraction of a muscle cell in the heart or blood vessels or rate of electrical firing or production of chemical messengers in nerve cells. Calcium antagonists block calcium channels. There are many types of calcium channels. Medicines can be selective to bind just with one type (e.g. heart and blood vessel...

TorreyPines Therapeutics Muscarinic Agonist NGX267 Meets Primary Endpoint in a Phase II Clinical Trial in Patients with Xerostomia

...city and rigidity, xerostomia and cognitive disorders. The company is currently developing four product candidates, two ionotropic glutamate receptor antagonists and two muscarinic receptor agonists. Further information is available at www.torreypinestherapeutics.com . This press release contains fo...

Data Reported at ICAAC Indicates Selzentry(TM) Phase III Treatment-Naive Trial Shows Increased Efficacy When Used With Enhanced Trofile(TM) Assay

...tient virus. Trofile is the only clinically validated tropism assay and has been used to select patients in all phase II and phase III studies of CCR5 antagonists to date. In June 2008, optimization of Trofile made it substantially more sensitive at identifying very low levels of CXCR4 using virus (X4 or dual/...

SARcode and Sunesis Announce Start of Phase 1 Clinical Trial in Ocular Inflammatory Diseases

...nesis' LFA-1 technology to develop LFA-1 inhibitors in March 2006. "LFA-1 antagonists mediate both migration and adhesion of the white blood cells to sites of in...al company focused on the development of best in class small molecule LFA-1 antagonists as novel nonsteroidal immunomodulators/ anti-inflammatory agents for the tr...
antagonists in Medical Products

Angiotensin II

Description:...ng the pharmacological effect and efficiency of a wide variety of angiotensin converting enzyme inhibitors (ACE Inhibitors) or Angiotensin II receptor antagonists as well as for the efficiency of therapeutic approaches in treating congestive heart failure....
Company:Buhlmann Laboratories AG
antagonists in Medical Definition

Depolarization-induced suppression of inhibition

...HC, could evoke the same reduction in inhibitory currents caused by DSI. They also demonstrated that DSI could be prevented by cannabinoid receptor antagonists , drugs that block the actions of cannabinoid compounds. Other lines of evidence support the role of the CB1 receptor in DSI. This receptor is distr...
antagonists in Medical Dictionary

Thiamine

..., supplements, ... Thiamine (also spelled thiamin or designated as B 1) is a vitamin, which simply ... Thiamine works in a similar manner. ... antagonists of thiamine ... Discussion of function, deficiency, disease treatment, food sources and ... Thiamin (also spelled thiamine ) is a water-sol...

Tardive dyskinesia

...s a variety of dyskinesia manifesting as a side effect of long-term or high-dose use of dopamine antagonists, usually antipsychotics. Other dopamine antagonists that can cause tardive dyskinesia are drugs for gastrointestinal disorders and... Tardive dyskinesia information sheet compiled by NINDS, ...

Opiate withdrawal

... syndrome (NAS) due to opiate withdrawal may result in disruption of ... there is evidence in animals that withdrawal from opiates and opiate antagonists ... Comprehensive article detailing what is involved in an intervention to get someone to treatment. ... Safely Managing Opiate Withdrawal Sym...

Histamine

...ide: What Is Histamine ? ... Histamine helps fight off infection by making capillaries more permeable to ... Background: Histamine receptor antagonists have been shown to induce tumor ... The role of histamine receptor anatagonists in breast cancer is unclarified. ... Histamine H3-Recept...

Calcium channel blockers

...alcium channel blockers also have numerous other effects beyond their effects on ... Calcium channel blockers are also called calcium antagonists or calcium blockers . ... Tiếng Việt. Calcium Channel Blockers . What are calcium channel blockers ? ... Learn about calcium chann...
antagonists in Biological News

Pulmonary hypertension in children may result from reduced activity of gene regulator

... to humans, agonists to boost PPAR activity prevent the usual endothelial dysfunction that occurs in the first few weeks after birth. Conversely, PPAR antagonists cause endothelial dysfunction without the underlying heart defect. At its core, endothelial dysfunction is decreased ability of blood vessels to di...

Researchers may have found why women have an edge on salt-sensitive hypertension

...agonists, which are in use for pulmonary hypertension and under study for conditions such as diabetic nephropathy and uncontrolled hypertension. These antagonists block the action of ETA receptors which are believed to raise blood pressure and help reshape blood vessels into thick, rigid pipes. ETA receptors ...

New asthma research opposes current drug treatment, says UH prof

... to ban the LABA-only drugs and strengthen warnings on the combination drugs. Bond and his colleagues propose an alternative to stimulants, using antagonists (or beta blockers) instead. This approach, termed paradoxical pharmacology, suggests patients may be treated with medication that initially worsens t...

Better understanding of blood vessel constrictor needed to harness its power for patients

.... "Numerous drugs have been developed that are antagonists that can block these receptors with the idea they ...ulty moving blood through their body. The first antagonists blocked both known receptors: a and b; the next ge...l didn't work. A notable exception is endothelin-1 antagonists that reduce excessive pressure and tissue buildup ...

Certain anticancer agents could be harmful to patients with heart disease

...n St. Louis. The anticancer drugs which go by the strange name of hedgehog antagonists interfere with a biochemical process that promotes growth in some cancer c... online publication in the Journal of Clinical Investigation . Hedgehog antagonists are drugs that inhibit the hedgehog signaling pathway, a chain of biochemic...

NCI renewal grant to develop new cancer therapies

... "We can then utilize this information as a platform to develop novel combination regimens incorporating histone deacetylase inhibitors and NF-kappa B antagonists such as proteasome and IKK beta inhibitors in the treatment of acute leukemia and other hematologic malignancies." Grant and his team are already...

The endocannabinoids: Functional roles and therapeutic opportunities

... the pathogenesis of hepatic encephalopathy. Modulation of this system either by exogenous agonists specific for the CB2 receptors or possibly also by antagonists to the CB1 receptors may have therapeutic potential. The endocannabinoid system generally is involved in the protective reaction of the mammalian body...

Researchers seek to design first treatment for neuroAIDS

...ing for compounds that counter such toxins, with several now in human trials. These include antioxidant medications, calcium channel antagonists, NMDA antagonists like the Alzheimer's drug Memantine, platelet activating factor (PAF) inhibitors, and in the case of the new grant, drugs that inhibit glycogen syntha...

'Conversation stoppers' fight deadly bacterial infections

...ymes could represent an attractive drug target for a range of human disorders in which disruption of endocannabinoid signaling by cannabinoid receptor antagonists has proven beneficial." ...

Nanotechnology propels advances in regenerative medicine research

...ymes could represent an attractive drug target for a range of human disorders in which disruption of endocannabinoid signaling by cannabinoid receptor antagonists has proven beneficial." ...
antagonists in Biological Technology

Screening for potential beta 2-adrenergic receptor antagonists using CypHer5E and IN Cell Analyzer 1000

Introduction CypHer ™ 5, a pH sensitive dye, has shown utility in β2-adrenergic receptor agonist screening (1). CypHer5 has been used to obtain dose-response and rank-order potency data for both agonist and antagonist treatment of β2-adrenergic...

AEterna Zentaris: New Data Published on its Ghrelin Antagonist Compound, AEZS-123 (JMV2959), Supports its Use in Alcohol Addiction

...ions are blocked by administering ghrelin receptor antagonists such as AEZS-123, mice no longer show preference f...ty and eating disorders through the use of ghrelin antagonists to suppress appetite and fat deposition. In 2004...gned two agreements for the development of ghrelin antagonists with the Institut des biomolecules Max Mousseron o...

Human Genome Sciences Reports Positive Long-Term Data for BENLYSTA(TM) (Formerly LymphoStat-B(R)) in Patients With Active Systemic Lupus Erythematosus

...own healthy tissues. The presence of autoantibodies appears to correlate with disease severity. Preclinical and clinical studies demonstrate that BLyS antagonists can reduce autoantibody levels and help control autoimmune disease activity. About the Collaboration with GSK In August 2006, HGS and GSK ...

Neurocrine Biosciences Reports First Quarter 2009 Results

...sciences. Pipeline Highlights GnRH antagonists in Phase II Clinical Trials for Endometriosis ...inues to investigate the potential of certain GnRH antagonists in treating other hormone-dependent diseases in me... Corticotropin Releasing Factor (CRF1) Receptor antagonists for Anxiety/Depression and IBS The CRF coll...

ChemoCentryx Identifies Novel Small Molecule C5aR Antagonist

...eptors, ChemoCentryx researchers successfully applied the company's proprietary drug discovery technologies to identify and design small molecule C5aR antagonists and selected CCX168 based on its potency, selectivity and favorable pharmacokinetics. In preclinical models, C5a and its receptor C5aR have been show...

TorreyPines Therapeutics Reports First Quarter 2009 Financial Results

...igraine, acute and chronic pain, and xerostomia. The company currently has three clinical stage product candidates: two ionotropic glutamate receptor antagonists and one muscarinic receptor agonist. Further information is available at www.tptxinc.com . This press release contains forward-looking statemen...

TorreyPines Therapeutics Receives Notice of Non-Compliance with Nasdaq Continued Listing Requirements

...migraine, acute and chronic pain, and xerostomia. The company currently has three clinical stage product candidates: two ionotropic glutamate receptor antagonists and one muscarinic receptor agonist. Further information is available at www.tptxinc.com . This press release contains forward-looking statem...

CeNeRx BioPharma Awarded New Patent for its Innovative Compounds That Selectively Target Peripheral Cannabinoid Receptors

... or no central nervous system activity. CNS side effects associated with traditional cannabinoid agents can be significant. For example, cannabinoid antagonists targeting the CB1 receptor, such as agents being developed to treat obesity, have been associated with such central side effects as negative mood and ...

Stockholder Suits Related to TorreyPines Therapeutics, Inc. Dismissed

... such as migraine, chronic pain, and xerostomia. The company currently has three clinical stage product candidates: two ionotropic glutamate receptor antagonists and one muscarinic receptor agonist. Further information is available at www.tptxinc.com . This press release contains forward-looking s...

TorreyPines Therapeutics Reports Fourth Quarter and Full Year 2008 Results

...igraine, acute and chronic pain, and xerostomia. The company currently has three clinical stage product candidates: two ionotropic glutamate receptor antagonists and one muscarinic receptor agonist. Further information is available at www.tptxinc.com . This press release contains forward-looking s...
antagonists in Biological Definition

Hormone

...roid hormones. A recently identified and studied class of hormones is that of the "Hunger Hormones" - ghrelin , orexin and PYY 3-36 - and their antagonists - e.g. leptin . Spelling note Current North American and international usage is estrogen, gonadotropin. British usage retains the Greek dipht...
antagonists in Biological Dictionary

Sigma Factor

...t their transcriptional activity. Anti- sigma factors have been found in Escherichia coli, Salmonella, and T4 bacteriophage. Anti- sigma factors are antagonists to the sigma factors, which regulate numerous cell processes including flagellar production,... Sigma factors are classified into two struc...

SCAR

...appearance of scars . ... Scars shrink and become less noticeable as they age. ... ... in both the anime and manga, Scar is one of the primary antagonists throughout ... face, instead of healed into a scarred , deformed figure, is turned into a ... ...

N Terminus

...PPAR confers the ability to promote adipocyte ... Swapping the DBD along with the N terminus (DBD-/ and DBD-/) has no additional ... Functional antagonists of sonic hedgehog reveal the importance of the N terminus for activity ... that regions near the N terminus of the protein play a ... ...
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