Genetic Breakthrough Spells Hope for Lung Fibrosis Patients
... disease. The researchers found no evidence that infection or inflammation was the cause of accelerated IPF. They did find signs that the cells of the alveolar epithelium, the tissue that covers the surface of the lung's air sacs, were rapidly dying. "That could mean that drugs that are used to protect the...Over half of people with rheumatoid arthritis have periodontitis
...o modulate the inflammatory process in the periodontium (the tissues investing and supporting the teeth, including the cementum, periodontal ligament, alveolar bone, and gingival / gums). Dr Codrina Ancuta of the Grigore T Popa University of Medicine and Pharmacy, Rehabilitation Hospital, Iasi, Romania, who...Targeting the more lethal form of the cancer rhabdomyosarcoma
...domyosarcoma (RMS) is an aggressive muscle cancer that mostly affects children. The most common forms of RMS are embryonal rhabdomyosarcoma (ERMS) and alveolar rhabdomyosarcoma (ARMS). Although ARMS is less common than ERMS, it is associated with a much higher rate of mortality. A therapy tailored to the ARMS...U.S. Department of Defense Exercises $2.0 Million Option to Fund Cethromycin Development
...n at 75 mg/kg over 21 days offered 100% protection from tularemia infection. USAMRIID concluded that cethromycin's preferential accumulation in the alveolar cells of the lungs, combined with the oral bioavailability and once a day dosing make cethromycin an attractive candidate for use in tularemia therapy...Study sheds light on deadly lung disease
...de insight into extreme vulnerability to fibrosis associated with injury to alveolar epithelial cells (AECs)cells that line the tiny air sacs in the lungsaggrav...eomycin was found independent of inflammation, but associated with impaired alveolar epithelial repair. ...Reconstructing mandibular defects with bioengineered tooth and bone
... formation of not only the tooth crowns but also tooth root and surrounding alveolar bone was observed. However, since the omentum offers an environment quite d...econstructions in humans. This model is currently being modified to improve alveolar bone formation, regenerated dental tissue orientation, tooth root developme...HPV, periodontitis work in tandem to increase risk of tongue cancer
...te for whom data was available on both periodontitis and tumor HPV status. Cumulative history of periodontitis was determined by assessing the loss of alveolar bone, the bones that underlie and support the teeth, via X-ray. Tumor status was identified from paraffin-embedded tumor samples analyzed by polymer...Ascenta Therapeutics Highlights Multiple Data Presentations at Upcoming AACR Annual Meeting
... significantly reducing cell Children's viability in both embryonal and Hospital alveolar rhabdomyosarcoma cells with wild-type p53 --------- ---------------------------------- -------------- 1pm-...AVI BioPharma Reports Positive Pre-Clinical Influenza Data
...arison to untreated mice. Histological examination of the lungs showed that treated mice had reduced pathology when examined for infiltrating cells or alveolar damage. "These data, in combination with other pre-clinical research, reinforce our belief that NEUGENE antisense compounds are potentially well-...Heat-shock protein vaccine reduces alveolar bone loss
Heat-shock protein (HSP) can be utilized as a vaccine to cross-protect against multiple pathogenic species. Investigators from Pusan National University (South Korea) today presented the findings of a study they performed to evaluate the bacterium Porphyromonas gingivalis heat-shock protein (HSP) 6...Pitt team first to profile genes in acutely ill idiopathic pulmonary fibrosis patients
... was no evidence that infection or inflammation was the cause of disease acceleration, he noted. Instead, there were indications that the cells of the alveolar epithelium, which is the tissue that covers the surface of the air sacs, were rapidly dying. "That could mean that drugs that are used to protect ...Harvard scientists solve mystery about why HIV patients are more susceptible to TB infection
...ecimens from the HIV-positive patients and found increased levels of a molecule called IL-10, which elevated the amount of a protein called "BCL-3" in alveolar macrophages and that reduced their ability to ward off TB infection. "HIV and TB represent two of the most significant health challenges in human...Dual role in breast tissue for a protein involved in leukemia
...trogen receptor was over-expressed, Stat5a collaborated with it to promote growth of a type of precancerous lesion of the breast termed a hyperplastic alveolar nodule. "Our studies in in vivo mouse models illustrate a dual role for the Stat5a protein in breast tissue. While it can contribute to the growth o...Gene therapy appears safe to regenerate gum tissue
...stages for these studies will commence in the next year. The paper, called "Adenovirus Encoding Human Platelet-Derived Growth Factor-B Delivered to alveolar Bone Defects Exhibits Safety and Biodistribution Profiles Favorable for Clinical Use," is partially available online. It's scheduled to appear in the ...Study: Fluid buildup in lungs is part of the damage done by the flu
...only half as effective as fluid clearance from the lungs of uninfected mice. Lung infections have been known to cause problems with what is called alveolar fluid clearance, but the effects of the flu on the lungs had not been tested before, Davis said. The alveoli are air spaces deep inside the lungs wher...Shades of 1918? New study compares avian flu with a notorious killer from the past
...unch to the host's ability to recover from the infectious siege. The researchers observed that within 24 hours, H5N1 had caused severe bronchiolar and alveolar lesions in lung tissue. H5N1's penchant for infecting type II rather than type I pneumocytes is due to the receptor preference found in avian viru...Inherited genetic cause, possible treatment found for complex lung disorder
...enetic mutation that causes an inherited form of the lung disease Pulmonary alveolar Proteinosis (PAP). Reporting their results in the Nov. 24 Journal of Ex... where patients do not exhibit obvious symptoms, according to the Pulmonary alveolar Proteinosis Foundation. The researchers in this report were intrigued by th...Immunotherapy in high-risk pediatric sarcomas shows promising response
... also found that survival in these patients was at the higher end of what is generally seen with recurrent and/or metastatic Ewing's sarcoma (ESFT) or alveolar rhabdomyosarcoma (AR) the two sarcomas tested in this single arm study. The 22 enrolled patients who did not receive immunotherapy had a 31 percent f...Translational research patented first experimental treatment against idiopathic pulmonary fibrosis
...s to type 1 pneumocytes in alveoli, cells recovering the inner walls of the alveolar cavity. Occupying the same spaces, there are also type II pneumocytes, precursor cells that repair the damaged alveolar tissue. When idiopathic pulmonary fibrosis appears, this regeneration proce...Enzyme Immunoassay for Studying Intracellular Levels of cAMP
...tion to Jurkat cells, AC toxin has also been shown to elevate cAMP in monocyte macrophages, 10 polymorphonuclear leukocytes and alveolar macrophages, 11 natural killer cells 12 and HL-60 promyelocytic leukemia cells. 13 Conclusions The EIA cAMP Kit is a nonradioact...Goat Anti-PAX3 Polyclonal Antibody, Unconjugated from GeneTex
Description:...ociated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isof...