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alveolar in Medical News

Genetic Breakthrough Spells Hope for Lung Fibrosis Patients

... disease. The researchers found no evidence that infection or inflammation was the cause of accelerated IPF. They did find signs that the cells of the alveolar epithelium, the tissue that covers the surface of the lung's air sacs, were rapidly dying. "That could mean that drugs that are used to protect the...

Over half of people with rheumatoid arthritis have periodontitis

...o modulate the inflammatory process in the periodontium (the tissues investing and supporting the teeth, including the cementum, periodontal ligament, alveolar bone, and gingival / gums). Dr Codrina Ancuta of the Grigore T Popa University of Medicine and Pharmacy, Rehabilitation Hospital, Iasi, Romania, who...

Targeting the more lethal form of the cancer rhabdomyosarcoma

...domyosarcoma (RMS) is an aggressive muscle cancer that mostly affects children. The most common forms of RMS are embryonal rhabdomyosarcoma (ERMS) and alveolar rhabdomyosarcoma (ARMS). Although ARMS is less common than ERMS, it is associated with a much higher rate of mortality. A therapy tailored to the ARMS...

U.S. Department of Defense Exercises $2.0 Million Option to Fund Cethromycin Development

...n at 75 mg/kg over 21 days offered 100% protection from tularemia infection. USAMRIID concluded that cethromycin's preferential accumulation in the alveolar cells of the lungs, combined with the oral bioavailability and once a day dosing make cethromycin an attractive candidate for use in tularemia therapy...

Coalition for Pulmonary Fibrosis and American Thoracic Society Announce Recipients of 2009-10 Research Awards

... "Contribution of Epithelial Mesenchymal Transition (EMT) to Pulmonary Fibrosis." EMT is induced by transforming growth factor beta signaling in the alveolar epithelium and plays a pivotal role in determining whether the response to tissue injury leads to normal repair or lung fibrosis. Dr. Tanjore's study...

Frost & Sullivan Recognizes Neotropix's Approach to the Treatment of Small Cell Lung Cancer and Neuroendocrine Cancers

...cancer and carcinoid cancer. It can also potentially treat children with neuroblastoma, Wilms' tumor, Retinoblastoma, Ewing's sarcoma, Rhabdoid tumor, alveolar rhabdomyosarcoma, and glioblastoma. This virus, through a receptor-mediated process, selectively targets neuroendocrine tumor cells that express ...

Study sheds light on deadly lung disease

...de insight into extreme vulnerability to fibrosis associated with injury to alveolar epithelial cells (AECs)cells that line the tiny air sacs in the lungsaggrav...eomycin was found independent of inflammation, but associated with impaired alveolar epithelial repair. ...

Kristin Chenoweth to Perform Benefit Concert for 3 Angels Memorial Fund titled, 'Kristin Chenoweth, This One's Personal: A Concert to Stop ACD'

...er, at seven weeks old to a disease called ACD. This is the third child Craig has lost to the disease, making it nothing short of a genetic mystery. alveolar Capillary Dysplasia (ACD) is a thought to be rare genetic lung disease that has killed every baby known to be diagnosed with it. Prior to Lincoln's de...

Reconstructing mandibular defects with bioengineered tooth and bone

... formation of not only the tooth crowns but also tooth root and surrounding alveolar bone was observed. However, since the omentum offers an environment quite d...econstructions in humans. This model is currently being modified to improve alveolar bone formation, regenerated dental tissue orientation, tooth root developme...

HPV, periodontitis work in tandem to increase risk of tongue cancer

...te for whom data was available on both periodontitis and tumor HPV status. Cumulative history of periodontitis was determined by assessing the loss of alveolar bone, the bones that underlie and support the teeth, via X-ray. Tumor status was identified from paraffin-embedded tumor samples analyzed by polymer...
alveolar in Medical Technology

Keryx Biopharmaceuticals, Inc. Announces Positive Preliminary Phase 2 Data on KRX-0401 in Patients with Chemo-Insensitive Rare Sarcoma

...0%) Extra-Skeletal Myxoid 13 2 (15%) 5 (38%) alveolar Soft Part 10 3 (30%) 3 (30%) ... activity of perifosine is being evaluated in patients with chondrosarcoma, alveolar soft part sarcomas and extra-skeletal myxoid chondrosarcomas. Patients are ...

Further Data on Safety and Efficacy of Cethromycin Presented at 47th Interscience Conference on Antimicrobial Agents and Chemotherapy

...isella tularensis strains. Cethromycin had significant in vitro activity against Francisella tularensis. Cethromycin preferentially accumulates in the alveolar cells of the lungs, which may enhance efficacy when used as a postexposure prophylaxis for preventing pneumonic tularemia among individuals exposed to...

Further Data on Safety and Efficacy of Cethromycin Presented at 47th Interscience Conference on Antimicrobial Agents and Chemotherapy

...isella tularensis strains. Cethromycin had significant in vitro activity against Francisella tularensis. Cethromycin preferentially accumulates in the alveolar cells of the lungs, which may enhance efficacy when used as a postexposure prophylaxis for preventing pneumonic tularemia among individuals exposed to...

Ascenta Therapeutics Highlights Multiple Data Presentations at Upcoming AACR Annual Meeting

... significantly reducing cell Children's viability in both embryonal and Hospital alveolar rhabdomyosarcoma cells with wild-type p53 --------- ---------------------------------- -------------- 1pm-...

AVI BioPharma Reports Positive Pre-Clinical Influenza Data

...arison to untreated mice. Histological examination of the lungs showed that treated mice had reduced pathology when examined for infiltrating cells or alveolar damage. "These data, in combination with other pre-clinical research, reinforce our belief that NEUGENE antisense compounds are potentially well-...
alveolar in Medical Products

Anti-GBM-IgG

Description:... Enzyme immunoassay for the quantitative determination of IgG autoantibodies against type IV collagen of glomerular or alveolar basement membrane (GBM) in serum and plasma....
Company:DLD Diagnostika GmbH

Irri-Cath® Suction Systems

Description:... Irri-Cath® catheters help decrease the need for frequent suctioning and provide an alternative to fiber-optic bronchoscope for bronchial alveolar lavage as a diagnostic aid in opportunistic infections. All Portex® Irri-Cath® suction systems are latex-free. The Irri-Cath® suct...
Company:Portex
alveolar in Medical Definition

High Frequency Ventilation

...ion, atelectatic regions will inflate, however the alveoli will be unstable and will collapse during the expiratory phase of the breath. This repeated alveolar collapse and expansion (RACE) will cause VILI. By opening the lung and keeping the lung open RACE (and VILI) is reduced. Types of High Freque...

Proteopathy

... corneal dystrophy Keratoepithelin Cutaneous lichen amyloidosis Keratins Corneal lactoferrin amyloidosis Lactoferrin Pulmonary alveolar proteinosis Surfactant protein C (SP-C) Critical illness myopathy (CIM) Hyperproteolytic state of myosin ubiquitination Referen...
alveolar in Medical Dictionary

Viral pneumonia

...nia in... Pneumonia is an inflammatory illness of the lung. Frequently, it is described as lung parenchyma/alveolar inflammation and abnormal alveolar filling with fluid . Pneumonia is a lung infection that can be caused by different types of germs, ... Wheezing may be more common in viral ...

Surfactant

..."http://en.wikipedia.org /wiki/ Surfactant " ... Pulmonary surfactant is a surface-active lipoprotein complex formed by type II alveolar cells. The proteins and lipids that surfactant comprises have both a hydrophilic region and a hydrophobic region. By adsorbing to the... A surf...

Soft tissue

...ncerous) tumors that can develop from fat, muscle, nerve, ... types of soft tissue tumors is important. ... Soft Tissue Sarcoma Key Terms: alveolar rhabdomyosarcoma , Brachytherapy , Cytogenetics , Dermatofibrosarcoma protuberans , Embryonal rhabdomyosarcoma Many soft tissue sarcomas are...

Rhabdomyosarcoma

...ers resources on the cancer and its treatment. Rhabdomyosarcoma and alveolar rhabdomyosarcoma treatment, for a rare soft-tissue cancer at Mayo Clini... rhabdomyosarcoma is increased in children with the genetic disorder ... alveolar rhabdomyosarcoma cells usually have a rearrangement of chromosomes 2 .....

Respiratory alkalosis

... Respiratory alkalosis results from increased alveolar respiration leading to decreased plasma carbon dioxide concentration. This leads to decreased hydrogen ion and freely ionized blood calcium ...

Respiratory acidosis

...e respiratory acidosis can be life threatening when a sudden and sharp ... Overview: Respiratory acidosis is a clinical disturbance due to alveolar hypoventilation. ... Acute respiratory acidosis is present when an abrupt failure of ... Respiratory acidosis is a condition in which a bu...

Pulmonary edema

...... Pulmonary Edema . WHAT YOU SHOULD KNOW ... INTRODUCTION Neurogenic pulmonary edema (NPE) is an increase in pulmonary interstitial and alveolar fluid due to, and usually developing rapidly after, acute central ... Pulmonary edema . Symptoms: Heart Failure. in heart failure. see also...

Pulmonary Fibrosis

... disease (ILD), also known as diffuse parenchymal lung disease (DPLD), refers to a group of lung diseases affecting the interstitium . It concerns alveolar epithelium, pulmonary capillary endothelium,... Idiopathic pulmonary fibrosis (IPF), formerly known as cryptogenic fibrosing alveolitis, is a ...

Pneumonia

... Pneumonia is an inflammatory illness of the lung. Frequently, it is described as lung parenchyma/alveolar inflammation and abnormal alveolar filling with fluid . Comprehensive overview of the respiratory disease, symptoms, causes, diagnosis, and treatment. Explains about the infe...

Periodontitis

...atory diseases affecting the periodontium — that is, the tissues that surround and support the teeth. Periodontitis involves progressive loss of the alveolar bone around the teeth,... Periodontitis — Comprehensive overview covers symptoms, causes, treatment, prevention of this ... Periodontitis ca...
alveolar in Biological News

Heat-shock protein vaccine reduces alveolar bone loss

Heat-shock protein (HSP) can be utilized as a vaccine to cross-protect against multiple pathogenic species. Investigators from Pusan National University (South Korea) today presented the findings of a study they performed to evaluate the bacterium Porphyromonas gingivalis heat-shock protein (HSP) 6...

Pitt team first to profile genes in acutely ill idiopathic pulmonary fibrosis patients

... was no evidence that infection or inflammation was the cause of disease acceleration, he noted. Instead, there were indications that the cells of the alveolar epithelium, which is the tissue that covers the surface of the air sacs, were rapidly dying. "That could mean that drugs that are used to protect ...

Harvard scientists solve mystery about why HIV patients are more susceptible to TB infection

...ecimens from the HIV-positive patients and found increased levels of a molecule called IL-10, which elevated the amount of a protein called "BCL-3" in alveolar macrophages and that reduced their ability to ward off TB infection. "HIV and TB represent two of the most significant health challenges in human...

Dual role in breast tissue for a protein involved in leukemia

...trogen receptor was over-expressed, Stat5a collaborated with it to promote growth of a type of precancerous lesion of the breast termed a hyperplastic alveolar nodule. "Our studies in in vivo mouse models illustrate a dual role for the Stat5a protein in breast tissue. While it can contribute to the growth o...

Gene therapy appears safe to regenerate gum tissue

...stages for these studies will commence in the next year. The paper, called "Adenovirus Encoding Human Platelet-Derived Growth Factor-B Delivered to alveolar Bone Defects Exhibits Safety and Biodistribution Profiles Favorable for Clinical Use," is partially available online. It's scheduled to appear in the ...

Study: Fluid buildup in lungs is part of the damage done by the flu

...only half as effective as fluid clearance from the lungs of uninfected mice. Lung infections have been known to cause problems with what is called alveolar fluid clearance, but the effects of the flu on the lungs had not been tested before, Davis said. The alveoli are air spaces deep inside the lungs wher...

Shades of 1918? New study compares avian flu with a notorious killer from the past

...unch to the host's ability to recover from the infectious siege. The researchers observed that within 24 hours, H5N1 had caused severe bronchiolar and alveolar lesions in lung tissue. H5N1's penchant for infecting type II rather than type I pneumocytes is due to the receptor preference found in avian viru...

Inherited genetic cause, possible treatment found for complex lung disorder

...enetic mutation that causes an inherited form of the lung disease Pulmonary alveolar Proteinosis (PAP). Reporting their results in the Nov. 24 Journal of Ex... where patients do not exhibit obvious symptoms, according to the Pulmonary alveolar Proteinosis Foundation. The researchers in this report were intrigued by th...

Immunotherapy in high-risk pediatric sarcomas shows promising response

... also found that survival in these patients was at the higher end of what is generally seen with recurrent and/or metastatic Ewing's sarcoma (ESFT) or alveolar rhabdomyosarcoma (AR) the two sarcomas tested in this single arm study. The 22 enrolled patients who did not receive immunotherapy had a 31 percent f...

Translational research patented first experimental treatment against idiopathic pulmonary fibrosis

...s to type 1 pneumocytes in alveoli, cells recovering the inner walls of the alveolar cavity. Occupying the same spaces, there are also type II pneumocytes, precursor cells that repair the damaged alveolar tissue. When idiopathic pulmonary fibrosis appears, this regeneration proce...
alveolar in Biological Technology

Cardium Announces New Orthobiologics Product Initiative Extending Gene Activated Matrix Technology to Deliver Bone Growth Factors

...l Transduction, (Lin, et al., J Periodont Res , 2008; 43: 440-449); and (4) Adenovirus Encoding Human Platelet-Derived Growth Factor-B Delivered to alveolar Bone Defects Exhibits Safety and Biodistribution Profiles Favorable for Clinical Use, (Chang, et al., Human Gene Therapy , 2009 May; 20: 486-496). T...

Depth of MedImmune's Respiratory Disease Research Program Highlighted at Annual Meeting of the American Thoracic Society

...:15 p.m., Metro Toronto Convention Centre, Area B. -- Monocytes and Macrophages in Inflammation, Immunity and Injury (Poster Session: Role for alveolar Macrophages in Limiting Primary RSV Immunopathology, publication page A623) - Tuesday, May 20 from 8:15 a.m. - 4:15 p.m., Metro Toronto Conven...

Enzyme Immunoassay for Studying Intracellular Levels of cAMP

...tion to Jurkat cells, AC toxin has also been shown to elevate cAMP in monocyte macrophages, 10 polymorphonuclear leukocytes and alveolar macrophages, 11 natural killer cells 12 and HL-60 promyelocytic leukemia cells. 13 Conclusions The EIA cAMP Kit is a nonradioact...
alveolar in Biological Products

Goat Anti-PAX3 Polyclonal Antibody, Unconjugated from GeneTex

Description:...ociated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isof...
Company:GeneTex
alveolar in Biological Dictionary

Maxilla

...ds do not have a maxilla in the strict... The alveolar process is the thickened ridge of bone that contai...nes that bear teeth. It is also referred to as the alveolar bone. In humans, the tooth-bearing bones are the maxilla and the mandible. The mineral content of alveolar bone is mostly... Lifestyle, fitness & he...

Lobule

...of a lobe. ... ... lobule from Webster's New World College Dictionary. Meaning of lobule . ... Branches within the primary lobule give rise to alveolar ducts, ... lobule usage ... Within each lobule , hepatocytes are arranged into hepatic cords separated by ... The Liver Lobule , from Blue Hi...

Interstitial cells

...on of Interstitial cells in the Online Dictionary. Meaning of Interstitial cells . ... In the lungs, scattered interstitial cells and a few alveolar ... Definition of interstitial cell in the Online Dictionary. Meaning of interstitial cell . ... Interstitial Cell Stimulating Hormone. ...

Cork cell

... : Cell Sample Size Colors Shape Alive or Dead. Cork ... Cork is a natural product. Each cell contains an air-like gas the cell walls ... alveolar cell structure but from openings – pores – in the cork tissue, called ... ...

Bronchioles

... bronchi and bronchioles with secondary infection, usually involving ... ... in the membranous and respiratory bronchioles and rupture of the alveolar ... At least 50 bronchioles were examined per animal, and the injury score (IS) was ... ...

Alveoli

...y? Breathing! ... There are about 600 million alveoli in your lungs and if ... Now that's a load of alveoli ! ... Along the distal end of an alveolar duct, the alveoli are arranged into grape-like clusters. ... routes to and from the alveoli if an obstruction occurs. ... The alveoli are sma...
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