Receptor protein appears to be key in breakdown of kidney filtration
... showed that uPAR can associate with and activate another receptor protein, alphavbeta3
integrin, leading to podocyte motility. Blocking this step in the uPAR-con...sin L and to conduct a clinical trial with small molecules blocking uPAR or alphavbeta3
integrin, says Reiser, an assistant professor of Medicine at Harvard Medica...