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agonists in Medical News

Galenea and Organix Announce Exclusive License Agreement for 5-HT2C Agonists for the Treatment of Obesity

CAMBRIDGE and WOBURN, Mass., Oct. 28 /PRNewswire/ -- Galenea Corp. today announced the signing of an agreement with Organix, Inc. and its academic collaborators that gives Galenea a license to 5-HT2C agonists for the treatment of obesity and other related disorders. The license grants Galenea ...

Beta Agonists May Alter the Immune System

New research at Wake Forest University School of Medicine suggests that certain inhaled asthma medications – as well as similar chemicals our bodies produce during times of high stress – may worsen diseases such as asthma // , heart failure and lupus that involve inflammation. The scientific t...

Sundia MediTech Appoints Dr. Chen Chen as Senior VP of Chemistry

... factor-I/IGF-binding protein. In addition, Dr. Chen identified the first selective antagonist of the melanocortin-5 receptor, and discovered numerous agonists and antagonists for the melanocortin-4 receptor for eating disorders. Dr. Chen has extensive experience in CNS drug research and GPCRs as drug ...

NUCYNTA(TM) (tapentadol) CII Immediate Release Tablets Now Available for Relief of Moderate to Severe Acute Pain

...NTA(TM) in situations where the physician or pharmacist is concerned about an increased risk of misuse and abuse. All patients treated with mu-opioid agonists require careful monitoring for signs of abuse and addiction. NUCYNTA(TM) may be abused by crushing, chewing, snorting or injecting the product. Thes...

TGen and USC researchers find genetic markers to help fight diabetes

... expected improvement in insulin sensitivity. TZDs are a class of insulin-sensitizing drugs used to treat type 2 diabetes mellitus (T2DM). TZDs are agonists for the nuclear receptor peroxisome proliferator-activated receptor-g (PPARG). Although the exact mechanism by which TZDs act is not yet known, data i...

Asthma Drugs Get 'Precaution' Labeling for Possible Psychiatric Side Effects

...2 (HealthDay News) -- The U.S. Food and Drug Administration on Friday requested that the makers of a class of asthma drugs called leukotriene receptor agonists place a "precaution" on the drugs' labeling, warning of the potential for neuropsychiatric events. The drugs in question include the blockbuster m...

InteKrin Therapeutics Announces INT131 Phase 2a Results at the 2009 American Diabetes Association Annual Meeting

...esigned to retain the well validated and robust insulin sensitizing efficacy of PPARgamma while minimizing the typical side effects seen with the full agonists TZDs Actos(R) and Avandia(R). PPARgamma activation treats insulin resistance, a key etiological feature in the onset and subsequent progression of ty...

Perforomist(R) Inhalation Solution Data in Patients With Moderate to Severe COPD to Be Presented at the International Conference of the American Thoracic Society

... twice-daily maintenance dosing of a nebulized long-acting beta2-adrenergic agonists ( LABAs) such as Perforomist Inhalation Solution. For example, this COPD ...ion belongs to a class of medications known as long-acting beta2-adrenergic agonists (LABAs). LABAs may increase the risk of asthma-related death. Data from...

Here to Help(TM): Unique Program Combines Direct Personal Assistance With Web-Based Resources to Improve Opioid Dependence Treatment Outcomes

...tical reasons. First, it acts on the brain in a way similar to full opioid agonists (e.g., prescription opioid painkillers, heroin or methadone) to retain pati... does not stimulate the same level of opioid-induced brain activity as full agonists do, and thus does not produce the maximal euphoric effect of a full opioid ...

Perforomist Inhalation Solution data to be presented at American Thoracic Society conference

...n for many COPD patients at earlier treatment stages who could benefit from twice-daily maintenance dosing of a nebulized long-acting beta2-adrenergic agonists (LABAs) such as Perforomist Inhalation Solution. For example, this COPD treatment may be a valuable clinical option for many patients whose symptoms ...
agonists in Medical Technology

Idera Pharmaceuticals Announces Presentations of Preclinical Data on New Potential Oncology Applications of its TLR9 Agonists at AACR

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Apr 18, 2007 - Idera Pharmaceuticals, Inc. (AMEX: IDP) today announced two presentations of data for two new potential applications in oncology of its novel agonists of Toll-like receptor 9 (TLR9) at the Annual Meeting of the American Association for Cancer Resear...

Schering-Plough Announces U.S. Filing of Mometasone Furoate/Formoterol Fumarate Combination for the Maintenance Treatment of Asthma

... Important Safety Information for FORADIL AEROLIZER FORADIL belongs to a class of medications known as long-acting beta2-adrenergic agonists or LABAs. In patients with asthma, LABAs may increase the chance of asthma related death. Therefore, FORADIL should only be used as additional therapy...

Bionovo's Estrogen Receptor Beta Selective Drugs Have Unique Gene Expression and Cell Type Specificity

...gulate a number of genes differently than estradiol, a hormone therapy commonly used to treat women's health issues. This discovery indicates that ERb agonists might be safer than current estrogens used in hormone therapy. The study also demonstrates the cell type selectivity of Menerba (MF101) and Liquiritig...

Neurocrine Biosciences Presents Elagolix Data

...ndometriosis. Likewise, while peptide gonadotropin-releasing hormone (GnRH) agonists such as Lupron(R) (leuprolide acetate) and Zoladex(R) (goserelin acetate) a...lashes throughout the course of therapy. Most importantly, because all GnRH agonists suppress estrogen to very low levels, long-term treatment is not possible d...

Arena Pharmaceuticals Announces the Presentation of Lorcaserin Phase 3 BLOOM Data at the American Diabetes Association's 69th Scientific Sessions

... number of risks and uncertainties. Such forward-looking statements include statements about lorcaserin's potential to be the first in a new class of agonists or treatment option; lorcaserin's selectivity; enrollment in the lorcaserin Phase 3 program; lorcaserin's patent coverage; and Arena's strategy, inter...

InteKrin Therapeutics to Present at the 2009 American Diabetes Association Annual Meeting

...ically proven anti-diabetic efficacy of PPAR gamma activation, while mitigating or eliminating the well recognized side effects of TZD full PPAR gamma agonists rosiglitazone and pioglitazone (Avandia(R) and Actos(R) respectively). About InteKrin ( www.InteKrin.com ) InteKrin Therapeutics is a private...

New Phase 3 Study of Tapentadol Immediate Release Tablets Published in Current Medical Research and Opinion Journal

...NTA(TM) in situations where the physician or pharmacist is concerned about an increased risk of misuse and abuse. All patients treated with mu-opioid agonists require careful monitoring for signs of abuse and addition. NUCYNTA(TM) may be abused by crushing, chewing, snorting or injecting the product. These...

Dendreon Presents Preclinical Data Demonstrating Activity of TRPM8 Agonist, D-3263, in Benign Prostatic Hyperplasia

...is an ion channel that is triggered by cold temperatures and small-molecule agonists and belongs to the melastatin subfamily - one of seven subfamilies of TRP p... in cell biology and in pathology. Dendreon has synthesized small molecule agonists including D3263 that activate the TRPM8 ion channel and induce cell death. ...

Dendreon Initiates Phase 1 Clinical Trial of Small Molecule Targeting TRPM8 in Cancer

...is an ion channel that is triggered by cold temperatures and small-molecule agonists and belongs to the melastatin subfamily - one of seven subfamilies of TRP p... in cell biology and in pathology. Dendreon has synthesized small molecule agonists including D3263 that activate the TRPM8 ion channel and induce cell death. ...

VentiRx Pharmaceuticals Initiates Phase I Clinical Trial of VTX-1463, a Novel TLR8 Agonist for the Treatment of Allergic Rhinitis

..., April 16 /PRNewswire/ -- VentiRx Pharmaceuticals, Inc., a biopharmaceutical company focused on the development of novel Toll-Like Receptor 8 (TLR8) agonists for the treatment of cancer, respiratory and inflammatory diseases, announced today that it has initiated a Phase I clinical trial of VTX-1463, a sele...
agonists in Medical Products

Ichor Hematology Analyzer

Features:...h cell type through the instruments microaperture Traditional laboratory agonists - Plateletworks uses collagen and ADP, the same agonists used to perform platelet aggregation in the traditional laboratory setting ...
Company:Helena Laboratories
agonists in Medical Dictionary

Anhidrosis

...goes unrecognized until a substantial amount of heat or ... anhidrosis ( ′anhī′drōsəs ) ( medicine ) Absent or deficient secretion of sweat. ... agonists that might treat anhidrosis ? ... Anhidrosis and fibromyalgia? ... CIPA Congenital Insensitivity to Pain with Anhidrosis (CIPA) is a rare ge...
agonists in Biological News

Research suggests beta agonists may alter the immune system

New research at Wake Forest University School of Medicine suggests that certain inhaled asthma medications ?as well as similar chemicals our bodies produce during times of high stress ?may worsen diseases such as asthma, heart failure and lupus that involve inflammation. The scientific team led b...

UCLA researchers discover new molecular pathway for targeting cancer, disease

...bit aberrant Hh signaling. "The hedgehog Hh signaling pathway is an important regulator of tumor formation, and these findings suggest that LXR agonists may be novel treatments for a wide variety of human cancers," Matsui said. According to researchers, utilizing this new treatment pathway could...

Microparticle immune response modifier shows broad effects against recurrent or metastatic cancer

...combat disease by mobilizing and expanding a broad range of intrinsic host defence mechanisms. Unlike first generation IMRs such as Toll-like receptor agonists or interferon alpha, each of which have a limited spectrum of activity and lack the ability to treat a broad range of malignant diseases, MIS416 acts ...

Pulmonary hypertension in children may result from reduced activity of gene regulator

...ese lambs, whose four-chambered hearts are essentially identical to humans, agonists to boost PPAR activity prevent the usual endothelial dysfunction that occur...continues to go well, the researchers hope to begin clinical trials of PPAR agonists in 2010. ...

Addiction: Insights from Parkinson's disease

...o result from excessive dopaminergic treatment, illustrate the link between dopamine, personality and addiction." PD patients treated with dopamine agonists had an incidence of pathological gambling as high as 8% compared to less than 1% in the general population. In PD patients who develop addictive diso...

New asthma research opposes current drug treatment, says UH prof

...r long-term asthma management than the currently used beta-2 adrenoreceptor agonists (or stimulants). The beta-2 adrenoreceptor is a receptor found in many...ymptoms. In addition, several studies have shown chronic use of the beta-2 agonists (or stimulants) can negatively affect asthma control and airway hyperrespon...

New treatment mechanisms for schizophrenia

...ead author on this project, comments, While treating patients with receptor agonists can be highly effective therapy, drugs that increase the action of the tran...animal model of schizophrenia. These findings suggest that 7 nAChR agonists including SSR180711 could be potential therapeutic drugs for cognitive defi...

The endocannabinoids: Functional roles and therapeutic opportunities

...hat the endocannabinoid system may play an important role in the pathogenesis of hepatic encephalopathy. Modulation of this system either by exogenous agonists specific for the CB2 receptors or possibly also by antagonists to the CB1 receptors may have therapeutic potential. The endocannabinoid system general...

JCI table of contents: Aug. 9, 2007

...lux in cardiomyocytes causes the cells to die by necrosis and the mice to die of heart failure. Necrotic cell death and heart failure were enhanced by agonists of beta-adrenergic receptors and abrogated by inhibitors of beta-adrenergic receptors. They were also abrogated in mice lacking cyclophilin D, which i...

Nitric oxide: Key to cardiovascular and pulmonary function and drug effectiveness

... A naturally occurring molecule in the body appears to control whether certain medications, such as beta adrenergic receptor agonists used in acute heart failure or in inhalers for asthma, lose their effectiveness over time. Nitric oxide is a molecule produced by the body that cont...
agonists in Biological Technology

Pharmos Announces Agreement to Sell Certain CB2 Selective Agonists

ISELIN, N.J., Feb. 18 /PRNewswire-FirstCall/ -- Pharmos Corporation (Nasdaq: PARS ) announced today that it has entered into an agreement with an Israel based company, Reperio Pharmaceuticals Ltd. (Reperio) for the sale of the patent rights and technical know how related to the compound known as...

Dynavax Issued Landmark Patent Covering Second-Generation TLR9 Agonists

BERKELEY, Calif., Aug. 16 /PRNewswire-FirstCall/ -- Dynavax Technologies Corporation (Nasdaq: DVAX ) today announced that the U.S. Patent Office has issued the company a broad composition of matter patent covering the company's proprietary second-generation TLR9 agonists. The claims cover a ...

Screening for β2-adrenergic receptor agonists using the pH-sensitive dye,CypHer5, and the IN Cell Analyzer 3000

Introduction High-throughput screening for potential targets is a major requirement in drug development and a key application is in the area of receptor activation, particularly G-protein coupled receptors (GPCRs) (1).

It is estimated that there are st...

New Report Just Published: World Prostate Cancer Therapeutics Market Report

... 4. Treatment Options for Prostate Cancer II-32 Hormonal Therapy II-32 Medical Hormone Therapy II-32 LHRH Analogs II-33 Dose of LHRH agonists for Advance Prostate Carcinoma Treatment II-33 Anti-Androgens II-34 Leading Non-Steroidal Anti-androgen Hormonal Therapy Drugs for Prostat...

AEterna Zentaris Presents Data Supporting Evaluation of AEZS-108 in Prostate Cancer at ASCO Meeting

...lls appear to express LHRH receptors; - Even tumors persisting or relapsing after castration or prolonged hormonal treatment with LHRH agonists retain the expression of LHRH receptors; - The continued expression of these receptors supports the concept of targeting prostatic LHR...

Amgen Exercises Option for Exclusive License to Cytokinetics' Cardiac Contractility Program That Includes CK-1827452

...ere represents one of the most thoroughly characterized protein machines in human biology. Current inotropic agents, such as beta-adrenergic receptor agonists or inhibitors of phosphodiesterase activity, increase cardiac cell contractility by increasing the concentration of intracellular calcium, which furth...

AEterna Zentaris to Present Data Supporting Evaluation of AEZS-108 in Prostate Cancer at Upcoming ASCO Meeting

... 31, 2009: # 5103: Expression of LHRH receptors in prostate cancer cells prior to therapy, following castration, or following treatment with LHRH agonists Lead Author: Stephen Liu, MD Poster Session: 2 pm - 6 pm (Level 2, West Hall C) Perifosine Additionally, AEterna Zentaris' partner, Kery...

Schering-Plough Announces Changes to its Global Collaboration with Novartis to Develop Combination Therapies for Asthma and COPD

...ast 15 minutes before exercise. Important Safety Information FORADIL belongs to a class of medications known as long-acting beta2-adrenergic agonists or LABAs. In patients with asthma, LABAs may increase the chance of asthma related death. Therefore, FORADIL should only be used as additional therapy...

CeNeRx BioPharma Awarded New Patent for its Innovative Compounds That Selectively Target Peripheral Cannabinoid Receptors

...d CB2 cannabinoid receptors. The company is initially pursuing cannabinoid agonists for the treatment of pain (peripheral neuropathy), glaucoma and spasticity ...ral side effects as negative mood and depression. Furthermore, cannabinoid agonists targeting CB1 receptors, including candidates being developed for pain reli...

FDA Approves SYMBICORT(R) for Chronic Obstructive Pulmonary Disease (COPD)

...needed for patients being transferred from systemically active corticosteroids to inhaled corticosteroids. WARNING: Long-acting beta2-adrenergic agonists may increase the risk of asthma-related death. Therefore, when treating patients with asthma, SYMBICORT should only be used for patients with asthma n...
agonists in Biological Products

PPARGamma-Competitor Assay Kit Green from Invitrogen

Description:...in the regulation of glucose and lipid metabolism. agonists include the (TZD) class of anti-diabetic agents ca...ne (Avandia) and Pioglitazone (Actos) are two PPAR agonists currently marketed for treatment of type 2 diabetes. PPAR agonists may also be therapeutically important in the treat...
Company:Invitrogen
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