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H9N2 avian flu vaccine paired with adjuvant provokes strong human immune response at low doses

When combined with an immune-boosting substance called an adjuvant, low doses of an experimental vaccine against a strain of avian influenza (H9N2) provoked a strong antibody response in human volunteers, report scientists supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. The clinical trial of 96 adults was conducted...
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Surgery and Adjuvant Therapy Can Work for Pancreatic Cancer

In the largest single-institution retrospective study to date, researchers at Mayo Clinic Cancer Center have shown that giving patients// both radiation and chemotherapy after completely removing invasive pancreatic cancer may improve overall survival rates. The American Cancer Society reports that while the incidence of pancreatic cancer has decreased over the last few years, it rem...

Bird-flu Vaccine Adjuvant Contract Goes to Novartis

Swiss-based global pharmaceutical giant Novartis bagged the contract to make a chemical that would boost the effectiveness of bird-flu vaccines. The $54.8 million contract// was finalised on Wednesday. The company already has more than $300 million in federal contracts to fight a possible bird-flu outbreak in humans. Two other firms were also awarded contracts on Wednesday...

New Adjuvant Breast Cancer Treatments Found Cost-effective

Two new studies have found that new adjuvant treatments for breast cancer are cost-effective at improving survival. Published in the August 1, 2007 issue of Cancer, a journal of the American Cancer Society, the two studies looked at the cost-effectiveness of different drugs for the management of adjuvant therapies for early breast cancer. In a Canadian economic study...
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adjuvant at Medicine Technology

New Study Shows Doxorubicin Plus Paclitaxel Followed by Weekly Paclitaxel as Adjuvant Therapy for High Risk Breast Cancer Warranted in Place of Doxorubicin Plus Cyclophosphamide Followed by Paclitaxel

22 US Oncology Affiliated Physicians Participate in ASCOProceedings HOUSTON, June 04, 2007 /PRNewswire/ -- A leading cancerresearcher affiliated with the US Oncology Research Networkpresented findings from a randomized, multicenter phase III trialthat compared the disease-free survival (DFS) obtained with tworegimens of adjuvant therapy for patients with high-risk breastcancer. Th...

Updated Overall Survival Data From Pivotal Herceptin Adjuvant Studies in HER2-Positive Breast Cancer

CHICAGO--(BUSINESS WIRE)--Jun 4, 2007 - Genentech, Inc. (NYSE:DNA)today announced updated results from a joint analysis of two PhaseIII clinical trials studying Herceptin(R) (trastuzumab) for theadjuvant treatment of HER2-positive breast cancer. Data presentedat the 43rd Annual Meeting of the American Society of ClinicalOncology (ASCO) showed that, with median follow-up of nearly threeyears...

Vical's Vaxfectin Adjuvant With Needle-free Delivery Enhances DNA Vaccine Performance; Yields Antibody Responses Comparable to Electroporation Without Tolerability Issues

MALAGA, Spain, May 23, 2007 /PRNewswire-FirstCall/ -- VicalIncorporated today announced that in a recently completed animalstudy, a DNA vaccine formulated with the company's patentedVaxfectin(TM) adjuvant and delivered by needle-free injectionyielded significantly higher antibody responses than anunformulated DNA vaccine delivered by needle and syringe. In aseparate animal study, electro...

Vical's Vaxfectin Adjuvant Achieves Dose-Sparing Effect With Seasonal Influenza Vaccine

SAN FRANCISCO, April 11, 2007 /PRNewswire-FirstCall/ -- VicalIncorporated today announced that a seasonal influenza vaccineformulated with the company's Vaxfectin(TM) adjuvant generated upto 60-fold higher antibody responses than an unformulated vaccineat the same dose in a recently completed study in mice. Formulationof sanofi pasteur's Fluzone(R) commercial vaccine withVaxfectin(TM) al...
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