PATH Malaria Vaccine Initiative and Crucell to test new malaria vaccine approach

...Crucell's novel prime-boost vaccine approach against the malaria parasite, Plasmodium falciparum. This approach uses Crucell's proprietary recombinant adenoviruses (a type of virus associated with the common cold and other mild respiratory infections) to deliver a malaria antigen to the immune system. Dr. Jaap...

Now we know what blocks the effects of a newly developed anticancer therapy

...uthors therefore suggest that identifying whether or not a tumor expresses CEACAM6 and the downstream proteins required to block tumor cell killing by adenoviruses might provide a way to predict the response of patients to adenovirus-based therapies, and that these proteins might provide targets for the developme...

JCI online early table of contents: May 1, 2009

...uthors therefore suggest that identifying whether or not a tumor expresses CEACAM6 and the downstream proteins required to block tumor cell killing by adenoviruses might provide a way to predict the response of patients to adenovirus-based therapies, and that these proteins might provide targets for the developme...

Milestone tumor virus publication by Elsevier journal Virology

...ive state-of-the-art publication. In the field of viral oncology, particularly the studies of the small DNA tumor viruses (the polyomaviruses, the adenoviruses and the papillomaviruses) have led to fundamental discoveries that have advanced our understanding of basic biology. They have helped unravel some of ...

NovaBay Pharmaceuticals Announces New Preclinical Data to be Presented at the American Academy of Dermatology (AAD) 67th Annual Meeting

... broad therapeutic index with broad spectrum activity against bacteria of all types, including multidrug resistant species, shedding viruses including adenoviruses and herpes viruses, yeasts and fungi. In addition, NVC-422 has previously shown, in-vivo , to be safe at expected therapeutic doses in the nose, bla...

Nose-spray vaccine against botulism effective in first tests

...ses' own reproductive genes have been removed. Past studies have shown that adenoviruses expressing protein antigens can be delivered by the mucosal route. In addition, adenoviruses can be quickly and inexpensively mass produced, making them an attractive p...

Researchers Report Stem Cell Advance

...nd their colleagues circumvented this problem by delivering the genes using adenoviruses instead, which do not insert their viral DNA into a cell's chromosomes. iPS... Though he praised the study, Eggan noted several caveats. First, though adenoviruses do not normally integrate their DNA into the host cell's chromosomes, somet...

Scientists discover a mechanism that can send cells on the road to cancer

...00 is very important in terms of regulating cell growth in normal and cancer cells, Dr. Tansey said. So were taking a cue from the history of work on adenoviruses and were leaving E1A behind to concentrate on Myc and p400. For us, now, the next step is to learn more about the p400-Myc connection. ...

In blood vessel stents, innovative materials allow better control, delivery of gene therapy

...controlled local release of therapeutic genes at a disease site. In an animal study, the research team used their new synthetic formulation to bind adenoviruses to bare metal stents, tiny metal scaffolds inside the carotid arteries of rats. Adenovirus served as a gene therapy vector to carry genes for an enzym...

Scientists shine new light on inflammatory diseases

...he pathogenesis of inflammatory diseases such as rheumatoid arthritis. The mechanism may also shed some light on why gene therapy experiments that use adenoviruses to deliver genes to humans have run into problems. The study will appear online on March 16 in the journal Nature Immunology. Tumor necrosis factor...

Adenoviruses in Medical Technology

In Blood Vessel Stents, Innovative Materials Allow Better Control, Delivery of Gene Therapy

...ontrolled local release of therapeutic genes at a disease site. In an animal study, the research team used their new synthetic formulation to bind adenoviruses to bare metal stents, tiny metal scaffolds inside the carotid arteries of rats. Adenovirus served as a gene therapy vector to carry genes for an enzym...

Aeras, Crucell and South African Tuberculosis Vaccine Initiative Announce Encouraging Preliminary Results of Tuberculosis Vaccine Clinical Trial in South Africa

...virus serotype 5 (Ad5), without compromising large-scale production capabilities or the immunogenic properties of Ad5. AdVac(R) technology is based on adenoviruses that do not regularly occur in the human population, such as Ad35. In contrast to, for instance, Ad35 antibodies, antibodies to Ad5 are widespread amo...

Adenoviruses in Medical Products

VIKIA Rota-Adeno

Description:...e, chromatographic immunoassay which simultaneously detects rotaviruses and adenoviruses in stool specimens. Rotaviruses and adenoviruses are responsible for the majority of pediatric diarrhea cases....
Company:bioMerieux, Inc.

Adenoviruses in Medical Dictionary

Adenoviruses

Adenoviruses are medium-sized (90–100 nm), nonenveloped (naked) icosahedral viruses composed of a nucleocapsid and a double-stranded linear DNA genome. There are over 52 different serotypes in humans, which are responsible... Features virus information, symptoms, diagnosis, prevention, and ...

Adenovirus

... ... More about Adenovirus Infections: Causes and symptoms Diagnosis Treatment Prognosis Prevention Resources Adenovirus Infections Definition adenoviruses The usual predisposing factor for young birds is adenovirus . ... There is not an effective vaccine for adenovirus , so we must just let it ru...

Adenoviruses in Biological News

Gamma globulin effective in treating eye infections caused by adenoviruses

PITTSBURGH, Aug. 28 Gamma globulin, a type of antibody isolated from blood samples that used to be routinely given to health care workers and international travelers to protect them from infectious diseases, is a highly effective treatment for pinkeye with little apparent toxicity, according to a...

Contagious obesity? Identifying the human adenoviruses that may make us fat

There is a lot of good advice to help us avoid becoming obese, such as "Eat less," and "Exercise." But here's a new and surprising piece of advice based on a promising area of obesity research: "Wash your hands." There is accumulating evidence that certain viruses may cause obesity, in essence ma...

Protein analysis methods, viral vectors featured in Cold Spring Harbor Protocols

...Spring Harbor Protocols . Genetically modified adenoviruses serve as one of the most versatile and efficient g... use today. Laboratories throughout the world use adenoviruses for the delivery of DNA to cells for basic science...e therapy applications. Unlike most other vectors, adenoviruses can infect post-mitotic cells, which makes them pa...

Researchers engineer pancreatic cell transplants to evade immune response

...cting them from rejection. They did so by harnessing the innate ability of adenoviruses to evade the body's immune surveillance system. (Adenoviruses infect tissu...iratory tract, eyes, intestines, and urinary tract). After infecting cells, adenoviruses produce proteins that prevent the cells from signaling the immune system th...

Gene therapy anti-cancer research featured in Scientific American

... 1940s, virotherapy now relies heavily on adenoviruses, a cause of the common cold that has been studied and altered extensively for medical research. adenoviruses have the ability to shuttle targeted segments of DNA into a tumor cell and make biochemical changes that minimize damage to healthy cells. ...

Three-in-one virus killer prevents common, often fatal infections

...apies and more practical than cell-based therapies that target EBV and CMV separately, both of which are carried in roughly 80 percent of all people. adenoviruses are common viruses carried in all populations. "There is no safe and effective therapy for patients with adenovirus infections at the moment, so ...

Targeted virus compels cancer cells to eat themselves

...h team also clarified the mechanism by which such conditionally replicating adenoviruses (CRAs) infect and kill cancer cells. Autophagy is a protective process ...njections of hTERT-Ad on average lived 53 days. Those receiving the control adenoviruses lived on average 29 days. Two of the hTERT-Ad mice survived 60 days and had...

Polymer gel can block toxic leakage problem in gene therapy

...-cancer gene therapy that uses relatively harmless adenoviruses to infect tumor cells. Once in a targeted tumor, g... blood vessel walls and other access points, these adenoviruses cannot reach the majority of tumor cells by being ...ancer. In that study, the researchers injected adenoviruses that produce glowing proteins in order to trace wh...

Adenoviruses in Biological Technology

Avian Adenovirus Genotyping Diagnostic Service

...erformance of breeding birds, clear diagnosis of the presence of pathogenic adenoviruses (and hence their appropriate control) has been difficult historically due t...r vein, determination of the relationship (or lack of) between source flock adenoviruses and those isolated in progeny flocks and the resultant causal relationship ...

Oncolytics Biotech Inc. Announces Issuance of 26th U.S. Patent

...y announced that it has been granted U.S. Patent 7,344,711 entitled "Use of adenoviruses Mutated in the VA Genes for Cancer Treatment." The claims describe methods of treating cancer using adenoviruses that are modified to selectively replicate in cancer cells that have an act...

Superior Gene Silencing Using Adenoviral Vectors

... been described in the literature (1). Recombinant adenoviruses have several advantages over ...Alleles in vivo To demonstrate that adenoviruses are useful for decreasing gene expressi...niversity of Iowa, injected recombinant adenoviruses expressing siRNAs targeting green fluorescent ...

Delivering siRNA Using Adenoviral Vectors

...a variety of animal species. adenoviruses are popular gene delivery veh... independent of cell cycle, so adenoviruses can be used to express RNA in...he fact that most recombinant adenoviruses elicit an immune response in animal ...

Generate Adenovirus Vectors in E. coli by Homologous Recombination with the AdEasy Adenoviral Vector System

...cells Tanya Hosfield Lisa Eldridge Stratagene Recombinant adenoviruses provide a versatile means of gene delivery and expression. We describe th...elected more quickly and easily than traditional methods. Recombinant adenoviruses are a versatile tool for gene delivery and expression. Several features o...

Adenoviruses in Biological Definition

Gene therapy

...ors in gene therapy 3.1 Retroviruses 3.2 adenoviruses 3.3 Adeno-associated viruses 4 Problems...s which look promising — retroviruses and adenoviruses . Retroviruses are small RNA based viruses. Be...topped growing and were broken down by the body. adenoviruses are larger, DNA-based viruses, which can carry mor...

Virus classification

...miniviridae Family Circoviridae Family Nanoviridae Family Parvoviridae - e.g. Parvovirus B19 (most depend on coinfection with adenoviruses for growth) Unassigned genera Anellovirus ; type species: Torque teno virus RNA viruses Group III - dsRNA viruses (doub...