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Adenoviral in Medical News

American Medical Association Clears Path for Adenoviral Conjunctivitis - 'Pink Eye' - Detector

SARASOTA, Fla., Nov. 7 /PRNewswire/ -- Rapid Pathogen Screening Inc., (RPS) -- a leading developer of point-of-care diagnostic devices for ocular diseases -- announced today that the American Medical Association will issue a new Current Procedural Terminology (CPT) code that will cover the RPS...

PATH Malaria Vaccine Initiative and Crucell to test new malaria vaccine approach

...Vac technology and PER.C6 manufacturing platform. The vaccine candidate is made by inserting the CSP gene from the P. falciparum malaria parasite into adenoviral vectors, which act as a 'vehicle' for vaccination delivery. This prime vaccine candidate is currently being tested in a Phase 1 study in partnership w...

Adenoviral vector specifically targeted to EphA2 receptor in pancreatic cancer cells

...linical studies have demonstrated poor efficacy of adenoviral gene therapy because of the absence of adenoviral binding sites on pancreatic cancer cells such as t...ntry therefore seems a promising option to improve adenoviral entry into pancreatic cancer cells and to enhance ...

Interferon Reduces, Eliminates Viral Infections in Heart Failure Patients

... interferon beta-1b (IFNB-1b) treatment eliminates cardiotropic viruses and may improve the clinical outcomes of patients with chronic enteroviral and adenoviral heart disease," said Heinz Peter Schultheiss, M.D., the lead author of the study and a professor of medicine in the Department of Cardiology and Pneum...

Scientists discover a mechanism that can send cells on the road to cancer

...embers include molecular biologists from Stony Brook University in New York. Using a Tumor Virus to Illuminate Function The team focused on an adenoviral oncogene called E1A, and a protein that it codes for with the same name. Both have received a great deal of attention over the years, said Dr. Tansey,...

Scientists identify novel way to prevent cardiac fibrosis

...To test this possibility, the scientists treated fibroblast cells in culture in ways that altered Epac expression, increasing Epac expression using an adenoviral construct. Using this strategy to overexpress Epac, we produced an anti-fibrotic effect, thereby inhibiting the synthesis of collagen said Insel. ...

Scientists shine new light on inflammatory diseases

...lain how a patient involved in a University of Pennsylvania gene therapy experiment that used an adenovirus to deliver the gene died. Host response to adenoviral vectors is dependant on both IRF1 and TNF. What we have described is that TNF has both pathogenic affectsit helps to sustain some of these inflamma...

Blocking protein kills prostate cancer cells, inhibits tumor growth, Jefferson scientists find

...ate cancer cells to be viable. They blocked the proteins expression and function in several ways, including siRNA inhibition, antisense inhibition and adenoviral gene delivery of an inhibitory form of Stat5. All of these techniques killed the prostate cancer cells in cell culture. The researchers also showed wh...

Lymphatic vessel and lymph node function are restored with growth factor treatment

...imicked removal of axillary lymph nodes in patients in response to metastatic breast cancer. They found that treatment of lymph node-excised mice with adenoviral VEGF-C gene transfer vectors induced robust growth of the lymphatic capillaries, which gradually underwent an intrinsic remodeling, differentiation an...

New study shows that therapeutic gene expression can be sustainable for 1 year

...chanism that is normally present in humans. The researchers demonstrated in an animal model that the delivery system for the gene, a novel gutted adenoviral vector called HC-Adv, is completely invisible to the immune system. Vectors previously used to deliver genes carried minute amounts of viral proteins ...
Adenoviral in Medical Technology

Alcon Commences Phase 2 Clinical Trial of NovaBay's NVC-422 for Viral Conjunctivitis

...viral disease is principally caused by adenoviruses, but also can be caused by other viruses, such as enterovirus. There is no specific treatment for adenoviral conjunctivitis, which can take up to three weeks or longer to clear on its own. Bacterial conjunctivitis is caused by a variety of bacteria and is la...

Celladon Provides MYDICAR(R) Program Update of First-In-Human Trial for Advanced Heart Failure at American Society of Gene Therapy Annual Meeting

...ome and are considered non-mutagenic. In addition, they have not been associated with the types of inflammatory reactions observed in trials involving adenoviral vectors, which are known to induce acute inflammation of tissues due to activation of the body's immune system. Patients with heart failure may a...

Celladon Announces Presentation of Clinical Data From First-in-Human MYDICAR(R) Trial for Advanced Heart Failure at American Heart Association Scientific Sessions

...ome and are considered non-mutagenic. In addition, they have not been associated with the types of inflammatory reactions observed in trials involving adenoviral vectors, which are known to induce acute inflammation of tissues due to activation of the body's immune system. About Heart Failure Heart failure ...

Epeius Biotechnologies Applauds the Belated Scholarship of Their Academic Contemporaries in 2007, As Targeted Gene Therapy Comes of Age in Clinical Medicine

... in Nature (Nature Reviews, Genetics, 2007, 8:573-587) entitled "Engineering Targeted Viral Vectors for Gene Therapy." Among the flotsam and jetsam of adenoviral shipwrecks, and the ruminative discourses on "Obstacles to Systemic Targeting," was an intriguing preface stating that "the first clinical trials have...

Multiple NIH Phase 2 HIV Vaccine Trials Using Vical's Technology Produce Encouraging Results

... cannot reconstitute into an infectious virus. The adenoviral vector component uses a replication-defective adenoviral vector to shuttle the same non-infectious gene seq... VRC scientists and was manufactured by Vical. The adenoviral vector vaccine was developed by VRC in collaborati...

Vical Reports Second Quarter 2007 Financial Results, Allowance of Pandemic Influenza IND and Other Advances in Product Development Programs

...rship for AIDS Vaccine Evaluation (PAVE). The PAVE trial will test a vaccine regimen combining a DNA prime based on Vical's technology with an adenoviral vector boost in up to 8,500 volunteers at sites in the United States, Africa, the Caribbean and South America to determine its potential to pr...

Introgen and Clinical Collaborators to Report New Results with Advanced-Stage Cancer Therapies at Upcoming Medical Meetings

...sponse criteria and biomarkers associated with increased survival following adenoviral p53 gene therapy (ADVEXIN) in patients with recurrent squamous cell carcino...rian Hamster Model, Abstract #668: Presentation during "Immune Responses to adenoviral Vectors" poster session on Fri, June 1, from 5:15- 8:15 p.m. in Hall 4AB at...
Adenoviral in Biological News

Amarna Therapeutics B.V. and TNO announce SVac research and development partnership

...ene delivery vector platform has a number of unique properties compared to other viral gene delivery vectors such as lentiviral, poxviral, alphaviral, adenoviral and adeno-associated virus (AAV) vector systems. SVac is non-immunogenic in humans, highly stable, safe to use and can be cost effectively produced in...

Researchers engineer pancreatic cell transplants to evade immune response

...egin to rise, returning to pre-transplant disease levels. Dr. Goldstein and his colleagues genetically engineered these beta cells to include three adenoviral genes responsible for making immunosuppressive proteins. Diabetic mice that received these engineered foreign beta cells maintained normal glucose co...

Yamanaka eliminates viral vector in stem cell reprogramming

... shown, each step forward reveals a new set of challenges." Dr. Yamanka's team began this series of experiments by replacing the retrovirus with an adenoviral vector. While transfections with the genes on separate vectors didn't work, they did work when the genes were arranged in a specific order on a single...

Nanoparticles for delivery of prostate cancer treatment

... for a clinical trial. "The advantage of nanoparticle vectors is that they do not reproduce, are not immunogenic, and are easier to produce than adenoviral vectors," said Garen. The nanoparticles will have a tag on their outside that binds to the tumor blood vessels. After binding, they are taken up by th...

Abnormal overexpression of p53 is a predictive molecular biomarker

...espond to Advexin therapy than those whose tumor showed little p53 protein. Advexin is a gene based drug, injected directly into tumors, which uses an adenoviral vector to deliver the wild type p53 gene to tumor cells. Results were presented at the first meeting on Molecular Diagnostics in Cancer Therapeutic...

Reversing 'hibernating' heart muscle focus of UB researchers

...search facilities and mass spectrometry at UB. "By using therapies similar to those that are used clinically in patients, such as angioplasty and adenoviral gene transfer to over-express growth factors in the heart, we can identify how changes in the molecular pathways responsible for the adaptation to dec...
Adenoviral in Biological Technology

Performance of Ad-A-Gene Cyclic AMP Response Element-Nitroreductase (CRE-NTR): an adenoviral vector gene delivery system

Key words: adenoviral vector ● viral transduction ● NTR ● IN Cell Analyzer ● gene delivery Biological assays developed in cultured and primary cells can greatly aid secondary screening as well as lead and target validation, but ...

Performance of Ad-A-Gene EGFP-MAPKAP-k2: an adenoviral vector gene delivery system

Key words: adenoviral vector • viral transduction • EGFP • IN Cell Analyzer • gene delivery Biological assays developed in cultured and primary cells can greatly aid secondary screening as well as lead and target validation, but the...

Performance of Ad-A-Gene EGFP-Glucocorticoid Receptor (EGFP-GCCR): an adenoviral vector gene delivery system

Key words: adenoviral vector • viral transduction • EGFP • IN Cell Analyzer • gene delivery There is a requirement in the drug discovery process to investigate lead candidate drugs arising from primary screens and to validate those ...

Superior Gene Silencing Using Adenoviral Vectors

Mediating RNA interference (RNAi) with recombinant adenovirus expressing siRNAs has only recently been described in the literature (1). Recombinant adenoviruses have several advantages over other methods of nucle...

Delivering siRNA Using Adenoviral Vectors

Efficiently deliver an siRNA expression construct into a variety of mammalian cells and organisms Ideal for many primary and other difficult to transfect cells Modified CMV promoter efficiently expres...

Generate Adenovirus Vectors in E. coli by Homologous Recombination with the AdEasy Adenoviral Vector System

Efficient gene transfer and high-level protein expression within a variety of cells Tanya Hosfield Lisa Eldridge Stratagene Recombinant adenoviruses provide a versatile means of gene delivery and expression. We describe the AdEasy adenoviral vector system, ###,W ...

Imugene and Merial Establish Strategic Alliance

..., chemicals and drugs. Imugene owns the worldwide rights to the Fowl adenoviral Vector Delivery System for poultry and the Porcine adenoviral Vector Delivery System for pigs. For more information please visit t...

Lentigen Corporation Announces Exclusive Licensing Agreement With Case Western Reserve University to Develop Novel Stem-Cell Therapy for Brain Cancer

...icles that can deliver genes or RNAi into cells with up to 100% efficiency and stability. By comparison, other viral vector systems such as non-viral, adenoviral and adeno-associated viral vectors have not been shown to achieve both high and stable gene delivery in dividing cells. Gene delivery is accomplishe...

The Genesis of Gendicine: The Story Behind the First Gene Therapy

...hemotherapy. BPI: What role does the adenoviral vector play? Peng: Upon intratumor in...mental contamination. More importantly, infected adenoviral DNA will not integrate into the human host cell ...production of gene therapeutics using an adenoviral vector. I used the Cell-Cube (parallel-pl...

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Adenoviral in Biological Products
Adenoviral in Biological Dictionary

Tropism

...out tropism in the free online English dictionary and encyclopedia. ... tropism (trpzm) ... tropism ... A mosaic virus strategy may improve adenoviral tropism in human gene therapy. ... DOUBLE TROPISM AND DOCUMENTARY: THE DRAW OF THE OTHER PLACE (Michigan ... Pronunciation of tropism . t...

Shuttle vector

...1B region which permit the easy deletion of a gene or genes therein, ... GenScript's codon optimization technology can increase the ... These adenoviral shuttle vectors are compatible with the Clontech Adeno-XTM Expression System. ... ...

Directional cloning

...fficient directional cloning of recombinant adenovirus vectors using DNA-protein complex. ... allows the directional cloning of genes into adenoviral ... Directional cloning was carried out according to the Xi- cloning procedure ... USER Friendly cloning has been used for the directional ...
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