American Medical Association Clears Path for Adenoviral Conjunctivitis - 'Pink Eye' - Detector
SARASOTA, Fla., Nov. 7 /PRNewswire/ -- Rapid Pathogen Screening Inc.,
(RPS) -- a leading developer of point-of-care diagnostic devices for ocular
diseases -- announced today that the American Medical Association will
issue a new Current Procedural Terminology (CPT) code that will cover the
PATH Malaria Vaccine Initiative and Crucell to test new malaria vaccine approach
...Vac technology and PER.C6 manufacturing platform. The vaccine candidate is made by inserting the CSP gene from the P. falciparum malaria parasite into adenoviral
vectors, which act as a 'vehicle' for vaccination delivery. This prime vaccine candidate is currently being tested in a Phase 1 study in partnership w...
Adenoviral vector specifically targeted to EphA2 receptor in pancreatic cancer cells
...linical studies have demonstrated poor efficacy of adenoviral
gene therapy because of the absence of adenoviral
binding sites on pancreatic cancer cells such as t...ntry therefore seems a promising option to improve adenoviral
entry into pancreatic cancer cells and to enhance ...
Interferon Reduces, Eliminates Viral Infections in Heart Failure Patients
... interferon beta-1b (IFNB-1b) treatment eliminates cardiotropic viruses
and may improve the clinical outcomes of patients with chronic enteroviral
heart disease," said Heinz Peter Schultheiss, M.D., the lead
author of the study and a professor of medicine in the Department of
Cardiology and Pneum...
Scientists discover a mechanism that can send cells on the road to cancer
...embers include molecular biologists from Stony Brook University in New York.
Using a Tumor Virus to Illuminate Function
The team focused on an adenoviral
oncogene called E1A, and a protein that it codes for with the same name. Both have received a great deal of attention over the years, said Dr. Tansey,...
Scientists identify novel way to prevent cardiac fibrosis
...To test this possibility, the scientists treated fibroblast cells in culture in ways that altered Epac expression, increasing Epac expression using an adenoviral
Using this strategy to overexpress Epac, we produced an anti-fibrotic effect, thereby inhibiting the synthesis of collagen said Insel. ...
Scientists shine new light on inflammatory diseases
...lain how a patient involved in a University of Pennsylvania gene therapy experiment that used an adenovirus to deliver the gene died. Host response to adenoviral
vectors is dependant on both IRF1 and TNF.
What we have described is that TNF has both pathogenic affectsit helps to sustain some of these inflamma...
Blocking protein kills prostate cancer cells, inhibits tumor growth, Jefferson scientists find
...ate cancer cells to be viable. They blocked the proteins expression and function in several ways, including siRNA inhibition, antisense inhibition and adenoviral
gene delivery of an inhibitory form of Stat5. All of these techniques killed the prostate cancer cells in cell culture. The researchers also showed wh...
Lymphatic vessel and lymph node function are restored with growth factor treatment
...imicked removal of axillary lymph nodes in patients in response to metastatic breast cancer. They found that treatment of lymph node-excised mice with adenoviral
VEGF-C gene transfer vectors induced robust growth of the lymphatic capillaries, which gradually underwent an intrinsic remodeling, differentiation an...
New study shows that therapeutic gene expression can be sustainable for 1 year
...chanism that is normally present in humans.
The researchers demonstrated in an animal model that the delivery system for the gene, a novel gutted adenoviral
vector called HC-Adv, is completely invisible to the immune system. Vectors previously used to deliver genes carried minute amounts of viral proteins ...
Adenoviral in Medical Technology
Alcon Commences Phase 2 Clinical Trial of NovaBay's NVC-422 for Viral Conjunctivitis
...viral disease is principally caused by adenoviruses, but also can be caused by other viruses, such as enterovirus. There is no specific treatment for adenoviral
conjunctivitis, which can take up to three weeks or longer to clear on its own. Bacterial conjunctivitis is caused by a variety of bacteria and is la...
Celladon Provides MYDICAR(R) Program Update of First-In-Human Trial for Advanced Heart Failure at American Society of Gene Therapy Annual Meeting
...ome and are considered non-mutagenic. In addition, they have not been associated with the types of inflammatory reactions observed in trials involving adenoviral
vectors, which are known to induce acute inflammation of tissues due to activation of the body's immune system.
Patients with heart failure may a...
Celladon Announces Presentation of Clinical Data From First-in-Human MYDICAR(R) Trial for Advanced Heart Failure at American Heart Association Scientific Sessions
...ome and are considered non-mutagenic. In
addition, they have not been associated with the types of inflammatory
reactions observed in trials involving adenoviral
vectors, which are known
to induce acute inflammation of tissues due to activation of the body's
About Heart Failure
Heart failure ...
Epeius Biotechnologies Applauds the Belated Scholarship of Their Academic Contemporaries in 2007, As Targeted Gene Therapy Comes of Age in Clinical Medicine
... in Nature (Nature Reviews, Genetics, 2007,
8:573-587) entitled "Engineering Targeted Viral Vectors for Gene Therapy."
Among the flotsam and jetsam of adenoviral
shipwrecks, and the ruminative
discourses on "Obstacles to Systemic Targeting," was an intriguing preface
stating that "the first clinical trials have...
Multiple NIH Phase 2 HIV Vaccine Trials Using Vical's Technology Produce Encouraging Results
... cannot reconstitute into an infectious virus. The adenoviral
component uses a replication-defective adenoviral
vector to shuttle the
same non-infectious gene seq... VRC scientists and was manufactured by Vical.
vector vaccine was developed by VRC in collaborati...
Vical Reports Second Quarter 2007 Financial Results, Allowance of Pandemic Influenza IND and Other Advances in Product Development Programs
...rship for AIDS Vaccine Evaluation (PAVE). The PAVE trial will test a vaccine regimen combining a DNA prime based on Vical's technology with an adenoviral
vector boost in up to 8,500 volunteers at sites in the United States, Africa, the Caribbean and South America to determine its potential to pr...
Introgen and Clinical Collaborators to Report New Results with
Advanced-Stage Cancer Therapies at Upcoming Medical Meetings
...sponse criteria and biomarkers associated with
increased survival following adenoviral
p53 gene therapy (ADVEXIN)
in patients with recurrent squamous cell carcino...rian Hamster Model, Abstract #668: Presentation
during "Immune Responses to adenoviral
Vectors" poster session on
Fri, June 1, from 5:15- 8:15 p.m. in Hall 4AB at...
Adenoviral in Biological News
Amarna Therapeutics B.V. and TNO announce SVac research and development partnership
...ene delivery vector platform has a number of unique properties compared to other viral gene delivery vectors such as lentiviral, poxviral, alphaviral, adenoviral
and adeno-associated virus (AAV) vector systems. SVac is non-immunogenic in humans, highly stable, safe to use and can be cost effectively produced in...
Researchers engineer pancreatic cell transplants to evade immune response
...egin to rise, returning to pre-transplant disease levels.
Dr. Goldstein and his colleagues genetically engineered these beta cells to include three adenoviral
genes responsible for making immunosuppressive proteins. Diabetic mice that received these engineered foreign beta cells maintained normal glucose co...
Yamanaka eliminates viral vector in stem cell reprogramming
... shown, each step forward reveals a new set of challenges."
Dr. Yamanka's team began this series of experiments by replacing the retrovirus with an adenoviral
vector. While transfections with the genes on separate vectors didn't work, they did work when the genes were arranged in a specific order on a single...
Nanoparticles for delivery of prostate cancer treatment
... for a clinical trial.
"The advantage of nanoparticle vectors is that they do not reproduce, are not immunogenic, and are easier to produce than adenoviral
vectors," said Garen. The nanoparticles will have a tag on their outside that binds to the tumor blood vessels. After binding, they are taken up by th...
Abnormal overexpression of p53 is a predictive molecular biomarker
...espond to Advexin therapy than those whose tumor showed little p53 protein. Advexin is a gene based drug, injected directly into tumors, which uses an adenoviral
vector to deliver the wild type p53 gene to tumor cells.
Results were presented at the first meeting on Molecular Diagnostics in Cancer Therapeutic...
Reversing 'hibernating' heart muscle focus of UB researchers
...search facilities and mass spectrometry at UB.
"By using therapies similar to those that are used clinically in patients, such as angioplasty and adenoviral
gene transfer to over-express growth factors in the heart, we can identify how changes in the molecular pathways responsible for the adaptation to dec...
Adenoviral in Biological Technology
Adenoviral in Biological Products
Adenoviral in Biological Dictionary
...out tropism in the free online English dictionary and encyclopedia. ... tropism (trpzm) ... tropism ... A mosaic virus strategy may improve adenoviral
tropism in human gene therapy. ... DOUBLE TROPISM AND DOCUMENTARY: THE DRAW OF THE OTHER PLACE (Michigan ... Pronunciation of tropism . t...
...1B region which permit the easy deletion of a gene or genes therein, ... GenScript's codon optimization technology can increase the ... These adenoviral
shuttle vectors are compatible with the Clontech Adeno-XTM Expression System. ... ...
...fficient directional cloning of recombinant adenovirus vectors using DNA-protein complex. ... allows the directional cloning of genes into adenoviral
... Directional cloning was carried out according to the Xi- cloning procedure ... USER Friendly cloning has been used for the directional ...