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activating in Medical News

Drugs Activating PXR May Help In Treating Niemann-Pick type C disease

Scientists at Washington University School of Medicine in St. Louis and other institutions have reported that experimental findings suggest that drugs that activate// pregnane X receptor (PXR) my help in the treatment of Niemann-Pick type C (NPC) disease. NPC is progressive neurodegenerative disor...

Unlocking the key to human fertility

... Iles. Detailed analyses of the DNA in the 'open', less tightly packaged conformation, showed this DNA carries much of the information critical for activating genes essential for directing the development of the embryo. Further investigations showed the same conformation to exist in the sperm of several unre...

Boehringer Ingelheim to Commence Phase III Study Investigating the Role of BIBW 2992 as First-Line Treatment for Non-Small Cell Lung Cancer (NSCLC) Patients with EGFR Mutations

...ng, Chih-Hsin et al., "BIBW 2992, a novel irreversible EGFR/HER2 tyrosine kinase inhibitor, in chemonaive patients with adenocarcinoma of the lung and activating EGFR mutations (LUX-Lung 2)." 2009 WCLC, Oral Presentation #1200.22. (5) De Greve, J. et al., "Clinical activity of BIBW2992, an irreversible inhib...

Food additive may one day help control blood lipids and reduce disease risk

...pid and glucose metabolism. When doctors prescribe fibrate drugs to lower triglycerides and elevate good cholesterol in the blood, those drugs work by activating PPAR-alpha. Although fibrates activate the protein, no one previously had identified any naturally occurring substance that could perform that task....

Gene Mutation Could Be Key to Rare Blood Vessel Disease

...ical techniques, the researchers found that thrombomodulin not only protects blood from excess clotting, but it also prevents complement proteins from activating and damaging endothelial cells. In patients with aHUS and thrombomodulin mutations, the mutated thrombomodulin was less effective at interfering wi...

New Gene May Signal Aggressive Breast Cancer

...rexpression also impacts the RAS protein, which previous research has implicated in tumor growth. Researchers said RCP may promote breast cancer by activating the RAS signaling pathway. Developing treatments that target RCP may represent a new way to slow down tumor growth. The study provides new insight ...
activating in Medical Technology

Vectibix(R) in Combination With Chemotherapy Significantly Improved Progression-Free Survival in First-Line Metastatic Colorectal Cancer

...utcomes with respect to the presence or absence of activating mutations in KRAS in the tumor itself. Tumor K... Importantly, in patients with tumors harboring activating KRAS mutations, PFS was significantly inferior i...uld not be used in patients with tumors containing activating KRAS mutations." Detailed efficacy and ...

Radius' Investigational Bone Anabolic Agent, BA058, Increased Bone Mineral Density (BMD) at Key Fracture Sites in Phase 2 Clinical Trial in Postmenopausal Osteoporosis

...mation. Though they act through the same receptor, PTHrP and its analogs play a distinct biological role from the PTH (parathyroid hormone) peptide by activating different signaling responses--PTH regulates calcium homeostasis and bone resorption by acting primarily on target cells in bone and kidney, whereas P...

Cordex Signs European Development Partnership for ATPotent(TM) Sperm Motility Drug

...ly functions. ATP is released from cells under physiologic and pathophysiologic conditions; extracellular ATP acts as a local physiologic regulator by activating cell surface receptors called P2 receptors. Extracellular ATP plays an important role in sperm maturation in the male reproductive tract and is a mand...

Cephalon Provides Clinical Update on Lestaurtinib in Relapsed Acute Myelogenous Leukemia

...y announced results from a pivotal clinical trial of lestaurtinib (CEP-701) in patients with relapsed acute myelogenous leukemia (AML) expressing FLT3 activating mutations. The study was designed to show the benefit of lestaurtinib in this patient population when given in sequence with standard induction chemo...

Agennix Receives Fast Track Designation From FDA for Talactoferrin in Combination With Sunitinib for Renal Cell Carcinoma

...tening diseases including RCC and NSCLC. Talactoferrin mediates its anti-cancer activity by targeting dendritic cells which play an important role in activating innate and adaptive immunity. After being transported into the gut associated lymphoid tissue (GALT), the largest immune organ in the body, orally ad...

Boehringer Ingelheim to Present New Phase II Clinical Data on Two Lead Oncology Compounds at ASCO 2009

... Second-line Treatment of NSCLC Patients with EGFR activating Mutations - (1,2) -The First Presentation of ... 2992 in NSCLC patients who test positive for EGFR activating mutations.(5) "It is well documented that 'a...), in patients with adenocarcinoma of the lung and activating EGFR mutations after failure of 1 line of chemothe...
activating in Medical Products

Autologous Platelet Gel

Description:...mber of factors including serotonin, fibronectin, adenosine diphosphate, thromboxane A, platelet factor 4, platelet derived growth factor and platelet activating factor. Release of these factors cause a chemotactic response and initiates the process of migration between the endothelial cells....
Company:Blood Recovery Systems, Inc.

D-Stat Dry

Features:... Cleaving endogenous fibrinogen to fibrin. activating clotting factors VIII, V and XIII and stimulating platelet aggregation. In vitro testing using standard coagulation tests demonstrated the clot speed ...
Company:Vascular Solutions, Inc.

Surgistat II Electrosurgical Generator.

Features:...urgical effect with power control dials. Performs most common office-based electrosurgical procedures. Provides ability to change power settings while activating the generator. Accepts preferred accessories. Manufactured to the highest standards of quality in electrosurgical technology. Increased patient safety...
Company:Valleylab

Surgistat Electrosurgical Generator

Features:...urgical effect with power control dials. Performs most common office-based electrosurgical procedures. Provides ability to change power settings while activating the generator. Includes both monopolar and bipolar outputs. Accepts preferred accessories standard 3-pin pencil, most standard footswitching devices (...
Company:Valleylab
activating in Medical Definition

Thymocyte

...elf-peptides presented on MHC class I or MHC class II. If T cells bearing these T cell receptors were to enter the periphery, they would be capable of activating an immune response against self, resulting in autoimmunity . Negative selection is the process evolved to reduce this risk. During negative selection...
activating in Medical Dictionary

Monocyte

...t Defenses. Warren Strober, M.D. ... MONOCYTE , GRANULOCYTE, CALPROTECTIN, CLONE: 27E10, MAB ANTI-HUMAN, RHESUS MONKEY ... ENDOTHELIAL- MONOCYTE activating POLYPEPTIDE II (EMAP II), 20KD, CLONE: 546-2, ... Currently, monocyte -derived DCs are the most widely used, because they can be ... Efficiency o...

Leukocytes

...ulf and destroy invading microbes when ... ... migration of emigrated leukocytes was recorded continuously using time-lapse videomicroscopy. ... activating factor increased leukocyte adhesion to a ... Immunofluorescent Staining of Mouse and Rat Leukocytes . The Uses of Fc Block™ in Immunophenotyp...

Immunoglobulin

...ew years. ... Intravenous immunoglobulin in primary antibody deficiency ... The binding of immunoglobulin Fc to inhibitory (FcγRIIb) and activating (FcγRI ... Fuller HL, Del Mar C. Immunoglobulin treatment for respiratory syncytial virus infection. ... This review assesses immunoglobu...
activating in Biological News

Antibody targeting of glioblastoma shows promise in preclinical tests, say Lombardi researchers

...rate how this antibody latches onto a receptor that studs the outside of glioblastoma cells, preventing a growth factor protein from binding to it and activating growth pathways in the tumors. "We desperately need new treatments for glioblastoma, and these findings have given us hope that a new approach may...

Fox Chase researchers uncover one force behind the MYC oncogene in many cancers

... Philadelphia (July 27, 2009) DLX5, a gene crucial for embryonic development, promotes cancer by activating the expression of the known oncogene, MYC, according to researchers from Fox Chase Cancer Center. Since the DLX5 gene is inactive in normal adults, it...

Protein that promotes cancer cell growth identified

...ly deleted or silenced in tumors, suggesting that it was giving cancer cells a leg up in some other way. Our studies suggest that Caspase-8 does so by activating the MAPK pathway through Src." Using immuno-blot assays, the scientists showed that EGF signaling was absent in a cancer cell line that is deficien...

UCLA researchers discover new molecular pathway for targeting cancer, disease

...Molecular Endocrinology , scientists found that by activating a receptor in cells called the liver X receptor (L...ing the study, researchers performed various tests activating LXR receptors in cells and found that specific gen... The next stage of the research will focus on activating the LXR pathway using various pharmacological mole...

2 Fred Hutchinson Cancer Research Center scientists receive Presidential Early Career Award

...ents may play in preventing prostate and colorectal cancer. Selenium, for example, found in grains, bread, eggs, meat and fish, plays a key role in activating a small number of enzymes called selenoenzymes, which can protect cells against DNA damage that can lead to cancer. Peters and colleagues are studying...

Fate in fly sensory organ precursor cells could explain human immune disorder

... sensory organ cells in the absence of Arp3 protein. In addition, they found that under normal conditions vesicles (tiny bubbles) containing the Notch activating protein Delta travel to the top of the daughter cell to a structure rich in actin. This specialized actin structure contains many membrane protrusions...
activating in Biological Technology

Quark Pharmaceuticals Presented At ARVO Data Showing That PF-04523655 Enters Retinal Cells And Elicits Its Pharmacologic Effect Via Target Gene Knock-Down Without Activating TLR3

FREMONT, Calif., May 11 /PRNewswire/ -- Quark Pharmaceuticals, Inc., a development-stage pharmaceutical company discovering and developing novel RNA interference (RNAi)-based therapeutics, today announced that Elena Feinstein, M.D., Ph.D., Chief Scientific Officer, presented a study titled, "PF-04...

Debiopharm and MSM Protein Technologies Sign Agreement for Research and Development of Debio 0929, a Novel Oncology Biologic

... inside signal transduction pathways and, ultimately, cellular responses. A G-protein is an intracellular membrane associated protein, responsible for activating the signalling cascade. GPCRs are coupled to G-proteins. GPCRs are the largest, most versatile group of membrane receptors and also the most pharmaceu...

Israeli scientists show bacteria can plan ahead

...i , the scientists found that when the wine yeast feel the heat, they begin activating genes for dealing with the stresses of the next stage. Further analysis sho... it up with maltose. After several months, the bacteria had evolved to stop activating their maltose genes at the taste of lactose, only turning them on when malt...

New MIT radio chip mimics human ear

...that are sent to the brain. As sound waves enter the cochlea, they create mechanical waves in the cochlear membrane and the fluid of the inner ear, activating hair cells (cells that cause electrical signals to be sent to the brain). The cochlea can perceive a 100-fold range of frequencies in humans, from 10...

Oncothyreon's PX-866 is effective in preclinical model of pulmonary fibrosis

...rtant role in a number of human diseases that cause fibrosis, or scarring, of the lungs," said Dr. Hardie. "Our model in mice mimics these diseases by activating this pathway in the lungs with a growth factor called transforming growth factor alpha. PX-866 prevented both the deterioration in lung function and t...

Amira Initiates Phase I Clinical Trial of Novel DP2 Antagonist

...at inflammatory disease linked to the phospholipid pathways. Amira has a partnership with GlaxoSmithKline for the development of FLAP (5-lipoxygenase activating protein) inhibitors in respiratory and cardiovascular disease. Amira combines the rigor of a big pharmaceutical company with the ingenuity and energy ...
activating in Biological Products

Mouse Anti-PRKAR2 Monoclonal Antibody, Unconjugated, Clone RS17 from GeneTex

Description:... Mouse monoclonal [RS17 ] to PRKAR2 cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase (AMPK), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of...
Company:GeneTex

IRS Extract from GeneTex

Description:...ein fraction of cell extract that binds to anion exchange resin. This fraction is essentially ubiquitin-free and ATP-free. GTX80877 contains ubiquitin activating enzyme (E1), most ubiquitin conjugating enzymes (E2s), ubiquitin C-terminal hydrolases (UCHs) and the 20S and 26S proteasomes. GTX80877 is ideal for d...
Company:GeneTex

26S Proteasome Fraction Extract from GeneTex

Description:...roteins include those linked to cystic fibrosis, Angelmans syndrome, and Liddle syndrome. GTX80880 contains the full Hela cell compliment of ubiquitin activating enzyme (E1), ubiquitin conjugating enzymes (E2s), 20S and 26S proteasomes, isopeptidase, proteasome PA28/11S REG complex, and ubiquitin ligase enzymes...
Company:GeneTex

Ubiquitin/Proteasome Fraction II Extract from GeneTex

Description:...ein fraction of cell extract that binds to anion exchange resin. This fraction is essentially ubiquitin-free and ATP-free. GTX80878 contains ubiquitin activating enzyme (E1), most ubiquitin conjugating enzymes (E2s), ubiquitin C-terminal hydrolases (UCHs) and the 20S and 26S proteasomes. GTX80878 is ideal for d...
Company:GeneTex
activating in Biological Definition

Apoptosis

...the Fas pathways. Keep in mind, however, that both activating and inhibiting factors are present at each step of...s been shown to fire-off the pathway that leads to activating the caspases [9] . Fas ( a.k.a. Apo-1 or CD95...las), which they called Apaf-1 (apoptotic protease activating factor). The team published their results in an ar...

Cancer

...nstability increases to a point where the cell loses whole chromosomes , or has double ones. Also, the DNA methylation pattern of the cell changes, activating and deactivating genes more or less at random. Cells that divide at a high rate, such as epithelials , show a higher risk of becoming tumor cells t...
activating in Biological Dictionary

Ubiquitin

...l ubiquitin -like molecules have been discovered, ... All products relating to Ubiquitin ... Ubiquitin beginning with A - J ... E1 Ubiquitin activating Enzyme antibody. IHC-P, WB, ELISA, IP. Rabbit polyclonal ... Ubiquitin -conjugating enzymes, also known as E2 enzymes and more rarely as ... The...

Reflex arc

...ons do not pass directly into the brain, but synapse in the spinal cord. This characteristic allows reflex actions to occur relatively quickly by activating spinal... reflex arc n. Physiology. The neural path of a reflex . ... In a three neuron reflex arc list the direction and the stages o...

Polyadenylation

...minology,biology terms,biology abbreviations ... "cytoplasm ic polyadenylation element binding protein" ... Thus the role of polyadenylation in activating c-mos mRNA differs from its role ... Cytoplasmic polyadenylation is often correlated with, and can cause, ... This process is concomitant with th...

Limbic system

... the input and output ... Historically, it was the anatomic basis of the concept of the limbic system . ... THE LIMBIC SYSTEM . THE RETICULAR activating SYSTEM . ELECTRO-ENCEPHALOGRAMS (EEGs) ... The limbic system , in association with the hypothalamus, is regarded to be the ... ...

Inducer

... inducer n. One that induces, especially a substance that is capable of activating transcription from specific genes within a cell Computer Scientist &am...ne English dictionary and encyclopedia. ... inducer - an agent capable of activating specific genes ... Selfboot Inducer Files. Beats Of Rage. Macintosh He...

Cofactors

...tes. mostly structural sites Ca2+, Zn2+ exceptions Cu2 ... Organometallic cofactors . Porphyrins. Cobalamin. Metal chelation by ... Groups Without activating Cofactors Appear to Have a Slower Progression to AIDS ... The idea that parasites are possible cofactors for AIDS has been expressed by ... S...
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(Date:7/27/2014)... (PRWEB) July 27, 2014 According to ... "Endoscopy Devices Market (Endoscopes, Endoscopic Operative Devices, and Visualization ... and Forecast, 2013-2019" the global endoscopy devices market was ... expected to grow at a CAGR of 6.8% from ... USD 36.9 billion in 2019. , Endoscopy procedures are ...
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(Date:7/27/2014)... Scientists have discovered a new species of mayfly in the ... of India. In fact, this is the first time that ... been collected in peninsular India. , The new species, called ... T. Soldan for his substantial contribution to the understanding of ... authors of a study that describes the new mayfly in ...
(Date:7/27/2014)... "big data," a single computer cannot always find the ... distributed across a cluster of computers that analyze a ... mine your web history to present you with targeted ... favorite book or movie. But big data is about ... monitoring brain activity are generating unprecedented quantities of information. ...
(Date:7/25/2014)... burn scars on this false-color image from the Terra satellite ... year,s rash of wildfires in Eastern Russia. The burn ... green background. The wildfires have broken across the remote ... in this false-color image from the MODIS instrument, it ... fires that continue. Two recent image features noted below show ...
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