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Actin in Medical News

St. Jude Scientists Discover a New Mechanism Controlling Neuronal Migration

...time-lapse imaging to establish that Myosin II and actin made up the machinery of neuronal migration. Worki...ators used fluorescent dyes to label Myosin II and actin proteins, as well as key cell structures. The scie...of micromovies that revealed how the Myosin II and actin proteins and cell structures behaved during migrat...

Damon Runyon Cancer Research Foundation awards prestigious fellowships to 17 top young scientists

...nia, is studying cell motility in the context of the developing nervous system. He aims to understand how external cues are coupled to changes in the actin cytoskeleton. As cell motility is essential for normal development as well as for cancer metastasis, new insights into the basic biology of motility ...

Australian team reveals world-first discovery in a 'floppy baby' syndrome

...tic condition by replacing missing skeletal muscle actin a protein integral in allowing muscles to contract with similar actin found in the heart. "Earlier in our search to t...of children who, despite having no skeletal muscle actin in their skeletal muscle due to their genetic muta...

From mother to daughters: A central mystery in cell division solved

...hich is assembled from two protein filament types, actin and myosin, that are also used in muscle. During...e contraction, the myosin filaments move along the actin filaments and constrict the ring. Constriction "... the contractile ring is built from long, straight actin filaments, which serve as tracks on which myosin f...

Researchers gain new insight on wonder of cell division

...mitosis, where a cell divides into two identical daughter cells. The researchers have opened a new window on the assembly and activity of a ring of actin and myosin filaments that contract to pinch a cell at just the right time. They focused on key proteins whose roles drive signaling mechanisms that pr...

Jacobs-Wagner named Howard Hughes Investigator

... of proteins at particular locations and times within the life cycle of cells. Scientists in the last few years, for instance, have discovered that actin and tubulin, two proteins crucial in determining the shape of eukaryotic cells are also at work in bacteria. Jacobs-Wagner found that some bacteria a...

Penn researchers discover 'modus operandi' of heart muscle protein

...ed actin. Whats more, Lmod directs the assembly of actin to form the pumping unit of the heart. The finding...tropomodulin [Tmod] that was already known to bind actin filaments in muscle cells. We found that one part ...es that made us suspect that it could assemble the actin filaments of the heart muscle. This is exactly wha...

How red blood cells nuke their nuclei

...mammalian red blood cell nears maturity, a ring of actin filaments contracts and pinches off a segment of t...c 2 and mDia2 are involved in building the ring of actin filaments. We were very interested in that Rac ...hese proteins are known for their role in creating actin fibers in many body cells, and a necessary compone...

Scripps research scientists find new genetic mutation that halts the development of lupus

...nd gives more impetus to study these genes for autoimmunity. Because the actin cytoskeleton is essential for many crucial cellular functions and involves ...isms in specific cell types, these new findings highlight the importance of actin regulation in lupus pathogenesis. They also suggest that alteration of an a...

Researchers find new way to block destructive rush of immune cells

...y that cell skeleton contractile force is used to drive T cell migration, with MyH9 as the mechanical link. Captured images show fluorescently tagged actin (which partners with LFA-1 to grip the surface) gathering at the front end of the cell, and fluorescently tagged MyH9 gathering at the tail end in cyc...

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Actin in Biological News

Building memories with actin

Memories aren't made of actin filaments. But their assembly is crucial for long-term potentiation (LTP), an increase in synapse sensitivity that researchers think helps to lay down memories. In the July 13, 2009 issue of the Journal of Cell Biology ( www.jcb.org ), Rex et al. reveal that LTP's a...

Fate in fly sensory organ precursor cells could explain human immune disorder

...ell to a structure rich in actin. This specialized actin structure contains many membrane protrusions that ... "Normally, Delta is presented at the top of the actin structure," said Bellen. It is then encapsulated i...red for the trafficking of Delta to the top of the actin structure," said Bellen. Notch signaling is r...

Advance in understanding cellulose synthesis

...ivery of the cellulose synthase complexes to their place of action. They also looked at the role in trafficking of a structural element called the actin cytoskeleton that helps move organelles and maintains the cell's shape. They found that it appears to be required for the general distribution of the ...

Protein linked to mental retardation controls synapse maturation, plasticity, CSHL team finds

... this family are known to be key regulators of the actin cytoskeleton and affect many aspects of neuronal development," Van Aelst notes. The actin cytoskeleton is the gossamer, filament-like scaffo...o dendritic spines, where it locally regulates the actin cytoskeleton -- as it turns out, in proximity to a...

Healing wounds with lasers, vehicles that drive themselves, other cutting-edge optics

... ensemble of slender rods made out of an abundant protein called actin. The actin rods are constantly growing and shrinking inside of cells. The direction in...on of optical waves to create a field around the cells in which the growing actin rods line up like a compass in the Earth's magnetic field. These optical fi...

Mayo Clinic researchers discover and manipulate molecular interplay that moves cancer cells

..., Ph.D., has been investigating a process known as actin remodeling at the leading edge - the most forward ...g tumor cells. "The events that reorganize the actin cytoskeleton at the leading edge are complex a mu... be turned off if cancer cells are to migrate." actin filaments help make up the cytoskeleton of cells. ...

When intestinal bacteria go surfing

...: a part of the cellular supportive skeleton - the actin skeleton - is rearranged in such a manner that the...o the bacteria bring the host cells to convert the actin skeleton? Researchers at the Helmholtz Centre for ...ost cell. EspFU then triggers the signal for local actin conversion. "It has been unclear thus far how t...

A budding role for a cellular dynamo

...yeast to the human body. Part of the cytoskeleton, actin assembles into networks of filaments that give the...Brandeis researchers raise the curtain on how this actin maintains just the right filament length to keep t...Bruce Goode, set out to discover how the length of actin fibers is controlled. By answering this question, ...

Lamin A/C deficiency is 'unnerving'

... nuclear positioning by causing the mislocalization of two other proteins: Nesprin-1, which spans the outer nuclear membrane and anchors nuclei to the actin cytoskeleton, and SUN2, which spans the inner nuclear membrane, linking Nesprin to lamin A/C. Although lamin A/C is ubiquitously expressed, LMNA defec...

Dictyostelium cells shown to lay 'breadcrumb trail' as first step in multicellular formation

...ructures. Kriebel et al. now show that ACA is packaged into intracellular vesicles that cluster at the rear of cells in a process that is dependent on actin and microtubule networks. They also show that de novo protein synthesis is required to maintain the asymmetrical distribution of the ACA vesicles. ...
Actin in Biological Technology

Amgen Exercises Option for Exclusive License to Cytokinetics' Cardiac Contractility Program That Includes CK-1827452

...in cardiac contraction. Cardiac contractility is driven by the cardiac sarcomere, a highly ordered cytoskeletal structure composed of cardiac myosin, actin and a set of regulatory proteins, and is the fundamental unit of muscle contraction in the heart. The sarcomere represents one of the most thoroughly...

Researchers decode viral process that prepares cells for HIV infection

...e protein is then used to cut through the cortical actin cytoskeleton (the circular layer that lies just be...ates cofilin, which cuts and modifies the cortical actin cytoskeleton and permits the virus to cross it." ...raction with, or viral alteration of, the cortical actin cytoskeleton. "Now we have a basic understandi...

Detection and quantitation of low-abundant proteins with ECL Plex fluorescent Western blotting

... A model system, with two-fold serial dilutions of human apotransferrin and actin (not shown), was used to optimize system performance (Fig 2). Protein could...s, showed proportional increase when compared and quantitatively related to actin (Fig 4).

Conclusion...

Multiplex protein detection with the ECL Plex fluorescent Western blotting system using the Ettan DIGE Imager

...16395 Bovine cardiac muscle actin (Sigma-Aldrich) A3653 ...lutions from 5 ng to 0.6 pg. Bovine cardiac muscle actin was loaded in a two-fold dilution series from 150 ... of human apotransferrin and bovine cardiac muscle actin was loaded onto Novex 12% Tris-glycine gels in fou...

Efficient RNAi-mediated gene silencing in neuronal cells using QIAGEN siRNA and TransMessenger Transfection Reagent*

... DNA was. Cells were targeted with siRNA 58 days after plating. Double immunofluorescence labeling of MAP2 and the unrelated protein actin was performed 48 to 68 hours after transfection. The expression of MAP2 was specifically reduced in 7080% of cells, whereas the expression ...

L2

... Detection methods for transfection: The expression of EGFP driven by the insect actin promotor can be detected clearly after 24-48 hours by FACS analysis or under a fluorescence microscope. ...

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Actin in Biological Definition

Actin

Actin is a globular protein that polymerize helicaly forming actin filaments (or microfilaments ), which like the other two components of the cellular cytoskeleton form a three-dimensional network inside an eukariotic cell . Actin filaments provide mechanical support for the cell, de...

Actin

Actin is a globular protein that polymerize helicaly forming actin filaments (or microfilaments ), which like the other two components of the cellular cytoskeleton form a three-dimensional network inside an eukariotic cell . Actin filaments provide mechanical support for the cell, de...

Acrosome

...overing the ovum . Acrosome reaction When the sperm comes in contact with ZP3 in the zona pellucida, this reaction takes place, during which actin polymerizes to form the acrosomal process ; also, the acrosomal vesicle fuses with the plasma membrane of the egg cell, and digestive enzymes are ...

Acrosome

...overing the ovum . Acrosome reaction When the sperm comes in contact with ZP3 in the zona pellucida, this reaction takes place, during which actin polymerizes to form the acrosomal process ; also, the acrosomal vesicle fuses with the plasma membrane of the egg cell, and digestive enzymes are ...

Biomechanics

...cell biology have much to offer in the way of explaining the active and passive properties of living tissues. For example, the binding of myosin to actin is based on the biochemical reaction, where C a 2 + and ATP move the troponin and tropomyosin to allow for the crossbridges to bind to...

Cytoskeleton

...") 1 The eukaryotic cytoskeleton 1.1 actin Filaments 1.2 Intermediate Filaments 1.3 Mic...ontain three kinds of cytoskeletal filaments. actin Filaments Main article: microfilaments . Ar... nm. in diameter, this filament is composed of two actin chains oriented in an helicoidal shape. They are m...

Muscle

...s are myofibrils ; myofibrils contain sarcomeres , which are composed of actin and myosin . Individual muscle cells are lined with endomysium . Muscle ... types of muscle have significant differences, but all use the movement of actin against myosin to produce contraction and relaxation. In skeletal muscle...

Myosin

...n is a motor protein filament found in muscle tissue . Together with actin filaments, myosin provides the mechanism for muscle contraction , utilizi...sed of three different filament systems, the thin filaments assembled by actin proteins, the thick filament system consisting of myosin as well as th...

Protein

...cells and much of the structure of animals is also protein: microtubules, actin , intermediate filaments, collagen and keratin are components of skin, ...n, and dynein. Muscles are composed largely of the proteins myosin and actin . Working with proteins Proteins can be picky about the environment ...

Pseudopod

...ace extends a membrane process, named lamellipodium . Polymerization of actin takes place and form filaments at the leading edge, which subsequently will blend into one another to form networks. We suppose that actin polymerization is at the origine of the force propelling the cell forwards....
Actin in Biological Dictionary

Actin

Actin is a globular, roughly 42-kDa highly conserved protein found in all eukaryotic cells where it may be present at concentrations of over 100 μM. It is also one of the most highly-conserved proteins, differing by no more... Alpha-skeletal actin induces a subset of muscle genes ind...

Sarcomere

..... Sarcomere - Definition of Sarcomere at Dictionary.com a free online dictionary ... Sarcomeres are divided into bands of filaments made of actin or myosin. ... II. Events within the sarcoplasm and sarcomere . A. Release of calcium from the SR. ... The resulting shortening of the sarcome...

Rhizoid

...al cells of vascular plants. ... Root hairs are a specialized form of rhizoid . ... The rhizoid pole is marked by a cortical patch of dynamic actin that repositions ... Preferential accumulation at the presumptive rhizoid was first detectable at 4 h ... Cell-sheet and rhizoid remains occur...

Myosin

...Each myosin molecule is composed of two ... actin n. A protein found in muscle that together wit... involved in cytoplasmic streaming, which ... But actin and myosin working together allow muscle cont...ne dictionary with ... Myosin and the protein actin form the contractile units (sarcomeres) of skelet...

Muscle contraction

... Muscle fiber generates tension through the action of actin and myosin cross-bridge cycling. While under tension, the muscle may lengthen, shorten or remain the same. Though the term ' contraction '...

Muscle

...about muscle in the free online English dictionary and encyclopedia. muscle system, ... Muscle cells contain filaments made of the proteins actin ... Much of muscle contraction ... Muscle is the contractile tissue of the body and is derived from the mesodermal ... like slow muscle , i...

Microtubules

...ow structures that are distributed throughout the cytoplasm of eukaryotic cells, providing The internal framework of a cell, composed largely of actin filaments and microtubules . ... Microtubules are slender cylindrical structures that exhibit a cytoplasmic ... Microtubules act as a scaffol...

Microfilament

...i/ Microfilament " ... Microfilament actin cytoskeleton of mouse embryo fibroblasts , s...in isothiocyanate - phalloidin Microfilaments (or actin filaments microfilament n. Any of the minute... throughout the cytoplasm of cells, composed of actin and functioning primarily in maintaining the T...

Endocytosis

...e up to 80%, buy or rent. New and used books like Exocytosis and Endocytosis Methods in Molecular Biology 2nd edition by... ENDOCYTOSIS AND THE actin CYTOSKELETON. ENDOSOMES AS MOTILE SIGNALING PLATFORMS IN MAMMALS ... Endocytosis is the internalization of plasma membrane proteins ... ...

Cytoskeleton

...internal framework of a cell, composed largely of actin filaments and ... actin cytoskeleton of mouse embryo fibroblasts, st...tic ... The Cytoskeleton . Index to this page. actin Filaments. Intermediate Filaments. Microtubules .....
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(Date:4/17/2014)... PLOS Pathogens , children who live in regions of ... immune response to infection with malaria parasites that may ... and illness and partially control the growth of malaria ... develop future interventions that prevent or mitigate the disease ... 200 million cases of malaria occur worldwide, resulting in ...
(Date:4/17/2014)... (April 17, 2014) Two recent papers by ... and colleagues may help scientists develop treatments or ... fever, Japanese encephalitis and other disease-causing flaviviruses. , ... and molecular genetics at the School of Medicine ... Hughes Medical Institute, and colleagues recently published articles ...
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(Date:4/17/2014)... in the Cell Press journal Current Biology ... rather novel sex lives. The Brazilian insects, which represent ... Neotrogla , are the first example of an animal ... been identified in several different animals, Neotrogla ... is also reversed," says Kazunori Yoshizawa from Hokkaido University ...
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(Date:4/17/2014)... researchers, led by the Australian National University (ANU), ... changes and deep-sea temperature variability over the past ... better understand the climate surrounding ice ages over ... determine the relationship between carbon dioxide levels, global ... the University of Southampton (UoS) and the National ...
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