Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
Foreveryone doing or reading a paper about microarray-based experiments,reproductibility, especially inter-lab, is the #1 concern. Can I trustthese results? If I redo the same experiment in one month, will I beable to compare both? The NIH recently demonstrated that microarrays experiments performed in d...Iron Deficiency Sparks Dramatic Changes In Gene Expression
Researchers at Duke University Medical Centerhave demonstrated for the first time what happens inside a cell when itis deprived of the essential nutrient iron. Iron is found abundantly inred meats, shellfish dried fruits, whole grains, spinach, seeds andother foods.Their study in yeast cells demonstrated that iron-starved cellspreserve the little iron they possess by shutting down the major...Alcohol's effects on gene expression in the central nervous system
Alcohol's primary target is the central nervous system (CNS), where it influences neurotransmission to produce intoxication. Scientists can now use microarray technology to study brain function gene by gene. Symposium proceedings published in the February issue of Alcoholism: Clinical & Experimental Research address the effects of alcohol on what is called "gene expression" in the CNS regions...Unexpressed But Indispensable -- The DNA Sequences That Control Development
Amidst the hoopla over the exact number of genes we have in our genome—more than a fruitfly, fewer than a rice plant—a more fundamental genetic truth has often been obscured. The expression of 20,000?0,000 genes is under the control of an uncounted host of non-coding sequences, which bind transcription factors and thereby regulate when and where genes are expressed. Unlike coding sequences, whose...Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
In a first, Carnegie Mellon University scientists have "programmed" cells to make their own contrast agents, enabling unprecedented high-resolution, deep-tissue imaging of gene expression. The results, appearing in the April issue of Nature Medicine, hold considerable promise for conducting preclinical studies in the emerging field of molecular therapeutics and for monitoring the delivery of ther...ProXPRESS 2D Proteomic Imaging System, Professional Package from PerkinElmer
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Description:ProXPRESS 2D Multi-User Applications Package The ProXPRESS 2D Proteomic Imaging System is a highly sensitive imaging system for both proteomic and general life science research applications. ProXPRESS 2D provides unparalleled flexibility, enabling the use of all dyes in the UV and VIS spectrum range with its CCD-base...ProXPRESS 2D Proteomic Imaging System, Basic Package from PerkinElmer
Description:ProXPRESS 2D Proteomic Imaging System, Basic Package The ProXPRESS 2D Proteomic Imaging System is a highly sensitive in imaging system for both proteomic and general life science research applications. ProXPRESS 2D provides unparalleled flexibility, enabling the use of all dyes in the UV and VIS spectrum range with i...microRNA Expression Profiling - Comprehensive Service from LC Sciences
Description:LC Sciences provides a genome-wide microRNA (miRNA) expression profiling service using Paraflo technology and proprietary probe design, which enable highly sensitive and specific direct detection of miRNAs (1-3). We have standard arrays for mature miRNA of all species available in the latest version of the Sanger miRBase database (Release 8.2). Our service is comprehensive and includes small RNA...ImageXpress 5000A from Molecular Devices
Description:The ImageXpress 5000A automated cellular imaging and analysis system is an integrated hardware and software system designed specifically for rapid acquisition and analysis of fluorescence images for high throughput cell-based screening. ImageXpress is fast. Scanning an entire 384-well plate at full resolution (1280 x 1024 pixels), with two fluorescence images per well, takes less than 13 minut...An Epitope Tagging Vector for Gene Expression in Mammalian Cells
Stratagene The pCMV-Tag1 vector is an epitope tagging vector designed for geneexpression in mammalian cells. A target gene inserted into the pCMV-Tag1 vectorca...Antibodies for Studying NMDA Receptor Protein Expression and Synapse-Specific Immunolabeling
Danny Q. Hoang Michael Browning Xinping Yang PeterPingerelli Stratagene Cloning Systems, Inc. Stratagene introduces affinity purified antibodies for NMDA receptorsubunits that are useful for studying expression of the NR2A, NR2B and NR2Csubunit proteins...High-Level Expression of Peanut Allergens Affected by Rare Codon Usage
Biochemical & Molecular Allergology, Research Center Borstel, Germany By using Stratagenes BL21-CodonPlus(DE3)-RIL cells * withextra copies of E. coli, argU, ileY, and leuW tRNA genes,it is possible to attain high-level expression...Versatile Vectors for Ponasterone A- Inducible Control of Gene Expression in Mammalian Cells
Stratagene mammalian expressionsystem allows tightc...Innovative Tissue Array Technology for High-Throughput Screening of Gene Expression
Stratagene tissue arrayslides offer further refinement of tissue array technology through optimizedtissue fixation and processing procedures that preserve tissue morphology,antigenicity of pr...Reducing genetic expressions may help breast cancer patients
Reducing the expression of a gene called BRCC36 in cells of breast cancer makes them more responsive to radiation //therapy. The gene BRCA1 is the one that is activated by the radiation process in breast cancer, and expression of BRCC36 inhibits the former protein. Most breast cancer cells have elevated levels of BRCC36 when compared to normal breast cells. Working with the cell line M...High expression of interferon induces lupus disease
Scientists had been able to find a biomarker that will help in medical practitioners to diagnose lupus disease in their early state only for effective treatment.// Lupus is a condition that happens when the body’s tissues are affected by the body’s own immune system. Patients affected with lupus may produce abnormal antibodies in their blood that may attack the body’s own tissues than...Controlled Gene Expressions Can Cure Many Diseases
Researchers had found a new technique to control genetic expressions by silencing some expressions of the gene.// This technique is all set to cure many diseases and health conditions. Researchers at UT Southwestern Medical Center had developed this new approach that could theoretically produce a drug for the treatment or cure of almost any disease In two papers appearing in...Genetic Expressions Can Influence The Process Of Aging
Researchers of Cold Spring Harbor laboratory have discovered that the loss of a gene called p63 accelerates the process of aging. Similar versions of the gene are present in many organisms, including humans // . Drawing parallels from mice, the researchers had concluded that the p63 gene is likely to play a fundamental biological role in aging-related processes. To study how the p63 g...Generic Drugs Usage In US Can Save $20 Billion – Express Script Surve
Though there is lot of controversies over the usage of Generic drugs in India and other countries.// Now US based company Express Script has done a survey to find out that usage of generic drugs in US could have saved $20 billion in 2004 which would be more in the future. Though it is well known that US policies are also governed by big companies which include pharmaceutical industries, w...PromegaExpress Expands Easy Access to Products with New Cabinet
MADISON, Wis.--(BUSINESS WIRE)--Jun 21, 2007 - ThePromegaExpress(TM) on-site stocking program just added a newlysized ambient cabinet to its line of on-site appliances. Thislatest addition serves as great option to meet individual labinventory requirements for smaller areas when space is at a premiumbut immediate access to life science tools is a necessity. Themid-sized cabinet can also be...