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Xeroderma in Medical News

Enhanced skin cancer risk linked to defects in cellular aging controls

...isk and pigmentation. Researchers from Spain investigated the molecular mechanisms underlying skin cell telomere dysfunction using a mouse model of xeroderma Pigmentosum (XP), a disease in which patients have increased sensitivity to ultraviolet (UV) radiation. Their studies revealed that these mice have im...

New year brings new hope to children born with cleft lip, palate

...09. Non-profit organizations that have received grants for first quarter missions include: Children of the Americas, Healing the Children Northeast, xeroderma Pigmentosa Foundation, and Nicaplast. ASPS Member Surgeons participating in these medical missions will do so in coordination with one of the ab...

New Year Brings New Hope to Children Born With Cleft Lip, Palate

...09. Non-profit organizations that have received grants for first quarter missions include: Children of the Americas, Healing the Children Northeast, xeroderma Pigmentosa Foundation, and Nicaplast. ASPS Member Surgeons participating in these medical missions will do so in coordination with one of the ...

How defects in 1 gene cause 3 distinct and devastating human diseases

...sometimes at neighboring sitescan spell the difference between cancer-prone xeroderma pigmentosa, the aging disorder known as Cockayne syndrome and another aging...art site or the site of DNA damage. Defects in XPD are known to underlie xeroderma pigmentosa (XP), Cockayne syndrome (CS) and trichothiodystrophy (TTD). Alth...

Skin Cancer Risk Increases With Ultraviolet-B Radiation Exposure

...adiation is the commonest cause of skin cancer and is responsible for breaking DNA strands in exposed skin cells. Patients who have a condition called xeroderma pigmentosum are unable to repair these broken strands and hence are at increased risk of developing skin cancer. Li-E Wang, M.D., and Qingyi Wei, M.D....
Xeroderma in Medical Technology

Dimericine(R) Receives FDA Fast Track Designation for Treatment Of Photosensitivity in XP Patients

...5) for treatment of solar and ultraviolet photosensitivity in patients with xeroderma Pigmentosum (XP). Dimericine, also known as T4N5 Liposome Lotion, is a topi... the thousands of people who suffer from the life-threatening disease XP." xeroderma pigmentosum, or XP, is a rare genetic disorder that blocks the body's natur...
Xeroderma in Medical Dictionary

Xeroderma Pigmentosum

... xeroderma pigmentosa, or XP, is an autosomal recessive g...This disorder leads to multiple basal cell... xeroderma pigmentosa, or XP, is an autosomal recessive g...her skin malignancies at a young age. In... xeroderma pigmentosum . Authoritative facts about the ski...
Xeroderma in Biological News

Researchers probe a DNA repair enzyme

...d repair such damage. Mutations in the human members of this helicase family impede DNA repair and may contribute to breast cancer, Fanconi Anemia and xeroderma pigmentosum. The researchers studied the archaeal version of Rad3. Archaea are microbes whose DNA repair systems are closely related to those of ...

Buildup of damaged DNA in cells drives aging

...fects in one DNA repair mechanism, nucleotide excision repair (NER), causes xeroderma pigmentosum, a rare disease in which people have a 2,000-fold increased ris...tient had a mutation in XPF, because mutations in this gene typically cause xeroderma pigmentosum, which is a disease characterized primarily by skin and other c...

Heal thyself: Systems biology model reveals how cells avoid becoming cancerous

...eventually be used to develop drugs to boost DNA repair in response to environmental toxins and possibly treat inherited degenerative diseases such as xeroderma pigmentosum, a disease in which the body's ability to repair DNA damage caused by ultraviolet light is disabled, ataxia telangiectasia, a progressive,...

Enzyme crystal structure reveals 'unexpected' genome repair functions

...on and nucleotide excision repair (NER), as well as other cell processes. "XPB was initially identified as the gene responsible for NER defects in xeroderma pigmentosum patients, who are hypersensitive to light and have a dramatically increased risk of skin cancer," says John A. Tainer, a professor at Scri...

Discovering the first steps in transcription-coupled repair

...erties of cells from patients with Cockayne Syndrome (CS) versus those with xeroderma pigmentosum (XP), two different hereditary diseases with a common feature: ...lly significant because XPB and XPD, the other two proteins associated with xeroderma pigmentosum that can cause Cockayne Syndrome when defective (in addition to...
Xeroderma in Biological Technology

AGI Dermatics President to be Keynote Speaker at the 11th Annual Sunscreen Symposium

... & Drug Administration recently granted Fast Track designation for Dimericine for treatment of solar and ultraviolet photosensitivity in patients with xeroderma Pigmentosum (XP), a rare genetic disorder that blocks the body's natural ability to repair DNA damage caused by ultraviolet light. AGI Dermatics is a...
Xeroderma in Biological Dictionary

Xeroderma pigmentosum

... xeroderma pigmentosa, or XP, is an autosomal recessive ge... This disorder leads to multiple basal cell... xeroderma pigmentosa, or XP, is an autosomal recessive ge...s disorder leads to multiple basaliomas and... xeroderma pigmentosum is a rare ... ...
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