Xenopus

Skin color studies on tadpoles lead to cancer advance

... identified a compound which, when introduced into xenopus Laevis tadpoles, blocks the movement of the pigmen...gs to fight skin cancer in humans." The species xenopus Laevis (South African clawed frog) is more closely... mechanisms are involved in causing cancer in both xenopus tadpoles and humans. Until the 1960s,...

Neuroscientists show insulin receptor signaling regulates structure of brain circuits

...xperiments performed in the laboratory of CSHL Professor Hollis Cline, Ph.D., and reported this week in the journal Neuron . These experiments, in xenopus tadpoles, show that insulin receptor signaling in neurons regulates the maintenance of synapses, contributes to the processing of sensory information ...

New Studies On Zebrafish Could Aid in Treating Birth Defects

...d graduate student Bryce A. Mendelsohn from Washington University in St. Louis. For many years, scientists have relied on the mouse and the frog xenopus laevis as research models for vertebrates (animals with backbones), but zebrafish have an important advantage for studying early development: It is po...

Xenopus in Biological News

Carnegie donates landmark clones to biology

...re activity by using mutant proteins that cannot shut the pores off with their C-terminus to see how they work in yeast and immature eggs of the frog xenopus in the presence of ammonium. The researchers were totally surprised that the mechanism in which three subunits regulate each other was found in t...

Carnegie's Donald Brown receives lifetime achievement award from Society for Developmental Biology

...olleagues developed a strategy to analyze the complexities of the hormone-gene interactions. He used thyroid hormone-induced metamorphosis in the frog xenopus laevis to identify genes and gene pathways regulated by the hormone. This work provides the foundation for understanding how hormones control the deve...

New regulatory mechanism discovered for cell identify and behavior in forming organs

...produce insulin?" The study involved embryos of xenopus frogs, a species indigenous to Africa often used i...mple roundworms to humans. Previous research in xenopus has established that a low level of activity from ...ed the Sfrp5 protein, the resulting Sfrp5-depleted xenopus embryos had smaller foregut cavities filled with u...

Forsyth scientists trigger cancer-like response from embryonic stem cells

...man genetic diseases such as Romano-Ward and Jervell-Lange-Nielsen syndromes. The team interrupted the flow of potassium through KCNQ1 in parts of the xenopus frog embryo. This resulted in a striking alteration of the behavior of one type of embryonic stem cell: the pigment cell lineage of the neural crest. ...

NIH EUREKA award funds research at WPI aimed at turning adult skin cells into stem-like cells

...cting a comprehensive study of the contents of the xenopus extract, systematically searching for specific com... is to identify and characterize components of the xenopus extract that can induce pluripotency in adult cell...have shown that cells induced to pluripotency with xenopus extract have a much longer life span than we expec...

Biophysical Society announces 2008 International Travel Awards

...nfiguration and Hydration of Curved and Ripples States of Lipid Interphases. Silvina B. Gayol, Centro de Neurociencia de Valparaiso, Chile, In xenopus Oocytes Glycosylation of Shaker K+ Channels Alters its Expression in the Plasma Membrane and Activation Kinetics. Iffath A. Ghouri, University ...

New insight into the mechanisms of voltage sensing and transduction in biological processes

...phatase activity, and whether depolarisation or hyperpolarisation induced the phosphatase activity. By expressing phosphoinositide-specific sensors in xenopus oocytes and applying both electrophysiology and imaging of phosphoinositides, it was shown that enzyme activity is activated upon depolarisation (not ...

ATR checkpoint-activating DNA structure

...tructure in an experimental system will enable us to control, quantitative and probe checkpoint signaling responses in unprecedented ways." Using xenopus egg extracts as a cell-free system, the researchers found that single-stranded DNA annealed with primers specifically triggers the ATR-mediated checkp...

Leptin found to control appetite and limb development in frogs

...e whether the tadpole has adequate energy reserves---in the form of body fat - to start metamorphosis at an appropriate time. Finding leptin in the xenopus genome was no small feat. The sequence for the "obese" gene that makes leptin is quite different between frogs and humans, so Denver's lab had some pu...

Forsyth scientists gain greater understanding of how embryos differentiate left from right

...sical event that is crucial for correct asymmetry: the flow of hydrogen ion or H+ flux. A pharmacological screen implicated the H+-pump H+-V-ATPase in xenopus (frog) embryo asymmetry, where it directs left- and right-sided gene expression. The cell cytoskeleton is responsible for the LR-asymmetric localizati...

Xenopus in Biological Technology

Beyond associations: Colorectal cancer culprit found

...h colorectal cancer, and found that it resides in a DNA sequence that is conserved in many other species so well conserved that they were able to use xenopus frogs as a model organism to test the biological consequences of this SNP. The group found that the SNP causes the expression of a nearby gene, calle...

Quantitation of DNA for Automated Sequencing Using the VersaFluor Fluorometer

... was isolated by a homology screen of a xenopus muscle genomic library using a 32 P-dCTP ...A λZap (Stratagene) cDNA clone for xenopus xHif was also isolated using a homology screen ... to sequence the entire 2.2 Kb cDNA for xenopus hypoxia inducible factor, xHIF, in several runs, a...

Xenopus in Biological Products

Mouse Anti-Xenopus laevis Xenopus nuclear factor, xnf7 Antibody, Unconjugated from Developmental Studies Hybridoma Bank

Description: 37-1A9...
Company:Developmental Studies Hybridoma Bank

Mouse Anti-Xenopus laevis Xenopus nuclear factor Antibody, Unconjugated from Developmental Studies Hybridoma Bank

Description: b6-2A12...
Company:Developmental Studies Hybridoma Bank

Rabbit Anti-Human ASIP / PAR3 Monoclonal Antibody,, Clone ZMD.283 from Invitrogen

Description:...nteracting protein/ partitioning defective 3). This antigen is not related to the protease-activated-receptors also called PAR. Reactivity: Human Dog xenopus (positive controls: Caco-2 MDCK A6 cell lysates). Applications: Western blotting Immunoprecipitation...
Company:Invitrogen

Nanoject II, 220 VOLT from Drummond Scientific Company

Description:... our 10uL positive displacement microdispenser was being modified to inject xenopus oocytes. We modified this unit by redesigning the microdispenser to elimina...he precise delivery of sample. Although previous models are excellent for xenopus injections, the smaller tips and smaller injection volume may allow the use...
Company:Drummond Scientific Company

Mouse Anti-Nop1p / Fibrillarin Monoclonal Antibody, Unconjugated, Clone A00104.01 from GenScript Corporation

Description:...n gene is located on chromosome 19 (19q13.1). Fibrillarin proteins have been cloned and sequenced from several other species (Mouse, accession P35550, xenopus accession P22232, C. elegans accession Q22053, and S. pombe accession P35551). The N terminal 80 amino acids contain multiple copies based on the pept...
Company:GenScript Corporation

Xenopus in Biological Definition

Developmental biology

...s in developmental biology include the following: Chordates Lancelet Branchiostoma lanceolatum Zebrafish Danio rerio Frogs xenopus laevis Chicken Gallus gallus Mouse Mus musculus ( Mammalian embryogenesis ) Invertebrates Sea urchin Round worm Caenor...

Genome project

...S virus Arbacia punctulata the purple-spined sea urchin Caenorhabditis elegans a nematode worm Brachydanio rerio Zebrafish xenopus laevis The African clawed toad Oryzias latipes A medakafish Takifugu rubipres A pufferfish See also model organism Int...

Xenopus in Biological Dictionary

Xenopus

Xenopus is a genus of highly aquatic frogs native to Sub-Saharan Africa. There are 18 species in the Xenopus genus. They are known collectively as African Clawed Frogs or Platanna. The best-known species belonging to this... The African clawed frog is a species of South African aquat...

Wild-type

...n genetics, the wild - type organisms serve as the original ... ... laevis laevis - Imported wild type (pigmented) Our Imported wild type xenopus laevis are very ... Lab bred frogs never are exposed to the same rigid standards ... wild type - The most frequent allele or genotype found...

Wildtype

...d type (genetics), ...code. ... Aspects of the topic wild-type are discussed in the following places at Britannica. ... Our Imported wild type xenopus laevis are very hardy animals. Lab bred frogs never are exposed to the same rigid standards and tests as in nature. ... ...

Wild type

...tp://www.pdunited.co.uk /pokescreens/screenshots1 .html. Take ... ... laevis laevis - Imported wild type (pigmented) Our Imported wild type xenopus laevis are very ... complete metamorphosis, all types of fierce weather conditions ... Definition of wild type from the Merriam-Webster Onlin...

SnRNA

... receptor ... In this way these five proteins and a U snRNA assemble into the export complex. ... Arrows indicate the nucleotide changes in xenopus U2 snRNA . ... Lanes 2 and 5 are U2-depleted oocytes supplemented with synthetic U2 snRNA . ... Cell death and differentiation is a monthly r...

Pseudogene

... A pseudogene structure in 5S DNA of xenopus laevis" ... The putatively functional Mkrn1-p1 pseudogene is neith... gene but cannot be transcribed. ... A pseudogene structure in 5S DNA of xenopus laevis" ... The discovery of a functional nitric oxide synthase (NOS) p...

Polyadenylation

...efine gene boundaries, predict number of ... its one-base variant) is a highly conserved polyadenylation signal and is ... Polyadenylation in xenopus Development. cis elements. trans factors. ... POLYADENYLATION IN THE CENTRAL NERVOUS SYSTEM. POLYADENYLATION AND THE MECHANISMS OF ... Cleava...

Origin of replication

...form a " ... group of enzymes at the replication fork moves away from the origin , unwinding ... By contrast, the replication origins of xenopus and Drosophila early cleavage ... The somatic cells of metazoans organize their replication origins in yet another ... Some ARS sequences...

Oogenesis

...at HighBeam.com. Free Trial, Credit Card Required. ... appearance of the xenopus oocyte as it progresses through oogenesis . A morph sequence of successive stages during xenopus oogenesis . Size of Movie: 908 K ... Britannica online encyclopedia art...

Neurula

...ein-coding gene nfrl-A. Represented by 10 ESTs from 5 cDNA libraries. ... xenopus laevis neurula -specific ferredoxin reductase-like ... Neurula ,biolog...la II. 19. Late neurula III. 20. Late neurula IV. Early Tailbud ... xenopus neurula left-right asymmetry is respeficied by microinjecting TGF-beta5...