XIAP

Critical link in cell death pathway revealed

... The role of a protein called xiap in the regulation of cell death has been identifie...lecular Genetics of Cancer division has found that xiap (X-chromosome-linked inhibitor of apoptosis protei...ll Research in Germany, has found that the protein xiap is the discriminating factor between type I and ty...

Gene Defects Determine Susceptibility to Cancer and Bone Marrow Failure

... be a key explanation for the increased tumor susceptibility seen in patients with dyskeratosis congenita. ‘Two other proteins found in the study, xiap and Bcl-xL, are involved in regulating the normal dying off of cells, a process called programmed cell death or apoptosis. These particular proteins h...

XIAP in Medical Technology

Ascenta Therapeutics Highlights Multiple Data Presentations at Upcoming AACR Annual Meeting

...scientists at Human Genome Sciences, Inc., studies of HGSI's TRAIL receptor agonist monoclonal antibodies in combination with Ascenta's small molecule xiap inhibitors, will be presented in a poster session on Tuesday, April 17 (1pm-5pm). The full schedule of presentations featuring Ascenta's technology is...

VioQuest Pharmaceuticals Announces Data Presentation for Its Akt Inhibitor VQD-002, at American Association for Cancer Research Annual Meeting

...l prostate epithelial cells. In PC3 cells, roscovitine reduced abundance of xiap but not Mcl-1, whereas API-2 induced Bim. The effect of roscovitine was mim...depletion of Cdk9, but not Cdk7 by RNA interference. Moreover, depletion of xiap or Cdk9 by RNA interference was sufficient to sensitize PC3 and PC-3M cells...

XIAP in Biological News

Burnham researchers present at 100th AACR Meeting

...t Nanoparticle-induced Vascular Blockade in Prostate Cancer. Jason Garrison, Ph.D., who will discuss ARTS and Siah Collaborate in a Novel Pathway for xiap Degradation Shi Ranxin, Ph.D., who will present two papers: Cyclosporin A Sensitizes Cancer Cells to Death Receptor-Mediated Apoptosis and Chemical B...

XIAP in Biological Technology

Ascenta Therapeutics Announces Results of Preclinical Evaluation of AT-406 in Multiple Cancer Models

...tiate breakdown of the cancer cell. AT-406 is thought to mimic the activity of Smac (second mitochondria-derived activator of caspases) by binding to xiap and preventing it from inhibiting caspase activation. Upon binding, AT-406 induces rapid degradation of cIAP-1/2 proteins and promotes apoptosis thro...

Aegera Therapeutics Initiates A Randomized Phase 2 Combination Study of AEG35156 for 1st Line Treatment of Non-Small Cell Lung Cancer

...apy, without harming healthy cells. Aegera's published data with AEG35156, both in vitro and in vivo, strongly supports this hypothesis, and validates xiap as a novel drug target for the development of anti-cancer therapeutics. About Aegera Therapeutics Inc. Aegera Therapeutics is a clinical sta...

Aegera Therapeutics' phase 1/2 clinical trial results selected for oral presentation at 2008 ASH Annual Meeting

...that data from its phase 1/2 clinical trial of the xiap antisense oligonucleotide, AEG35156, will be highl... presentation is entitled "Phase I/II Trial of the xiap Antisense Oligonucleotide (AEG35156) in Combinatio...e "Pharmacodynamic Study of Phase 1/2 Trial of the xiap Antisense Oligonucleotide (AEG35156) in Combinatio...

XIAP in Biological Products

Smac/DIABLO, Human, Recombinant, E. coli from Calbiochem

Description:...d promotes caspase activation through the neutralization of IAPs, including xiap (Cat. No. PF137). Biological activity: IC 50 ~500-1500 nM to reverse the inhibition of xiap (500 nM) on Z-DEVD-AFC (Cat. No. 264150) cleavage in activated cell extract...
Company:Calbiochem