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Wnt in Medical News

Fate Therapeutics to Present Data on Stimulation of Osteogenic Activity Using Small Molecule Modulators of Wnt Pathway

LA JOLLA, Calif., and BARCELONA, July 8 /PRNewswire/ -- Fate Therapeutics, Inc. announced today the presentation of data from its research on small molecule modulators of the Wnt pathway for osteo-regeneration at the 7th Annual Meeting of the International Society for Stem Cell Research (ISSCR...

Nuvelo Announces Publication of Preclinical Data From Wnt Therapeutics Program

SAN CARLOS, Calif., June 5 /PRNewswire-FirstCall/ -- Nuvelo, Inc. (Nasdaq: NUVO ) today announced the publication of preclinical data from the company's Wnt Therapeutics program showing that the R-spondin family of proteins activate the Wnt pathway, a signaling pathway that is critical for ce...

Arthritis and the Wnt Factor

An article by Nakamura et al., "Expression profiles and functional analyses of Wnt-related genes// in human joint disorders," will appear in the July issue of The American Journal of Pathology. The article revolves around the protein, Wnt. Wnt is a proto-oncogene since its disruption can lead to c...

Cell Pathway May Be Key to Lung Cancer's Spread

...tiated by mutations in other genes, so we were surprised that a hyperactive wnt pathway would be responsible for metastasis in lung cancer," said the study...r therapies. "Our findings suggest that using treatments that target the wnt pathway may help prevent lung cancer from repeatedly seeding itself through...

Mapping gene expression with Gene Expression Atlas

...l blood? Both questions can also be combined to focus on particular genes and their role in a specific disease, such as identifying members of the wnt signalling pathway that are expressed in cancer. The Atlas collates data from over 1000 different independent studies, mainly microarray experiment...

JCI table of contents: March 23, 2009

...that block the action of proteins that inhibit the wnt signaling pathway. However, dysregulated wnt signaling is associated with several cancers. Furt...now shown that the gene responsible for making the wnt signaling pathway inhibitor WIF1 is silenced in hu...

Study finds biological clue in brain tumor development

...ukaemia Group (CCLG), have studied the role of the wnt biological pathway in central nervous system primi...ment. The research also highlighted a link between wnt pathway activation and patient survival patients ...way activation. The reason for the link between wnt pathway activation and better patient prognosis is...

New research sheds light on how stem cells turn into blood cells

...earch Institute. This is the first time researchers have been able to show the importance of one particular cell pathway known as the noncanonical wnt pathway in prompting stem cells to specialize and become blood cells. The pathway appears to organize the stem cells so that they can respond to sign...

Targeting the protein AEG1 impairs human liver cancer growth in mice

...orm a tumor in mice limited further growth. Further analysis revealed that the effects of AEG1 were mediated, in part, via its ability to activate the wnt signaling pathway. ...

JCI online early table of contents: Feb. 16, 2009

...orm a tumor in mice limited further growth. Further analysis revealed that the effects of AEG1 were mediated, in part, via its ability to activate the wnt signaling pathway. TITLE: Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression AUTHOR CONTACT: Devanand Sar...
Wnt in Medical Technology

Curis Announces Hedgehog and Wnt Antagonist Data Presentation at AACR

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Apr 17, 2007 - Curis, Inc. (NASDAQ:CRIS), a drug development company focused on novel targeted medicines primarily for cancer treatment, today announced that its data was included in two presentations at the 98th Annual Meeting of the American Association for Canc...

Nuvelo Announces Positive Phase 1b Proof-of-Concept Data With Anticoagulant NU172

...nduced mucositis and inflammatory bowel disease. In addition, Nuvelo is pursuing research programs in leukemia and lymphoma therapeutic antibodies and wnt signaling pathway therapeutics to further expand its pipeline and create additional partnering and licensing opportunities. Information about Nuvelo...

Nuvelo Initiates Phase 1B Clinical Trial of Anticoagulant NU172

...nduced mucositis and inflammatory bowel disease. In addition, Nuvelo is pursuing research programs in leukemia and lymphoma therapeutic antibodies and wnt signaling pathway therapeutics to further expand its pipeline and create additional partnering and licensing opportunities. Information about Nuvelo...

Nuvelo Announces Positive Proof-of-Concept Data With Anticogulant NU172

...nduced mucositis and inflammatory bowel disease. In addition, Nuvelo is pursuing research programs in leukemia and lymphoma therapeutic antibodies and wnt signaling pathway therapeutics to further expand its pipeline and create additional partnering and licensing opportunities. Information about Nuvelo...

Nuvelo Announces Preclinical Data for NU206 Demonstrating Potent Therapeutic Activity in Oral Mucositis Models

...lls and accelerated cell repair by stimulating the wnt pathway, a signaling pathway that is critical for ...ogic agents that can be used to enhance endogenous wnt signaling in vivo, and provide therapeutic potenti... repair. Rspo proteins are novel regulators of the wnt pathway and were first identified by Nuvelo as pot...

Nuvelo Announces Phase 2 SONOMA-3 Trial Did Not Meet Target Product Profile and Discontinues Alfimeprase Development

...half of this year. We also continue to generate exciting discoveries in our wnt therapeutics and cancer antibody programs, which we expect will become incr...e its research programs in leukemia and lymphoma therapeutic antibodies and wnt signaling pathway therapeutics to further expand its pipeline and create ad...

Nuvelo Initiates Phase 1 Clinical Trial of Thrombin Inhibitor, NU172

...tor in Phase 1 development for use as a potential short-acting anticoagulant during medical or surgical procedures; and preclinical candidate NU206, a wnt pathway modulator for the potential treatment of chemotherapy/radiation therapy-induced mucositis and inflammatory bowel disease . In addition, Nuvelo...

Nuvelo Begins Phase 2 Trial and Receives Fast Track Status for Alfimeprase in Patients With Acute Ischemic Stroke

...icoagulant during medical or surgical procedures. In addition, Nuvelo expects to continue its research programs in leukemia therapeutic antibodies and wnt signaling pathway therapeutics to further expand its pipeline and create additional partnering and licensing opportunities. Information about Nuvelo...

Nuvelo Announces Alfimeprase SONOMA-2 Catheter Occlusion Data Presentation Webcast and Conference Call

...icoagulant during medical or surgical procedures. In addition, Nuvelo expects to continue its research programs in leukemia therapeutic antibodies and wnt signaling pathway therapeutics to further expand its pipeline and create additional partnering and licensing opportunities. Information about Nuvelo i...

Southern Research Institute to Present at the 2007 American Association For Cancer Research Annual Meeting

...g poster (#4385) "Opposing Roles of Dkk1 in LRP6 Stabilization and wnt Signaling: Implication for wnt Ligand- induced LRP6 Down-regulation" from 1:00 p.m. - 5:00 p.m. ...
Wnt in Biological News

Prostate cancer uses Wnt signaling proteins to promote growth of bone tumors

Prostate cancer is a cruel disease. Left untreated, prostate cancer cells often metastasize, or spread, to bone where they form fracture-prone tumors that are extremely painful. More than 80 percent of men who die from prostate cancer die with metastatic disease in their bones. But scientists kn...

Arthritis: What Wnt wrong?

The cellular signaling protein Wnt, which is involved in embryonic development and cancer, contributes to disease progression of both rheumatoid arthritis and osteoarthritis. The article by Nakamura et al., "Expression profiles and functional analyses of Wnt-related genes in human joint disorders,"...

MS study offers theory for why repair of brain's wiring fails

...ed in a cascade of biochemical events known as the wnt (pronounced "wint") pathway, whose importance has ... tissues, including the brain. Until now, however, wnt had not been linked to myelin production or repair. "This is the first evidence implicating the wnt pathway in multiple sclerosis," says lead author S...

UT Southwestern researchers disrupt biochemical system involved in cancer, degenerative disease

...hin cells controlled by a class of proteins called wnt (pronounced "wint"). wnt proteins help control embryonic development in man...dy tissues. Misregulation of cellular responses to wnt proteins, however, is associated with a broad rang...

New regulatory mechanism discovered for cell identify and behavior in forming organs

...known antagonist of Wnt. Without this restriction, wnt signaling runs amok and the frog's foregut, liver ...f disorganized cell growth. "We point out that wnt has two key roles here one controlling the cell e...llege of Medicine. "Without Sfrp5 controlling what wnt does in both pathways, things go horribly wrong in...

Building the blood-brain barrier

...constructing the BBB. In brain endothelial cells, wnt signaling was active during the time of maximum va..., but not after the BBB matured. Activation of the wnt signaling pathway in vivo and in vitro promoted BB...and inactivation prevented it. In vitro increasing wnt signaling also strengthened junctions between non-...

Why binge drinking is bad for your bones

...the amounts of RNA disrupted two molecular pathways responsible for normal bone metabolism and maintenance of bone mass. These pathways are called the wnt signaling pathway and the Intergrin signaling pathway. "We found that the expressions of certain genes important for maintaining bone integrity are...

Identification of protein able to stimulate production of T-cells

...archers also showed that Wnt4 does not mediate these changes in gene expression through the intracellular pathway normally activated by members of the wnt family, i.e. stabilization of a signalling protein called -catenin, but rather through an alternative pathway involving members of the JNK fam...

Science expands Science Signaling, featuring research related to medical advances, and more

...1676-1679 (2008). Colorectal Carcinoma The wnt signal transduction pathway is a critical player i...r suppressor known as APC, a negative regulator of wnt signaling, results in colorectal carcinoma. Although APC is a well known inhibitor of wnt signaling, now it appears that in fruit flies APC ...

Stem cells and cancer: cancer pathways that also control the adult stem cell population

...oing this, they have found that a mechanism called wnt signalling drives this process and is necessary to...part of the intestine. Under normal circumstances wnt signalling is turned down once the stem cells have...ur work shows that Apc has a role in switching off wnt signalling, controlling the adult stem cell popula...
Wnt in Biological Technology

Histogen Hair Regrowth Clinical Trial Presented at ISHRS Annual Meeting

... first naturally stabilized, bioactive solution of wnt proteins and their cofactors, which have been impl...ty and efficacy of our HSC product, which contains wnt proteins and other growth factors important to hai... demonstration that compounds containing bioactive wnt increase hair growth in humans." While a...

Histogen to Present Preliminary Hair Regrowth Clinical Results at Stem Cell Summit

...d then harvesting the naturally secreted embryonic wnt proteins, growth factors, and other synergistic bi... naturally stabilized and bioactive formulation of wnt proteins and natural cofactors, which are thought ...ow these effects in a clinical setting using human wnt proteins." Histogen began this outside-U....

ARCA biopharma to Present at 27th Annual JPMorgan Healthcare Conference

...rt-acting anticoagulant during medical or surgical procedures; and NU206, a wnt pathway modulator in Phase 1 development for the potential treatment of che...suing research programs in leukemia and lymphoma therapeutic antibodies and wnt signaling pathway therapeutics to further expand its pipeline and create ad...

Nuvelo Shareholders Approve Issuance of Common Stock Pursuant to Merger Agreement With ARCA biopharma

...rt-acting anticoagulant during medical or surgical procedures; and NU206, a wnt pathway modulator in Phase 1 development for the potential treatment of che...suing research programs in leukemia and lymphoma therapeutic antibodies and wnt signaling pathway therapeutics to further expand its pipeline and create ad...

Nuvelo Announces Positive Results from Phase 1 Clinical Trial of NU206 in Healthy Volunteers

...creted protein that acts as a key regulator of the wnt pathway, the critical pathway that stimulates cell...uring medical or surgical procedures; and NU206, a wnt pathway modulator in Phase 1 development for the p...n leukemia and lymphoma therapeutic antibodies and wnt signaling pathway therapeutics to further expand i...

Nuvelo and ARCA biopharma Advance Toward Completion of Merger

...rt-acting anticoagulant during medical or surgical procedures; and NU206, a wnt pathway modulator in Phase 1 development for the potential treatment of che...suing research programs in leukemia and lymphoma therapeutic antibodies and wnt signaling pathway therapeutics to further expand its pipeline and create ad...

Histogen Announces Start of Hair Regrowth Clinical Evaluation

...th. ReGenica is the first naturally stabilized and bioactive formulation of wnt proteins and natural cofactors, which are thought to act in the formation o...produced. It is the first naturally stabilized and bioactive formulation of wnt proteins and natural cofactors, which are thought to act in the formation o...

ARCA biopharma to Present at JMP Securities Healthcare Focus Conference

...nduced mucositis and inflammatory bowel disease. In addition, Nuvelo is pursuing research programs in leukemia and lymphoma therapeutic antibodies and wnt signaling pathway therapeutics to further expand its pipeline and create additional partnering and licensing opportunities. Information about Nuvelo...

Nuvelo and ARCA biopharma Announce Merger Agreement Creating Late-Stage Cardiovascular Biotechnology Company

...nduced mucositis and inflammatory bowel disease. In addition, Nuvelo is pursuing research programs in leukemia and lymphoma therapeutic antibodies and wnt signaling pathway therapeutics to further expand its pipeline and create additional partnering and licensing opportunities. Information about Nuvelo...

Nuvelo Initiates Phase 1 Clinical Trial of NU206 in Healthy Volunteers

...otein, NU206, the company's lead compound from its wnt Therapeutics Program. This double-blind, placebo-c...creted protein that acts as a key regulator of the wnt pathway, the critical pathway that stimulates cell...uring medical or surgical procedures; and NU206, a wnt pathway modulator in Phase 1 development for the p...
Wnt in Biological Dictionary

Tracheae

..."Quote of the Day" to Your Site or Blog Now! ... of Trachea . Related Definitions: Of, Trachea . Quotes. Copyright 2009 BrainyMedia.com ... Seven wnt homologues in Drosophila: A case study of the developing tracheae ... This experiment suggests that the tracheae are not particularly sensitive to...

Myotome

...clopedia Articles Quickly. ... myotome my·o ... The two myotome regions specified by different factors. • The epaxial myotome is specified by wnt proteins from the dorsal neural tube ... The myotome in zebrafish retains a permanent record of original somite ... Although the contour ...
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