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Warfarin in Medical News

Right warfarin dose determined by 3 genes

Researchers at Uppsala University, together with colleagues at the Karolinska Institute and the Sanger Institute, have now found all the genes the determine the dosage of the blood-thinning drug warfarin. The findings are published in the scientific journal PLoS Genetics . "We have previously ...

Genetics Should Decide Warfarin Dose, Study Reiterates

What works for some people might be dangerous for others,, FRIDAY, March 20 (HealthDay News) -- Researchers have confirmed previously reported genetic factors that may help doctors more accurately prescribe the proper dosage of the blood thinner warfarin to people at high risk of cardi...

Genetics May Help Fine-Tune Warfarin Dosage

Formula that includes DNA data proves faster, more accurate in early tests WEDNESDAY, Feb. 18 (HealthDay News) -- A DNA test could make prescribing the widely used anticoagulant warfarin safer by predicting the lowest effective dose, a new study finds. The U.S. Food and Drug Adminis...

Study Weighs Cost, Benefit of Gene Tests Before Warfarin Rx

The screens resulted in better patient outcomes but at high price, researchers say TUESDAY, Jan. 20 (HealthDay News) -- Genetic testing isn't cost-effective in guiding initial dosing of the blood thinner warfarin in patients with atrial fibrillation (a type of abnormal heart rhythm), a...

Optimal Warfarin Dosing Improves Anticoagulation Control

Increasing time within the therapeutic range of utmost importance, study finds TUESDAY, Dec. 30 (HealthDay News) -- While the anticoagulant warfarin can be highly effective in preventing strokes and treating venous thromboembolism, doctors have long struggled with finding the best way ...

Study shows optimal dose management of warfarin improves anticoagulation control

Boston, MA Researchers from Boston University School of Medicine (BUSM) have determined the optimal dose-management strategy to derive maximal benefit from warfarin therapy and improve patient outcomes. Results of the study appear online in the December 2008 issue of the Journal of Thrombosis and...

DNA Direct and Iverson Genetics Announce Partnership to Provide Personalized Patient Reports for Warfarin Dosing Test Results

Interactive Tool Aims to Improve Genetic Healthcare and Educate Patients SAN FRANCISCO and SEATTLE, July 10 /PRNewswire/ -- DNA Direct, Inc. and Iverson Genetic Diagnostics, Inc. today announced that the companies will collaborate to offer personalized reports for individuals receiving Iverson...

AutoGenomics Receives FDA Clearance for its INFINITI(TM) Warfarin Assay

CARLSBAD, Calif., Jan. 24 /PRNewswire/ -- AutoGenomics, a leader in developing automated molecular testing solutions announced today that it has obtained clearance from the Food and Drug Administration (FDA) for its INFINITI 2C9-VKORC1 Multiplex Assay for Warfarin. The company has already rece...

Genetic Test Predicts Response to Warfarin

Using it could save money and lives, expert says WEDNESDAY, March 5 (HealthDay News) -- Variations of a gene that determines a person's sensitivity to warfarin are important in determining the initial doses of the anti-clotting drug, researchers report. That information already is b...

Drug interactions with warfarin

Anticoagulants (e.g., warfarin) and antiplatelet drugs (e.g., acetylsalicylic acid) are key therapeutic agents in the treatment of cardiovascular diseases. In this study, Joseph Delaney MSc, Dr. James Brophy and colleagues looked for drugdrug interactions in 4,028 cases with a diagnosis of gastroi...

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Warfarin in Medical Technology

New Phase II Data Show Safety of Once-Daily Oral Factor Xa Inhibitor, DU-176b, Comparable to Warfarin in Patients With Non-Valvular Atrial Fibrillation

SAN FRANCISCO, Dec. 7 /PRNewswire-FirstCall/ -- Patients with non-valvular atrial fibrillation receiving either 30 mg or 60 mg once-daily dose of DU-176b, an investigational oral Factor Xa inhibitor, experienced comparable safety and tolerability compared to those taking warfarin, according to new...

Medicare Announces Expanded Coverage for Warfarin Patients Monitoring Clotting Time at Home

Decision makes convenient self-testing a financial reality for more anticoagulation patients INDIANAPOLIS, March 19 /PRNewswire/ -- Medicare Part B will now cover and pay for meter training, equipment and supplies for all long-term warfarin users who monitor their prot...

Harvard Medical School-Partners HealthCare Center for Genetics and Genomics Successfully Completes Evaluation of AutoGenomics 2C9-VKORC1 Panel to Assess Warfarin Sensitivity

CARLSBAD, Calif., Aug. 17 /PRNewswire/ -- AutoGenomics, a leader in developing automated molecular testing solutions, announced today that its CYP450 2C9-VKORC1 panel that it submitted to the FDA for 510(k) clearance late last year, has now been evaluated by the Harvard Medical School-Partners...

Harvard Medical School-Partners HealthCare Center for Genetics and Genomics Successfully Completes Evaluation of AutoGenomics 2C9-VKORC1 Panel to Assess Warfarin Sensitivity

CARLSBAD, Calif., Aug. 17 /PRNewswire/ -- AutoGenomics, a leader in developing automated molecular testing solutions, announced today that its CYP450 2C9-VKORC1 panel that it submitted to the FDA for 510(k) clearance late last year, has now been evaluated by the Harvard Medical School-Partners...

Analysis of Edoxaban Phase II Data Provides Insight Into Reduced Bleeding Events Seen in Once-Daily Dosing

.../N=244 or 60mg/N=180 administered twice daily), or warfarin (N=250) dose-adjusted locally to a target Internat...linded to the edoxaban dose; however, those taking warfarin were aware they were randomized to the warfarin arm. Bleeding events were evaluated usi...

Value of Genetic Testing for Preventing Blood Clots Unproven, According to New AHRQ Study

... outcomes, but they found research indicating that keeping patients who have a genetic tendency to develop blood clots on blood-thinning drugs such as warfarin reduces the chance of a future clot. This benefit appears to be similar to that seen in patients who do not have the genetic tendency to develop blood...

TriLink BioTechnologies, Inc. Announces Supply Agreement With Osmetech Molecular Diagnostics

...n (CFCD) System and the eSensor(R) XT-8 System for warfarin Sensitivity. As part of the agreement, TriLin...vailable for Cystic Fibrosis Carrier Detection and warfarin Sensitivity testing, respectively. The eSensor(R)... while planned menu expansion includes an extended warfarin panel with the proprietary 4F2 marker, a venous th...

D-Pharm Submits Investigational New Drug Application and Special Protocol Assessment to the FDA for Phase III Trial of DP-b99 in Acute Stroke Patients

...held with the FDA in January 2008. The program included additional toxicity studies, a drug interaction study with rtPA, and an interaction study with warfarin in healthy volunteers, as well as scale-up and optimization of the DP-b99 manufacturing process. The planned Phase III trial is a randomized, d...

AstraZeneca Submits NDA for Low Dose Aspirin/Esomeprazole Combination Product

...biopsies from patients treated long-term with omeprazole, of which NEXIUM is an enantiomer. As with all PPIs, patients treated concomitantly with warfarin may need to be monitored for increases in INR and prothrombin time. Like other proton pump inhibitors, esomeprazole may interfere with the absorption ...

Beating Blood Clots after Joint Replacement

...ccording to Dr. Friedman. Currently, there are several types of prophylaxis available, and are not limited to: Oral agents, like warfarin Injectable agents, like low molecular weight heparins Mechanical compression, sleeves on a patient's legs to help stimulate blood flow...
Warfarin in Medical Products

ProTime Microcoagulation System

Description:... The ProTime Microcoagulation System monitors warfarin for use by healthcare professionals and for patient self-testing. Enhancements include an easy-to-read back-lit display and an operator rechargeable ...
Company:ITC
Warfarin in Medical Dictionary

Thromboembolism

... HCM develop aortic thromboembolism . ... Original Article from The New England Journal of Medicine -- Incidence of Cancer after Prophylaxis with warfarin against Recurrent Venous Thromboembolism Original Article from The New England Journal of Medicine -- High Plasma Levels of Factor VIII and the ...

Purpura

...etechiae, purpura , and ecchymosis do not become pale (blanch) with pressure. ... Leukemia ( purpura and ecchymosis) Drugs. Anticoagulants such as warfarin or ... purpura n. A condition characterized by hemorrhages in the skin and mucous membranes that result in the appearance of purplish spots or...
Warfarin in Biological News

American College of Medical Genetics responds to new FDA labeling decision for warfarin

BETHESDA, MD August 23, 2007 On August 16, the Food and Drug Administration approved new labeling information for the blood-thinner warfarin, sold under the brand name Coumadin. The new label suggests that one can prescribe higher or lower doses that may be safer for patients with variations in t...

Genetic testing not cost-effective in guiding initial dosing of common blood thinner

... used to guide initial dosing of the blood-thinner warfarin may not be cost-effective for typical patients wit...2009, edition of Annals of Internal Medicine . warfarin is commonly prescribed to prevent blood clotting, ...d and Drug Administration changed the labeling for warfarin in 2007, suggesting that clinicians consider genet...

The American Society of Human Genetics hosts 58th Annual Meeting in Philadelphia

...ease treatments and therapies presented at the ASHG 2008 meeting, including: the results of a genome-wide association scan for genetic determinants of warfarin dosage, a successful enzyme replacement therapy for Type I Gaucher Disease, and breakthrough research on a new treatment that has the potential to be ...

Launching a global alliance for pharmacogenomics

...ythm that can cause sudden cardiac arrest Working with the International warfarin Consortium to tailor initial doses of the anti-clotting drug warfarin based on the genetic profiles of patients A steering committee will ma...

Genetics determine optimal drug dose of common anticoagulant

...als metabolize drugs differently, varying doses of warfarin are needed for the drug to be effective in each patient. Too much warfarin can cause severe bleeding, and too little can caus...ns have had to roughly estimate an initial dose of warfarin and then continually monitor a patients Internatio...

Genetic variation alters response to common anti-clotting drug

... Millions of people take the anticoagulant drug warfarin to prevent harmful clotting after a heart attack, stroke, or major surgery. But the proper dose of warfarin can vary greatly and can be hard to predict. Some ...y certain people require a lower or higher dose of warfarin to get its full benefits. This line of work ultima...
Warfarin in Biological Technology

Genetic information personalizes warfarin prescribing

MADISON Warfarin, one of the world's most widely used drugs, is also one of the trickiest to prescribe. Half of those who take it are at risk of serious problems when given the standard starting dose. Now, in one of the first illustrations of "personalized medicine" based on genetic informatio...

D-Pharm Receives FDA Clearance to Commence a Phase III Trial of DP-b99 in Acute Stroke Patients

...held with the FDA in January 2008. The program included additional toxicity studies, a drug interaction study with rtPA, and an interaction study with warfarin in healthy volunteers, as well as scale-up and optimization of the DP-b99 manufacturing process. About DP-b99 DP-b99 is a unique neuropr...

Atritech Completes $30 Million Financing

...e PROTECT AF trial results this weekend at the ACC. Our results would be of significant interest to any patient with atrial fibrillation currently on warfarin therapy." added Bullock. The PROTECT AF results will be unveiled at the Late Breaking Clinical Trial session during the I2 Summit Scientific Mee...

FDA Approves KAPIDEX(TM) (Dexlansoprazole) delayed release capsules for the Treatment of GERD

... drugs for which gastric pH is important for bioavailability (e.g., ampicillin esters, digoxin, iron salts, ketoconazole). Patients taking concomitant warfarin may require monitoring for increases in international normalized ratio (INR) and prothrombin time. Please see the complete prescribing informatio...

deCODE Study Expands Clinical Utility of deCODE AF(TM) for Improving the Diagnosis of Atrial Fibrillation and Preventing Stroke

...ing all of their stroke and TIA patients with deCODE AF(TM), doctors can identify those who should be monitored for AF. And for those who evidence AF, warfarin may be the best therapy. With our partner Medicomp we are now planning a multicenter study pairing the use of deCODE AF(TM) with ambulatory digital ca...

FDA Approves ACIPHEX(R) (rabeprazole sodium) 20 mg for Short-Term Treatment of GERD in Adolescents

...e. The most common side effect possibly related to ACIPHEX is headache. Symptom relief does not rule out other serious stomach conditions. Patients on warfarin (such as Coumadin(R)) may need to be monitored more closely by their doctor. To learn more, talk to your doctor and see the full product information a...

Roche Diagnostics Launches CoaguChek XS Plus System to Provide New PT/INR Point-of-Care Solution for Non-Waived Anticoagulation Services

...tion management approach, the CoaguChek XS Plus System can help physicians and laboratorians provide their patients with the current best practices in warfarin management," said Randy Pritchard, Director of Strategic Marketing for Point of Care Diagnostics at Roche Diagnostics. "That can help them increase th...

Dey L.P. and Critical Therapeutics Launch Twice-Daily ZYFLO CR(TM) (Zileuton) Extended-Release Tablets for the Chronic Treatment of Asthma

... medication. Patients taking ZYFLO CR(TM) and theophylline should reduce the theophylline dose by 50%. Patients taking ZYFLO CR(TM) and propranolol or warfarin should be monitored and doses adjusted as appropriate. Most common side effects associated with the use of ZYFLO CR(TM) and ZYFLO(R) are sinusitis, na...

PNH Patients Treated with Soliris(TM) Experienced Dramatic Reduction in Blood Clots During Clinical Trials

...d updated review of 7 previously published patients. J Neurol. 2005;252:1379-1386. (10) Hall C, Richards S, Hillmen P. Primary prophylaxis with warfarin prevents thrombosis in paroxysmal nocturnal haemoglobinuria (PNH). Blood. 2003;102:3587-3591. (11) Rosse WF, Nishimura J. Clinical manife...
Warfarin in Biological Products

Rabbit Anti-Warfarin Polyclonal Antibody, Unconjugated from Abcam

Description:... Rabbit polyclonal to warfarin ( Abpromise for all tested applications). Antigen: Chemical / Small Molecule conjugated to KLH...
Company:Abcam
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