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Vorinostat in Medical News

Recurrent Gliomas: Vorinostat Shows Anti-cancer Activity

CHICAGO Findings presented today at the American Society of Clinical Oncology Annual Meeting by Eva Galanis, M.D., a Mayo Clinic oncologist, reveals that a novel application of the drug vorinostat shows activity in patients with recurrent glioblastoma multiforme. The study was conducted by North ...

VCU Massey Cancer Center spearheads novel clinical study for lymphoma patients

...me inhibitors such as bortezomib and histone deacetylase inhibitors such as vorinostat in leukemia and other hematologic malignancies. Other cancer centers are cu...and previously was approved for patients with progressive multiple myeloma. vorinostat has been approved for use in patients with cutaneous T-cell lymphoma. D...

New treatment for advanced prostate cancer

...an now confirm that a very low level of bicalutamide is capable of inhibiting cancer cell proliferation by more than 10-fold when combined with either vorinostat or 17AAG, making our current treatments much more effective and causing fewer side effects," says Dr Lisa Butler. All the drugs needed for combinat...

ZOLINZA (vorinostat) in combination with bortezomib demonstrated clinical activity

...rcia-Vargas, M.D., senior director, Clinical Oncology, Merck Research Laboratories. These data provide a preliminary evaluation of the combination of vorinostat with bortezomib in patients with advanced multiple myeloma, including those who've previously received bortezomib therapy. Larger clinical studies ar...
Vorinostat in Medical Technology

Karmanos Cancer Institute Researchers Present Breast Cancer Advancements at Conference

... with Aminoflavone Prodrug (also known as AFP464) and found that AFP464 and vorinostat work together to inhibit the growth of triple-negative breast cancer cells....s with AFP464," she said. "The synergism is very impressive. We always knew vorinostat can reprogram the expression of cancer cells." AFP464 has been in Phas...

Arno Therapeutics, Inc. Completes $18 Million Financing and Reverse Merger with Laurier International, Inc.

...of the Pan-DAC and Akt pathways. In preclinical studies, AR-42 has demonstrated greater potency and a competitive profile in tumors when compared with vorinostat (SAHA), the leading marketed histone deacetylase inhibitor. Arno plans to initiate Phase I studies of AR-42 and AR-12 in early 2009. Arie Belldegrun...
Vorinostat in Biological News

NCI renewal grant to develop new cancer therapies

...efractory acute leukemia or myelodysplastic syndrome. Additionally, the team has recently received approval to lead a multi-institutional trial of vorinostat and bortezomib, a proteasome inhibitor, in patients with refractory diffuse lymphocytic B-cell lymphoma or mantle cell lymphoma. ...

New molecules discovered that block cancer cells from modifying cell DNA

...tabine (Dacogen), both for the treatment of myelodysplastic syndrome, diseases in which the production of blood cells by the bone marrow is disrupted. vorinostat (Zolinza) also works to turn back on silenced genes, and is approved for use in cutaneous T cell lymphomas. Dr. Nelson noted that the Prostate Can...
Vorinostat in Biological Technology

Tigris Pharmaceuticals Presents Results of Breast Cancer Research at AACR Annual Meeting

...nhibitor, such as the suberoylanilide hydroxamic acid (SAHA), also known as vorinostat (Zolinza(R), Merck & Co. Inc.), the cells became very sensitive to AFP-...ve types with AFP-464," said Dr. Burger. "The synergism between AFP-464 and vorinostat in the triple negative breast cancer cell lines is very impressive." A...

FDA Accepts IND for Arno Therapeutics' Pan-DAC / Akt Inhibitor, AR-42

...aling kinase dephosphorylation. In preclinical studies, AR-42 has demonstrated greater potency and a competitive profile in tumors when compared with vorinostat (also known as SAHA and marketed as Zolina (R) by Merck), the leading marketed histone deacetylase inhibitor. Arno in-licensed the exclusive worldwide...

Arno Therapeutics Completes License Agreements for the Exclusive Rights to Novel, Targeted Cancer Compounds

...ms as well. In preclinical studies OSU-HDAC42 has demonstrated greater potency and a competitive profile in solid and liquid tumors when compared with vorinostat (SAHA), the leading marketed compound in the class. "We are extremely pleased to be developing these two exciting and novel molecules for the treatm...
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