Vasopressin

FDA Approves SAMSCA(TM) (tolvaptan), the First and Only Oral Vasopressin Antagonist to Treat Patients With Clinically Significant Hypervolemic and Euvolemic Hyponatremia

Once-Daily SAMSCA Increases Serum Sodium Levels Through Increase in Free Water Clearance TOKYO and PRINCETON, N.J., May 21 /PRNewswire/ -- Otsuka Pharmaceutical Co., Ltd. (OPC) and Otsuka Pharmaceutical Development and Commercialization, Inc. (OPDC) announced today that the U.S. Food and Drug...

FDA Accepts Final Section of NDA Filing for LUCASSIN(R)

...ferred to Ikaria following marketing approval. LUCASSIN is a synthetic vasopressin analogue that acts via the vasopressin V1 receptor as a systemic vasoconstrictor, mainly in the splanchnic (abdomi...

Astellas Launches Vaprisol(R) (Conivaptan Hydrochloride Injection) Premixed in 5% Dextrose for the Treatment of Hyponatremia

... Arginine vasopressin (AVP) receptor antagonist now available in new pre...d and developed by Astellas, Vaprisol, an arginine vasopressin (AVP) receptor antagonist, is the first and only a...sults from elevated levels of the hormone arginine vasopressin (AVP), which regulates water and salt balance in t...

2009 DeLee Humanitarian Award goes to Marshall Lindheimer, M.D., of the University of Chicago

...lation during pregnancy. Working with John Davison, of Newcastle upon Tyne University, England, Lindheimer mapped out how regulation of the hormone vasopressin affected fluid retention during pregnancy. Understanding this process led them to predict the existence of an as-yet-unrecognized disease, now known ...

ReachMD XM 157 Announces Medical Information Feature on Treatment Options for Management of Hyponatremia

... CHICAGO, Oct. 27 /PRNewswire/ -- ReachMD XM 157 announces a new "Medical Industry Feature of the Week" highlighting a vasopressin receptor antagonist and its effects on management of euvolemic and hypervolemic hyponatremia in the hospital setting. ReachMD XM 157, the first and ...

Ikaria(R) Acquires North American Rights to LUCASSIN(R) From Orphan Therapeutics

...oal to make LUCASSIN available for HRS Type 1 patients in the U.S., who currently have no approved drugs available to them." LUCASSIN is a synthetic vasopressin analogue that acts via the vasopressin V1 receptor as a systemic vasoconstrictor, which appears to increase effective arterial volume and improved ren...

Two-Drug Treatment Didn't Improve Cardiac Arrest Survival Rates

...News) -- Injecting the artery-constricting hormone vasopressin in addition to adrenaline did not improve survival...years ago described promising results of combining vasopressin and epinephrine -- the formal name of adrenaline -...t report in guidelines saying that a first shot of vasopressin might be substituted for adrenaline, the tradition...

Orphan Therapeutics Announces Initiation of Rolling NDA Submission for LUCASSIN(R) (terlipressin) for the Treatment of Hepatorenal Syndrome Type 1

...BOUT LUCASSIN(R) (terlipressin) LUCASSIN(R) (terlipressin) is a synthetic vasopressin analogue that acts via the vasopressin V1 receptor as a systemic vasoconstrictor, resulting in an increase in effe...

New Class of Drugs Might Treat Many Conditions

...emorrhage, psychotic disorders and glaucoma, Belgian researchers report. Vaptans, short for vasopressin-receptor antagonists, work by targeting the vasopressin hormone system, which plays an important role in controlling blood and water volume in the body. These drugs, which can be taken orally or intravenous...

Two Drugs Found Equal in Treatment of Septic Shock

... But vasopressin might be slightly better than norepinephrine in le...ealthDay News) -- The artery-tightening medication vasopressin holds no overall advantage over an older drug, nor... of severe septic shock, a new study finds. But vasopressin did appear to be better for less severe cases in t...

Vasopressin in Medical Technology

Study Shows Vasopressin Receptor Antagonist VAPRISOL(R) (Conivaptan Hydrochloride Injection) Significantly Increased Serum Sodium Concentration in Patients with Euvolemic & Hypervolemic Hyponatremia

- Phase III data published in the American Journal of Nephrology - DEERFIELD, Ill., Sept. 20 /PRNewswire-FirstCall/ -- Astellas Pharma US, Inc. today announced that its Phase III data on VAPRISOL was published in the September issue of the American Journal of Nephrology. In this study, VAPR...

Vantia Therapeutics' Lead Candidate VA106483 Demonstrates Positive Anti-diuretic Effect in Phase IIa Trial in Nocturia

...ts its effect directly in the kidney by binding to vasopressin (V2) receptors, which regulate water balance. It w...imated to be worth in excess of $500m. The hormone vasopressin is involved in the regulation of the body's water content and as a vasopressin agonist VA106483 has been shown to act as an anti-...

Vantia Therapeutics' Pipeline Continues to Mature

... patients and completing in H2 2010. VA111913 is a vasopressin antagonist, with dysmenorrhoea (painful menstruati...imated to be worth in excess of $500m. The hormone vasopressin is involved in the regulation of the body's water content and as a vasopressin agonist VA106483 has been shown to act as an anti-...

Study Shows VAPRISOL(R) is Effective in Increasing Serum Sodium Levels and Well-Tolerated in Patients With Euvolemic or Hypervolemic Hyponatremia

...ng conditions such as pneumonia, chronic obstructive pulmonary disease and impaired heart function." VAPRISOL is the first in a new class of arginine vasopressin (AVP) receptor antagonists. VAPRISOL blocks both V1a and V2 vasopressin receptors, resulting in increased urine output without increased sodium loss. ...

ECLIPSE Data on Effects of Otsuka's Investigational Novel Treatment, Tolvaptan, on Advanced Heart Failure Patients' Hemodynamics and Urine Output Featured in Heart Failure Society of America's Late Breaking Trials

... PRINCETON, N.J., Sept. 19 /PRNewswire/ -- A single dose of Otsuka's investigational oral medication tolvaptan, a vasopressin receptor antagonist, resulted in favorable changes in hemodynamics associated with a significant increase in urine output in patients with advanced he...

Everest Data on Short- and Long-Term Use of Otsuka's Investigational Novel Treatment, Tolvaptan, Published in Journal of the American Medical Association and Featured in ACC's Late Breaking Clinical Trials

...es of the international landmark trial Efficacy of vasopressin Antagonism in Heart Failure Outcome Study with Tol...small molecule designed to be an antagonist of the vasopressin V2 receptor, which plays a role in the kidney's re..."Short-Term Clinical Effects of Tolvaptan, an Oral vasopressin Antagonist, in Patients Hospitalized for Heart Fai...

Vasopressin in Medical Products

Arginine Vasopressin Hormone

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Arginine Vasopressin (AVP, Antidiuretic Hormone, ADH)

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Vasopressin (AVP) RIA Test

Description:... Arginine vasopressin (AVP), also known as Antidiurectic Hormone (ADH), is synthesized in the hypothalamus and is transported via exonal flow to the posterior pituitary for...
Company:Diagnostic Systems Laboratories, Inc.

Vasopressin in Medical Dictionary

Nephrogenic Diabetes Insipidus

...diabetes insipidus (NDI) is a kidney disorder characterized by the ... X-linked nephrogenic diabetes insipidus is caused by a defect in the vasopressin ... Disease information about nephrogenic diabetes insipidus including its symptoms and treatment. Nephrogenic diabetes insipidus ...

ADH

... Arginine vasopressin (AVP), also known as vasopressin, argipressin or a... hormone found in most mammals, including humans. vasopressin is a peptide hormone. It is derived from a preproh...tidiuretic hormone ( ADH ) test, also called the vasopressin test, is a test for ... Certain drugs can either i...

Vasopressin in Biological News

The neurobiology of musicality related to the intrinsic attachment behavior?

...sic (p To elucidate the neurobiological basis of music in human evolution and communication the researchers demonstrated an association of arginine vasopressin receptor 1A (AVPR1A) gene variants with musical aptitude. In the previous studies the AVPR1A gene and its homologies have been associated with social,...

2 genes influence social behavior, visual-spatial performance in people with Williams syndrome

...ty of other genes, GTF2I might regulate signal pathways determining the structure and function of the brain or the production of neurohormones such as vasopressin and oxytoxin. Oxytoxin plays a key role in the desire to seek social interactions and trusting others, which might explain why for children with Willi...

Gene associated with pair-bonding in animals has similar effects in human males

... Variation in the gene for one of the receptors for the hormone vasopressin appears to be associated with how human males bond with their partners, according to an international team of researchers. The researchers found ...

Runners -- Let thirst be your guide

...when endurance exercisers drink more fluid than their kidneys can excrete. The hormone that determines how much fluid a kidney can excrete is arginine vasopressin (AVP), which is released from the pituitary gland when a person is becoming dehydrated in order to force the kidneys to conserve water. At rest, a per...

Are dancers genetically different than the rest of us? Yes, says Hebrew University researcher

... two genes that provide the code for the serotonin transporter and arginine vasopressin receptor 1a. Both genes are involved in the transmission of information...ontributes to spiritual experience, among many other behavioral traits. The vasopressin receptor has been shown in many animal studies to modulate social communica...

Animal models show that anabolic steroids flip the adolescent brain's switch for aggression

...called vasopressin. By three weeks of withdrawal, vasopressin levels subsided in parallel with the aggressive be...s regulates aggression and social behavior. Thus, vasopressin ?already known to stimulate that area ?appears to ...dolescents don't take the ultimate recovery of the vasopressin system to mean it's OK to use the drugs. "It's ou...

Rodent social behavior encoded in junk DNA

...bution of brain receptors that bind to the hormone vasopressin differed dramatically between monogamous and polyg... peppered throughout these regulatory areas of the vasopressin receptor gene. "It was considered junk DNA beca...rchers first showed in cell cultures that the vole vasopressin receptor microsatellites could modify gene express...

Endocannabinoids ?the brain's cannabis ?demonstrate novel modes of action to stress

...hibitory synaptic transmission In an in vitro study, a multi-center Japanese team led by Atsushi Soya focused on the supraoptic nucleus (SON) where vasopressin and oxytocin are synthesized. They found that a synthesized cannbinoid (CP55,940) inhibited both excitatory and inhibitory synaptic transmission and t...

Newly discovered genetic disease sheds light on body's water balance

...ered almost 50 years ago to be an overabundance of vasopressin (also called antidiuretic hormone). However, when ...tors took advantage of new, rapid tests to measure vasopressin in these two infants, they found no detectable lev...or many physiological processes. Normally, when vasopressin binds to the V2R, it stimulates a chain of events ...

Love's all in the brain: fMRI study shows strong, lateralized reward, not sex, drive

...in the ventral pallidum portion of the basal ganglia in people with longer romantic relationships. It's in this region where receptors for the hormone vasopressin are critical for vole pair-bonding, or attachment. "Humans have evolved three distinct but interrelated brain systems for mating and reproduction ?...

Vasopressin in Biological Technology

Sex Steroid Regulation of Vasopressin Levels Secreted by hNT Neurons*

hNT Neurons used to imitate neurodegeneration Rob D. Dickerman a Thomas Fungwe b N.Y. Zachariah a Walter J. McConathy a,b a Department of Medicine, b Department of Biomedical Sciences, University of North Texas Health Science Center This article describes an in...

Vantia Therapeutics Appoints Rachel Morten as Head of Regulatory Affairs

... VA106483 acts directly in the collecting ducts of the kidney by binding to vasopressin 2 receptors, decreasing urine volume. Clinical data indicate that VA106483 ...e uterus during menstruation causing severe pain. VA111913 acts by blocking vasopressin 1a receptors in smooth muscle in the uterus wall, which in response to elev...

Noninvasive Medical Technologies Helps Make Young Tennessee Woman's Wishes Come True

...d at the base of the brain, the pituitary gland secretes a hormone known as vasopressin that triggers the kidneys to regulate normal storage and release of bodily ...vel of her fullness, her physical symptoms and each time she took her nasal vasopressin within a 24-hour period. Through regular conversations with Humphrey, trend...

FDA Approves Astellas' Vaprisol(R) (Conivaptan Hydrochloride Injection) Premixed in 5% Dextrose for the Treatment of Hyponatremia

... Arginine vasopressin (AVP) receptor antagonist now approved in single-u...d and developed by Astellas, Vaprisol, an arginine vasopressin (AVP) receptor antagonist, is the first and only a...sults from elevated levels of the hormone arginine vasopressin (AVP), which regulates water and salt balance in t...

U.S. Food and Drug Administration Advisory Committee Recommends Approval of Tolvaptan, an Investigational Treatment for Hyponatremia

...gonist of the vasopressin V2 receptor, which is located predominantly in the kidney and plays a role in the regulation of fluid retention in the body. vasopressin V2 antagonists work by selectively blocking the V2 receptor. This mechanism of action hinders water reabsorption and results in increased free water e...

New Drug Application for Tolvaptan, Otsuka's Investigational Novel Oral Treatment for Worsening Heart Failure and Hyponatremia, Accepted by the U.S. Food and Drug Administration

...a novel, investigational small molecule designed to be an antagonist of the vasopressin V2 receptor, which plays a role in the kidney's regulation of fluid excreti...000; 342 (21):1581-1589. 8. Gheorghiade M, Gottlieb SS, Udelson JE, et al. vasopressin V2 Receptor Blockade With Tolvaptan Versus Fluid Restriction in the Tre...

Receptor Binding Assays using Fluorescence Polarization Detection: the [FP]2TM Characterized Tracers

... is provided in Table 3 for these peptides and for vasopressin and Bombesin(6-14) also. An example of a scatter plot for vasopressin binding to the V 1b receptor subtype is provided ...s performance data obtained in a similar manner to vasopressin for all the peptides listed in Table 1. In most ca...

Vasopressin in Biological Products

Rabbit Anti-ARG. Vasopressin Polyclonal Antibody, Unconjugated from GeneTex

Description: Rabbit Antibody to ARG. Vasopressin The antibody blocks with the arginine vasopression peptide. Cells are found in the paraventricular and supraoptic nucleus and fibers are found throughout the hypothalmus in rat brain of 4% FA perfused tissue. Immunogen: Arginine Vasopression Cys-Tyr-Phe-Gln-...
Company:GeneTex

Rabbit Anti-Arg Vasopressin Polyclonal Antibody, Unconjugated from ImmunoStar, Inc.

Description: Raised to arginine vasopressin coupled to bovine thyroglobulin with carbodiimide ....
Company:ImmunoStar, Inc.

Anti-Arginine Vasopressin Receptor Polyclonal Antibody, Unconjugated from CHEMICON

Description: Arginine vasopressin receptor (AVP-V2), rat. The peptide used for immunization has no significant similarity with AVP V1a or V1b receptors....
Company:CHEMICON

Mouse Anti-Human Vasopressin Monoclonal Antibody, Unconjugated, Clone VAS 2-10-8 from Meridian Life Science, Inc.

Description: MAb to Vasopressin Preservative: NaN3...
Company:Meridian Life Science, Inc.

Vasopressin in Biological Definition

Hormone

...xamples are catecholamines and thyroxine . Peptide hormones consist of chains of amino acids. Examples of small peptide hormones are TRH and vasopressin . Peptides composed of scores or hundreds of amino acids are referred to as proteins. Examples of protein hormones include insulin and growth hormone....

Kidney

... hypothalamus , which notifies the pituitary gland via negative feedback . The pituitary gland secretes antidiuretic hormone, otherwise known as vasopressin (or stops the secretion if water is in excess), which causes a change in the water absorption of the kidney tubule. Tissue fluid concentration thus r...

Neurotransmitter

...es ): Bombesin/GRP: bombesin gastrin releasing peptide (GRP) Gastrins: gastrin cholecystokinin (CCK) Neurohypophyseals : vasopressin oxytocin neurophysin I neurophysin II Neuropeptide Y: neuropeptide Y (NY) pancreatic polypeptide (PP) peptide YY (PYY) ...

Vasopressin in Biological Dictionary

Epinephrine

...am in response to physical or mental Hypersensitivity to epinephrine or any component of the ... Eligible patients were randomized to intravenous vasopressin (40 units) or epinephrine (1 mg) ... All about Epinephrine . View complete and up to date Epinephrine information - part of the Drugs.com trus...

Collecting tubules

...ed cortical collecting tubules (CCT) from rabbit kidney were perfused with ... Endosomes from kidney collecting tubule cells contain the vasopressin ... Stoner LC, Burg MB, Orloff J. Ion transport in cortical collecting tubule ; effect of amiloride. ... dilution by the collecting tubule . ...