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Gene variations explain drug dose required to control seizures

Determining which variants of particular genes patients with epilepsy carry might enable doctors to better predict the dose of drugs necessary to control their seizures, suggest basic findings by researchers at the Duke University Institute for Genome Sciences & Policy (IGSP) and the University College London. Patients often undergo a lengthy process of trial and error to find the dose of ant...

Researchers map of genetic variations implicated in disease

Sequence differences in less than 0.2% of the 3-billion-base human genome play a vital role in a bewildering variety of human disease. Today, researchers from the Wellcome Trust Sanger Institute and the Cambridge University's Cambridge Institute for Medical Research, together with international colleagues report in PLoS Genetics their detailed maps of differences implicated in disease as well as...

Variations in detoxifying genes linked to Lou Gehrig's disease

Genetic variations in three enzymes that detoxify insecticides and nerve gas agents as well as metabolize cholesterol-lowering statin drugs may be a risk factor for developing sporadic amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease), and possibly responsible for a reported twofold increased risk of ALS in Gulf War veterans. These findings, from a study led Teepu Siddique, M.D...

A new kind of mutation could explain numerous phenotypic variations in various species

The authors describe the discovery of a novel class of mutations that disrupt the function of a gene and thereby cause a specific phenotype. The mutation created the appearance of an "illegitimate" microRNA (miRNA) recognition site in a gene that did not have it in its normal form. In this study, the gene concerned is the myostatin. This gene is expressed in the skeletal muscle and the function...

Gene variations contribute to aggression and anger in women

Ever wonder why some women seem to be more ill-tempered than others? University of Pittsburgh researchers have found that behaviors such as anger, hostility and aggression may be genetic, rooted in variations in a serotonin receptor gene. Indrani Halder, Ph.D., of the Cardiovascular Behavioral Medicine Program at the University of Pittsburgh, will present the findings today at the American Psycho...
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Variations In ingredients From Brand to Brand

According to a recent study by Taiwanese experts , people buying the popular herbal medicine may be actually getting virtually none. St John's Wort, or Hypericum, can have mild antidepressant effects, although doctors warn it can interfere with the effects of other medicines.// None of the tablets tested had as much of the active ingredient as claimed, said the researchers. Two ch...

Gene Variations Raise the Risk of Childhood Cancer Survivors

Despite surviving the risk of cancer, children were still at the threat of suffering from congestive heart failure due to the complication of the drugs they received during the cancer treatment//. The researchers studied anthracyclines, a commonly used class of anticancer drugs known to cause heart damage in some patients. The research team investigated two groups of childhood cancer su...

Genetic Variations In Detoxifying Genes Lead To Lou Gehrig's diseases

A new study links the genetic variations in detoxifying enzymes for developing Lou Gehrig's diseases//. The study shows that the genetic variations in three enzymes, which are used to detoxify insecticides and nerve gas agents as well as for metabolising cholesterol lowering, statin drugs might be a risk factor for developing irregular ‘Amyotrophic lateral sclerosis’ (ALS, or Lou Gehr...

Food Costs At Hospitals Show Mystifying Variations

New figures reveal puzzling variations on how hospitals spend for meals for their patients. An area-wise breakdown shows that some health boards are spending four times the amounts spent by others.// The report says that NHS Lothian spends an average of ￡61 on patients' meals per week as compared to the Scottish average of ￡59. According to The Scotsman newspaper, there are...

Stroke Risk Higher with Gene Variations

Specific genetic variations have been linked to an increased risk of stroke in younger women, according to a University of Maryland researchers which has added to the growing evidence of possible genetic influences in stroke. // The study results, which appear in the August issue of Human Molecular Genetics, indicate an increased risk ranging from 50 to 100 percent depending on the parti...

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Gene Chips to Detect CYP Variations: A New Step Toward Customized Medical Therapy.

The FDA approval of BiDil for heart failure in African American patients has underscored the concept that two patients can respond differently to the same medication. This concept holds true for a wide variety of everyday medications, and in many cases is due to individual gen...
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