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Valproic in Medical News

Hyperion Therapeutics Raises $60 Million Series C

...etite, body odor (probably caused by its metabolite phenylacetate) and bad taste or taste aversion. Patients with urea cycle disorders should not take valproic acid, haloperidol, or steroids as these drugs have been reported to increase blood ammonia levels, and probenecid may affect the kidneys' excretion. U...

Hyperion Therapeutics Announces Results of Phase I Study in Patients With Liver Cirrhosis

...etite, body odor (probably caused by its metabolite phenylacetate) and bad taste or taste aversion. Patients with urea cycle disorders should not take valproic acid, haloperidol, or steroids as these drugs have been reported to increase blood ammonia levels, and probenecid may affect the kidneys' excretion. U...

Epilepsy Drug Impairs Baby's Intelligence

...udy is that the danger of neurocognitive impairment is real with the use of valproic acid (valproate)," said Dr. Inna Vaisleib, a pediatric neurologist and epileptologist at Children's Hospital of Pittsburgh. "Not using valproic acid in women of childbearing age is a good idea, as approximately half of ...

Hyperion Therapeutics Completes Phase 2 Data Analysis and Schedules End of Phase 2 Meeting With FDA for HPN-100 in the Chronic Treatment of Urea Cycle Disorders

...etite, body odor (probably caused by its metabolite phenylacetate) and bad taste or taste aversion. Patients with urea cycle disorders should not take valproic acid, haloperidol, or steroids as these drugs have been reported to increase blood ammonia levels, and probenecid may affect the kidneys' excretion. U...

Repligen Initiates Phase 2b Clinical Trial of RG2417 in Bipolar Disorder

...average lifetime financial burden of bipolar disorder in the United States is about $625,000 per patient. Although lithium and anticonvulsants such as valproic acid have substantially improved the prognosis of bipolar disorder, many individuals are unable to tolerate treatment-related side effects, and incomp...

Epilepsy drug may help Alzheimer's patients

...l of Experimental Medicine . The anti-seizure drug valproic acid improved memory and reduced brain lesions in ... Vancouver, Canada, showed that treating mice with valproic acid soon after the onset of disease shrank the br...ta-amyloid, which builds up to toxic levels in AD. valproic acid helped mice less as their disease progressed,...

Common epilepsy drug could prevent and treat Alzheimer's disease

... team led by UBC Psychiatry Prof. Weihong Song, who is also the Jack Brown and Family Professor and Chair in Alzheimer's Disease at UBC, found that if valproic Acid (VPA) is used as a treatment in early stages of AD memory deficit is reversed. The study, published in the Journal of Experimental Medicine, r...

Jazz Pharmaceuticals, Inc. Announces LUVOX CR Launch Plans and Reports Development Pipeline Progress at Investor Day Presentation

...also disclosed three additional early-stage programs: a solid oral dosage form of sodium oxybate; a new chemical entity that is a structural analog of valproic acid for the treatment of epilepsy and bipolar disorder; and a new chemical entity that is a triple reuptake inhibitor for major depressive disorder. ...

FDA Extends Review Timeline for Additional Indication for Antibiotic DORIBAX(TM)

... airway management, as clinically indicated. Carbapenems may reduce serum valproic acid concentrations to subtherapeutic levels, resulting in loss of seizure ...ative antibacterial or anticonvulsant therapy should be considered if serum valproic acid concentrations cannot be maintained in the therapeutic range or seizur...

Chemical signature of manic depression discovered by scientists

...ively using the mood-stabilising drugs lithium and valproic acid, the reasons why these treatments work are po... used rat models to see the effects of lithium and valproic acid on the metabolite makeup of non-bipolar brain...disorder. The study also suggests that lithium and valproic acid work by restoring the balance of these neurot...
Valproic in Medical Technology

Hyperion Therapeutics Receives Orphan Drug Designation for HPN-100 for the Treatment of Urea Cycle Disorders

...etite, body odor (probably caused by its metabolite phenylacetate) and bad taste or taste aversion. Patients with urea cycle disorders should not take valproic acid, haloperidol, or steroids as these drugs have been reported to increase blood ammonia levels, and probenecid may affect the kidneys' excretion. U...

Karmanos Cancer Institute Researchers Study New Drug Combinations to Treat Childhood Leukemia

...A-approved cytarabine is a major cause of treatment failure in AML. Scientists considered clofarabine, approved by the FDA in 2004, and paired it with valproic acid (VPA), typically used to treat epilepsy. They found the two drugs worked together to dramatically stimulate cell death. "We considered an ol...

Hyperion Therapeutics Announces Results for Phase II Study in Urea Cycle Disorders

...tite, body odor (probably caused by its metabolite phenylacetate) and bad taste or taste aversion. Patients with urea cycle disorders should not take valproic acid, haloperidol, or steroids as these drugs have been reported to increase blood ammonia levels, and probenecid may affect the kidneys' excretion. ...

New Data Show In Vitro Potency of Doripenem Against Resistant Bacteria

... airway management, as clinically indicated. Carbapenems may reduce serum valproic acid concentrations to subtherapeutic levels, resulting in loss of seizure ...ative antibacterial or anticonvulsant therapy should be considered if serum valproic acid concentrations cannot be maintained in the therapeutic range or seizur...

FDA Requires Additional Information on DORIBAX for Treatment of Hospital-Acquired Pneumonia

... airway management, as clinically indicated. Carbapenems may reduce serum valproic acid concentrations to subtherapeutic levels, resulting in loss of seizure ...ative antibacterial or anticonvulsant therapy should be considered if serum valproic acid concentrations cannot be maintained in the therapeutic range or seizur...

Hyperion Therapeutics Completes Enrollment in Phase 1/2 Clinical Trial in Patients With Urea Cycle Disorders

...etite, body odor (probably caused by its metabolite phenylacetate) and bad taste or taste aversion. Patients with urea cycle disorders should not take valproic acid, haloperidol, or steroids as these drugs have been reported to increase blood ammonia levels, and probenecid may affect the kidneys' excretion. U...

Repligen Announces Plans to Initiate a Phase 2b Trial for RG2417 in Bipolar Disorder

...d States is about $625,000 per patient, depending on resistance to treatment and persistence of symptoms. Although lithium and anticonvulsants such as valproic acid have substantially improved the prognosis of bipolar disorder, many individuals are unable to tolerate treatment-related side effects, and incomp...

Repligen Reports Positive Phase 2a Clinical Trial Results of RG2417 for Symptoms of Bipolar Disorder

...d States is about $625,000 per patient, depending on resistance to treatment and persistence of symptoms. Although lithium and anticonvulsants such as valproic acid have substantially improved the prognosis of bipolar disorder, many individuals are unable to tolerate treatment-related side effects, and incomp...

Hyperion Therapeutics Announces Enrollment of First Patient in Phase 1/2 Clinical Trial of GT4P in Patients With Urea Cycle Disorders

...etite, body odor (probably caused by its metabolite phenylacetate) and bad taste or taste aversion. Patients with urea cycle disorders should not take valproic acid, haloperidol, or steroids as these drugs have been reported to increase blood ammonia levels, and probenecid may affect the kidneys' excretion. U...

Aptivus(R) (tipranavir) Capsules Granted Full Approval by the U.S. FDA

...tions. -- Caution should be used when prescribing valproic acid. valproic acid may be less effective due to decreased valproic acid plasma concentrations. -- Use caution wh...
Valproic in Medical Products

Valproic Acid

Description:... For the quantitative in vitro determination of valproic Acid in human serum...
Company:Randox Laboratories Ltd.
Valproic in Medical Dictionary

Fatty liver

... does not result in fatty liver . ... Symptoms, Treatment and Prevention of Fatty Liver ... Microvesicular fatty liver may be caused by valproic acid toxicity and high-dose ... What is Nonalcoholic Fatty Liver Disease (NAFLD) / Nonalcoholic ... The most common form of NAFLD is a non s...
Valproic in Biological News

Universitat Autonoma de Barcelona researchers first to clone mice in Spain

...tal and Elena Ibez are studying whether the use of valproic acid could contribute to an increase in the succes...imately 1% for mice using standard procedures. valproic acid is an inhibitor of the enzyme histone deacety... three groups of cloned embryos in their research: valproic acid in the first group, trichostatin in the secon...

UNC launches study of liver injury caused by drugs

...eloped severe liver injury due to one of four specific drugs. The four are the tuberculosis drug isoniazid, the anti-seizure medications phenytoin and valproic acid, and the antibiotic amoxicillin-clavulanate potassium. "Eligible patients from anywhere in North Carolina or neighboring states who are willin...
Valproic in Biological Technology

FDA Advisory Committee Provides Opinion of DORIBAX(TM) for the Treatment of Hospital-Acquired Pneumonia

... airway management, as clinically indicated. Carbapenems may reduce serum valproic acid concentrations to subtherapeutic levels, resulting in loss of seizure ...ative antibacterial or anticonvulsant therapy should be considered if serum valproic acid concentrations cannot be maintained in the therapeutic range or seizur...

New Aptivus(R) (tipranavir) Oral Solution Approved for Treatment-Experienced Pediatric and Adolescent HIV Patients

...ions. -- Caution should be used when prescribing valproic acid. valproic acid may be less effective due to decreased valproic acid plasma concentrations. -- Use caution when ...

FDA Approves DORIBAX(TM) for the Treatment of Complicated Intra-Abdominal and Complicated Urinary Tract Infections

...d airway management, as clinically indicated. Carbapenems may reduce serum valproic acid concentrations to subtherapeutic levels, resulting in loss of seizure ...ative antibacterial or anticonvulsant therapy should be considered if serum valproic acid concentrations cannot be maintained in the therapeutic range or seizur...

Hyperion Therapeutics, Inc. Announces Senior Management Team and $15M Financing Event

...etite, body odor (probably caused by its metabolite phenylacetate) and bad taste or taste aversion. Patients with urea cycle disorders should not take valproic acid, haloperidol, or steroids as these drugs have been reported to increase blood ammonia levels, and probenecid may affect the kidneys' excretion. U...

Patient Treatment for Bipolar Disorder Varies Depending on Doctor Specialty; Well Designed Clinical Trials May Be The Answer

...commended first-line monotherapies for bipolar mania: lithium (99 percent), valproic acid (95 percent) and atypical antipsychotics, such as AstraZeneca's Seroqu...1 percent prescribe Seroquel; however only half of PCPs currently prescribe valproic acid or Lamictal. When treating depressive symptoms, psychiatrists follow A...
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