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Valproate in Medical News

Guidelines: Pregnancy Safe with Epilepsy, but Valproate Should be Avoided

ST. PAUL, Minn., April 27 /PRNewswire-USNewswire/ -- New guidelines developed by the American Academy of Neurology and the American Epilepsy Society show it's relatively safe for women with epilepsy to become pregnant, but caution must be taken, including avoiding one particular epilepsy drug that...

Pregnant Women With Epilepsy Should Avoid Valproate

New guidelines stress that, with good planning, most moms-to-be will do fine,,,, MONDAY, April 27 (HealthDay News) -- Despite recent concerns about fetal malformations linked to the anti-seizure medication valproate, most women with epilepsy can expect to have a relatively uneventful ...

Mode Of Action Of The Anti-Convulsant Valproate

Researchers from Australia have recently shown, using a yeast-based in vitro bioassay for steroid hormones that valproate, a commonly used anti-convulsant for the treatment of epilepsy and bipolar disorder, is an anti-androgen and anti-progestin. // Anti-convulsant treatment is associated wit...

Epilepsy Drug Valproate and Lamotrigine Linked To Malformed Fetus

In a study in the March issue of Neurology, the epilepsy drug Valproate has been linked to malformation of fetus //when prescribed to pregnant ladies. For pregnant women with epileptic seizures, often the drug Valproate is prescribed. The new study shows that women who took the drug in their ...

INVEGA(R) Approved as the First and Only Treatment for Schizoaffective Disorder

...ects enrolled received ongoing treatment with a mood stabilizer and/or antidepressant during the studies. The most commonly used mood stabilizers were valproate and lithium. The most commonly used antidepressants were SSRIs and SNRIs. Efficacy was evaluated using the positive and negative symptom scale ...

Anti-epilepsy drug risk on cognitive function for unborn children

...orn to women taking the anti-epileptic drug sodium valproate whilst pregnant, are likely to have an IQ of six t...s suggest that children exposed to the drug sodium valproate had lower IQ results than children exposed to othe...aid "Our research looked at how exposure to sodium valproate and other AEDs in the womb affected children's eve...

FDA Approves Lamictal(R)XR(TM); An Extended-Release Once-Daily, New Generation Treatment for Epilepsy

...amictal XR is not approved for use in children less than 13 years old. The risk of getting a rash is higher if taking Lamictal XR while taking valproate (Depakene(R) (valproic acid) or Depakote(R) (divalproex sodium), taking a higher starting dose of Lamictal XR than a healthcare provider prescribed or...

FDA Grants Approval for Use of RISPERDAL(R) CONSTA(R) as Both a Monotherapy and Adjunctive Therapy in the Maintenance Treatment of Bipolar I Disorder

...plications (sNDAs) for the use of RISPERDAL(R) CONSTA(R) (risperidone) Long-Acting Treatment as both monotherapy and adjunctive therapy to lithium or valproate in the maintenance treatment of Bipolar I Disorder. Bipolar Disorder is a brain disorder that causes unusual shifts in a person's mood, energy a...

FDA Approves Lamictal(R) ODT(TM) Orally Disintegrating Tablets

...gher chance of getting this serious skin reaction while taking Lamictal. The risk of getting a rash is higher if taking Lamictal while taking valproate (Depakene(R) (valproic acid) or Depakote(R) (divalproex sodium)), taking a higher starting dose of Lamictal than a healthcare provider prescribed ...

Epilepsy Drug Impairs Baby's Intelligence

... When taken during pregnancy, valproate lowers IQ, study finds,,,, WEDNESDAY, ...when tested at age 3, children who were exposed to valproate in the womb had IQ scores up to nine points lower ...chool of Medicine in Atlanta. "We don't think that valproate should be used as a first choice for any woman of ...
Valproate in Medical Technology

New Data Published in Neurology Show Once-Daily Lamictal XR Significantly Reduced Partial Seizures in Patients with Epilepsy

...as young as 2 years and 2) for conversion to monotherapy in adults with partial seizures taking carbamazepine, phenytoin, phenobarbital, primidone, or valproate as the single AED. Safety and effectiveness of Lamictal have not been established 1) as initial monotherapy, 2) for conversion to monotherapy from AE...

New Data Shows Once a Day Lamictal XR is Effective in Treating Patients with Partial Seizures

...as young as 2 years and 2) for conversion to monotherapy in adults with partial seizures taking carbamazepine, phenytoin, phenobarbital, primidone, or valproate as the single AED. Safety and effectiveness of Lamictal have not been established 1) as initial monotherapy, 2) for conversion to monotherapy from A...
Valproate in Medical Products

Free Valproate

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
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Valproate in Biological News

Epilepsy drug shows potential for Alzheimer's treatment

...ath of nerve cells in the brain linked to many forms of dementia. Sodium valproate - which is marketed as the anti-seizure drug Epilim - has been shown by sci...y to double within a generation unless new treatments are found. Sodium valproate has been used for many years to suppress epileptic seizures and the many su...

NARSAD announces 2008 Prizes for Outstanding Achievement in Research on Mental Health Disorders

...rials, leading to their approval by the Food and Drug Administration (FDA) and wide dissemination to patients. These have included the anticonvulsants valproate (Depakote) and lamotrigine (Lamictal), and the atypical antipsychotic quetiapine (Seroquel). These agents have vastly enlarged our treatment armamenta...

Researchers seek to design first treatment for neuroAIDS

... suicide. Maggirwar was the first to theorize that interfering with this pathway could protect against neuroAIDS, and to prove his theory using sodium valproate and lithium, existing epilepsy drugs that turned out to be GSK-3b inhibitors. Gelbard and Maggirwar; along with received in 1999 one of the first gr...

'Smart' genetic therapy helps the body to heal itself

...rived from SMA patients. Later, they showed that valproate also raised SMN levels in neuronal tissues such as... ten parents of SMA patients who were treated with valproate for four months. We saw that valproate significantly increased SMN levels in blood. Bas...

Molecular mechanism may explain how fevers spark seizures

...le seizures or not?" Macdonald said. Several studies have investigated treating children with anti-seizure medications such as phenobarbital or sodium valproate to prevent recurrent febrile seizures, but the studies showed only limited benefit to the approach, Macdonald said. "That idea has gone by the way...
Valproate in Biological Technology

Multiple Vimpat(R) (lacosamide) Studies Presented at American Epilepsy Society Annual Meeting

...gine (31.2 percent), levetiracetam (29.0 percent), valproate (23.6 percent), and topiramate (22.3 percent). At ...vetiracetam (37.6 percent vs. 17.6 percent) -- valproate (45.3 percent vs. 21.3 percent) -- Topiramate ...vetiracetam (43.4 percent vs. 19.4 percent) -- valproate (47.5 percent vs. 26.9 percent) -- Topiramate ...

Beyond Seizure Control in the Treatment of Epilepsy With New Anti-Epileptic Drug, Zebinix(TM)

...seizures. New England Journal of Medicine 313:145-151, 1985. (14). Mattson, RH, Cramer, JA, et al, VA Cooperative Study Group. A comparison of valproate with carbamazepine for the treatment of partial seizures and secondarily generalized tonic-clonic seizures in adults. New England Journal of Medicine,...
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