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Vaccinia in Medical News

Transplant drug stimulates immune memory

...tor of the Emory Transplant Center and chair of the Department of Surgery, to show that rapamycin had similar effects in rhesus macaques infected with vaccinia virus as in mice. That research was conducted at Emory's Yerkes National Primate Research Center. Rapamycin, also called sirolimus, was approved by...

Aethlon Medical Discloses New HIV/AIDS Treatment Data

...ever (EHF), Lassa hemorrhagic fever (LHF), H5N1 avian influenza (Bird Flu), the reconstructed 1918 influenza virus (r1918), West Nile virus (WNV), and vaccinia and Monkeypox (MPV), which both serve as models for human smallpox infection. The studies were conducted with the assistance of researchers represent...

Aethlon Medical Confirms Hemopurifier(R) Is a Treatment Candidate Against Swine Flu Virus

...ever (EHF), Lassa hemorrhagic fever (LHF), H5N1 avian influenza (Bird Flu), the reconstructed 1918 influenza virus (r1918), West Nile virus (WNV), and vaccinia and Monkeypox (MPV), which both serve as models for human smallpox infection. The studies were conducted with the assistance of researchers represent...

Aethlon Medical Announces Engagement of RedChip Companies to Initiate Investor and Media Relations Programs

...ever (EHF), Lassa hemorrhagic fever (LHF), H5N1 avian influenza (Bird Flu), the reconstructed 1918 influenza virus (r1918), West Nile virus (WNV), and vaccinia and Monkeypox (MPV), which both serve as models for human smallpox infection. The studies were conducted with the assistance of researchers representi...

Aethlon Medical Announces CEO Interview and Corporate Presentation Available Online

...ever (EHF), Lassa hemorrhagic fever (LHF), H5N1 avian influenza (Bird Flu), the reconstructed 1918 influenza virus (r1918), West Nile virus (WNV), and vaccinia and Monkeypox (MPV), which both serve as models for human smallpox infection. The studies were conducted with the assistance of researchers representi...

Different type of colon cancer vaccine reduces disease spread, Jefferson scientists show

...em and be useful for anti-cancer vaccines. Dr. Waldman, postdoctoral fellow Adam Snook, Ph.D., and their colleagues engineered viruses adenovirus, vaccinia and rabies to express the protein guanylyl cyclase C (GCC), which is normally found in the intestinal lining (and in metastatic colon cancer). The re...

JCI online early table of contents: April 8, 2008

...(ECTV). Indeed, TLR9-deficient mice succumbed to much lower doses of ECTV than did normal mice. By contrast, the strongly attenuated poxvirus modified vaccinia virus Ankara (MVA) induced both TLR9-dependent and TLR9-independent immune responses. It was then found that the ability of MVA to induce TLR9-indepen...

Nanoemulsion vaccines show increasing promise

...s vaccine because it would use nanoemulsion-killed vaccinia virus, says Baker. Anna U. Bielinska, Ph.D., a ...e immunity. When the mice were exposed to live vaccinia virus to test the vaccines protective effect, all ...id. The researchers conclude that the nanoemulsion vaccinia vaccine offers protection equal to that of the exi...

Researchers discover new battleground for viruses and immune cells

...une system arsenal. The scientists labeled the T cells with a fluorescent marker, injected them back into the mice, and then infected the animals with vaccinia virus, the virus used to make smallpox vaccine, engineered to express a brilliantly colored protein. Using a multiphoton microscope, a highly spe...

American Chemical Society's Weekly PressPac -- Jan. 30, 2008

... used to compare proteins produced by both monkeypox virus (MPV) and by the vaccinia virus (VV), which is the basis for current smallpox vaccines. The researche...E #3 FOR IMMEDIATE RELEASE Comparative Proteomics of human Monkeypox and vaccinia Intracellular Mature and Extracellular Enveloped Virions DOWNLOAD FULL TE...
Vaccinia in Medical Technology

Aethlon Medical to Present at the 2009 RedChip Small-Cap Investor Conference on June 16, 2009

...ever (EHF), Lassa hemorrhagic fever (LHF), H5N1 avian influenza (Bird Flu), the reconstructed 1918 influenza virus (r1918), West Nile virus (WNV), and vaccinia and Monkeypox (MPV), which both serve as models for human smallpox infection. The studies were conducted with the assistance of researchers represent...

GeoVax Starts Injections for Phase 2a Human HIV/AIDS Vaccine Trial in USA

... of experience and knowledge in human vaccine development." GeoVax's unique two component vaccine, a recombinant DNA and a recombinant modified vaccinia Ankara (MVA), is designed to stimulate both anti-HIV T cell and anti-HIV antibody immune responses. Stimulation of both T cells and antibodies differ...

GeoVax's Phase 2a HIV/AIDS Vaccine Human Trials to Begin in North and South America

...ts will first be administered a GeoVax HIV-1 DNA vaccine which "primes" the immune system followed by the second vaccine, GeoVax's HIV-1 MVA (Modified vaccinia Virus) boost. Both vaccines express the three major proteins of the AIDS virus. These proteins mimic more than 50% of the components of the AIDS virus...

Bavarian Nordic Reports Successful Safety Data From Phase II Study With IMVAMUNE(R)

...E(R) in a declared emergency. In support of using IMVAMUNE(R) as a smallpox vaccine in individuals otherwise contraindicated to receive conventional vaccinia vaccines, Bavarian Nordic has performed a large Phase II study in HIV infected subjects with CD4 counts between 200 and 750 cells/microl to compare th...

Karolinska Institutet to Test Vical's Vaxfectin(R) Adjuvant With Preventive Vaccine against HIV Under Sponsorship of Swedish Institute for Infectious Disease Control

... virus. The HIV DNA vaccine was developed by the SMI and the Karolinska Institutet in Sweden. The viral vector boost vaccine component uses a Modified vaccinia Ankara (MVA) virus (the virus that causes cowpox) to shuttle the same non-infectious gene sequences into the body. The boost vaccine component was dev...

Karolinska Institute to Test Vical's Vaxfectin(R) Adjuvant with Preventive Vaccine against HIV Under Sponsorship of Swedish Institute for Infectious Disease Control

...s virus. The HIV DNA vaccine was developed by the SMI and the Karolinska Institute in Sweden. The viral vector boost vaccine component uses a Modified vaccinia Ankara (MVA) virus (the virus that causes cowpox) to shuttle the same non-infectious gene sequences into the body. The boost vaccine component was dev...

AlphaVax Continues to Expand the Use of Its Vaccine Platform

...oteins, could provide humoral responses comparable to those obtained with a licensed vaccine. Furthermore, the AlphaVax vaccine protected mice against vaccinia virus challenge and non-human primates against a lethal challenge with monkeypox virus. The details of this work will be presented by Dr. Kurt Kamrud,...

GeoVax Labs, Inc. Reports Fourth Quarter and Year-End 2007 Financial Results

...Trial participants will be administered GeoVax HIV-1 DNA vaccine which "primes" the immune system followed by GeoVax's HIV-1 MVA (Modified vaccinia Virus) boost. Both vaccines deliver over 50% of the AIDS virus components but can not cause AIDS. Safety and immunological results from earlie...

GeoVax Labs, Inc. Third Quarter Financial Results and Operational Update

...Trial participants will be administered GeoVax HIV-1 DNA vaccine which "primes" the immune system followed by GeoVax's HIV-1 MVA (Modified vaccinia Virus) boost. Both vaccines deliver over 50% of the AIDS virus components but cannot cause AIDS. Safety and immunological results from earlier...

Tumor Eradication Article Published by Cancer Research

...Tumors in Nude Mice with an Intravenously Injected Light-Emitting Oncolytic vaccinia Virus," documents animal studies that have resulted in complete eradication...cancer cells without harming healthy tissues or organs. GL-ONC1 is based on vaccinia virus, which was used safely in millions of people as the vaccine against s...
Vaccinia in Medical Dictionary

Virus

...ically ... Description: Four DEN-1 virus strains were isolated from humans with classical ... Parent: Dengue virus type 1 ... Like the major vaccinia virus (VV) core protein precursors, p4b and p25K, the 25 ... The mutant virus was designed to have Tet operator in front of A12L open reading .....

Vaccination

...tion is contraindicated for certain groups. ... anti- vaccination information and nationwide support groups ... Vaccinated people can transmit vaccinia virus ... Complications of smallpox vaccination , Maryland 1968. ... Global Insight's unique perspective provides the most comprehensive econ...
Vaccinia in Biological News

Study characterizes eczema patients most at risk for dangerous viral infections

...r institutions in the NIH-funded Atopic Dermatitis vaccinia Network. The findings, published June 25 in the on...ead infections of their skin by herpes simplex and vaccinia viruses. The herpes simplex virus is common but on...x skin infection is known as eczema herpeticum. vaccinia virus, which is used in smallpox vaccinations, can...

New study indicates smallpox vaccination effective for decades

...at in the event of a smallpox bioterrorist attack, vaccinia smallpox vaccine should be used first on individua...ination or smallpox were included. Although the vaccinia virus vaccine was used since the late 18th century...be protective levels of neutralizing antibodies to vaccinia indefinitely and do not require booster vaccinatio...

A step forward in virology

... The vaccinia virus has a problem: it is a giant among viruses a...n strategy In order to infiltrate a cell, the vaccinia virus exploits the cellular waste disposal mechani...oon as the cell dies and is broken into parts. The vaccinia virus itself also car-ries this official waste tag...

Ugandan monkeys harbor evidence of infection with unknown poxvirus

...es to characterize the virus. An initial screening for antibodies to the vaccinia virus yielded positive results in about one-quarter of the monkeys tested. ...ted the monkeys looked a little bit like monkeypox virus, a little bit like vaccinia virus, a little bit like cowpox virus, but not exactly like any of them, he...

Tips from the Journals of the American Society for Microbiology

...acy in mice challenged with smallpox. Wyeth IL-15 included a strain of the vaccinia virus derived from the Dryvax vaccine and MVA IL-15 incorporated a modified strain of the vaccinia virus Ankara which is currently being considered as a substitute for the Dr...

Genetic factors are linked to fever following smallpox vaccination

...ctions that range from fatigue to serious illness. In recent studies testing the safety and potency of stored smallpox vaccine, which uses live vaccinia virus, some individuals developed fevers. The authors of the study, Samuel L. Stanley Jr., MD, and colleagues at Washington University, St. Louis Uni...

A new tool against brain disease

... also activated in the T cells of people with Epstein-Barr virus, which is a persistent infection, but much lower on T cells of persons immunized with vaccinia virus, a live virus vaccine against smallpox that is effectively cleared by the immune system. According to Walker, those findings indicate that activ...

How HIV 'exhausts' killer T cells

... also activated in the T cells of people with Epstein-Barr virus, which is a persistent infection, but much lower on T cells of persons immunized with vaccinia virus, a live virus vaccine against smallpox that is effectively cleared by the immune system. According to Walker, those findings indicate that activ...

Cyclosporine inhibits hepatitis C virus in vitro

...dication is Tacrolimus, although Cyclosporine is also used. The latter drug has been shown to have anti-viral activity against HIV, herpes simplex and vaccinia virus, leading researchers to speculate it might also inhibit hepatitis C virus. To examine this hypothesis, they analyzed the impact of the drug in a...

Novel virus entry mechanism could lead to new drugs against poxviruses

...ibes how the Imperial College London team discovered the mechanism allowing vaccinia virus to shed its outer lipid membrane and enter cells. The mechanism is un...re to be released into the cell. In contrast, the extracellular form of vaccinia virus has two lipid membranes, meaning a single fusion event will not relea...
Vaccinia in Biological Technology

GeoVax Labs, Inc. Provides Clinical Studies Update

...y the ultimate safety of the vaccine. The Technology GeoVax's unique two component vaccine, a recombinant DNA and a recombinant modified vaccinia Ankara (MVA), is designed to stimulate both anti-HIV T cell and anti-HIV antibody immune responses. Stimulation of both T cells and antibodies differe...

Aethlon Medical Announces Data Supported Strategy to Increase Hepatitis-C (HCV) Cure Rates

...ever (EHF), Lassa hemorrhagic fever (LHF), H5N1 avian influenza (Bird Flu), the reconstructed 1918 influenza virus (r1918), West Nile virus (WNV), and vaccinia and Monkeypox (MPV), which both serve as models for human smallpox infection. The studies were conducted with the assistance of researchers represent...

New study indicates smallpox vaccination effective for decades

...at in the event of a smallpox bioterrorist attack, vaccinia smallpox vaccine should be used first on individua...ination or smallpox were included. Although the vaccinia virus vaccine was used since the late 18th century...be protective levels of neutralizing antibodies to vaccinia indefinitely and do not require booster vaccinatio...

New study indicates smallpox vaccination effective for decades

...at in the event of a smallpox bioterrorist attack, vaccinia smallpox vaccine should be used first on individua...ination or smallpox were included. Although the vaccinia virus vaccine was used since the late 18th century...be protective levels of neutralizing antibodies to vaccinia indefinitely and do not require booster vaccinatio...

Peregrine Pharmaceuticals Reports Studies Published in 'Science' Highlight Key Role of Phosphatidylserine (PS) in Viral Infections

... CEO of Peregrine. "In particular, we believe that the paper discussing the vaccinia virus(1) independently confirms some of the key mechanisms underlying the a...s with advanced solid tumors, and Phase II cancer trials are underway. 1. vaccinia Virus Uses Macropinocytosis and Apoptotic Mimicry to Enter Host Cells, Jaso...

Nanoemulsion vaccines show increasing promise

...s vaccine because it would use nanoemulsion-killed vaccinia virus, says Baker. Anna U. Bielinska, Ph.D., a ...e immunity. When the mice were exposed to live vaccinia virus to test the vaccines protective effect, all ...id. The researchers conclude that the nanoemulsion vaccinia vaccine offers protection equal to that of the exi...

Nasal Vaccine for Smallpox Confers High Levels of Immunity Without Safety Risks

...Michigan have demonstrated their nasally delivered vaccinia vaccine can protect animals against 77 times the p...the safety risks of current vaccines for smallpox. vaccinia virus is related to smallpox virus and builds immu...gh level of safety because it contains inactivated vaccinia virus, not the live virus contained in current sma...

Oncolytics Biotech Inc. Announces Issuance of 8th Canadian Patent

...e claims describe methods of selectively removing cancer cells ex vivo from blood stem cells and other organs using various viruses including modified vaccinia viruses, herpes simplex viruses, parapoxviruses and adenoviruses. "This patent broadens coverage in the area of using other modified oncolytic virus...

Transgene's Therapeutic Vaccine TG4010 Shows Promising Preliminary Phase IIb Data in Advanced Non-Small Cell Lung Cancer

...the second quarter of this year and final data by the fourth quarter of 2008." About TG4010 cancer vaccine TG4010 (MVA-MUC1-IL2) uses the Modified vaccinia Ankara virus vector, a poxvirus that combines distinguishing advantages for an optimized systemic vaccination: - MVA is a highly attenuated strain w...

Government Expands Trial With IMVAMUNE(R) Smallpox Vaccine in Persons With Atopic Dermatitis/Eczema

...dvised not to be given the smallpox vaccine.(3) Bavarian Nordic's new, patented developmental smallpox vaccine, IMVAMUNE(R), is based on the Modified vaccinia Ankara (MVA) virus. In contrast to traditional smallpox vaccines, MVA is a live virus that does not replicate in human cells which means that the pote...
Vaccinia in Biological Products

ScriptCap m7G Capping System from EPICENTRE Biotechnologies

Description:... ScriptCap™ m7G Capping system features the vaccinia capping enzyme and all of the components needed to produce a Cap 0 on the end of di- or triphosphate RNA transcripts. These kits feature high efficien...
Company:EPICENTRE Biotechnologies

Vaccinia DNA Topoisomerase I from EPICENTRE Biotechnologies

Description:... Topoisomerase I from vaccinia virus is a type I eukaryotic topoisomerase that removes both positive and n.... The protein has a molecular weight of 32000. Unit Definition: One unit of vaccinia Topoisomerase I will convert 1 m g of supercoiled DNA (Form 1) to relaxed c...
Company:EPICENTRE Biotechnologies

Vaccinia DNA Topoisomerase I from EPICENTRE Biotechnologies

Description:... Topoisomerase I from vaccinia virus is a type I eukaryotic topoisomerase that removes both positive and n.... The protein has a molecular weight of 32000. Unit Definition: One unit of vaccinia Topoisomerase I will convert 1 m g of supercoiled DNA (Form 1) to relaxed c...
Company:EPICENTRE Biotechnologies
Vaccinia in Biological Definition

Vaccine

...y to a disease, in order to prevent or ameliorate the effects of infection by any natural or 'wild' strain of the organism. The term derives from vaccinia , the infectious viral agent of cowpox , which, when administered to humans, provided them protection against smallpox . Contents showTocT...
Vaccinia in Biological Dictionary

Synapton

...ysics of Complex System, Weizmann ... Horesh O, Simchen G, Friedmann A: Morphogenesis of the synapton during yeast meiosis. ... Smallpox Vaccine, vaccinia Vaccine. Snap Back® Sodium Bicarbonate ... Synagis™ Synalar® Synalgos®-DC. Synapton ® Synemol® Synercid® Synthroid® Syntocinon® ... Home About Us ...

Concatemer

... sequences linked in series ... composed of DNA from each strand of the concatemer junction. ... is proposed to account for resolution of the vaccinia virus concatemer junction. ... ... strand exchange of the concatemer junctions (deLange and McFadden, 1990) ... However, the model of mp1 ...
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