Pluronic L-81 is a potential anti-diabetic drug?
... and propylene oxide. It has been reported that a nonionic L-81, effectively inhibits absorption of dietary lipids from the intestine and secretion of vldl
and LDL from the liver. Although L-81 is a potent anti-obesity drug, its potential in alleviating obesity-induced insulin resistance and type 2 diabet...
JCI online early table of contents: March 9, 2009
...ecause these mice also had reduced levels of the fat transporting molecules vldl
and LDL in the blood. The results of further analysis using additional mous...ases the secretion of VLDL.
TITLE: Hepatic insulin signaling regulates vldl
secretion and atherogenesis in mice
Pittsburgh scientists find protein may be key to new therapies for elevated triglycerides
... of insulin to regulate the activity of FoxO1, led to the overproduction of vldl
and hypertriglyceridemia in mice. Mice that were made to be deficient in FoxO1 in the liver experienced reduced MTP and vldl
Having determined FoxO1s role in the liver, Childrens resear...
JCI table of contents: May 22, 2008
...s triglycerides and the triglyceride-rich molecule vldl
are risk factors for heart disease and diabetes. vldl
production is dependent on both the regulator of b...a relationship between the liver protein FoxO1 and vldl
Using cultured human liver cell...
Grapefruit compound may help combat hepatitis C infection
... hitching a ride onto the natural lipoprotein-cholesterol metabolic pathway. Since earlier evidence has shown that naringenin can reduce secretion of vldl
from liver cells, the researchers examined whether the compound might also lower HCV secretion from infected cells. Their experiments confirmed that n...
New Health Corp. Introduces Heart Savior(TM), the Ultimate Natural Heart Health Product
...ula was found to be effective in improving several aspects of
blood lipids. This study showed Heart Savior lowered LDL (bad) cholesterol
by up to 34%, vldl
up to 76%, triglycerides up to 76% and total cholesterol
up to 28%, while helping to improve circulatory health.
"As a Cardiac Surgeon, I'm often he...
GlaxoSmithKline Obtains Exclusive U.S. OTC Marketing Rights to MEVACOR(R) (lovastatin) from Merck & Co., Inc.
...the major abnormality (Type IIb
hyperlipoproteinemia), it has not been studied in conditions where the
major abnormality is elevation of chylomicrons, vldl
or IDL (i.e.,
hyperlipoproteinemia types I, III, IV, or V).***
The NCEP classification of cholesterol levels in pediatric patients with a
How Good Are Vitamins For You ?
...ipid peroxides and decreases levels of VLDL, or very low density lipoprotein, and LDL, or low-density lipoprotein. After its secretion from the liver, vldl
is converted in the bloodstream to LDL, the so-called bad form of cholesterol. The liver is the major source of lipoproteins that block arteries.
Atherotech Receives Patent for ApoB Measurement
...er in Sandy, Utah. Cobble is a primary care physician, board-certified lipidologist and certified hypertension specialist. "It aligns with non-HDL and vldl
more accurately and is an important treatment target recently confirmed by both the American College of Cardiology and the American Diabetes Associati...
VAP Cholesterol Test Helps In Search For New Heart Disease Drugs
...mproved lipid profile of mutation carriers included: significantly lower levels of non-HDL, very low density lipoprotein (VLDL), VLDL3 (the most-dense vldl
subfraction), intermediate density lipoprotein (IDL), real LDL, and remnant lipoprotein cholesterol. Higher (cardioprotective) levels of both HDL2 and...
VAP(R) Cholesterol Test Helps Researchers Identify Treatment Effects of Combination Therapy
...nd fenofibrate, both
as separate therapy and in coadministration, produced beneficial changes in
the distribution of lipoprotein subclasses within the vldl
to LDL density
range. The combination of ezetimibe/simvastatin + fenofibrate produced
greater reductions in VLDL, IDL, and LDL (relative to other trea...