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VIII in Medical News

Analysis of Four Large Post-Marketing Surveillance Studies Describe Clinical Effects of Sucrose-Formulated Recombinant Factor VIII

BOSTON, July 13 /PRNewswire/ -- New data pooled from four large, "real world" post-marketing surveillance studies showed that sucrose-formulated recombinant factor VIII (rFVIII-FS) reduced bleeding and provided data regarding adverse events in more than 950 patients with mild-to-severe hemophilia ...

FDA Approves New 3000 IU Vial Size for Kogenate(R) FS, antihemophilic factor (recombinant)

...or safe reconstitution and fast recombinant factor viii treatment in a small, tamper-evident box with anti...lic factor (recombinant) , is a recombinant factor viii treatment indicated for the control and prevention...hilia A Hemophilia A, also known as factor viii deficiency or classic hemophilia, is largely an in...

Bayer HealthCare Announces Recipients of 2009 International Hemophilia Nursing Fellowship

... and Thailand to Australia and Argentina. For more information visit: www.wfh.org . About Hemophilia A Hemophilia A, also known as factor viii deficiency or classic hemophilia, is largely an inherited bleeding disorder in which one of the proteins needed to form blood clots in the body is mis...

Bayer HealthCare Awards $2.5 Million to Advance Hemophilia Research and Improve Patient Care

... to develop neutralizing antibodies (inhibitors) against replacement Factor viii proteins. In another study, Early Career Investigator Award recipient Micha...wards.com . About Hemophilia A Hemophilia A, also known as factor viii deficiency or classic hemophilia, is largely an inherited bleeding disorder...

Bayer HealthCare Launches Hemophilia Self-Infusion Training Program

...ve designed to make infusion of recombinant factor viii easier for both patients with hemophilia A and for...educed levels of the blood clotting protein factor viii leading to prolonged or uncontrolled bleeding epis...of this disease may require the infusion of factor viii therapy sometimes once, twice or three times per w...

Wyeth Pharmaceuticals and Catalyst Biosciences Announce Agreement to Develop and Commercialize Factor VIIa Products

...digit royalties on sales of products resulting from the collaboration. "This collaboration serves as an excellent fit with our recombinant Factor viii and Factor IX hemophilia products and provides us with an opportunity to expand Wyeth's hemophilia franchise," says Mikael Dolsten, President, Wyeth R...

Strides Made in Hemophilia Research

...tic gene become inserted into the genome of the targeted cells. Fifty weeks after the treatment, mice injected with these nanoparticles had Factor viii levels that were the same as those of normal mice. Bleeding times were also similar to those of normal mice. According to a news release from the j...

Experts reach consensus on diagnosis and treatment of bleeding disorders in women

...ults from a deficiency in, or a dysfunction of, von Willebrand factor (VWF), a protein necessary for normal platelet adhesion and protection of factor viii (FVIII) from proteolysis in the circulation. The prevalence of menorrhagia in women with VWD is 74-92%. Although the majority of women who present ...

Patient Convenience Focus of New Upgrades to HeliTrax System by CSL Behring

...fective blood coagulation proteins known as factor viii or factor IX. The most common form of the disease ...classical hemophilia, in which the clotting factor viii is either deficient or defective. Hemophilia B is ...t Helixate FS Helixate FS is a recombinant factor viii product indicated for the treatment of hemophilia ...

CSL Behring Marks World Hemophilia Day with $2M Coagulation Factor Donation to World Federation of Hemophilia

...L Behring has committed to donating to WFH two (2) million units of factor viii concentrate (FVIII) each year for the next three (3) years. The donation, t...very pleased to announce it on World Hemophilia Day 2009." Factor viii is an essential blood clotting factor. FVIII is concentrated from donated b...
VIII in Medical Technology

Clinical Data Suggest Decreased Bleeding Risk in People With Severe Hemophilia A While Maintaining Factor VIII Levels Above One Percent

Results Highlighted in Oral Presentation at International Symposium of Thrombosis and Haemostasis GENEVA, July 10, 2007 /PRNewswire-FirstCall/ -- Baxter Healthcare Corporation today announced the presentation of findings from the ADAPT (Analysis of Data from ADVATE(R) Prospective Trials) study pro...

Inspiration Biopharmaceuticals, Inc. Initiates Phase 1 Clinical Trial of IB1001 for the Treatment of Hemophilia B

...xcess of seven billion dollars annually. There are two types of hemophilia, hemophilia A and hemophilia B. Hemophilia A is caused by a lack of Factor viii and hemophilia B is caused by a deficiency of Factor IX. About Inspiration Biopharmaceuticals Inspiration Biopharmaceuticals was founded in ...

Jennerex Treats First Patients in Phase 2 JX-594 Trial for Liver Cancer

...tis B (Hepavax), the first Epidemic Hemorrhagic Fever vaccine and the world's second chicken pox vaccine. Green Cross is developing recombinant Factor viii and Factor IX for hemophilia, Hepatitis B Immunoglobulin monoclonal antibody for liver transplantation, anticancer drugs such as Greenstatin (anti-ang...

Pivotal Phase III Data Confirm the Efficacy and Safety of Arpida's Intravenous Iclaprim in Treating Patients With Complicated Skin and Skin Structure Infections

... MRSA Surveillance Summary 2007. Available at http://www.cdc.gov/ncidod/dhqp/ar_mrsa_surveillanceFS.html . Accessed October 22, 2008. viii Kuehnert MJ et al. Emerging Infectious Diseases 2005; 11: 868-72. ix Klevens, RM et al. Journal of the American Medical Association. 2007;...

FDA Approves Bayer HealthCare's Kogenate(R) FS Treatment for Routine Prophylaxis in Children with Hemophilia A

...roval provides these patients with the only factor viii treatment that the FDA has determined safe and eff...he FDA approval of Kogenate FS as the first factor viii treatment product in the U.S. to be used to replenish factor viii levels in a prophylactic manner marks a significan...

Bayer HealthCare Celebrates 20th Anniversary of Kogenate(R) Product Line and 8 Billion IU Milestone at 2008 WFH World Congress

...n Bonn, Germany. This advent of recombinant factor viii technology represented a leap forward in the deliv...only company with a long-acting recombinant factor viii protein in human clinical trials. We are also crea...ilic Factor [Recombinant]) is a recombinant factor viii treatment indicated for the treatment of hemophili...

Catalyst Biosciences Selects Drug Development Candidate in Factor VIIa Program for Hemophilia

...ficiency of a protein required for normal blood coagulation, such as factor viii (hemophilia A) or factor IX (hemophilia B) in addition to factor VIIa for r...umber of hemophilia A patients develop inhibitory antibodies against factor viii and therefore become refractory to this treatment. These patients are then ...

Inspiration Biopharmaceuticals Announces Filing of IND for Novel Recombinant Factor IX Product, IB1001, for the Treatment of Hemophilia B

...which only 25% currently receive therapy. There are two types of hemophilia, hemophilia A and hemophilia B. Hemophilia A is caused by a lack of Factor viii and hemophilia B is caused by a deficiency of Factor IX. About Recombinant Protein Manufacturing Technology Inspiration Biopharmaceuticals uses nove...

Neose Announces Presentation of Positive Preclinical Data on GlycoPEGylated Factor VIIa at the XXI Congress of the International Society on Thrombosis and Haemostasis

...and for the prevention of bleeding during surgery or invasive procedures in patients with congenital hemophilia with inhibitors to coagulation factors viii or IX. The worldwide market for recombinant Factor VII was approximately $1 billion in 2006, with Novo Nordisk being the only participant. About Neo...

Prothrombin Time Comes in Small (CLIA-Waived) Packages

... levels is necessary to plan or evaluate anticoagulant therapy, to diagnose various inherited conditions, such as hyperhomocystinemia, elevated factor viii levels, dysfibrinogenemia, factor XII deficiency and disorders of plasmin generation, and to assess acquired conditions, such as pregnancy, postoperat...
VIII in Medical Dictionary

Thromboembolism

...with Warfarin against Recurrent Venous Thromboembolism Original Article from The New England Journal of Medicine -- High Plasma Levels of Factor viii and the Risk of Recurrent Venous Thromboembolism Venous thromboembolism . BIBLIOGRAPHIC SOURCE(S) ... for venous thromboembolism are presen...

Hemophilia A

...ugh all ... Hemophilia A is characterized by deficiency in factor viii clotting activity ... Individuals with moderately severe hemophilia A s... the gene. ... Patients with severe hemophilia A (hereditary factor viii deficiency) continue ... It is possible that a significant number of hemop...

Hemophilia

...icle about haemophilia , a hereditary genetic illness that impairs the body's ability to control bleeding. Deficiency in coagulation factor viii is the most common cause of hemophilia . ... Hemophilia is quite rare, with only about 1 instance in every 10,000 births (or ... In severe ...

Factor VIII assay

... Chromogenic assays for testing Factor viii :C activity in plasma or concentrates, ... Factors Affecting the Factor viii :C Reactivity When Tested in Purified Systems ... Factor viii assay . Contents of this page: Alternative Names...

Compress

...LZ78. Professional software for the design and analysis of ASME Section viii pressure vessels and heat exchangers. ... The COMPRESS 2008 Verification ...d ... Professional software for the design and analysis of ASME Section viii pressure vessels and TEMA UHX heat exchangers. ... COMPRESS Overview ... ...
VIII in Biological News

Work in mice will contribute to the study of hereditary diseases that lead to blindness

...wise, some of the results obtained have been presented in oral communications and posters in different national and international scientific meetings: viii European Meeting on Glial Cell Functions in Health and Disease (Londres), VII European Meeting on Glial Cell Functions in Health and Disease (Amsterda...

UT scientist receives hemophilia research award

...shortage of a blood-clotting protein called Factor viii and current treatments include injections of synth...e systems that are resistant to replacement Factor viii and produce antibodies that attack the synthetic p...lls that trigger the production of the anti-Factor viii antibodies in people with Hemophilia A, which in t...

Removing DNA repair gene causes metabolic syndrome

...orts to clone and crystallize homologs to the Escherichia coli endonuclease viii gene. E. coli endonuclease viii is part of a pathway of enzymes involved in repairing DNA damaged by free r...

HIV inserts into human genome using a DNA-associated protein

...erapy delivery. Retroviral vectors are often used to introduce therapeutic genetic sequences into human chromosomes, such as in the delivery of Factor viii for hemophilia patients. HIV integrates into active transcription units on chromosomes within the nucleus of human cells. These units are sites th...

Promising therapies for haemophilia & heart disease

...Australian males is born with haemophilia in severe, moderate or mild form. People with haemophilia rely on intravenous infusion of recombinant Factor viii clotting protein. Professor Denisa Wagner and her Harvard colleagues have made ground-breaking discoveries that provide hope of an alternative treat...

Gene therapy advance treats hemophilia in mouse models

...o have Hemophilia A, which is also known as factor viii deficiency. The findings appear in the Sept. 1 iss...mutation that leaves them with little to no factor viii protein to prevent uncontrolled bleeding. Individu...therapy because if you could just raise the factor viii activity from less than 1 percent of normal to wit...

Redesigned protein accelerates blood clotting

...reatment consists of genetically engineered factor viii administered by injection, but one quarter of those born with no factor viii suffer severe immune reactions that render the tre... Center have been studying the structure of factor viii for 20 years, and are making subtle changes in the...
VIII in Biological Technology

China Biologic Receives SFDA Approval for Clinical Trial of Human Coagulation Factor VIII

TAIAN CITY, Shandong, China, Sept. 17 /Xinhua-PRNewswire-FirstCall/ -- China Biologic Products, Inc. (OTC Bulletin Board: CBPO) ("China Biologic" or the "Company"), one of the leading plasma-based pharmaceutical companies in the People's Republic of China ("PRC"), today announced that the Comp...

Inspiration Biopharmaceuticals Presents Safety Data on IB1001, a Novel Recombinant Factor IX for the Treatment of Hemophilia at the International Society on Thrombosis and Haemostasis (ISTH) Annual Meeting

...cess of seven billion dollars annually. There are two types of hemophilia, hemophilia A and hemophilia B. Hemophilia A is caused by a lack of Factor viii and hemophilia B is caused by a deficiency of Factor IX. About Inspiration Biopharmaceuticals Inspiration Biopharmaceuticals was found...

VIRxSYS Publishes New Study on RNA Therapy

...ed the liver to make more apoA-I protein than it normally does, and in separate experiments we instructed the liver to make the correct form of Factor viii instead of a mutated form. We also added an RNA molecule that makes a monoclonal antibody that is not normally produced in liver," said VIRxSYS Execut...

Catalyst Biosciences Expands Scientific Advisory Board With Leading Experts in Protease Therapeutic Discovery and Development

...ers of thrombotic diseases, including the common human mutation Factor V Leiden. Studies of the bleeding disease combined deficiency of factors V and viii by the Ginsburg lab identified mutations in two genes that define a novel pathway for the transport of a select subset of proteins from the ER to the ...

ThromboGenics and BioInvent Start Phase II Trial of TB-402, a Novel, Long Acting Anticoagulant for Deep Vein Thrombosis (DVT) Prophylaxis

...swire-FirstCall/ -- - Trial to Assess the Benefits of Partial Factor viii Inhibition in Patients Undergoing Knee Replacement Surgery ThromboGe...iver important clinical benefits due to it only partially inhibiting Factor viii activity even when given in very high doses. This novel mode of action is e...

Lentigen and Expression Therapeutics Sign Hemophilia Co-Development Agreement

...otting disorder caused by a mutation in the factor viii gene resulting in a deficiency of factor viii protein. Lentigen and Expression Therapeutics will...treatments for Hemophilia: a novel chimeric factor viii protein for direct injection and a cell therapy th...

China Biologic Products Reports Strong Third Quarter 2008 Results

...eceived approval to commence clinical trial of Human Coagulation Factor viii product ("FVIII"), a coagulation treatment for hemophilia and mass hemo... received SFDA approval for the clinical trials of Human Coagulation Factor viii ("FVIII"), a coagulation treatment for hemophilia and mass hemorrhaging. It...

New Recombinant XYNTHA Now Available for Patients with Hemophilia A

...nt), Plasma/Albumin-Free, a new recombinant factor viii product for both the control and prevention of ble...pments of the Company's current recombinant factor viii product, ReFacto(R) Antihemophilic Factor (Recombi...ophilia A are deficient in a key protein -- factor viii -- that is vital in the clotting mechanism to prev...

CSL Behring's Innovative HeliTrax(SM) System Helps Physicians Manage Hemophilia A Patients

...-year-old son Tyler's severe hemophilia and Factor viii deficiency since October 2007. "I love it," says...ate(R) FS Helixate(R) FS is a recombinant factor viii treatment for hemophilia A that offers convenient ... with a 2.5 mL volume diluent; no available factor viii product has a smaller diluent size. The 2000 IU vi...

Video: CSL Behring Provides $1.2M Grant for World's First Study of Postpartum Women with VWD, Common Bleeding Disorder

...er they give birth." In all women, von Willebrand factor (VWF) and factor viii (FVIII) levels increase throughout the third trimester and then decrease to...od, von Willebrand Factor: Ristocetin cofactor activity (VWF:RiCoF), factor viii (FVIII) and von Willebrand factor antigen (VWF:Ag) levels will be measured....
VIII in Biological Products

Goat Anti-Human Factor VIII Polyclonal Antibody, Unconjugated from Abcam

Description: Goat polyclonal to Factor VIII, prediluted ( Abpromise for all tested applications). Antigen: Full length native protein (purified) (Human): Factor VIII from blood. Entrez GeneID: 2157 Swiss Protein ID: P00451...
Company:Abcam

Mouse Anti-EGFr VIII Antibody, Unconjugated from Invitrogen

Description: Request Info...
Company:Invitrogen

Human / Mouse / Rat Blood Vessels (CD31 / Von Willebrand Factor (vWF)) IHC staining Kit from CHEMICON

Description:...vWF only) tissues. • The most widely used endothelial cell markers for studying angiogenesis/neovascularization are von Willebrand Factor (Factor viii Related Antigen) and CD31 (PECAM-1). von Willebrand Factor is synthesized by endothelial cells, causing adhesion of platelets to injured vessel walls ...
Company:CHEMICON
VIII in Biological Definition

Collagen

...st interstitial tissue, assoc. with type I Type VI collagen - most interstitial tissue, assoc. with type I Type VII collagen - epithelia Type viii collagen - some endothelial cells Type IX collagen - cartilage, assoc. with type II Type X collagen - hypertrophic and mineralizing cartilage ...
VIII in Biological Dictionary

Stele

...mon. Smart Shopping at mySimon. Online Shopping at DirectTextBook.com - Save up to 80%, buy or rent. New and used books like La stele de Ptolemee viii Evergete II a Heracleion Underwater Archaeology... stele . Definition from Wiktionary, a free dictionary. Jump to: navigation, search. See also s...

Nucleon

...ns ... the two- nucleon system, the ... Online Shopping at DirectTextBook.com - Save up to 80%, buy or rent. New and used books like Antiproton 86 viii European Symposium on Nucleon Antinucleon Interactions... butions of the nucleon , as well as the steady rate of improvements made in the ... n...

Lenticel

...on of lenticel , meaning of lenticel , lenticel anagrams, lenticel synonyms ... Words starting with lenticel by next letter. Words ... ISHS viii International Mango Symposium EFFECT OF PACKHOUSE PROCEDURES ON LENTICEL DISCOLOURATION OF MANGOES ... can induce or reduce lenticel discolouratio...

Endonuclease

...f damaged ... IPR003651 Endonuclease III-like, iron ... Endonuclease viii from <em>E. coli</em> acts as both an N-glycosylase and an AP-lyase. ... Endonuclease viii Reaction Buffer (10X) Enzyme Properties. Heat ... <em>Tth</em&g...

Base modification

...ed . Yes, it is possible! ... I'm interested in all modification that will improve my quarter mile performance. ... ... Cohen's ride is a 98 Mark viii Base model with a factory roof, heated seats, and ... He is in the automotive aftermarket industry and knew the dealer so he ... RNA Base Modi...
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