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VEGFR in Medical News

Bayer to Present Data on Development Compound BAY 73-4506 at 45th Annual Meeting of the American Society of Clinical Oncology

... (TK). BAY 73-4506 has been shown to inhibit tumor growth in preclinical models by hitting targets along a spectrum of angiogenic pathways, including vegfr and TIE2. BAY 73-4506 has also been shown to prevent the proliferation of tumor cell lines while promoting apoptosis (cell death) by directly targeti...

Abbott to Present Data on Novel Cancer Treatments at American Society of Clinical Oncology Annual Meeting

...molecule that provides simultaneously potent and specific inhibition of the vegfr and PDGFR families. Both compounds were discovered by Abbott scientists and...molecule that provides simultaneously potent and specific inhibition of the vegfr and PDGFR families that is in Phase I clinical trials for solid tumors and ...
VEGFR in Medical Technology

Bayer Announces New Data on Novel Anti-cancer Compound BAY 73-4506

...TK). In preclinical studies, BAY 73-4506 has been shown to inhibit tumor growth by hitting targets along a spectrum of angiogenic pathways, including vegfr and TIE2. BAY 73-4506 has also been shown in preclinical studies to prevent the proliferation of tumor cell lines while promoting apoptosis (cell dea...

Millennium Presents New Data on Investigational Drugs for Novel Cancer Targets at EORTC-NCI-AACR Symposium

...a. -- Unique enzymatic profile of a potent and selective BEGFR/PDGFR tyrosine kinase inhibitor, TAK-593: potent pseudo-irreversibility against vegfr and PDGFR -- Lead investigator: H. Miki, Takeda Pharmaceutical Company, Japan -- Abstract #50: Poster -- TAK-593, a potent and selectiv...

Exelixis Reports XL647 Clinical Data at AACR-NCI-EORTC Conference

...24 /PRNewswire-FirstCall/ -- Exelixis, Inc. (Nasdaq: EXEL ) today reported updated data from a phase 2 study of XL647, an inhibitor of EGFR, HER2 and vegfr kinases, in previously untreated, clinically selected non-small cell lung cancer (NSCLC) patients. The data continue to show encouraging anti-tumor ac...

Updated Phase 1 Data for Exelixis' XL184 Demonstrate Pharmacodynamic and Clinical Anti-Tumor Activity

...stCall/ -- Exelixis, Inc. (Nasdaq: EXEL ) today reported encouraging data from an ongoing phase 1 trial of XL184, a potent inhibitor of MET, RET, and vegfr kinases, in patients with advanced solid tumors or lymphoma. Anti-tumor activity has been observed in a variety of cancers at doses that are not assoc...

New Data for XL880, XL647 and XL184 to Be Presented at AACR-NCI-EORTC

...se-escalation study of the safety and pharmacokinetics (PK) of XL184, a vegfr and MET kinase inhibitor, administered orally to patients (pts) with ad...y of the safety, pharmacokinetics (PK) and pharmacodynamics of XL880, a vegfr and MET kinase inhibitor, administered daily to patients (pts) with adv...

Ascenta Therapeutics Highlights Multiple Data Presentations at Upcoming AACR Annual Meeting

...orally active pan-Bcl-2 family Zhang, MD, protein inhibitor in combination PhD with dual-Raf/MEK and vegfr Ascenta kinase inhibitor sorafenib Therapeutics (Nexavar(R)) --------- --------- ----------...

New Data Show Pfizer's Axitinib Prolonged Overall Survival in Advanced Pancreatic Cancer When Combined with Standard of Care Chemotherapy

... that axitinib (AG-013736), an investigational oral, selective inhibitor of vegfr 1, 2,3 (vascular endothelial growth factor receptors 1, 2, 3) combined with...t yet known. About Axitinib Axitinib is an oral, selective inhibitor of vegfr 1, 2, 3 (vascular endothelial growth factor receptors 1, 2 and 3), which ha...
VEGFR in Biological Technology

Telik Reports Preclinical Results at AACR Annual Meeting

...echanism of Action of Orally Active Aurora Kinase/ vegfr Inhibitors; Abstract # 1764 Aurora kinases are ...ong and equipotent inhibition of Aurora kinase and vegfr kinase, with IC50s less than 10 nM. These ...dule. Drug inhibition of aurora kinase and vegfr activity in tumor samples of treated animals was e...

Telik's Aurora Kinase-VEGFR Dual Inhibitor Program Meets a Preclinical Development Milestone

... PALO ALTO, Calif., Aug. 21 /PRNewswire-FirstCall/ -- Telik, Inc. (Nasdaq: TELK ) announced today that the lead compounds of its Aurora kinase and vegfr dual inhibitor program met a significant development milestone. Aurora kinase is a critical signaling enzyme whose function is required for cancer cel...
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