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VEGF in Medical News

Scientists Learn How Cancer Drugs Cause Hypertension

....C., said in a school news release. "Our studies in mice show that blocking vegf causes hypertension because it disrupts an important biological system -- t...d vessel health." The researchers used an antibody to block an important vegf receptor called VEGFR2. After about a week, the mice that received a high d...

Brain Scan May Help Predict Cancer Drug Response

...ood vessels that provide the tumor with oxygen and nutrients. Avastin blocks VEGF, the researchers explained. "When we realized that high levels of vegf are linked to greater cell death and increased water movement, we were able to predict the patients' response to Avastin before they began treatment,"...

Asian spice could reduce breast cancer risk in women exposed to hormone replacement therapy

...development of certain tumors by increasing production of a molecule called vegf that helps supply blood to the tumor. By blocking the production of VEGF, r...e proliferation of breast cancer cells. Curcumin inhibits progestin-induced vegf secretion from breast cancer cells, Hyder said. "Curcumin and other pot...

Anti-angiogenesis treatment improves hearing in some NF2 patients

...at now need to be reevaluated." She adds that the study also suggests that vegf the angiogenesis factor blocked by bevacizumab may have a role in nerve p...al trial of a drug treatment for NF2. We are testing an exciting new, oral vegf inhibitor that will be easier for patients to take bevacizumab is administ...

UNC scientists identify growth factor as possible cancer drug target

... angiogenesis has been identified - vascular endothelial growth factor or vegf - and drugs to inhibit vegf are already in use. But not all tumors respond to the therapy initially or ...

Vandetanib shows clinical benefit when combined with docetaxel for lung cancer

... "Both receptors are active in lung cancer. EGFR targets the tumor cell and vegf targets the blood vessels, so, with vandetanib, we're really targeting the ...de effects is quite striking, said Herbst, because other agents that target vegf are associated with increased toxicity, including pulmonary bleeding. As...

Why do people with Down syndrome have less cancer?

...essel walls) showed a decreased growth response to vegf when they had an extra copy of Dscr1. An extra cop... colleagues showed that these extra genes suppress vegf signaling via a specific signaling pathway inside ... little has been known about the internal pathways vegf activates once it binds to cellular receptors; mos...

Gene Therapy Improves Diabetic Neuropathy in Study

... patients who received three sets of injections of vegf gene in one leg and 11 patients who received a pla...ths after treatment, the patients who received the vegf gene injections showed greater improvements in sen...in Boston, said in a hospital news release. The vegf gene used in the study is active without packaging...

Castrate resistant prostate cancer: New therapeutic approaches

... growth factor (VEGF), a potent angiogenic growth factor, and its receptor have evoked a lot of interest," according to Dr Gleave. Bevacizumab targets vegf and is a promising angiogenesis inhibitor in this indication. Other agents in late stage trials include sunitinib. Clusterin is a stress-induced, m...

Use of Avastin and Erbitux in the Adjuvant Setting and Launches of Emerging Agents Will Drive the Colorectal Cancer Drug Market to $7.8 Billion in 2017

...g therapies that will launch for colorectal cancer over the next several years, AstraZeneca's Recentin, Pfizer's Sutent and Sanofi-Aventis/Regeneron's vegf Trap will account for 9.2 percent of market sales in 2017 in the United States, France, Germany, Italy, Spain, the United Kingdom and Japan. Alth...
VEGF in Medical Technology

Bayer and Regeneron Extend Development Program for VEGF Trap-Eye to Include Central Retinal Vein Occlusion

Two Phase 3 studies to start in the second half of this year BERLIN and TARRYTOWN, N.Y., April 30 /PRNewswire-FirstCall/ -- Bayer HealthCare AG and Regeneron Pharmaceuticals, Inc. (Nasdaq: REGN ) today announced that the companies are extending their global development program for VEGF Trap...

Pieris Reports Development Progress for Anticalin(R) PRS-050, a Next Generation VEGF Antagonist

FREISING-WEIHENSTEPHAN, Germany, February 3 /PRNewswire/ -- Pieris AG, a biopharmaceutical company developing Anticalins(R), a novel class of targeted human protein therapeutics, reports today that it has made significant progress in the development of its Anticalin(R) candidate PRS-050, a pot...

SF1126, Semafore's PI3 Kinase Inhibitor, Found to Block Angiogenic Signaling From Both VEGF and Bv8 in Multiple Cell Lines

INDIANAPOLIS, Aug. 26 /PRNewswire/ -- Semafore Pharmaceuticals Inc. announced data presented at the Seventh International Congress on Targeted Therapies in Cancer in Washington, D.C., showing additional antiangiogenic activity of vascular-targeted PI3 kinase (PI3K) inhibitor SF1126, by blockin...

Bayer and Regeneron Dose First Patient in Second Phase 3 Study for VEGF Trap-Eye in Wet Age-Related Macular Degeneration

International Study to Evaluate Efficacy and Safety in Treating a Leading Cause of Blindness LEVERKUSEN, Germany, MONTVILLE, New Jersey and TARRYTOWN, New York, May 8 /PRNewswire-FirstCall/ -- Bayer HealthCare AG and Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN ) tod...

PTC Therapeutics Presents Encouraging Phase 1 Results of its Novel VEGF Inhibitor, PTC299, at 30th Annual San Antonio Breast Cancer Symposium

- Company Initiates Phase1b/2 Clinical Trial in Breast Cancer - SAN ANTONIO and SOUTH PLAINFIELD, N.J., Dec. 17 /PRNewswire/ -- PTC Therapeutics, Inc. (PTC), a biopharmaceutical company focused on the discovery, development, and commercialization of small-molecule drugs targeting post-tran...

Positive Interim Phase 2 Data Reported for VEGF Trap-Eye in Age-Related Macular Degeneration

TARRYTOWN, N.Y. & LEVERKUSEN, Germany--(BUSINESS WIRE)--Mar 27, 2007 - Regeneron Pharmaceuticals, Inc. (Nasdaq: REGN) and Bayer HealthCare AG (NYSE: BAY) today announced positive preliminary data from a pre-planned interim analysis of a Phase 2 randomized study of their VEGF Trap-Eye in patient...

Positive Results Using Affitech-Identified Human Antibody That Blocks VEGF Binding to VEGF Receptor 2 in Preclinical Cancer Model Reported by Peregrine

OSLO, Norway--(BUSINESS WIRE)--Apr 23, 2007 - Affitech AS, the human antibody therapeutics company announced today that Peregrine Pharmaceuticals, Inc. reported positive in vivo test results of R3, a fully human monoclonal antibody developed by Affitech, in a pancreatic cancer model at the recently...

Entremed Presents Results of ENMD-2076 Phase 1 Study in Advanced Cancer Patients

...lorectal cancer. ENMD-2076 was well-tolerated when administered daily. In addition, plasma soluble KDR (VEGFR2), a marker of effect against the vegf receptor, was reduced in all patients when compared to baseline. Side effects included hypertension and low blood counts, consistent with the known t...

Keryx Biopharmaceuticals Reports Single Agent Phase 2 Data of KRX-0401 (Perifosine) Further Demonstrating KRX-0401's Activity in the Treatment of Advanced Metastatic Renal Cell Cancer

...o Progressed after Failing Treatment Either with a vegf Receptor Inhibitor or after Treatment with both a vegf Receptor Inhibitor and an mTOR Inhibitor NE... (RCC) progressing after prior therapy (Rx) with a vegf receptor," was presented earlier today in a poster...

ULURU Inc. to Present Altrazeal(TM) Clinical Evidence and Advanced Therapeutic Research at the Diabetic Foot Global Conference (DFCon) 2009

...e laboratory and in vivo animal models. Data is presented on the delivery of small molecule therapeutics and the delivery of the therapeutic protein, vegf to a wound bed in a porcine model resulting in dramatic differences in the effects of controlled release on the healing endpoint. Dr. John St. John, ...
VEGF in Medical Products

Symphony PCS

Features:...platelet concentrate. Consistently yields three to six times the baseline level of platelets. Growth factors found in platelets - PDGF, TGF-, EGF, and vegf - are also increased three to six times. Quick, automated system makes platelet concentrate available in less than 15 minutes, eliminating intraoperat...
Company:DePuy Orthopaedics, Inc.

Symphony II

Features:...platelet concentrate. Consistently yields three to six times the baseline level of platelets. Growth factors found in platelets - PDGF, TGF-, EGF, and vegf - are also increased three to six times. Quick, automated system makes platelet concentrate available in less than 15 minutes, eliminating intraoperat...
Company:DePuy Orthopaedics, Inc.
VEGF in Biological News

A crystal ball for brain cancer?

.... Cancer cells secrete a growth factor called vegf that spurs the growth of new blood vessels to supp...mors with more water motion would also have higher vegf levels," explained Pope. "Because Avastin targets... Avastin. "When we realized that high levels of vegf are linked to greater cell death and increased wat...

Green tea may affect prostate cancer progression

...dothelial growth factor (VEGF) and prostate specific antigen (PSA). HGF and vegf are good prognostic indicators of metastatic disease. The study included....5 days. Findings showed a significant reduction in serum levels of HGF, vegf and PSA after treatment, with some patients demonstrating reductions in lev...

A longer lasting tumor blocker

...Agents that block a vessel-promoting factor called vegf have shown promise in human clinical trials. But r...pared the efficacy of inhibitors against M-CSF and vegf in mice with a certain kind of bone tumor. Three w...e type of vessel growth that was blocked. Blocking vegf prevented dangerous vessels from growing such as t...

Stem cells replace stroke-damaged tissue in rats

... time. The next stage of the research will be to include a factor called vegf with the particles. vegf will encourage blood vessels to enter the new tissue. Professor Douglas ...

Stress may hasten the growth of melanoma tumors

...etics, member of the university's Comprehensive Cancer Center and director of the IBMR. One of the proteins vascular endothelial growth factor, or vegf plays a key role in stimulating the growth of new blood vessels needed to feed a growing tumor, a process called angiogenesis. The other two proteins...

First trial in patients with a potential treatment of the incurable ALS muscle disease

... previously shown the possibilities for the use of vegf in the treatment of ALS through work in animal mod...treatable. VEGF: a promising candidate drug vegf is a substance that controls the growth of blood vessels. Unexpectedly, vegf also helps neurons survive under stressful conditi...

Researchers identify Achilles heel of common childhood tumor

...called vascular endothelial growth factor (VEGF). vegf usually binds to a specific receptor, one that sits on the outskirts of the cell and prevents vegf from telling the cell to proliferate. However, th...t ultimately stymied those receptors. That allowed vegf to trigger unchecked growth in the endothelial cel...

Gap junction protein vital to successful pregnancy, researchers find

...thelial growth factor (VEGF), is essential to angiogenesis. In the absence of Cx43, Laws found, the cells failed to differentiate or to produce enough vegf to spur blood vessel growth. "The formation of these new blood vessels is extremely critical for embryonic growth at this stage of pregnancy, when ...

Normalizing tumor vessels to improve cancer therapy

...ors, particularly vascular endothelial growth factor (VEGF). Tumors secrete vegf in abundance; it not only promotes blood vessel growth (angiogenesis), but makes them leaky. While blocking vegf action helps reduce leakiness and improves vessel function, the effects hav...

Researchers discover link between organ transplantation and increased cancer risk

...repressed this tumor growth. Several inhibitors of vegf are already in use in human cancer therapy. The...can reduce future cancer occurrence," he said. vegf expression is markedly increased in patients post-...abilized, it may be possible to lower the level of vegf expression to prevent tumor growth," he said. "We ...
VEGF in Biological Technology

PTC Therapeutics Initiates Phase 2 Clinical Trial of PTC299 in Patients with Neurofibromatosis Type 2

...ewscom.com/cgi-bin/prnh/20010919/PTCLOGO ) vegf plays a critical role in the formation of new bloo...roduction of VEGF, while sparing the physiological vegf expression necessary to maintain the growth and fu...g the post-transcriptional processes that regulate vegf formation. Overexpression of...

Peregrine Pharmaceuticals Licenses Anti-VEGF Antibodies to Affitech

... r84 is distinctive because it selectively blocks vegf from binding to vegf receptor 2 (VEGFR2), while non-selective agents such as Avastin block binding to both VEGFR2 and vegf receptor 1 (VEGFR1). Selective anti-VEGF agents s...

PTC Therapeutics Receives $2.6 Million in Government Grants

...ted tumors include surgery and radiation therapy. vegf plays a critical role in angiogenesis, or the form...ctor (VEGF) in tumors, while sparing physiological vegf expression. The grant awarded by the FDA Of...g the post-transcriptional processes that regulate vegf formation. Overexpression of...

AEterna Zentaris to Present Data Supporting Evaluation of AEZS-108 in Prostate Cancer at Upcoming ASCO Meeting

...C) Friday, May 29, 2009 #5034: Phase 2 study of perifosine in metastatic renal cell carcinoma (RCC) progressing after prior therapy (Rx) with a vegf receptor inhibitor. Lead Author: Nicholas Vogelzang, MD Poster Discussion: 5 pm - 6 pm (Level 2, West Hall F5) Sunday, May 31, 2009 #510...

Keryx Biopharmaceuticals Announces Poster Presentations Highlighting Clinical Activity of KRX-0401 (Perifosine) at the Upcoming Annual Meeting of the American Society of Clinical Oncology

... 29 th , 2009: #5034: Phase II study of perifosine in metastatic renal cell carcinoma (RCC) progressing after prior therapy (Rx) with a vegf receptor inhibitor. Lead Author: Nicholas Vogelzang, MD Poster Discussion: 5:00pm-6:00pm (Level 2, West Hall F5) Sunday, May 31 ...

Preclinical Data From Amgen's Oncology Pipeline to be Presented at AACR

...nism of Angiogenesis is More Complicated Than Understanding the Function of vegf - A Amgen Launches Angiogenesis Website THOUSAND OAKS, Calif., A..., involves multiple cellular regulators that include the angiopoietins, the vegf family and other regulators. Amgen has developed an interactive website tha...

Antiangiogenic Role of 2ME2 Demonstrated in Rheumatoid Arthritis Models

...e JK, Park EJ, Fogler WE, and Plum SM. An angiogenesis inhibitor, 2-methoxyestradiol, involutes rat collagen-induced arthritis and suppresses synovial vegf and bFGF gene expression. J Rheumatol 2008;35:2119- 28). (Logo: http://www.newscom.com/cgi-bin/prnh/20010620/ENMDLOGO ) Results from treatment s...

Genmab Announces Results for the First Nine Months of 2008

.... Genmab is working very actively on multiple pre-clinical cancer programs including antibodies directed to the clinically validated targets Her-2 and vegf as well as antibodies to two novel targets, Tissue Factor and a target expressed on cancer stem cells. Conference Call Genmab will hold a conferen...

Access Pharmaceuticals Presents New Data at International Symposium Showing Company's Angiolix(R) Monoclonal Antibody has Potential to Treat Cancer by Attacking Cancer Stem Cells

...adherin. Lactadherin causes angiogenesis through a vegf dependent mechanism. Several other drugs have been developed or are in development to block vegf and vegf induced angiogenesis, such as Avastin. In the pr...

ThromboGenics and BioInvent Announce a Strategic Alliance With Roche for TB-403, a Novel Anti-Cancer Antibody

...xygen and nutrients. This approach in turn is thought to stop the tumour from growing and spreading to other parts of the body. PlGF is a homologue of vegf and current preclinical evidence suggests that it may not affect normal, physiological angiogenesis and is predominantly involved in angiogenesis of m...
VEGF in Biological Products

Mouse Anti-Human VEGF R Monoclonal Antibody, Phycoerythrin Conjugated, Clone 89106, 49560, 54733 from R&D Systems

Description: Human VEGF R Phycoerythrin Sampler (Cl 89106, 49560, 54733)...
Company:R&D Systems

Rat Anti-Mouse VEGF R1 / Flt-1 Monoclonal Antibody, Phycoerythrin Conjugated, Clone 141522 from R&D Systems

Description: Mouse VEGF R1/Flt-1 Phycoerythrin MAb (Clone 141522) Keywords: Receptor Tyrosine Kinase, RTK, VEGFR1, VEGF Receptor 1 Protein Family: Receptor Tyrosine Kinases, VEGF/PDGF Family...
Company:R&D Systems

Rat Anti-Mouse VEGF R1 / Flt-1 Monoclonal Antibody, Allophycocyanin Conjugated, Clone 141522 from R&D Systems

Description: Mouse VEGF R1/Flt-1 Allophycocyanin MAb (Clone 141522) Keywords: Receptor Tyrosine Kinase, RTK, VEGFR1, VEGF Receptor 1 Protein Family: Receptor Tyrosine Kinases, VEGF/PDGF Family...
Company:R&D Systems

Mouse Anti-Human VEGF R3 / Flt-4 Monoclonal Antibody, Phycoerythrin Conjugated, Clone 54733 from R&D Systems

Description: Human VEGF R3/Flt-4 Phycoerythrin MAb (Clone 54733)...
Company:R&D Systems

Mouse Anti-Human VEGF R2 (KDR) Monoclonal Antibody, Unconjugated, Clone 89106 from R&D Systems

Description: Human VEGF R2 (KDR) MAb (Clone 89106)...
Company:R&D Systems

Rabbit Anti-VEGF Receptor 2, phospho (Tyr1214) Polyclonal Antibody, Unconjugated from Abcam

Description:... Rabbit polyclonal to vegf Receptor 2 (phospho Y1214) ( Abpromise for all tested applications). entrezGeneID: 3791 SwissProtID: P35968...
Company:Abcam

Rosmarinic acid from Biotrend Chemikalien GmbH

Description:...oliferation, migration, adhesion and tube formation of HUVEC cells. Also reduces intracellular reactive oxygen species (ROS) level, H(2)O(2)-dependent vegf expression and IL-8 release of endothelial cells. Formula: C 18 H 16 O 8 MolWeight: 360.31484 Store at: RT CAS: 20283-92-5 Sol...
Company:Biotrend Chemikalien GmbH

Mouse Anti-VEGF Receptor 1 Monoclonal Antibody, Unconjugated, Clone Flt-1 / EWC from Abcam

Description:... Mouse monoclonal [Flt-1/EWC] to vegf Receptor 1 ( Abpromise for all tested applications). entrezGeneID: 2321 SwissProtID: P17948...
Company:Abcam

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