FDA Approves Human Hookworm Vaccine for Phase I Safety Trials
As any dedicated video game player knows, the first requireme...Research advances quest for HIV-1 vaccine
Scientists have uncovered new information that may help guide design of vaccines for HIV-1, the virus that causes AIDS. A new detailed structural analysis of the complex formed by an anti-HIV antibody called 4E10 and its specific target provides insight into why this particular antibody is so broadly effective, a rare characteristic for HIV discovered thus far. The research is published in the Fe...A much-needed shot in the arm for HIV vaccine development
International efforts towards developing avaccine against HIV infection have been given a much-needed boost bythe publication today of the Global HIV/AIDS Vaccine Enterprise'sscientific strategic plan, published online in the freely available,open-access global health journal PLoS Medicine.The Global HIV/AIDS Vaccine Enterprise is an international alliance ofindependent agencies and organiz...Live Recombinant Adenovirus Vaccine Technique Explored
Researchers at the Johns Hopkins Bloomberg School of Public Health are exploring ways to develop new vaccines for a variety of illnesses using genetically modified adenoviruses, a common cause of respiratory infections. Oral adenovirus vaccines have long been proven to be safe and effective. The researchers believe their process for constructing a replicating live recombinant adenovirus could lea...Discovery of key protein's shape could lead to improved bacterial pneumonia vaccine
Scientists at St. Jude Children's ResearchHospital have discovered that the shape of a protein on the surface ofpneumonia bacteria helps these germs invade the human bloodstream. Thisfinding, published Dec. 16 online by the EMBO Journal, could helpscientists develop a vaccine that is significantly more effective atprotecting children against the disease. The St. Jude researchersdetermined t...Vaccinia DNA Topoisomerase I from EPICENTRE Biotechnologies
Description:Topoisomerase I from vaccinia virus is a type I eukaryotic topoisomerase that removes both positive and negative superhelical turns (also called right- and left-handed supercoils) from covalently closed DNA. The product of the reaction is a covalently closed, circular DNA with fewer positive or negative superhelical turns. DNA Topoisomerase I does not absolutely require Mg to functio...Vaccinia DNA Topoisomerase I from EPICENTRE Biotechnologies
Description:Topoisomerase I from vaccinia virus is a type I eukaryotic topoisomerase that removes both positive and negative superhelical turns (also called right- and left-handed supercoils) from covalently closed DNA. The product of the reaction is a covalently closed, circular DNA with fewer positive or negative superhelical turns. DNA Topoisomerase I does not absolutely require Mg to functio...Topoisomerase I (Vaccinia) from Molecular Cloning Laboratories (MCLAB)
Description:Ideal for relax positively and negatively supercoiled DNA in presence of EDTA Applications Studying the effects of supercoiling on transcription in vitro Studying chromatin reconstitution in vitro Determining the degree of supercoiling of naturally occurring DNA Detecting mutant plasmids that differ in length by only one base-pair Increasing restriction...New Mexico firm to make flu vaccine at Wisconsin BioManufacturing facility
Located at the University of Wisconsin-Madison's , the...Studies Offer New Insight into HIV Vaccine Development
MADISON-Mutations that allow AIDS viruses to escape detection by the immune system may also hinder the viruses' ability to grow after transmission to new hosts, scientists at the University of Wisconsin-Madison announced this week in the journal Nature Medicine. The discovery may help researchers design vaccines that exploit the notorious mutability of HIV by training the immune system t...First Vaccine Designed for Africa Cleared for Testing in Humans
The first AIDS vaccine candidate designed specifically for Africa will enter human trials this summer. The International AIDS Vaccine Initiative (IAVI) announced on July 11 at the 13th International AIDS Conference in Durban, South Africa, that the Medicines Control Agency (MCA) of the United Kingdom has approved Phase I testing of a DNA vaccine based on HIV subtype A, the most commo...Naked DNA Vaccination May Conquer Arthritis and Multiple Sclerosis
A novel modification of a new technology born of genetic engineering, and known as naked DNA vaccination, holds the potential of overcoming autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. The vaccine is currently being successfully tested in animals. In multiple sclerosis (MS) and rheumatoid arthritis (RA), the body essentially attacks itself, caus...New hope for cancer victims – will vaccine cure the deadly bug
One very deadly form of cancer is pancreatic cancer, though it isn’t very common. Globally it kills lakhs of people every year. And now there is some hope for the unfortunate victims. A new vaccine has been successfully tested on the pancreatic cancer victims and it has increased the survival rates in many. Vaccines are typically thought of as a way of preventing disease. In cancer, howe...Vaccine for Alzheimer’s diseas
Researchers developing a vaccine against Alzheimer’s disease have shown that it seems to stop mice with the condition losing their memory. The results boost hopes that such vaccines could delay or prevent similar symptoms in people. The vaccines reduces the build-up of protein deposits in mouse brains -the other major indicator of Alzheimer’s diseases. The pharmaceutical company Elan,...Rabies Antibody(Vaccine Response)
Description:ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' clients include more than half of the nation's university teaching hospitals and children's hospitals, maj...BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
LINCOLNSHIRE, Ill.--(BUSINESS WIRE)--Jul 11, 2007 - BioSantePharmaceuticals, Inc. (Amex: BPA) today announced new positiveresults demonstrating that its calcium phosphate (CaP)nanoparticle-based vaccine adjuvant, BioVant(TM), may serve as aneffective vaccine adjuvant for the development of a dose sparingvaccine against H5N1 avian flu, widely known as bird flu. The new results are based on...From Clinical Cancer Research: Rethinking Therapeutic Cancer Vaccine Trials
PHILADELPHIA, July 3, 2007-- Ongoing therapeutic cancer vaccinetrials have yet to show evidence of vaccines spurring apatient’s immune system to shrink tumors -- yet patients whoreceive these vaccines in trials tend to live longer and respondbetter to subsequent treatment. In the July 1 issue of ClinicalCancer Research, a journal of the American Association for CancerResearch, a te...Vaccine Can Prevent Cervical Cancer and Precancerous Lesions
LONDON, June 28, 2007--A cervical cancer vaccine has shown 90%efficacy for prevention of cervical cancer and precancerous lesionsassociated with the human papillomavirus (HPV) types targeted bythe vaccine, conclude authors of an Article published early Onlineand in the upcoming issue of The Lancet. HPV types 16 and 18 account for 70% or morecases of cervical cancer worldwi...