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Urate in Medical News

Elevated Urate Levels May Slow Parkinson's in Men

Those with highest amount had almost half the risk of needing to start treatment MONDAY, April 14 (HealthDay News) -- Men with naturally high levels of the antioxidant urate in their blood appear to develop the symptoms of Parkinson's disease slower than those with lower levels do, a ...

High Urate Levels in Blood Linked to Reduced Parkinson's Risk

A new study has found that high levels of urate in the blood is linked to a reduced risk of Parkinson's disease. The study, conducted by researchers at the Harvard School of Public Health (HSPH), was led by Marc Weisskopf, Assistant Professor of Environmental and Occupational Epidemiology. ...

The Gout & Uric Acid Education Society (GUAES) Announces New Survey Results Highlighting Major Gaps in Public Awareness of Gout

...he growing number of Americans living with gout, these myths need to be corrected." About Gout Gout is caused by an accumulation of sodium urate crystals in the joints and other tissues. These crystals form when there is an abnormally high level of uric acid in the blood (a condition known as h...

Experts Recommend Cherries For Pain Relief From Arthritis

...d Medicine. 1950;8:309-311. (3) Jacob RA, Spinozzi GM, Simon VA, Kelly DS, Prior RL, Hess-Pierce B, Kader AA. Consumption of cherries lowers plasma urate in healthy women, Journal of Nutrition. 2003;133:1862-1829. (4) Tall JM, Seeram, NP, Zhao C, Nair MG, Meyer RA, Raja SN. Tart cherry anthocyanins ...

FDA approves ULORIC (febuxostat) for the chronic management of hyperuricemia in patients with gout

... either through overproduction or underexcretion of uric acid or a combination of the two. Hyperuricemia is a precursor to gout; the higher a person's urate level, the greater the risk for developing gout. Gout is the most common inflammatory arthritis in men over age 40. According to the National Heal...

Pegloticase BLA Filing Accepted for Priority Review by FDA

...whom allopurinol is contraindicated. ABOUT PEGLOTICASE Pegloticase (formerly referred to as Puricase(R)) is a pegylated recombinant mammalian urate oxidase in development to control hyperuricemia and its clinical consequences in patients for whom conventional therapy is contraindicated or has been...

Studies examine treatment for gout and the condition's protective effects

... gout is to reduce acute attacks by lowering serum urate levels, which are usually high in this disease. At the same time, high serum urate levels have been shown to lower the risk of develo...ave shown that febuxostat is effective at lowering urate levels and that its dosage may not need to be adju...

New Drug Helps Relieve Gout

...enced mild to moderate side effects, including reactions to the infusion and joint pain. "The generally accepted goal of therapy is to reduce serum urate concentrations to less than 6 milligrams per deciliter, and we found that pegloticase can do that very, very quickly," study lead author Dr. John Sund...

Basketball Star Details His Struggle With Gout

...e range of foods, uric acid is usually dissolved in the blood, passed through the kidney, and excreted through urine. But in excess amounts, sodium urate can crystallize. In some cases, the resulting needle-like formations lodge and jab into joints, bringing about sudden and painful bouts of tenderness,...

NBA Coach Maurice Cheeks Teams Up with the Gout & Uric Acid Education Society (GUAES) to Call a 'Time Out for Gout'

...ly." Gout is caused by an accumulation of sodium urate crystals in the joints and other tissues. These cr...ricemia can lead to an accumulation of needle-like urate crystals that not only cause the acute attacks typ... to less than 6.0 mg/dL is helpful to reduce urate crystal accumulation and prevent the consequ...

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Urate in Medical Technology

Savient Provides Update on Pegloticase BLA

...85467097 ABOUT KRYSTEXXA (pegloticase) KRYSTEXXA (pegloticase) (formerly referred to as Puricase(R)) is a pegylated recombinant mammalian urate oxidase in development to control hyperuricemia and its clinical consequences in patients for whom conventional therapy is contraindicated or has been...

Arthritis Advisory Committee Recommends FDA Approval of Febuxostat for the Treatment of Hyperuricemia in Patients With Gout

... either through overproduction or underexcretion of uric acid or a combination of the two. Hyperuricemia is a precursor to gout; the higher a person's urate level, the greater the risk for developing gout. Gout is the most common inflammatory arthritis in men over age 40. According to the National...

Ardea Biosciences Identifies Lead Development Candidate for Gout, RDEA594

...ic acid excretion in animal models. These effects are believed to result in the lowering of serum uric acid observed with RDEA806. URAT1 is a specific urate transporter expressed in the kidney responsible for regulation of uric acid levels, and is a validated target for treatment of hyperuricemia and gout....

Michael J. Fox Foundation Announces $5.6-Million Award for Phase 2 Clinical Trial Studying Neuroprotective Potential of Inosine

... a naturally occurring chemical that gives rise to urate in the body -- to slow or stop the progression of ...Michael J. Fox Foundation since its inception. urate is a natural metabolite and major antioxidant in h...ious studies found that healthy people with higher urate levels in the blood had a reduced risk of developi...

Savient Pharmaceuticals Announces Acceptance of Two Gout-Related Abstracts for Poster Presentation at the European League Against Rheumatism (EULAR) 2007 Annual Congress

...an League Against Rheumatism (EULAR) 2007 Annual Congress taking place June 13 - 16th in Barcelona, Spain. Puricase is a PEGylated recombinant porcine urate oxidase currently in Phase 3 development for patients with treatment-failure gout. The abstracts selected for poster presentation on Thursday, June 1...
Urate in Medical Dictionary

Gout

... Gout is a disease hallmarked by elevated levels of uric acid in the bloodstream. In this condition, crystals of monosodium urate (MSU) or uric acid are deposited on the articular cartilage of joints, tendons, and surrounding... Joanne Larsen answers nutrition-related que...

Chronic gouty arthritis

... Gout is a disease hallmarked by elevated levels of uric acid in the bloodstream. In this condition, crystals of monosodium urate (MSU) or uric acid are deposited on the articular cartilage of joints, tendons, and surrounding... Chronic gouty arthritis is treated wi...
Urate in Biological Technology

Savient Announces New Date for FDA Arthritis Advisory Panel Review of KRYSTEXXA(TM) for Treatment Failure Gout

...d and assigned a revised PDUFA date of August 1, 2009. ABOUT KRYSTEXXA(TM) KRYSTEXXA (TM) (pegloticase) is a pegylated recombinant mammalian urate oxidase in development to control hyperuricemia and its clinical consequences in patients for whom conventional therapy is contraindicated or has been...

FDA Approves ULORIC(R) (febuxostat) for the Chronic Management of Hyperuricemia in Patients with Gout

... either through overproduction or underexcretion of uric acid or a combination of the two. Hyperuricemia is a precursor to gout; the higher a person's urate level, the greater the risk for developing gout. Gout is the most common inflammatory arthritis in men over age 40. According to the National He...

Savient's Pegloticase Data in Treatment-Failure Gout Patients Presented at 72nd Annual Meeting of the American College of Rheumatology Conference

...s, by approximately 40%, in the every two- week dosing arm of these randomized, controlled, clinical trials is believed to be the first time a urate lowering therapy has demonstrated a reduction of gout flares versus a placebo. New results presented from the GOUT 3 study show that for pati...

Ardea Biosciences to Present Data on Gout and Inflammation Programs at the 2008 ACR/ARHP Annual Scientific Meeting

...8, 2:45 p.m. - 3:00 p.m. PDT Abstract Title: MEK Inhibitor RDEA119 Suppresses Inflammatory Cytokine Production Induced by Monosodium urate Crystals Abstract Number: 1942 Session Name: Crystal Associated Arthropathies Location: Room 104 About Ardea Biosciences, Inc. Ardea Bioscience...
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