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Upstream in Medical News

Scientists Reverse Muscular Dystrophy in Mice

...ase. The strategy does have the potential to affect the multiple systems targeted by muscular dystrophy, Cwik said. "It's working very early, very upstream so it has the potential to impact many aspects of the disease," she said. "But we haven't looked at this at all in humans yet." More information ...

Sartorius Stedim Biotech Partners With Cell Culture Media Specialist SAFC Biosciences(R) to Provide World-Class Fluid Management and Liquid/Powder System Solutions

... Global agreement strengthens customized manufacturing solutions for upstream and downstream processing and moves the 'disposable factory' closer to real...s a leading provider of cell culture materials and development services for upstream and downstream processes in the biopharmaceutical industry. Providing an in...

Ben-Gurion U. researchers identify how stressed fat tissue malfunctions

... in the abdomen, and that it correlated with multiple biochemical markers for increased cardio-metabolic risk. Moreover, the expression of one of the upstream signaling components, a protein called ASK1, predicts whole-body insulin resistance (an endocrine abnormality that is strongly tied to diabetes and ca...

Stopping harmful oral bacteria in its path is goal for Case Western Reserve researcher

...pithelial and endothelial linings and then colonize," explains Han. "We want to block the bacteria before it can do any damage," Han says. "It's an upstream approach to go back to where the whole process begins and stop it from starting its destruction." Once it leaves the mouth, the invasion of the bact...

Marathon and Partners Announce Dramatic Results of Malaria Control Project on Bioko Island in Equatorial Guinea

...ns offshore Israel, the United Kingdom and West Africa. GEPetrol was established in 2001 as the National Oil Company of Equatorial Guinea and has upstream interests through participation in petroleum contracts with foreign oil companies. GEPetrol operates as a commercial entity alongside the Ministry of ...

A new take on growth factor signaling in tamoxifen resistance

...y proliferative, relatively tamoxifen-insensitive, phenotype and that this exists independently of HER2 overexpression. Targeting this pathway and its upstream mediators could prove to be a useful therapeutic strategy". The researchers used a new computational method of analysis of gene expression data cal...
Upstream in Medical Technology

Anthera's Varespladib Meets Primary Endpoint in Phase 2 FRANCIS Trial for the Treatment of Acute Coronary Syndrome

...idonic acid and subsequent production of leukotrienes¿ prostacyclins and other mediators of inflammation. These highly potent compounds inhibit novel¿ upstream steps in the inflammation cascade and have the potential to address a variety of diseases. For more information, please visit www.anthera.com. ...

SAFC Biosciences(R) and Vivalis Collaborate to Optimize Cell Culture Media for Vaccines Production

...w"> info-na@sial.com . About SAFC Biosciences: SAFC Biosciences is a leading provider of cell culture materials and development services for upstream and downstream processes in the biopharmaceutical industry. Providing an integrated services package in mammalian cell culture media development, alon...

Schering-Plough Announces Results of the Early ACS Trial

...r secondary endpoints of the trial. Significantly higher rates of bleeding and transfusions also were reported. "These results do not support the upstream use of double-bolus plus infusion eptifibatide as a routine course of treatment in ACS," said Enrico Veltri, M.D., group vice president of global clin...

Following Encouraging Results Anthera to Continue IMPACTS Trial for the Prevention of Acute Chest Syndrome in Patients With Sickle Cell Disease

...idonic acid and subsequent production of leukotrienes¿ prostacyclins and other mediators of inflammation. These highly potent compounds inhibit novel¿ upstream steps in the inflammation cascade and have the potential to address a variety of diseases. The company has also acquired exclusive and worldwide right...

Gene Found Activated in 70% of Prostate Cancer Cases, George Washington University Medical Center Scientists Report

...." The findings compare to "less than 5%" BP1 activity in normal cells. The researchers conclude that "These findings suggest that BP1 is an important upstream factor in the carcinogenic pathway of prostate cancer and that the expression of BP1 may reflect or directly contribute to tumor progression and/or in...

Enobia Pharma Appoints Industry Veterans with Commercial and Manufacturing Expertise to Expand Senior Management Team

...s plc. At Acambis, Dr. Aphale was responsible for R&D project management as well overseeing multiple vaccine manufacturing plants, which included cGMP upstream and downstream manufacturing, and a lyophilization facility. Dr. Aphale previously held Director level positions at Wyeth Vaccines and Diosynth Biotec...
Upstream in Medical Products

Ipump Pain Management System

Features:...p to 240 minutes. Control flow rates in 0.1 mL/hour increments for maximum flexibility with continuous flow rates up to 90 mL/hour. Downstream and upstream occlusion alarms notify the user of potential interruptions in medication flow. Programmable security options help create the ideal balance of secur...
Company:Baxter Healthcare

SR - Single Rectangular Head Camera

Features:...es, 3.0mm Intrinsic Spatial Resolution 9% Intrinsic Energy Resolution Uniformity Center of Rotation better than 0.5mm Upgradeable - upstream or downstream - unique to IS2 True all digital design - down to each PMT ...
Company:IS2 Medical Systems

SC - Single Circular Head Camera

Features:... 3.0mm Intrinsic Spatial Resolution 9% Intrinsic Energy Resolution Uniformity Center of Rotation better than 0.5mm Upgradeable - upstream or downstream - unique to IS2 True all digital design - down to each PMT One point non-circular SPECT set-up means no need to reset the camera...
Company:IS2 Medical Systems
Upstream in Biological News

New study ranks 'hotspots' of human impact on coastal areas

...certainly fail if they don't directly address what people are doing on land upstream from these locations." Nutrient runoff from upstream farms has caused a persistent "dead zone" in the Gulf of Mexico, where the ...

University of Houston diesel testing center teams with state transportation agency to cut emissions

...e emissions from medium- and heavy-duty diesel engines, using a control strategy that relies on a NOx concentration measurement by a sensor positioned upstream of the SCR catalyst. "The NOx sensor-based control strategy makes the system very suitable for retrofit applications," said M.A. Mannan, business ...

Muscle atrophy through thick but not thin

...me is responsible for degrading only some muscle components, whereas others fall victim to other ubiquitin ligases and autophagy. Inhibitors that work upstream to block signals that activate ubiquitin ligases and initiate autophagy are a better bet. ...

ExcellGene SA first company to offer contract manufacturing in 250 Liter OrbShake bioreactor

...ovative technologies for the production of recombinant proteins from mammalian cells in bioreactors. As a service company, ExcellGene generates entire upstream cell culture processes for its customers, from DNA to scalable manufacturing under cGMP. Additionally, the company provides protein production service...

Double trouble for water life

...ble to many freshwater and marine ecosystems. He adds that focusing on phosphorus alone ignores the fact that natural and human influences that affect upstream waters have significant adverse consequences on downstream waters. Therefore, it is essential to look at nutrient control measures and their effects a...

Supply-Chain Council Announces Winners of 2009 Supply Chain Excellence Awards

... shop floor execution between subcontractor and manufacturer with clear mapping to SCOR mega processes in order to gain process and data visibility of upstream and downstream supply chain," said Dr. Tom Janoshalmi, Chair of the SCC Technical Development Steering Committee and Manager, Corporate Strategy, SAP ...
Upstream in Biological Technology

SAFC Biosciences(R) Defines Hydrolysate Components That Enhance Chinese Hamster Ovary (CHO) Cell Line Protein Production

...DefinedComponents ) About SAFC Biosciences: SAFC Biosciences is a leading provider of cell culture materials and development services for upstream and downstream processes in the biopharmaceutical industry. Providing an integrated services package in mammalian cell culture media development, alon...

Finesse Solutions Forges Agreement With Leading Biotechnology Company for Single-Use Technology Exploration

...orms, and harmonize global bio-process information transfer. Our current product family provides comprehensive measurement and control solutions for upstream processes in the biotech and pharmaceutical industries. For more information, please visit us at www.finesse.com . ...

Virtify, Inc. Delivers Industry's First Enterprise Content Compliance Software Suite for Life Sciences Companies

...laborative content authoring, reviewing, archiving, and re-use - virtually eliminating inconsistencies and redundancies enterprise-wide. Virtx tailors upstream functions, such as content authoring and reviewing to meet electronic requirements and standards, while automating downstream functions such as assemb...

Finesse Solutions Expands Into State-of-the-Art Facility in San Jose, CA, USA

...orms, and harmonize global bio-process information transfer. Our current product family provides comprehensive measurement and control solutions for upstream processes in the biotech and pharmaceutical industries. For more information, please visit us at www.finesse.com . ...

GenVault Corporation Launches its Latest Centralized and Standardized Software Solution for Biobanking and Biological Sample Management, GenConnect 3.2

..., language-independent Web Services interface, and standardized flat-file import/export capabilities, GenConnect can be seamlessly integrated with any upstream or downstream informatics packages and databases. The latest example of this is the integration of GenConnect 3.2 to GenoLogics' Biomedical Informatic...

SAFC Biosciences(R) Expands Media Capability for Chinese Hamster Ovary (CHO) Cell Lines

...safcbiosciences.com . About SAFC Biosciences: SAFC Biosciences is a leading provider of cell culture materials and development services for upstream and downstream processes in the biopharmaceutical industry. Providing an integrated services package in mammalian cell culture media development, alon...
Upstream in Biological Products

Goat Anti-BRF2 Polyclonal Antibody, Unconjugated from GeneTex

Description:...BRF2 is one of the multiple subunits of the RNA polymerase III transcription factor complex required for transcription of genes with promoter elements upstream of the initiation site. BRF2 is directly recruited to the TATA-box of polymerase III small nuclear RNA gene promoters through its interaction with the...
Company:GeneTex

PinPoint™ Vector Sequencing Primer from Promega

Description:...nPoint™ Xa Vectors (Cat.# V2031, V2051, V2061). The primer hybridizes upstream of the Factor Xa site at nucleotides 325343, approximately 4050 base pairs upstream of the multiple cloning region and can be used to determine if an insert is...
Company:Promega

pAcAB4 Baculovirus Transfer Vector from BD Biosciences Pharmingen

Description:...and two AcNPV p10 promoters. Downstream of the first p10 promoter is a Sma I cloning site, followed by polyhedrin locus-derived termination sequences. upstream of this, an inverted polyhedrin promoter has been inserted containing Xba I and Stu I as single cloning sites, followed by a second p10 promoter, a Bg...
Company:BD Biosciences Pharmingen

In Situ Pan-Caspase Assay Kit from CHEMICON

Description:...inflammation. In apoptosis, caspases are responsible for proteolytic cleavages that lead to cell disassembly (effector caspases), and are involved in upstream regulatory events (initiator caspases). An active caspase consists of two large and two small subunits that form two heterodimers which associate in ...
Company:CHEMICON

In Situ Pan-Caspase Assay Kit, Sulforhodamine from CHEMICON

Description:...inflammation. In apoptosis, caspases are responsible for proteolytic cleavages that lead to cell disassembly (effector caspases), and are involved in upstream regulatory events (initiator caspases). An active caspase consists of two large and two small subunits that form two heterodimers which associate in ...
Company:CHEMICON

pMIR-hU6-Luc, Human U6 Luciferase Control Vector from Mirus Bio Corporation

Description:... fragments of DNA (sense and anti-sense strand expression cassettes). PCR Expression Cassettes can be cloned using either the Hind III or EcoR I site upstream of the promoter and Xho I or BamH I site downstream of the siRNA and termination sequence. The cloning sites used must be unique in the PCR product. H...
Company:Mirus Bio Corporation
Upstream in Biological Definition

Enhancer

...d close to the transcription initiation site to affect its transcription, as some have been found to bind several hundreds of thousands base pairs upstream or downstream of the start site. Enhancers can also be found inside introns . An enhancer's orientation may even be reversed without affecting its f...

Promoter

...ng sites Distal promoter Anything further upstream (but not an enhancer or other regulatory region wh...ts of two short sequences at -10 and -35 position upstream of the gene, that is, prior to the gene in the di...e allows a very high transcription rate. <-- upstream ...
Upstream in Biological Dictionary

Upstream

In geography, upstream literally means towards the source of a stream or river, or against the normal direction of water flow. Upstream is a society of Ambassadors for Reconciliation - people dedicated to ... Upstream Christian Initiatives, 37780 Dawson Road, Abbotsford. B.C. V3G 2K9 Canad...

UvrA

...7 YEAR PRESIDENT ... These Guidelines have been revised and agreed upon by all UVRA Town Directors. ... uvrA . Information for uvrA , and also upstream and downstream flanking ... Reported regulatory sites for uvrA : Genome coordinates. Source. Transcription factor ... Furthermore, the TFO was ...

Untranslated region

...lated region (UTR) ... Untranscribed Region . Other Resources. PubMed Google ... within a transcribed but untranslated region of the gene. upstream from the start codon. ... analysis of the 5'- untranslated region of SPR of. patient's DNA. ... Key role of the 3' untranslated region in t...

Transcription start site

...e transcription start site to just ... Transcription Factors Transcription factors are protein complexes that help RNA ... nucleotides upstream from the transcription start site (T is the nucleotide ... Transcription Binding Tools. Transcription Start Site Prediction. Proka...

TATA box

... is a transcription factor that binds specifically to a DNA sequence called the TATA box . This DNA sequence is found about 25-30 base pairs upstream of the transcription start site in some... TATA Box Binding Protein. The TATA box can be found in various species ranging from ... P...

Promoter site

...DNA that facilitates the transcription of a particular gene. Promoters are typically located near the genes they regulate, on the same strand and upstream . Learn Search Engine Marketing and SEO Tips & Advice from Professional SEOs Transcription start site . The basal promoter . An Analogy ....
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