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Unfolded in Medical News

MTV'S GYT Campaign Spurs Nationwide Movement to 'Get Yourself Tested'

...nt as needed. Since the launch of GYT on April 1, 2009, the call-to-action has been embraced by young people across the United States, as the campaign unfolded on-air, online, on mobile devices and in health centers. Some positive results from the month of April include: Planned Par...

Pandemic warning system keys on 'human factors'

... years ago stated that these sorts of decisions could be expected to evolve over several days to maybe two weeks, but not two days. So the events have unfolded much faster than people were expecting." The research was funded by a grant from the Indiana State Department of Health through Purdue's Healthcare...

Looking Forward: The Use of Health IT in Crisis

...aniel Hupert of the CDC on the use of health IT in crisis control, a topic of increasing interest and relevance in light of the recent event that have unfolded with the Swine influenza outbreak. The following quotes from Dr. Nathaniel Hupert are highlights of the podcast: On preparedness mode...

Protein-Folding Problem May Help Spur Alzheimer's

...isfolded proteins. But prolonged activation of the unfolded protein response -- such as that seen in Alzheimer...rdam and the University of Amsterdam believed that unfolded protein response contributed to brain damage throu...eimer's. The study revealed that markers of the unfolded protein response were expressed in areas of tau ac...

Worm provides clues about preventing damage caused by low-oxygen during stroke, heart attack

..."In some cells, hypoxia has been shown to generate unfolded proteins," says Crowder, the Dr. Seymour and Rose ...elopmental biology. "So then you have this load of unfolded proteins that may be toxic and promote cell death ...ke it resistant to hypoxia by reducing the load of unfolded proteins, and that's what we saw." Folding is i...

Radiologists diagnose and treat self-embedding disorder in teens

...and stone. The objects were embedded during injuries to the arms, ankles, feet, hands and neck. One patient had self-embedded 11 objects, including an unfolded metal paperclip more than six inches in length. Ultrasound guidance allowed the researchers to detect the presence and location of wood, crayons an...

Radiologists Diagnose and Treat Self-Embedding Disorder in Teens

...and stone. The objects were embedded during injuries to the arms, ankles, feet, hands and neck. One patient had self-embedded 11 objects, including an unfolded metal paperclip more than six inches in length. Ultrasound guidance allowed the researchers to detect the presence and location of wood, crayo...

Researchers identify toehold for HIV's assault on brain

...ded protein response" seen in the brains of HIV patients. Shape is everything for proteins, and they're nearly always useless or harmful when they are unfolded or misfolded. The problem in HIV patients is exacerbated because protein folding requires a great deal of energy energy that cells whose mitochondria...

Discovery of gene mechanism could bring about new ways to treat metastatic cancer

...s. "Cancer cells cannot accommodate or recover from stress the way normal, healthy cells can. When the ER is stressed in this way, the result is an unfolded protein response which overloads the system and shorts out the cancer cell. This prevents tumor development, growth and invasion and ultimately the c...

Officeinacar Introduces Deskinacar - The Truly 'Portable' Car Desk: the Lightweight Solution to a Businessperson's Travel Office Needs

.... The desk measures 22 inches by 16 3/4 inches while open and can be leveled in the passenger car seat with the attached poly-web belt. It can be used unfolded as a very large lap desk or can be quickly folded in half to create a heat-absorbing laptop desk, measuring 11 inches by 16 3/4 inches by 1 inch. Offi...
Unfolded in Medical Definition

Personalized medicine

...term emerged in the late 1990s with progress in the Human Genome Project . Research findings over the past decade, or so, in biomedical research have unfolded a series of new, predictive sciences that share the appendage -omics ( genomics , proteomics , metabolomics , cytomics ). These are opening the...
Unfolded in Biological News

UCSF researchers identify new drug target for Kaposi's sarcoma

...d, this is the first small-molecule inhibitor of a herpes virus protease to not only act outside the active site, but also to select for the partially unfolded protein to keep it from forming the dimer interface. Herpes viruses make up one of the most prevalent viral families, including eight human viruses...

Tips from the American Journal of Pathology

... of Amsterdam, The Netherlands discovered that the unfolded protein response contributes to nerve cell death i... presence of "tangles" of misfolded proteins. The unfolded protein response protects cells from the toxic eff...ded proteins; however, prolonged activation of the unfolded protein response, such as in Alzheimer's disease, ...

Scripps research scientists 'watch' as individual alpha-synuclein proteins change shape

...o directly observed in proteins like alpha-synuclein, which are known to be unfolded in isolation, says the study's senior investigator Ashok Deniz, an associat...ly is that the shape can actively change," Deniz says. "It starts off in an unfolded state, and as we increase the concentration of the lipid mimics, the protei...

Relationships in rank and file

...tational Biology" at the Gene Center Munich. "Take as an example folded and unfolded regions in proteins. In an unfolded region, the amino acid valine, for example, can usually mutate into any of ...

Properties of unusual virus revealed in research

...o the E. coli cell. "The diameter of the tube is narrower than the diameter of RNA polymerase," said Murakami. "This means that the enzyme must be unfolded into a longer and thinner structure in order to fit through the tube, and then it is refolded after it is injected into the cell." The ability of t...

Researchers study virus with unusual properties

...o the E. coli cell. "The diameter of the tube is narrower than the diameter of RNA polymerase," said Murakami. "This means that the enzyme must be unfolded into a longer and thinner structure in order to fit through the tube, and then it is refolded after it is injected into the cell." The ability of t...

Syracuse University partners with Serum Institute of India to develop vaccines for children

... a chemical solution, causing the protein to completely unfold. In its new, unfolded state, the tetanus protein is harmless, but is still recognized as tetanus ... wonderful molecule," Doyle says. "We need to get a better idea of what the unfolded protein looks like and try to predict areas that would make good targets fo...

Sudden Oak Death pathogen is evolving, says new study that reconstructs the epidemic

..., according to a new study led by researchers at the University of California, Berkeley. It provides, for the first time, evidence of how the epidemic unfolded in this state. "In this paper, we actually reconstruct the Sudden Oak Death epidemic," said Matteo Garbelotto, UC Berkeley associate extension spec...

RING finger protein 5 may guide treatment for muscle disease in older adults

...es, including sIBM. It is believed that ER stress is a response to misfolded-protein buildup; sensing the backlog, the ER recruits helpers through the unfolded Protein Response (UPR)chaperonins that increase the export of misfolded proteins to enable their breakdown and recycling. But, with prolonged stress,...

Proteins pack tighter in crowded native state

...es, we expected crowding to affect proteins in the unfolded state," said Rice biochemist Pernilla Wittung-Staf...eptide chain packs better," Cheung said. Also, the unfolded state becomes more compact, as predicted by excluded volume theory. These effects on the folded and unfolded states made the native state of the protein 20 deg...
Unfolded in Biological Technology

First ASMS Hites Award for Outstanding Research Publication Presented to Prof. Alison Ashcroft for Her Use of Waters Synapt HDMS System to Explore Protein Complexes

...y about it. "It's adding a new dimension to our research. We can now quantify the amount of protein that is in its native state and the amount that is unfolded and partially folded. We can also monitor which particular conformers are consumed during the assembly process. This is providing important new insigh...

Real-Time PCR: General Considerations, Rev A

...of any of the predicted template secondary structures. This ensures that the majority of possible secondary structures have been unfolded before the primer-annealing step. Follow these parameters when designing primers: Design primers with a GC content of 5060% ...
Unfolded in Biological Definition

Mitosis

...e: Telophase Daughter chromosomes arrive at poles by this stage. The nuclear membrane reforms around the genetic material and the chromosomes are unfolded back into chromatin. This is often followed by cytokinesis or cleavage , where the cellular membrane pinches off between the two newly separated...

Mitosis

...e: Telophase Daughter chromosomes arrive at poles by this stage. The nuclear membrane reforms around the genetic material and the chromosomes are unfolded back into chromatin. This is often followed by cytokinesis or cleavage , where the cellular membrane pinches off between the two newly separated...
Unfolded in Biological Dictionary

Protein folding

...rocess by which a polypeptide folds into its characteristic and functional three-dimensional structure from random coil. Each protein exists as an unfolded polypeptide or random coil when... a protein folding into 3-d structureSUPER COOL! ... A simple solution for folding a certain prot...

MRNA processing

...ing [1152 gene products] ... The European Bioinformatics Institute ... GO:0030969 UFP-specific transcription factor mRNA processing during unfolded protein response ... EUKARYOTIC mRNA PROCESSING . August 22 - 26, 2007. Abstract Deadline: June 6, 2007 ... Global & Genome-Wide Approache...

Lysozyme

...al infection by breaking ... Cytokines & Cells Online Pathfinder Encyclopaedia ... For lysozyme -like proteins see: LLP. ... Since partially unfolded Lysozyme exerts broad spectrum ... Lysozyme - Definition of Lysozyme at Dictionary.com a free online dictionary ... lysozyme ly·so·zyme (lī...
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Breaking Biology News(10 mins):Taking a stand: Balancing the BENEFITS and RISKS of physical activity in children 2Taking a stand: Balancing the BENEFITS and RISKS of physical activity in children 3
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