Uncoupling

Portola Pharmaceuticals Announces Several Scientific Presentations at International Society on Thrombosis and Haemostasis XII Congress

...y, July 13, 12:30-2:15 p.m. Location: Poster Area, Platelet Biology New Directions in Antithrombotic Drug Discovery: Pharmacological uncoupling of Arterial thrombosis from Hemostasis (Presentation #AS-TU-026) Presenter: David Phillips Date: Tuesday, July 14, 1:15-1:45 p.m. Loc...

Mini heart attacks lessen damage from major ones

...lving metabolites of the gas nitric oxide (NO). These lipids, including LNO2, then become attached to two proteins adenine nucleotide translocase and uncoupling protein 2 changing their shape such that they allow a proton leak across the mitochondrial membrane. The leak lowers the proton gradient just enough ...

Fighting diseases of aging by wasting energy

...mouse muscles were made inefficient by increasing the activity of so-called uncoupling protein 1 (UCP1). UCP1 disrupts the transfer of electrons from food to oxyg... study, Semenkovichs group used these mice to determine whether respiratory uncoupling in skeletal musclea tissue that adapts to altered heat production and oxyge...

Activating protein enhances average lifespan, limits age-related disease in mice

...ke more of a protein in their muscle tissue called uncoupling protein-1. Their littermates did not make excess uncoupling protein. In muscle tissue, uncoupling protein-1 converts the energy from food into heat ...

Chronotype, a Measure to Assess Patterns of Daily Activities

...an dwellers are typically exposed to less natural light than individuals inhabiting less densely populated areas. The authors propose that the gradual uncoupling of the circadian clock of city dwellers from local sun time may reflect the relative strength of natural-light and social cues in influencing activity...

Metabolic problems related to clogged arteries

..., the researchers found out those mice, which overproduced a protein called uncoupling protein-1 on the walls of the artery, with low energy levels, it can cause ...he drinking water for the mice to initiate the process of overproduction of uncoupling protein-1. As low energy level is one of the direct results of metab...

Defence against free radicals

... Unit in Cambridge found that molecules known as - uncoupling proteins can move a powerful free radical – called...disposed of safely. The research team suspect that uncoupling proteins could be an important part of the natural...rand says that, by understanding the exact role of uncoupling proteins in cells, new therapies could be develope...

Lean Protein Could Be Key to Obesity Drugs

...gs of the future.British scientists from drug giant SmithKline Beecham and the University of Cambridge have created mice with a human protein known as uncoupling Protein 3 (UCP3) that increases their metabolism.In what is every dieter's dream, the mice were able to eat more than normal mice but still weigh less...

Uncoupling in Medical Technology

Seahorse Bioscience Announces the XF96 Extracellular Flux Analyzer for Cellular Bioenergetics

...nd University, Sweden and the Buck Institute, Novato, CA. "Respiratory measurements allow us to quantify subtle changes in ATP turnover, mitochondrial uncoupling or respiratory chain inhibition that can immediately identify an interaction of a compound with the cell's energy generation pathways. Prior to the Se...

Uncoupling in Biological News

HIV-1 protease inhibitor induced oxidative stress in pancreatic B-cells: thymoquinone protection

...athione, whereas mitochondrial SOD levels remained unaffected in pancreatic beta-cells (INS-1 cells) exposed to nelfinavir. However, the mitochondrial uncoupling protein (UCP2) levels were up-regulated during nelfinavir induced oxidative stress and directly affected the ATP levels in these cells. A significant ...

Stowers Institute's Baumann Lab identifies key step in maturation pathway of telomerase

...nternal piece of RNA and gluing the flanking ends together are tightly coupled during intron removal. To our knowledge this is the first example where uncoupling of the first and second step of splicing generates a functional product in a single-step reaction." The work sheds light on human health by demon...

Making metabolism more inefficient can reduce obesity

...gues at Pennington Biomedical Research Center found that this may not be the case. They knocked-out two thermogenic genes in mice, Ucp1 (mitochondrial uncoupling protein) and Gdm (glycerol 3-phosphate dehydrogenase) and then fed the mice a high-fat diet while rearing them at a cool 20 C (68 F). Surprisingly...

Killer carbs -- Monash scientist finds the key to overeating as we age

...ement as to when our hunger is satisfied," Dr Andrews said. The free radicals also try to attack the hunger neurons, but these are protected by the uncoupling protein 2 (UCP2). Dr Andrews said the reduction in the appetite-suppressing cells could be one explanation for the complex condition of adult-onset...

Study confirms that low-calorie sweeteners are helpful in weight control

...evious studies in humans have shown that low-calorie sweeteners can be helpful in weight control. Everything old is new again: similar studies on the uncoupling of sweetness and calories in humans were conducted back in 1989 and to no great effect, noted Drewnowski. Among criticisms of the study identified b...

How appetite-stimulating brain cells work overtime during fasting

...oduction, or thermogenesis, in brown fat is the activation of mitochondrial uncoupling protein 1 (UCP1) by T3, the researchers said. The UCP1 activation, which is...ve at least three hormones, two cell types, and an unexpected interlocutor, uncoupling protein 2." ...

Slow brain waves play key role in coordinating complex activity

...d when the task is over, you want to decouple them and let them link up with someone else. Ryan has shown that the theta waves allow this coupling and uncoupling by locking into phase." Knight and his colleagues continue to probe the connection between waves of different frequency in the brain and are buildi...

Gardenia fruit compound starting point for diabetes therapy

...ical "genipin." Previously known for its ability to cross-link proteins, they now find that the chemical also blocks the function of the enzyme called uncoupling protein 2 (UCP2) through another mechanism. In both animals and humans, high concentrations of UCP2 appear to inhibit insulin secretion from the pancr...

Discovery clarifies role of peptide in biological clock

...system synchronizes and the secondary messenger systems as well," Herzog said. "We're getting closer to the heart and soul of circadian rhythmicity by uncoupling the (biological) clock." ...

Uncoupling in Biological Technology

New Cellular Bioenergetics Workshops Series Inaugurated by Seahorse Bioscience with Two of the World's Leading Bioenergetics Researchers

...Unit in Cambridge, UK. Dr. Brand is widely regarded as one of the leading authorities on mitochondrial function. His laboratory's work on the role of uncoupling proteins in the dissipation of energy and its connection to disease are at the forefront of biomedical research. The driving force behind his research...