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Unbound in Medical News

How chemotherapy drugs block blood vessel growth, slow cancer spread

...ug-treated and untreated cells and compared regions of DNA known to be bound by HIF-1. The sites that are bound by HIF-1 in untreated cells were found unbound in anthracycline treated cells. "We know that this class of drug prefers to bind to DNA sequences that are similar to the DNA sequence bound by HIF-1,...

Unbound Medicine Announces Download Support for iPhone(TM) and iPod(R) Touch Devices

...Va., Jan. 14 /PRNewswire-USNewswire/ -- Today, unbound Medicine, a leader in knowledge management solutio...y, Windows Mobile, and Palm OS devices strengthens unbound Medicine's position as a leading provider of point...tive iPhone application to become available on the unbound Platform is Nursing Central (TM), the best-sellin...

Consumers Being Misled Over Bioavailabity of Resveratrol

... there, producing an unlocking enzyme called glucuronidase, which is abundant at sites of inflammation, infection and malignancy. This enzyme releases unbound (free) resveratrol at the right time and place. It is nature's drug delivery system," says Sardi. This was all explained back in 2003-2004. [Biochemic...

Draining away brain's toxic protein to stop Alzheimer's

...y to be damaged compared to the same protein in healthy people. As a result, the Alzheimers patients had on average three to four times as much loose, unbound amyloid-beta floating in their bloodstreams high levels that would likely also be reflected in the brain. Zlokovics group decided to try to reduce...

Metastasis of Neuroblastoma linked to Loss Of Caspase-8 gene

...ure to the tissue. When caspase-8 goes and binds to these Integrin molecules it triggers apoptosis. But in case of tumor that is metastasizing the unbound Integrin molecules are free and when caspase-8 bind to it results in Integrin-mediated death (IMD). By this technique all the free and moving cancerou...
Unbound in Medical Technology

FDA Accepts Investigational New Drug Application for ARI-2243 and a First in Man Clinical Trial Set to Begin During the First Half of 2008

...st-in-class "soft drug" feature by which the compound becomes inactive when unbound to the target enzyme, thereby contributing to improvements in safety. Arisa... slowly, thereby preventing the degradation of GLP-1 at the site of action. unbound ARI-2243 then undergoes a unique non-enzymatic conversion as it passes thro...

InterMune Presents Research on ITMN-191 in Hepatitis C at Digestive Disease Week Meeting

...N-191 suggest that liver concentrations may underestimate its antiviral activity, since ITMN-191 will likely remain bound to the protease target after unbound drug is cleared from the liver." About ITMN-191 Preclinical toxicology and pharmacokinetic studies in multiple species suggest that ITMN-191 has a...

Arisaph Pharmaceuticals Announces Results of its Potent Smart DPP-4 Inhibitor, ARI-2243, at the ADA

...s rapidly and tightly to DPP-4 and once bound, the complex dissociates very slowly, thereby preventing the degradation of GLP-1 at the site of action. unbound ARI-2243 then undergoes a unique soft drug inactivation as it passes through the gut and into the systemic circulation, which limits the exposure of t...
Unbound in Medical Products

Unbound Surgery

Description:... unbound Surgery, published by unbound Medicine is an innovative digital resource that combines evidence-based cli...
Company:Unbound Medicine, Inc.

Free Testosterone RIA Test

Description:... Only 1-2% of circulating testosterone exists as unbound or free testosterone. The majority, approximately 60%, is bound to SHBG wit...e SHBG effectively inhibits testosterone action. Measurement of the free or unbound fraction of serum testosterone has been proposed as a means of estimating t...
Company:Diagnostic Systems Laboratories, Inc.

Testosterone RIA Test

Description:... glands [2,3]. The majority of circulating testosterone is bound by SHBG and a smaller portion is bound by albumin. Only 1-2% exists in circulation as unbound or free testosterone [4]. In males, testosterone, either directly or after conversion to DHT, normally functions in fetal Wolffian duct differentiat...
Company:Diagnostic Systems Laboratories, Inc.

Total T4 RIA Test

Description:...5-25% to transthyretin, 5-15% to albumin and a small percentage is bound to erythrocytes [1,2]. Less than 0.1% of the total T4 circulates in a free or unbound form. T4 binds to specific cell receptors and has diverse cellular and somatic effects. Measurement of total serum T4 levels is a standard and well-va...
Company:Diagnostic Systems Laboratories, Inc.

Total T4 EIA Test

Description:...5-25% to transthyretin, 5-15% to albumin and a small percentage is bound to erythrocytes [1,2]. Less than 0.1% of the total T4 circulates in a free or unbound form. T4 binds to specific cell receptors and has diverse cellular and somatic effects. Measurement of total serum T4 levels is a standard and well-va...
Company:Diagnostic Systems Laboratories, Inc.

Cortisol RIA Test

Description:...ing immune function, glucose counter-regulation, vascular tone, substrate utilization and bone metabolism [1,2,3]. Cortisol is excreted in urine in an unbound (free) form. Cortisol levels follow a ACTH-dependent circadian rhythm with peak levels in the early morning and a nadir at night. Increased amounts of...
Company:Diagnostic Systems Laboratories, Inc.

Free IGF-I IRMA Test

Description:... weight ternary complex with IGFBP-3 and ALS [1,2]. A smaller proportion of IGF-I circulates in association with other IGFBPs [2], and less than 5% is unbound or free IGF-I. It is believed that free IGF-I represents the biologically active fraction of IGF-I [3]. IGF-I concentrations in serum are dependent ...
Company:Diagnostic Systems Laboratories, Inc.

IGF-I IRMA Test (With Extraction)

Description:... weight ternary complex with IGFBP-3 and ALS [1,2]. A smaller proportion of IGF-I circulates in association with other IGFBPs [2], and less than 5% is unbound or free IGF-I. It is believed that free IGF-I represents the biologically active fraction of IGF-I [3]. IGF-I concentrations in serum are dependent ...
Company:Diagnostic Systems Laboratories, Inc.

IGF-I ELISA Test (With Extraction)

Description:... weight ternary complex with IGFBP-3 and ALS [1,2]. A smaller proportion of IGF-I circulates in association with other IGFBPs [2], and less than 5% is unbound or free IGF-I. It is believed that free IGF-I represents the biologically active fraction of IGF-I [3]. IGF-I concentrations in serum are dependent ...
Company:Diagnostic Systems Laboratories, Inc.

IGF-I IRMA Test (Non-Extraction)

Description:... weight ternary complex with IGFBP-3 and ALS [1,2]. A smaller proportion of IGF-I circulates in association with other IGFBPs [2], and less than 5% is unbound or free IGF-I. It is believed that free IGF-I represents the biologically active fraction of IGF-I [3]. IGF-I concentrations in serum are dependent ...
Company:Diagnostic Systems Laboratories, Inc.
Unbound in Medical Dictionary

Systole

...isovolumic systole but preserved overall systolic ... A selected short axis slice at (B) end-diastole and (C) end- systole is demonstrated. ... unbound MEDLINE | Systole journal articles. Search by keyword, journal, author or by EBM filters diagnosis, treatment, prognosis or etiology. Evidence-bas...

Hypocalcemia

...cemia , a low bood Explores where this mineral is stored in the body and how it is ... Thus, hypocalcemia causes problems only when the level of unbound calcium is low. ... INTRODUCTION Hypocalcemia may be associated with a spectrum ... Etiology of hypocalcemia in infants ... manifestations...

Hemoglobinuria

...rth decades of life and is Hemoglobinuria - Washington Hospital Center is located in Washington DC ... Hemoglobinuria is the presence of free, unbound hemoglobin in the urine, which is ... Hemoglobinuria . Definition ... This is called hemoglobinuria . ... Paroxysmal nocturnal hemoglobinuria...
Unbound in Biological News

Carnegie Mellon scientists develop fluorescent proteins for live cell imaging, biosensor design

...ften have a difficult time locating a target biomolecule inside living cells using other dye technologies because of background light given off by any unbound dye molecules. This background light obscures the biomolecules glow and therefore must be removed to successfully carry out the experiment. The ne...

Scientists develop new measure of 'socioclimactic' risk

...re for Theoretical Physics in Trieste, Italy, found that China, India and the United States - major greenhouse gas-emitting nations that are currently unbound by the Kyoto treaty - face substantial exposure relative to other nations, but that every area of the world faces high exposure in at least one catego...

American Chemical Society's Weekly Press Pac

...g HFCS. They found astonishingly high levels of reactive carbonyls in those beverages. These undesirable and highly-reactive compounds associated with unbound fructose and glucose molecules are believed to cause tissue damage, the researchers said. By contrast, reactive carbonyls are not present in table sug...

Marathon of nano-sprinters

...lament will stay close to that filament as long as the cargo and filament are still cross-linked by at least one bound motor. In such a situation, the unbound motor can rebind to the filament and then continue to pull the cargo ?in contrast to human sprinters, molecular motors don't get tired. This mecha...

Elusive HIV shape change revealed; Key clue to how virus infects cells

...ion three-dimensional images of the protein in its unbound form. They surmounted considerable technical chall...hich shape of gp120 ?bound to the CD4 receptor, or unbound ?is recognized by a person's antibodies. gp120's s...tes Harrison. "We can now compare the bound and unbound forms and try to understand whether there are any ...
Unbound in Biological Technology

Sixth Annual Healthcare Unbound Conference to Focus on Remote Monitoring, Home Telehealth & eHealth for Chronic Care Management & Wellness Promotion

ROLLING HILLS ESTATES, Calif., May 7 /PRNewswire/ -- The Sixth Annual Healthcare Unbound Conference & Exhibition, organized by The Center for Business Innovation (TCBI), will feature the coming together of consumer and healthcare technologies to facilitate participatory medicine . The Conf...

Fifth Annual Healthcare Unbound Conference to Focus on Remote Monitoring, Home Telehealth & eHealth for Disease Management & Wellness Promotion

ROLLING HILLS ESTATES, Calif., June 19 /PRNewswire-USNewswire/ -- The Fifth Annual Healthcare Unbound Conference and Exhibition, hosted by The Center for Business Innovation (TCBI), will feature the coming together of consumer and healthcare technologies to promote wellness and to help manage d...

Graphene yields secrets to its extraordinary properties

... conventional materials, the speed of electrons is related to their energy, but not in graphene. Although they do not approach the speed of light, the unbound electrons in graphene behave much like photons, massless particles of light that also move at a speed independent of their energy. This weird massl...

Researchers develop new way to see single RNA molecules inside living cells

... we gained the ability to distinguish a targeted RNA molecule from a single unbound probe because the former lit up two or three times brighter." For their ... probe designed with no target in the human genome. They were able to image unbound probes of both types as well as individual RNA molecules that had attached ...

Endotoxins and their Relevance in R&D ApplicationsLPS Detection & Removal Methods

...animal experiment thats why it can be transferred only with restriction to the human system. A further disadvantage is that only unbound LPS molecules can be detected. Therefore it can be possible that up to 30-50 lower values 10 are measured with the LAL test than wi...

High Sensitivity, Wide Dynamic Range, Horseradish Peroxidase (HRP) ELISA Using the LMax Microplate Luminometer (MaxLine Application Note #41)

...α present is bound by the immobilized antibody. After washing away any unbound substances, horseradish peroxidase (HRP)-linked polyclonal antibody specific for TNF-α is added to the wells. unbound antibody-enzyme reagent is removed by washing. An enhanced luminol/peroxide...

Measurement of Molecular Beacons in the SpectraMax Gemini Spectrofluorometer (MaxLine Application Note #36)

...Molecular beacons areappealing because they can be used in homogeneous solutions and obviate theneed to isolate probe/target hybrids from an excess of unbound hybridizationprobes. They have been used to monitor polymerase chain reactions. 3 Many combinations of fluorophores and quenchers are possible. K...

Immunoassay of Theophylline by fluorescence polarisation

...d by use of polarization measurements, which discriminate between bound and unbound fluorophores. The detection system includes a T-format sampling module moun...on measurements, eliminates interference from other fluorophores as well as unbound tags.

This example demonstrates that fluorescence immunoassay has, li...

Counting FlashPlates on the Wallac MicroBeta

...cintiPlates, then bound activity was read on the MicroBeta. The mass bound was determined by the differential between the known mass/DPM added and the unbound mass/DPM, using the known specific activity for the compound and the known efficiency of a LSC counter. The MicroBeta proved to read the opaque plate ...

Caspase-3 Activation - An Indicator of Apoptosis in Image-Based Assays

...yclonal antibody (Cell Signaling Technology, 9661, 1:100 dilution) in 5% goat serum and 0.3% Triton X-100 over night at 4C. Further wash steps removed unbound antibody prior to the addition of the secondary Alexa 488 goat anti-rabbit antibody (Invitrogen, A11034, 10μL/mL) and Hoechst 33342 dye (5 μ...
Unbound in Biological Products

Avidin, FITC conjugated/tagged from Invitrogen

Description:... azide and 50% glycerol. Avidin (from egg white) is conjugated with FITC. The conjugate is purified by molecular sieving and is completely free of unbound FITC. FITC-Avidin can be used for the detection or localization of biotinylated biomolecules....
Company:Invitrogen

XpressPack™ Luminescent Amplification Detection System, required for luminescent XpressPack™ from CHEMICON

Description:...Pack gene-specific kit). The hybrid complex is then reacted with streptavidin conjugated to AquaLite, a recombinant form of the photoprotein aequorin. unbound conjugate is removed by washing. When calcium cations are added, a blue light is emitted. This light is quantified using a microplate luminometer; the...
Company:CHEMICON

XpressPack™ Colorimetric Amplification Detection System, required for colorimetric XpressPack™ from CHEMICON

Description:...plate included in the XpressPack™ gene-specific kit). The hybrid complex is then reacted with streptavidin conjugated to horseradish peroxidase. unbound conjugate is removed by washing. When TMB substrate is added, a blue color develops. The reaction is stopped by the addition of an acid, changing the ...
Company:CHEMICON

IHC SELECT® APR KIT SINGLE SPECIES-RAT 150 TESTS from CHEMICON

Description:...n) is added and will react with the primary antibody present on the tissue. unbound antibody is removed by washing. The sample is then by incubated with the St...which binds to the biotin-labeled secondary antibody present on the tissue. unbound enzyme is removed by washing. The chromogenic development reagent, Fast Red...
Company:CHEMICON

FAM Poly Caspase Assay Kit from B-Bridge International

Description:...further enzymatic activity. Because the FAM-VAD-FMK FLICA reagent becomes covalently coupled to the enzyme, it is retained within the cell, while any unbound FAM-VAD-FMK FLICA reagent will diffuse out of the cell and is washed away. The remaining green fluorescent signal is a direct measure of the number o...
Company:B-Bridge International

TACE Fluorometric (MCA)) Assay Kit, InnoZyme™ from Calbiochem

Description:... enzyme inhibitors. An Anti-Human TACE-Coated 96-Well Plate is pre-coated with a monoclonal antibody specific for human TACE that captures the enzyme. unbound material is discarded, the plate is washed, and the activity of captured TACE is measured using an internally quenched fluorescent substrate, MCA-KPLG...
Company:Calbiochem

CaspaTag™ Pan-Caspase In Situ Assay Kit, Fluorescein from CHEMICON

Description:...nit of the active caspase heterodimer, thereby inhibiting further enzymatic activity. The bound labeled reagent is retained within the cell, while any unbound reagent will diffuse out of the cell and is washed away. The green fluorescent signal is a direct measure of the amount of active caspase present in t...
Company:CHEMICON

CaspaTag™ Pan-Caspase In Situ Assay Kit, Sulforhodamine from CHEMICON

Description:...nit of the active caspase heterodimer, thereby inhibiting further enzymatic activity. The bound labeled reagent is retained within the cell, while any unbound reagent will diffuse out of the cell and is washed away. The red fluorescent signal is a direct measure of the amount of active caspase present in the...
Company:CHEMICON

IHC SELECT® DAB KIT SINGLE SPECIES-RAT 150 TESTS from CHEMICON

Description:...n) is added and will react with the primary antibody present on the tissue. unbound antibody is removed by washing. The sample is then incubated with the Strep...which binds to the biotin-labeled secondary antibody present on the tissue. unbound enzyme is removed by washing. The chromogenic development reagent, 3,3' dia...
Company:CHEMICON

S-Protein Agarose from Novagen

Description:...tein under native or denaturing conditions. Crude samples are incubated with S-protein Agarose, which specifically retains STag fusion proteins. After unbound proteins are washed away, the target protein is released by incubation of the agarose beads with site-specific protease, leaving the STag peptide boun...
Company:Novagen
Unbound in Biological Definition

Affinity chromatography

...object is to remove an undesirable molecule from the initial mixture, then once the initial binding has been achieved, the material of interest is the unbound mixture, and the washing and elution steps can be omitted or used simply for analytical purposes. Specific Uses Affinity chromatography can be ...

Molecular biology

...olid support matrix like Sephadex or Sepharose beads, for example, can be used to remove a protein of interest from a complex solution. After washing unbound and non-specifically bound materials away from the "beads", the protein of interest is then eluted from the matrix, usually by adding a solution with ...
Unbound in Biological Dictionary

Venules

...er additional information on Venules from Biology-Online.org dictionary. ... arteries-arterioles-capilaries - venules -veins-vein-heart blood ... unbound MEDLINE | Venules journal articles. Search by keyword, journal, author or by EBM filters diagnosis, treatment, prognosis or etiology. Evidence-based...

G2 phase

... :: G2 Phase :: physiology :: [Kinetic features of a white rat hepatocyte population under hormonal disbalance before and after partial ... unbound MEDLINE | G2 Phase journal articles. Search by keyword, journal, author or by EBM filters diagnosis, treatment, prognosis or etiology. Evidence-ba...
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Breaking Medicine News(10 mins):Health News:Obesity Should Not Be a Hollywood Punchline, Weight Loss Doc Says 2Health News:Performance Physical Therapy Awarded with Jayne L. Snyder Private Practice of the Year 2014 2Health News:Scientists to Stanford: Research Shows Brain Exercises Can Work 2Health News:Scientists to Stanford: Research Shows Brain Exercises Can Work 3Health News:Scientists to Stanford: Research Shows Brain Exercises Can Work 4Health News:Lice Troopers Announces New Lice Treatment Clinic in Coral Gables to Service Key Biscayne, Coconut Grove, Kendall, Brickell & South Miami 2Health News:Project Veritas: James O’Keefe Interviews the Man Who Discovered Jonathan Gruber Videos 2
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