A potential new target for treatment of hormone refractory prostate cancer

...ociated protein and demonstrated that RNF6 induced ubiquitination of the AR and promoted AR transcriptional activity. ubiquitination is a common protein modification that mediates a d...lar activities. One of the best known functions of ubiquitination is to promote protein degradation. However,...

Penn scientists find a protein that inhibits Ebola from reaching out to infect neighboring cells

... demonstrated that ISG15 interacts with Nedd4 ubiquitin ligase and inhibits ubiquitination of VP40, thus blocking budding of VP40 VLPs. These data provide evidence of...a mechanism of action involving disruption of Nedd4 function and subsequent ubiquitination of VP40. This newest study has extended the teams knowledge of the repro...

What's been causing your knee to ache? Smurfs!

...own that an enzyme which controls the response of cells to growth factors may in fact be a major cause of osteoarthritis. The enzymes are called "Smad ubiquitination Regulatory Factors, or, smurfs, but unlike the small, loveable blue cartoon characters, researchers believe that a particular form of these regulatory...

Protein Targets for Carcinogenesis

...ects are the consequences. The knowledge about the ubiquitination reaction as well as the effect of ubiquitination on diverse cellular functions has already led to t...ther diseases. Our current view on protein ubiquitination as it is found in the textbooks has to be revised,...

Ubiquitination in Medical Technology

St. Jude Study Gives New Insights Into How Cells Accessorize Their Proteins

... of biochemical reactions that enable life. "The ubiquitination machinery is critical for the cell's proteins to b... the paper's senior author. "Basic insights into ubiquitination could ultimately have clinical application, becaus...led understanding of the workings of the intricate ubiquitination machinery. "The whole process of attaching ubiqu...

Ubiquitination in Medical Definition

Muscle atrophy

...bstrate is thus "poly-ubiquitinated", it is targeted for destruction by the proteasome . Particular enzymes in the ubiquitin/proteasome pathway allow ubiquitination to be directed to some proteins but not others - specificity is gained by coupling targeted proteins to an "E3 ubiquitin ligase ". Each E3 ubiquitin...

Proteopathy

...actoferrin Pulmonary alveolar proteinosis Surfactant protein C (SP-C) Critical illness myopathy (CIM) Hyperproteolytic state of myosin ubiquitination References ^ Walker LC and LeVine H (2000). "The cerebral proteopathies". Neurobiol Aging 21 : 559-561. PMID 10924770 . ...

Ubiquitination in Medical Dictionary

Enzyme

...se is the enzyme in the small intestine that digests lactose (the naturally ... The E1 ubiquitin-activating enzyme lies at the apex of the ubiquitination ... We find that this enzyme controls embryonic and larval development, sperm ... Information about enzyme in the free online English dictio...

Ubiquitination in Biological News

Bound for destruction: Ubiquitination protects against improper Notch signaling

The Notch pathway is an important molecular signaling mechanism whose existence has been known, or at least hinted at, for nearly a century since the identification of a mutant strain of Drosophila fruit flies with “notched?wings in Thomas Hunt Morgan’s lab in 1910. Later studies revealed that th...

Protein can help cells or cause cancer, Purdue researcher finds

...s. Topors binds itself to p53 molecules during the ubiquitination process. Phosphorylation is basically an instruction from Plk1 to increase its ubiquitination activity, which kills p53 molecules. Liu said p...s able to force cells in his lab to go through the ubiquitination or sumoylation process to show how p53 molecules w...

Lipid droplets lead a Spartin existence

... LD turnover: overexpressing or knocking-down the protein caused an increase in both the organelle's size and number. In turn, Spartin is regulated by ubiquitination by the ubiquitin ligase WWP1. Overexpressed WWP1 removed Spartin from LDs and promoted its degradation. A truncated form of Spartin found in a rare...

St. Jude study gives new insights into how cells accessorize their proteins

...of biochemical reactions that enable life. "The ubiquitination machinery is critical for the cell's proteins to b...ical Institute (HHMI) investigator. "Understanding ubiquitination can give us important knowledge about such biologi...the paper's senior author. "Basic insights into ubiquitination could ultimately have clinical application, becaus...

Glue inside the cell

...s the scientists could prove that this novel Malt1 ubiquitination is an essential step in the regulation of T cell a...ents inside the cell, Krappmann explains. However, ubiquitination provides an important advantage compared to conven...ment. Future work must address the status of Malt1 ubiquitination under pathological conditions, for instance in Mal...

Insight into natural cholesterol control suggests novel cholesterol-lowering therapy

...by attaching a protein called ubiquitin in a process called ubiquitination. ubiquitination is a common mechanism for stimulating protein degradation. Cholesterol itse...rect role for lanosterol as a selective, physiologic regulator of reductase ubiquitination and degradation," said DeBose-Boyd. That effect would, in turn, control the...

Ubiquitination in Biological Technology

RNAi Helps Illuminate the Inner Workings of the Cell Cycle: Synthetic RNAissance™ Genes Created by DNA2.0 Enable Key Research

...vented the mutant Cdc20 from becoming ubiquitinated. By eliminating the natural Cdc20 from cells using RNAi, the Cambridge group was able to show that ubiquitination of Cdc20 is required to prevent a cell from dividing before all of its chromosomes are lined up on the mitotic spindle. This cell cycle checkpoint is ...

Ubiquitination in Biological Definition

Histone

... primarily on their N-terminal tails, but also in their globular domains. Such modifications include methylation , acetylation , phosphorylation , ubiquitination , and ADP -ribosylation. This effects their function of gene regulation (see functions). In general, genes that are active have less bound hist...

Ubiquitination in Biological Dictionary

Western blot

...ow investigators to determine the molecular weight of a protein ... Immunochemistry Protocols: Western blot Antibody. Step 1 ... Contact us • ubiquitination Antibody • Western Blot Antibodies • Acetylation ... ...

Ubiquitin

... Ubiquitin is a small, highly-conserved regulatory protein that is ubiquitously expressed in eukaryotes. ubiquitination refers to the post-translational modification of a protein by the covalent attachment of one or more... ubiquitin ( yü′bikwə′tin ) ( biochem...