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Ubiquitin in Medical News

Damon Runyon Cancer Research Foundation awards prestigious fellowships to 17 top young scientists

... St. Jude Children's Research Hospital, Memphis, Tennessee, is studying how cell division is regulated, in part, by the attachment of a protein called ubiquitin to other proteins throughout the cell. Understanding how ubiqutin is attached to its targets and how this attachment is recognized by cellular machin...

Protein that suppresses androgen receptors could improve prostate cancer diagnosis, treatment

...ptor expression and activity went down. βarrestin2 locks up an androgen receptor by binding to it, then the pair bind to yet another protein, ubiquitin ligase, which tags the receptor as waste and the trio make their way to the cell's garbage dump. "The neat thing about it is βarrestin2 inhibits ...

Penn Medicine, CHOP researchers demonstrate first common genetic risk factors for autism

...d deleted or duplicated genes along two major central nervous system gene networks in children with autism spectrum disorders. The changes were on the ubiquitin pathway, which is responsible for regulating synaptic operations and nervous system development. One ubiquitin-related gene studied, UBE3A, was previo...

Gene helps protect tumor suppressor in breast cancer

...rotein is destroyed when it is bound by the enzyme NEDD4-1, which attaches targeting molecules called ubiquitins that mark PTEN for destruction by the ubiquitin proteasome complex. Lin and colleagues showed that Rak saves PTEN from degradation by attaching a phosphate group to the protein, blocking NEDD4-...

Proteasome inhibition affects epigenetic mechanisms

...says and Western blot analysis were performed using isolated nuclei. They found that chronic ethanol feeding caused a significant inhibition of the ubiquitin proteasome pathway in the nucleus, which led to changes in the turnover of transcriptional factors, histone modifying enzymes, and, therefore, affecte...

Blocking molecular pathway with whimsical name possible therapeutic target for pancreatic cancer

...ition. SINA produces a family of RING domain E3 ubiquitin ligases. In all creatures, ubiquitin ligases turn cell pathways on or off by degrading proteins. In humans, the SIAH ubiquitin ligases sit smack in the middle of the molecular p...

Penn scientists find a protein that inhibits Ebola from reaching out to infect neighboring cells

...with host proteins such as tsg101 and Nedd4, an E3 ubiquitin ligase. ubiquitin itself is thought to be exploited by Ebola virus t...chers demonstrated that ISG15 interacts with Nedd4 ubiquitin ligase and inhibits ubiquitination of VP40, thus b...

Quality control mechanism tags defective sperm cells inside the body

...process without a tag. A small protein called ubiquitin marks abnormal sperm cells, including cells that h...an optimal chance of fertilization. High levels of ubiquitin in the sperm can indicate low-sperm count or infer... In many cases, the cells that are tagged with ubiquitin are obviously abnormal with two tails or two heads...

Cancer stem cell marker also drives transcription in normal cells

...demonstrated that the newly identified subunits work together to remove the ubiquitin moiety from monoubiquitylated histone H2B, similarly to what has been previously described in yeast, but also remove the ubiquitin moiety from monoubiquitylated histone H2A. The latter modification is not f...

JCI table of contents: Nov. 8, 2007

...induced muscle damage and that inhibiting atrogin-1 function might protect against this unwanted side effect of statins. TITLE: The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity AUTHOR CONTACT: Stewart H. Lecker, Beth Israel Deaconess Medical Center, Boston, M...
Ubiquitin in Biological News

CSHL scientists discover new way in which ubiquitin modifies transcriptional machinery

Cold Spring Harbor, N.Y. During gene transcription the process inside the nucleus of cells by which DNA, the genetic material, is copied into RNA molecules a large, ever-changing multiprotein complex is enlisted to assist the DNA-copying enzyme in its challenging job. Like an exquisitely ch...

Muscle atrophy through thick but not thin

...as not known. MuRF1, an atrophy-related gene, is a ubiquitin ligase that "ubiquitylates," or tags a protein, by attaching a ubiquitin molecule, marking it for degradation by the cell. ...le components, whereas others fall victim to other ubiquitin ligases and autophagy. Inhibitors that work upstre...

Lipid droplets lead a Spartin existence

...essing or knocking-down the protein caused an increase in both the organelle's size and number. In turn, Spartin is regulated by ubiquitination by the ubiquitin ligase WWP1. Overexpressed WWP1 removed Spartin from LDs and promoted its degradation. A truncated form of Spartin found in a rare neuronal disease...

A paradigm shift in immune response regulation

... Their results show that interaction with a linear ubiquitin chain is crucial for nuclear factor kappa B activa...sphorylation) or the conjugation of small modifier ubiquitin (ubiquitination) - play a central role in control...rnational collaboration to investigate the role of ubiquitin modification in these pathways. The international...

Self-digestion as a means of survival

...ecules which are destined to be discarded are marked with the small protein ubiquitin and this is recognised by a receptor located at the gateway to the proteaso...h proteins have a similar chain-like structure. At one end they bind to the ubiquitin that marks the protein aggregates and organelles that are to be degraded. N...

New research helps explain genetics of Parkinson's disease

...B) . Both articles will be published online Monday, November 24 ( www.jcb.org ). Loss-of-function mutations in the gene Park2, which encodes an E3 ubiquitin ligase (Parkin), are implicated in half the cases of recessive familial early-onset Parkinson's disease. Several lines of evidence suggest that Parkin...

Conaway Lab identifies novel mechanism for regulation of gene expression

...in tags (called ubiquitin) from other proteins. The presence of one kind of ubiquitin tag on a protein can mark it for destruction, but others serve as marks to ... to regulate these enzymes is very important because promiscuous removal of ubiquitin marks could lead to a failure to regulate properly the activities or levels...

St. Jude study gives new insights into how cells accessorize their proteins

... given environment. One of the major functions of ubiquitin is to mark a protein for disposal when its job is ... to cullin-RING, it activates the enzyme to attach ubiquitin to its target protein. In this activation process ...nhibitor CAND1, activating cullin-RING to then put ubiquitin onto a different target protein. The open state al...

Model for angelman syndrome developed by University of Texas at Austin biologists

...ogy. The UBE3A protein is an enzyme that attaches a small protein called ubiquitin to other proteins. ubiquitin attachment signals that the tagged protein needs to be degraded. "The s...

Death, division or cancer? Newly discovered checkpoint process holds the line in cell division

...ays Yen. Yen, along with visiting researcher Avram Hershko, Ph.D., of Technion, discovered the ability of MCF2 to block mitosis by shutting down an ubiquitin ligase enzyme known as the anaphase-promoting complex/cyclosome (APC/C). Hershko was awarded the 2004 Nobel Prize for Chemistry along with former Fox ...
Ubiquitin in Biological Technology

Scotland Highlights New Partnerships and Cutting-Edge Drug Discovery Research

...yees. At this year's conference, Scotland will present a panel on 'The ubiquitin Story,' a look at an exciting new research area in which Scotland has inves...Institute for Cell Signaling (SCILLS) and the $14 million ITI Life Sciences ubiquitin Proteasome System (UPS) drug discovery program. Participating in the panel...

United States Recognizes Leading Scottish Scientist for Disease Research

...e field of life sciences is demonstrated by his longstanding commitment to collaboration across the industry. Recently, Sir Philip helped identify the ubiquitin Proteasome System (UPS) as a promising new source for key drug targets and is part of a global UPS research program partnering life sciences company M...

Cystic Fibrosis - Axentis Pharma Takes Over Patents and Continues Development of Innovative Platform Technology

... About the patent families The inventions which have now been acquired by Axentis Pharma describe the use of molecules for the enzymatic removal of ubiquitin markers in incorrectly folded proteins. The inventions also protect the use of the proteasome inhibitor Bortezomib (Velcade (R)) for second medical us...

Measurement of proteasome inhibition in live cells in Molecular Devices microplate fluorometers

..., an ATP-dependent process where unwanted proteins are multiply-tagged with ubiquitin (a 76-amino acid protein). 1 The tagged proteins are then transported to t...n; zFP506.1) that is degraded by the proteasome without the requirement for ubiquitin modification. 5 To convert ZsGreen into a proteasomal substrate, its C-ter...

Single-Cell Complementation of Barley Mlo Mutants Using a PDS-1000/He Hepta System

...ing sequences under the control of the strong constitutive maize ubiquitin 1 promoter was used for the barley experiments. For transformati... wild type and the GFP reporter genes whose expression is driven by a ubiquitin promoter. Approximately 24 hr after the biolistic transfer, we o...
Ubiquitin in Biological Products

Goat Anti-FbxL7 Polyclonal Antibody, Unconjugated from GeneTex

Description:...ter cyclin F in which it was originally observed, is an approximately 40-amino acid motif that binds SKP1. F-box proteins are components of modular E3 ubiquitin protein ligases called SCFs (SKP1, cullin, F-box proteins), which function in phosphorylation-dependent ubiquitination. Immunogen: Synthetic peptid...
Company:GeneTex

Rabbit Anti-Human COP9 signalosome complex subunit 2 Polyclonal Antibody, Unconjugated from Aviva Systems Biology

Description:...e COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes. The complex is also involved in phosp...
Company:Aviva Systems Biology

Ubiquitin Fraction I Extract from GeneTex

Description:...cade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted ...anion exchange resin. GTX80876 contains ubiquitin, ubiquitin conjugating enzymes (E2s), and ubiquitin ligases (E3s). GTX80876 is ideal for demonstrating...
Company:GeneTex

IRS Extract from GeneTex

Description:...cade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted ...lly ubiquitin-free and ATP-free. GTX80877 contains ubiquitin activating enzyme (E1), most ubiquitin conjugating enzymes (E2s),...
Company:GeneTex

26S Proteasome Fraction Extract from GeneTex

Description:...cade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted ...GTX80880 contains the full Hela cell compliment of ubiquitin activating enzyme (E1), ubiquitin conjugating enzymes (E2s), 20S and 26S proteasomes...
Company:GeneTex

Ubiquitin Fraction I from ABR-Affinity BioReagents

Description:...cade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted ... anion exchange resin. EP-500 contains ubiquitin, ubiquitin conjugating enzymes (E2s), and ubiquitin ligases (E3s). EP-500 is ideal for demonstrating ...
Company:ABR-Affinity BioReagents

Ubiquitin/Proteasome Fraction II Extract from GeneTex

Description:...cade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted ...lly ubiquitin-free and ATP-free. GTX80878 contains ubiquitin activating enzyme (E1), most ubiquitin conjugating enzymes (E2s),...
Company:GeneTex

26S Proteasome Fraction Extract from GeneTex

Description:...tial role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pa...
Company:GeneTex

UBC Fractions Extract from GeneTex

Description:...cade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted ...lactoglobulin. These conjugation fractions contain ubiquitin c-terminal hydrolases. The addition of ubiquitin aldehyde is recommended for the inhibition of UCHs...
Company:GeneTex

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Ubiquitin in Biological Definition

Proteasome

...ion, and has openings at the two ends to allow entry of the targeted protein. 26S proteasome The 26 S proteasome is used for the digestion of ubiquitin -marked proteins. It is located on both sides of a cell's nuclear membrane and consists of a 20S core protease particle and two 19S regulatory particl...

Signal transduction

... engaged in a hormone-receptor-complex can be deactivated, either by covalent modification (for example, phosphorylation), or by internalization (see ubiquitin ). Intracellular signal transduction Intracellular signal transduction is largely carried out by second messenger molecules. Ca ...

Transmembrane receptor

... transmembrane receptor. Most of them work through the intracellular domain. The most important ways are phosphorylation and internalization (see ubiquitin ). See also Signal transduction G protein Second messenger Neuromodulators ...
Ubiquitin in Biological Dictionary

Ubiquitin

Ubiquitin is a small, highly-conserved regulatory protein that is ubiquitously expressed in eukaryotes. Ubiquitination refers to the post-translational modification of a protein by the covalent attachment of one or more... ubiquitin ( yü′bikwə′tin ) ( biochemistry ) A small, 76-amino...

S phase

...f the mitotic cycle during which DNA ... S phase . ( 2009) ... Cell cycle articles relating to ' S phase inhibitors' ... Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase . ... ... activity is restricted to the G1- S phase of the cell cycle. ... During S p...

Proteome

...me -based plasma biomarkers for Alzheimer's disease" ... Proteome Resources provides enzymes, nucleases and protein expression services to ubiquitin and apoptosis research scientists in academic, government, ... Proteome Software would like to hear what you have to say about Proteomics, and...

Proteasome

...tic cells that is the site The scientific resource for elucidating the ubiquitin / Proteasome Pathway. ... Apoptosis meets proteasome , an invaluable therapeutic target of anticancer drugs. ... ubiquitin and Proteasome Proteasome , signalosome, & TPPII ('Zomes') subuni...
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