USC

Muscle-targeted gene therapy reverses rare muscular dystrophy in mice

Gene therapy methods that specifically target muscle may reverse the symptoms of a rare form of muscular dystrophy, according to new research in mice conducted by medical geneticists at Duke University Medical Center. Infants born with the inherited muscular disorder called Pompe disease usually die before they reach the age of two. The researchers also said their approach of targeting corrective...

X-Ray Beams And Fruit Fly 'Flight Simulator' Aid Scientists' View Of Muscle Power

What is the connection between a fly’s aerodynamic skill and human heart function? Using the nation’s most brilliant X-rays, located at the Advanced Photon Source at the U.S. Department of Energy’s Argonne National Laboratory, a cardiac molecular motors expert from the University of Vermont (UVM) and colleagues from the Illinois Institute of Technology (IIT) and Caltech performed research to answ...

Heart repair gets new muscle

Some organs in the human body deal with injury better than others. A flesh wound or muscle tear might hurt, but, assuming you are otherwise healthy, both will heal. The prognosis for a heart attack, on the other hand, is not so clear-cut. It has long been thought that cardiac cells (cardiomyocytes) lack the capacity for self-renewal and repair, impeding the chances of a full recovery from...

Young Blood Revives Aging Muscles, Stanford Researchers Find

Any older person can attest that aging muscles don't heal like young ones. But it turns out that's not the muscle's fault. A study in the Feb. 17 issue of Nature shows that it's old blood that keeps the muscles down. The study, led by Thomas Rando, MD, PhD, associate professor of neurology and neurological sciences at the Stanford University School of Medicine, built on previous work show...

Small worm yields big clue on muscle receptor action

Researchers at the University of Illinois at Chicago have identified an elusive subunit of a neurotransmitter receptor found in both humans and the much-studied laboratory nematode C. elegans which may open new pathways of research on muscle function. The neurotransmitter acetylcholine binds to two different nicotinic receptors at the nematode's neuromuscular junctions, causing them to con...

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USC at Biology Products

Interspecies Trial Array 2: N Brain, N Liver, N Muscle, N Kidney from CHEMICON

Description:Chemicon Select Tissue Arrays are intended for laboratory research use only. The individual tissues were fixed in neutral buffered formalin and embedded in paraffin. Tissue identification and diagnosis was performed by certified pathologists. Tissue cores were removed from their paraffin blocks and relocated into a new recipient paraffin block, in an array pattern, using Chemicons Advanced Tis...
Company:CHEMICON

Human Skeletal Muscle RACE-Ready cDNA from Ambion

Description:...
Company:Ambion

C2C12 cell line slides ( mouse: muscle; myoblast ) from GeneTex

Description:Mouse C2C12 cells were cultured in DMEM and harvested at the log phase of growth. In order to keep the antigens in their native forms, cells were fixed in acetone-methanol. The cells are arrayed on a 12-well (5 mm) adhesive coated slide, with each wells surface specifically treated to enhance cellular attachment and to minimize background staining. Each well is loaded with approximately 7. 5 x...
Company:GeneTex

Rabbit Anti-Nonmuscle Myosin II Heavy Chain B (MHC-B) Polyclonal Antibody, Unconjugated from Covance Research Products, Inc

Description:Polyclonal Antibody against Nonmuscle Myosin II Heavy Chain Isoform B *Predicted MW = 200 kD....
Company:Covance Research Products, Inc

Mouse Anti-muscle actin Monoclonal Antibody, Unconjugated, Clone HUC1-1 from Santa Cruz Biotechnology, Inc.

Description:muscle actin (HUC1-1)...
Company:Santa Cruz Biotechnology, Inc.

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USC at Biology Technology

Primary cells, rat heart muscle

Primary cells: Adult heart muscle cells from rat, 6...

Gq-coupled receptor assays using FLEXstation: M1 muscarinic receptor

SIMPLE, RAPID EXPERIMENTAL SET-UP AND DATA ANALYSIS DETERMINE EC EXCELLENT FOR ASSAY DEVELOP-MENT AS DEMONSTRATED BY Z FACTOR INTROD...

Delivery of pCMV-S DNA Using the Helios Gene Gun System Is Superior to Intramuscular Injection in Balb/c Mice

Andrew Conn, Lindy Durrant, and Ian Spendlove, Cancer ResearchCampaign Academic Unit, Nottingham City Hospital, Hucknall Road,Nottingham NG5 1PB, UK Gene gun immunization through the skin is a reliable and reproducible method of DNA vaccine delivery, and has been shown to be capable of inducing...

Laser Capture Microdissection of muscle fiber populations and expression analysis by RT-PCR

To locate gene products in distinct muscle fiber populations of different muscle allotypes, a novel protocol was established. A rapid method to distinguish muscle fiber types using histochemistry and...

USC at Biology Definition

Muscle

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Malpighian corpuscle

. They are also known as: —...

USC at Biology Dictionary

Voluntary muscle

: clusters of <a href="/ ?q=/ Biology-Diction...

Triceps muscle

and <a href="/ ?q=/ Biology-D...

Striated muscle

(or "voluntary"): attached to the <a href="/ ?q=/ ...

Smooth muscle

or "<a href="/ ?q=/ Biology-Dictionary/ involuntary_muscle" class="hiv"...

Skeletal muscle

and myoglobin, giving the <a href="/ ?q=/ Bio...

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USC at Medicine News

Mushroom and muscle loss

According to a study in The New England Journal of Medicine, twelve people were hospitalized for severe weakness and muscle loss after eating the mushrooms, and three of them died, wrote Dr. Regis Bedry of the poison center of University Hospital Pellegrin in Bordeaux, France.Bedry said he confirmed the mushroom's toxicity by feeding extracts to mice and measuring creatine kinase, an enzy...

Loss Of Dystrophin: Common Thread In Cancer And MS Muscle Wasting

Recent research conducted at the Ohio State University shows that a wasting condition responsible for nearly a third of cancer deaths involves the loss of an essential muscle protein that is also lost in people with muscular // dystrophy. The study findings, which appear in the November issue of the journal Cancer Cell, show that muscle cells lose significant amounts of the protein dy...

Women more susceptible to brain damage from ecstasy

Women are more likely than men to suffer brain cell damage from long-term use of the party drug ecstasy but the harm can sometimes be reversed if they stop taking the drug. Studies have shown that the popular all-night dance drug, known chemically as MDMA, can damage nerve endings that release serotonin, a brain chemical that regulates mood, memory, sleep and sex. The drug also appears to...

Blood Pressure Drugs maintain muscle strength

Drugs used to reduce blood pressure could help to keep elderly people fitter for longer by slowing the physical decline that accompanies age.// ACE inhibitors prevent high blood pressure by blocking an enzyme that causes blood vessels to constrict. The drugs also help to preserve muscle strength in patients suffering from congestive heart failure (CHF). Researchers said the drug...

New treatment for muscle spasms

Stiff person syndrome (SPS) causes the muscles in the limbs and body to tighten up suddenly. Spasms can be triggered by noise, touch or emotional distress. People with the condition are often too disabled// to walk or move, or are afraid to leave the house in case they suffer a spasm and fall. The condition resembles chronic tetanus. Scientists have developed a highly effective treatment...

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USC at Medicine Products

Madlab Muscle Hook

Description:This device allows for quick and easy insertion of sutures during ophthalmic surgical procedures. The "Quick Hook" has an angled groove through which a suture may be passed into the eyelet during the loading procedure. The geometry of the groove prevents the suture from falling out unintentionally....
Company:Bausch & Lomb Storz

Culler Reclus Muscle Hook

Description:7 mm flattened hook. Flat serrated handle with polished finish. Overall length: 4.9 inches....
Company:Bausch & Lomb Storz

Scobee Oblique Muscle Hook

Description:Curved shaft with flat 4.5 mm hook. Flat serrated handle with polished finish. Overall length: 5.3 inches....
Company:Bausch & Lomb Storz

Jameson Muscle Hook

Description:2.0 mm bulbous tip with 6 mm flat portion. Flat serrated handle with polished finish. Overall length: 5.4 inches. Most popular size or model....
Company:Bausch & Lomb Storz

Jameson Muscle Hook - Small

Description:Small bulbous tip with flat sides. Flat serrated handle with polished finish. Overall length: 5.1 inches....
Company:Bausch & Lomb Storz

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USC at Medicine Technology

Accelreon Pharma's ACE-031Shown to Increase Muscle Mass in Preclinical Studies

LUCCA, ITALY, ­ May 14, 2007-Acceleron Pharma, Inc., abiopharmaceutical company developing therapeutics for the treatmentof musculoskeletal, metabolic and cancer-related diseases, todayannounced results of a preclinical study with ACE-031 thatdemonstrated the ability of the compound to increase muscle massand strength in normal mice and in murine models of musculardystrophy. ACE-031...

Acceleron Pharma's ACE-031 Increases Muscle Mass and Strength in Preclinical Studies

LUCCA, Italy--(BUSINESS WIRE)--May 14, 2007 - Acceleron Pharma,Inc., a biopharmaceutical company developing therapeutics for thetreatment of musculoskeletal, metabolic and cancer-relateddiseases, today announced results of a preclinical study withACE-031 that demonstrated the ability of the compound to increasemuscle mass and strength in normal mice and in murine models ofmuscular dystrophy...

PTC Therapeutics Announces Additional Positive Interim Phase 2 Results of PTC124 in Duchenne Muscular Dystrophy

Data Presented at 59th American Academy of Neurology Annual Meeting BOSTON and SOUTH PLAINFIELD, N.J., May 04, 2007 /PRNewswire/ --PTC Therapeutics, Inc. (PTC), a biopharmaceutical company focusedon the discovery and development of small-molecule drugs targetingpost-transcriptional control processes, today announced positiveinterim data from a Phase 2 clinical trial of PTC124 in patientsw...

Insmed Announces Promising Results From IPLEX Phase II Myotonic Muscular Dystrophy Clinical Study

RICHMOND, Va.--(BUSINESS WIRE)--May 3, 2007 - Insmed Inc.(Nasdaq:INSM) today announced positive results from a Phase IIinvestigator-sponsored study of the company's drug, IPLEX(TM), inpatients with myotonic muscular dystrophy (DM1). Preliminary results of the clinical study, being conducted atthe University of Rochester School of Medicine and Dentistry,showed that six months of treatment...

Novelos Therapeutics and MUSC Present Two Posters at AACR 2007 Annual Meeting

NEWTON, Mass.--(BUSINESS WIRE)--Apr 16, 2007 - NovelosTherapeutics, Inc. (OTCBB: NVLT), a biopharmaceutical companyfocused on the development of therapeutics to treat cancer andhepatitis, today announced that the company, in collaboration withDr. Kenneth Tew and Dr. Danyelle Townsend of the Medical Universityof South Carolina (MUSC), is making two poster presentations at theongoing American...

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USC at Medicine Definition

Muscle atrophy

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USC at Medicine Dictionary

Spinal muscular atrophy

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Smooth muscle

options with your h...

Resuscitation

(CPR) is a lifesaving technique useful in many <a href="/ ?q=/ Medicine-Dictionary/ emerge...

Muscular Dystrophies

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Muscular dystrophy

, <a href="/ ?q=/ Medicine-Dictionary/ contracture" class="...

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