Mitochondrial Protein Maintains Appetite During Fasting
...found that during fasting there was an increase in ucp2
as well as an increase in the type 2-deiodinase en... hypothalamus.
When the mitochondrial protein ucp2
was activated due to fasting, the number of mitoch...hers also showed that “knock-out” mice that lacked ucp2
or type 2 deiodinase ate less after fasting.
How appetite-stimulating brain cells work overtime during fasting
...eed, the researchers found, animals lacking either ucp2
or an enzyme that stimulates thyroid hormone's pro...cal thyroid production, in parallel with increased ucp2
This fasting-induced, T3-mediated ucp2
activation resulted in mitochondrial proliferation...
Gardenia fruit compound starting point for diabetes therapy
...In both animals and humans, high concentrations of ucp2
appear to inhibit insulin secretion from the pancr...k of type 2 diabetes.
"We think the increase in ucp2
activity is an important component of the pathogen...ical School. "Our goal therefore was to discover a ucp2
inhibitor capable of working in intact cells, as s...